References

nogr

Экспериментальная и клиническая гастроэнтерология

Experimental and Clinical Gastroenterology

1682-8658

«Global Media Technologies»

10.31146/1682-8658-ecg-229-9-110-118

nogr-2892

Research Article

КЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯ

CLINICAL GASTROENTEROLOGY

Саркопения и неалкогольная жировая болезнь печени - сложные патогенетические взаимосвязи

Sarcopenia and non-alcoholic fatty liver disease - complex pathogenetic relationships

https://orcid.org/0000-0002-7603-8481

Ахмедов

В. А.

Akhmedov

V. A.

v_akhmedov@mail.ru

Мариненко

В. С.

Marinenko

V. S.

noemail@neicon.ru

Федеральное государственное бюджетное образовательное учреждение высшего образования «Омский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияOmsk State Medical UniversityRussian Federation

Федеральное государственное бюджетное образовательное учреждение высшего образования «Майкопский государственный технологический университет»РоссияMaikop State University of TechnologyRussian Federation

2024

06032025

09110118

2025

Ахмедов В.А., Мариненко В.С.

Akhmedov V.A., Marinenko V.S.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.nogr.org/jour/article/view/2892

Саркопения и неалкогольная жировая болезнь печени (НАЖБП) являются частыми проблемами, ассоциированными со старением. Несмотря на различия в методах диагностики, в последние годы появилась серия исследований в которых была выявлена тесная связь между саркопенией и НАЖБП. Саркопения и НАЖБП связаны целым рядом общих патогенетических механизмов, которые рассмотрены в представленной статье, включая роль резистентности к инсулину как на уровне печени, так и на уровне мышц, гормональный дисбаланс, роль системного воспаления, нарушения регуляции миокинов, дефицит витамина Д, роль неправильного питания и гиподинамии, роли гепатокинов и гипераммониемии, что указывает на двунаправленную взаимосвязь между саркопенией и НАЖБП.

Sarcopenia and non-alcoholic fatty liver disease (NAFLD) are common problems associated with aging. Despite the differences in diagnostic methods, a series of studies have appeared in recent years that have revealed a close relationship between sarcopenia and NAFLD. Sarcopenia and NAFLD are associated with a number of common pathogenetic mechanisms, which are discussed in the present article, including the role of insulin resistance at both the liver and muscle levels, hormonal imbalance, the role of systemic inflammation, dysregulation of myokines, vitamin D deficiency, the role of malnutrition and inactivity, the role of hepatokines and hyperammonemia, which indicates the bidirectional relationship between sarcopenia and NAFLD.

Саркопениянеалкогольная жировая болезнь печениинсулинорезистентностьгепатокинытестостерон

Sarcopenianon-alcoholic fatty liver diseaseinsulin resistancehepatokinestestosterone

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The authors declare that there are no conflicts of interest present.