nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-221-1-21-30nogr-2681Research ArticleКЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯCLINICAL GASTROENTEROLOGYИммунологические нарушения у детей с хроническим гастритом, ассоциированным с Helicobacter pylori и вирусом Эпштейна-БаррImmunological disorders in children with chronic gastritis associated with Helicobacter pylori and Epstein-Barr virushttps://orcid.org/0000-0002-5413-9599ВолынецГ. В.VolynetsG. V.volynec_g@mail.ruhttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinA. I.noemail@neicon.ruhttps://orcid.org/0000-0001-8837-9243НикитинА. В.NikitinA. V.noemail@neicon.ruhttps://orcid.org/0000-0002-6525-8665СкворцоваТ. А.SkvortsovaT. A.noemail@neicon.ruhttps://orcid.org/0009-0005-6939-4495КокиашвилиВ. С.KokiashviliV. S.noemail@neicon.ruНаучно-исследовательский клинический институт педиатрии и детской хирургии имени академика Ю.Е. Вельтищева ФГАОУ ВО РНИМУ им. Н. И. Пирогова Министерства здравоохранения Российской федерацииРоссияScientific Research Clinical Institute of Pediatrics and Pediatric Surgery named after Academician Yu.E. Veltishchev Federal State Autonomous Educational Institution of Russian National Research Medical University named after. N.I. Pirogov Ministry of Health of the Russian FederationRussian FederationНаучно-исследовательский клинический институт детства Министерства здравоохранения Московской областиРоссияResearch Clinical Institute of Childhood, Ministry of Health of the Moscow RegionRussian Federation202418012024012130Copyright © Волынец Г.В., Хавкин А.И., Никитин А.В., Скворцова Т.А., Кокиашвили В.С., 20242024Волынец Г.В., Хавкин А.И., Никитин А.В., Скворцова Т.А., Кокиашвили В.С.Volynets G.V., Khavkin A.I., Nikitin A.V., Skvortsova T.A., Kokiashvili V.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2681

Согласно современным представлениям, хронический гастрит - группа фенотипически схожих заболеваний, основой которых является поражение слизистой оболочки желудка различного генеза и различным потенциалом регенерации. Особый интерес представляет группа пациентов (в представленной статье - это дети), у которых поражения слизистой оболочки желудка ассоциированы с текущим инфекционным процессом обусловленным сочетанием двух причинно-значимых факторов - Helicobacter pylori (H. pylori) и вируса Эпштейна-Барр (ВЭБ). Полученные в результате исследования клеточного и гуморального звеньев иммунитета, аутоиимунитета и системы интеферона данные показывают значительные нарушения иммунологической реактивности у детей с хроническим гастритом, ассоциированным H. pylori и ВЭБ. Выявлены дисбаланс субпопуляций Т-лимфоцитов, нарушение функции В-лимфоцитов, дисиммуноглобулинемия и выраженный дисбаланс системы интерферонов с значительным снижением индуцированного синтеза ИФН-α и ИФН-γ лейкоцитами крови. Доказано угнетающее действие ВЭБ на различные звенья иммунитета, что обусловливает необходимость проведения иммунокорригирующего лечения. Результаты исследования могут свидетельствовать о триггерной роли ВЭБ в развитии аутоиммунного гастрита.

According to modern concepts, chronic gastritis is a group of phenotypically similar diseases, the basis of which is the lesion of the gastric mucosa of different genesis and different regeneration potential. Of particular interest is the group of patients (children in the presented article) in whom gastric mucosa lesions are associated with the current infectious process caused by a combination of two causative factors - Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV). The data obtained as a result of the study of cellular and humoral immunity, autoimmunity and interferon system show significant disorders of immunological reactivity in children with chronic gastritis associated with H. pylori and VEB. The imbalance of T-lymphocyte subpopulations, impaired function of B-lymphocytes, dysimmunoglobulinemia and pronounced imbalance of interferon system with a significant decrease in induced synthesis of IFN-α and IFN-γ by blood leukocytes were revealed. The suppressive effect of VEB on various links of immunity was proved, which necessitates immunocorrective treatment. The results of the study may indicate the trigger role of VEB in the development of autoimmune gastritis.

хронический гастритаутоиммунный гастритдетивирус Эпштейна-БаррHelicobacter pyloriсистема интерфероновВ лимфоцитыchronic gastritisautoimmune gastritischildrenEpstein-Barr virusHelicobacter pyloriinterferon systemB lymphocytesReferencesVolynets G.V. Etiological factors of chronic gastritis in children. Current pediatrics (Moscow). 2006; 5(3): 15-21. (in Russ)@@ Волынец Г.В. Этиологические факторы хронических гастритов у детей. Вопросы современной педиатрии. 2006; 5(3): 15-21.Volynets G.V. Etiological factors of chronic gastritis in children. Current pediatrics (Moscow). 2006; 5(3): 15-21. (in Russ)@@ Волынец Г.В. Этиологические факторы хронических гастритов у детей. Вопросы современной педиатрии. 2006; 5(3): 15-21.Volynets G.V., Khavkin A.I. Infectious markers and autoantibodies to parietal cells of the stomach in chronic gastritis in children. Journal of Infectology. 2017; 9(1): 49. (in Russ)@@ Волынец Г.В., Хавкин А.И. 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The authors declare that there are no conflicts of interest present.