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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">nogr-27</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ ФАРМАКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL PHARMACOLOGY</subject></subj-group></article-categories><title-group><article-title>ВОЗМОЖНОСТИ КОРРЕКЦИИ СЕКРЕТОРНОГО ИММУНИТЕТА У БОЛЬНЫХ С ИНФЕКЦИЕЙ HELICOBACTER PYLORI</article-title><trans-title-group xml:lang="en"><trans-title>THE CORRECTION OF THE LOCAL IMMUNE RESPONSE AT THE PATIENTS WITH HELICOBACTER PYLORI INFECTION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сарсенбаева</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sarsenbaeva</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смолягина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Smolyagina</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">Dodger.88@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахмедов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhmedov</surname><given-names>V. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО Южно-Уральский государственный медицинский университет МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>South Ural Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Гастроэнтерологический центр</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Chelyabinsk center of gastroenterology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБОУ ВПО Омский государственный медицинский университет МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Omsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>20</day><month>02</month><year>2016</year></pub-date><volume>0</volume><issue>2</issue><fpage>30</fpage><lpage>34</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сарсенбаева А.С., Смолягина А.В., Ахмедов В.А., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Сарсенбаева А.С., Смолягина А.В., Ахмедов В.А.</copyright-holder><copyright-holder xml:lang="en">Sarsenbaeva A.S., Smolyagina A.V., Akhmedov V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/27">https://www.nogr.org/jour/article/view/27</self-uri><abstract><p>Введение. Инфекция Helicobаcter pylori в силу высокой распространенности приковывает к себе взгляды исследователей во всем мире. Известно, что данный микроорганизм обитает не только в слизистой оболочке ЖКТ, но также определяется и в зубодесневом кармане. Цель работы - оценить возможности диагностики Helicobаcter pylori в полости рта и обосновать возможность включения в комплексную терапию препарата имудон. Результаты. На основании полученных результатов было выявлено, что включение топического иммуномодулятора имудон в комплексную терапию Helicobacter pylori-ассоциированных заболеваний приводит к снижению воспалительного потенциала за счет снижения концентрации TNFα, IL-6 в слюне и к повышению протективных свойств слюны в результате увеличения уровня муцина, а также достоверно снижает частоту рецидивов в течение года после проведенной терапии. Заключение. Практически важным для определения эффективности эрадикационной терапии является изучение содержимого зубо-десневого кармана для обнаружения генетического материала Helicobacter pylori, а также включать в комплексную терапию Helicobacter pylori-ассоциированных заболеваний иммуномодулятор имудон.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. Helicobacter pylori infection is due to the high prevalence in population attracts the clinical interest of researchers in the whole World. It is well known that this microorganism not only resides in the mucosa of the gastrointestinal tract, but is also defined in the periodontal pocket of the oral cavity. The aim of investigation - to evaluate Helicobacter pylori diagnostics in the mouth and prove a method of relief of the inflammatory process by applying immunomodulator Imudon. Results. On the basis of obtained results it was found that the inclusion of topical immunomodulator Imudon in the complex therapy of Helicobacter pylori-associated diseases leads to reduction of inflammatory potential through the decrease of the TNFα, IL-6 activity in saliva and to increase the protective properties of saliva as a result of increased levels of mucin, significantly reduces the frequency of relapses in the one year after therapy. Conclusion. It is practically important to determine the effectiveness of eradication therapy by the study of the contents of the tooth-gingival pocket for the detection of genetic material of Helicobacter pylori, as well as to include in the complex therapy of Helicobacter pylori-associated diseases of the immune modulator Imudon.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>зубодесневой карман</kwd><kwd>Имудон</kwd><kwd>полимеразная цепная реакция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Helicobаcter pylori</kwd><kwd>Helicobacter pylori</kwd><kwd>periodontal pocket</kwd><kwd>Imudon</kwd><kwd>polymerase chain reaction</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hunt RH, Xiao SD, Megraud F et al. Helicobacter pylori in developing countries. 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