nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-227-7-24-28nogr-2776Research ArticleКЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯCLINICAL GASTROENTEROLOGYМаркеры дефицита витамина B12Markers of vitamin B12 deficiencyhttps://orcid.org/0000-0003-1496-0689ТарасоваЛ. В.TarasovaL. V.tlarisagast18@mail.ruhttps://orcid.org/0000-0002-8339-9496ЦыгановаЮ. В.TsyganovaYu. V.noemail@neicon.ruhttps://orcid.org/0000-0001-9610-5234СтепановаА. А.StepanovaA. A.noemail@neicon.ruФГБОУ ВО «Чувашский государственный университет имени И. Н. Ульянова»РоссияChuvash State University n. b. I. N. UlyanovRussian Federation202422102024072428Copyright © Тарасова Л.В., Цыганова Ю.В., Степанова А.А., 20242024Тарасова Л.В., Цыганова Ю.В., Степанова А.А.Tarasova L.V., Tsyganova Y.V., Stepanova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2776

Цель исследования: провести анализ зарубежных научных публикаций по исследованиям маркеров дефицита витамина B12. Материалы и методы исследования. Был проведен литературный обзор зарубежных научных публикаций. Поиск исследований проводился с помощью базы данных PubMed с использованием запросов по темам: vitamin B12 deficiency, markers of vitamin B12 deficiency, cobalamin deficiency, markers of cobalamin deficiency, indicators of cobalamin deficiency in the body. Кроме того, проводился поиск с использованием данных научной электронной библиотеки elibrary.ru. Результаты и обсуждение. В ходе изучения данных, представленных в зарубежных научных публикациях, мы пришли к выводу, что основными показателями дефицита витамина B12 в организме человека является ряд маркеров: холотранскобаламин, гомоцистеин, метилмалоновая кислота. Однако данные маркеры имеют ряд особенностей, в связи с чем, они не получили широкого клинического признания. Заключение. Результаты исследования позволяют оценить острую необходимость в поиске новых достоверных и доступных маркеров дефицита витамина B12.

The purpose of the research is to analyze foreign scientific publications on research on markers of vitamin B12 deficiency. Materials and methods of research. A literary review of foreign scientific publications was conducted. The research was searched using the PubMed database using queries on the following topics: vitamin B12 deficiency, markers of vitamin B12 deficiency, cobalamin deficiency, markers of cobalamin deficiency, indicators of cobalamin deficiency in the body. In addition, a search was conducted using data from the scientific electronic library elibrary.ru. Results and discussion. In the course of studying the data presented in foreign scientific publications, we came to the conclusion that the main indicators of vitamin B12 deficiency in the human body are a number of markers: holotranscobalamin, homocysteine, methylmalonic acid. However, these markers have a number of features, and therefore they have not received widespread clinical recognition. The results of the study. The results of the study allow us to assess the urgent need to search for new reliable and accessible markers of vitamin B12 deficiency.

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The authors declare that there are no conflicts of interest present.