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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-229-9-75-85</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-2889</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Метаболически-ассоциированная жировая болезнь печени у детей: современный взгляд на патогенез, клинические особенности, методы диагностики и лечения</article-title><trans-title-group xml:lang="en"><trans-title>Metabolic-associated fatty liver disease in children: a modern view of the pathogenesis, clinical features, methods of diagnosis and treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1533-4498</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Комиссарова</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Komissarova</surname><given-names>M. Yu.</given-names></name></name-alternatives><email xlink:type="simple">komissarova_m_u@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-5292-5237</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мальцев</surname><given-names>Р. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Maltsev</surname><given-names>R. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-5463-7482</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филин</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Filin</surname><given-names>A. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-6186-4353</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алимов</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Alimov</surname><given-names>M. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9812-6899</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Евдокимова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Evdokimova</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0992-1709</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новикова</surname><given-names>В. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikova</surname><given-names>V. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ МО «Детский клинический центр им. Л.М. Рошаля»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Children’s Clinical Center named after L.M. Roshal</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО Санкт-Петербургский государственный педиатрический университет министерства здравоохранения РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg State Pediatric University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>06</day><month>03</month><year>2025</year></pub-date><volume>0</volume><issue>9</issue><fpage>75</fpage><lpage>85</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Комиссарова М.Ю., Мальцев Р.С., Филин А.М., Алимов М.М., Евдокимова Н.В., Новикова В.П., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Комиссарова М.Ю., Мальцев Р.С., Филин А.М., Алимов М.М., Евдокимова Н.В., Новикова В.П.</copyright-holder><copyright-holder xml:lang="en">Komissarova M.Y., Maltsev R.S., Filin A.M., Alimov M.M., Evdokimova N.V., Novikova V.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/2889">https://www.nogr.org/jour/article/view/2889</self-uri><abstract><p>Ожирение является одним из наиболее распространенных заболеваний в мире. По данным Всемирной Организации Здравоохранении (ВОЗ) в 2022 г. им страдали 890 миллионов людей. Среди них доля детского ожирения составляла 8,24%. За последние 32 года доля детского ожирения выросла на 6% и к 2022 году им страдало 160 млн детей. По динамике распространенности заболевания, ВОЗ предполагает, что на 2035 год количество детей и подростков от 5 до 19 лет, страдающих ожирением или избыточной массой тела, увеличится до 61% у мальчиков и 75% у девочек. По данным ВОЗ на 2022 г. в России частота детского ожирения колеблется от 4,45% до 8,4%. В структуре заболеваемости лица мужского пола преобладают над женским в соотношении 2:1. Одной из наиболее частых коморбидных патологий при ожирении является метаболически-ассоциированная жировая болезнь печени (МАЖБП), распространенность которой, на сегодняшний день, оценить не представляется возможным из-за недостаточно точных методов исследования. На данный момент отсутствуют клинические рекомендации, которые бы стандартизировали подход к диагностике и лечению этой коморбидной патологии, а также до сих пор актуален вопрос по поводу терминологии заболевания. Раннее выявление и терапия МАЖБП будут способствовать предупреждению развития необратимых изменений печени.</p></abstract><trans-abstract xml:lang="en"><p>Background: Obesity is one of the most common diseases in the world. According to the World Health Organization (WHO), 890 million people were suffering from it in 2022. Among them, the proportion of childhood obesity is 8,24%. Over the past 32 years, the proportion of childhood obesity has increased by 6% and 160 million children were suffering from it by 2022. According to the dynamics of the prevalence of the disease, WHO assumes that by 2035 the number of children and adolescents from 5 to 19 years old who are obese or overweight will increase to 61% in boys and 75% in girls. According to WHO data, the incidence of childhood obesity in Russia ranged from 4,45% to 8,4% by 2022. In the structure of morbidity, males predominate over females in the ratio 2:1. One of the most common comorbid pathologies in obesity is metabolically associated fatty liver disease (MAFLD), the prevalence of which, to date, cannot be estimated due to insufficiently accurate research methods. At the moment, there are no clinical recommendations that would standardize the approach to the diagnosis and treatment of this comorbid pathology, and the question of the terminology of the disease is still relevant. Early detection and therapy of MAFLD will help prevent the development of irreversible liver changes.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>метаболически-ассоциированная жировая болезнь печени</kwd><kwd>неалкогольная жировая болезнь печени</kwd><kwd>дети</kwd><kwd>ожирение</kwd><kwd>воспаление</kwd><kwd>биопсия печени</kwd><kwd>средиземноморская диета</kwd></kwd-group><kwd-group xml:lang="en"><kwd>metabolic-associated fatty liver disease</kwd><kwd>non-alcoholic fatty liver disease</kwd><kwd>children</kwd><kwd>obesity</kwd><kwd>inflammation</kwd><kwd>liver biopsy</kwd><kwd>mediterranean diet</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Milner E.B., Evdokimova N.V., Novikova V.P. et al. Cardiovascular risks in obese adolescents. Vopr. prakt. pediatr. (Clinical Practice in Pediatrics). 2022; 17(5): 83-89. 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