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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-225-5-5-11</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-2665</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕРЕДОВАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LEADING ARTICLE</subject></subj-group></article-categories><title-group><article-title>Эндоскопическая картина псевдополипоза при воспалительных заболеваниях кишечника</article-title><trans-title-group xml:lang="en"><trans-title>Endoscopic picture of pseudopolyposis in inflammatory bowel diseases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9055-5357</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Будзинская</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Budzinskaya</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">anastasiya.budzinskaya@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4523-3337</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белоусова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Belousova</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6499-2852</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терещенко</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Tereschenko</surname><given-names>S. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-5568-2931</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лапаева</surname><given-names>Л. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Lapaeva</surname><given-names>L. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Государственное бюджетное учреждение здравоохранения Московской области «Московский областной научно-исследовательский институт имени М. Ф. Владимирского»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Regional Research and Clinical Institute</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>18</day><month>05</month><year>2024</year></pub-date><volume>0</volume><issue>5</issue><fpage>5</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Будзинская А.А., Белоусова Е.А., Терещенко С.Г., Лапаева Л.Г., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Будзинская А.А., Белоусова Е.А., Терещенко С.Г., Лапаева Л.Г.</copyright-holder><copyright-holder xml:lang="en">Budzinskaya A.A., Belousova E.A., Tereschenko S.G., Lapaeva L.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/2665">https://www.nogr.org/jour/article/view/2665</self-uri><abstract><p>Цель. Оценить частоту встречаемости псевдополипов (ПП), а также их гистологическую структуру у больных с воспалительными заболеваниями кишечника (ВЗК). Материалы и методы. Было обследовано 165 пациентов с ВЗК (113 - с язвенным колитом (ЯК), 52 - с болезнью Крона (БК)). Всем пациентам проводилась илеоколоноскопия со взятием материала для гистологического исследования в случае, если были выявлены псевдополипы. Результаты исследования. Выявлено, что псевдополипы встречались в 27% у больных с ВЗК (при ЯК - в 29%, БК - 23%). В разные фазы воспалительного процесса при ЯК количество ПП было сопоставимо между собой. При БК статистически значимо чаще ПП были выявлены в стадии рубцов и вне обострения, чем в фазы инфильтрации и язв. При гистологическом исследовании биопсийного материала из ткани ПП чаще всего мы верифицировали гиперплазию, воспалительный полип и грануляционную ткань. Аденома была выявлена у двух пациентов при ЯК и БК. Крипт-абсцессы и дискомплексация крипт были обнаружены только при обострении ЯК. Заключение. Исходя из результатов нашего исследования, псевдополипы встречаются и при ЯК, и при БК в разные фазы воспалительного процесса, что говорит об отсутствии специфичности данных новообразований для какого-либо из ВЗК. Выявление большого количества ПП при выраженной стадии ЯК, на наш взгляд, говорит о связи ПП с агрессивно протекающей атакой, что может послужить одним из критериев прогноза течения ЯК. Клеточный состав ПП в большинстве случаев отражал воспаление или заживление эрозивно-язвенных дефектов, а также в небольшом количестве случаев - наличие аденомы. Таким образом, ПП требуют тщательного осмотра при проведении эндоскопического исследования, при возникновении подозрений на наличие неоплазии или дисплазии в ткани ПП необходимо взятие биоптатов для гистологического исследования.</p></abstract><trans-abstract xml:lang="en"><p>Aim. To evaluate the frequency of pseudopolypes (PP), as well as their histological structure in patients with inflammatory bowel diseases (IBD). Materials and methods. 165 patients with IBD were examined (113 with ulcerative colitis (UC), 52 with Crohn’s disease (CD)). All patients underwent ileocolonoscopy with taking the material for histological examination in case pseudopolypes were detected. Results. It was revealed that pseudopolypes were found in 27% of patients with IBD (in UC - in 29%, CD - 23%). In different phases of the inflammatory process in UC, the number of PP was comparable to each other. In CD, PP was statistically significantly more often detected at the stage of scars and outside of exacerbation than in the phases of infiltration and ulcers. During histological examination of biopsy material from PP tissue hyperplasia, inflammatory polyp and granulation tissue were verified. Adenoma was detected in one case in each of the IBD. Crypt abscesses and crypt discomplexation were found only with exacerbation of UC. Conclusion. Based on the results of our study, pseudopolypes occur in both UC and CD in different phases of the inflammatory process, which indicates the absence of specificity of these tumors for any of the IBD. The identification of a large number of PP at a pronounced stage of UC, in our opinion, indicates the connection of PP with an aggressive attack, which can serve as one of the criteria for predicting the course of UC. The cellular composition of PP in most cases reflected inflammation or healing of erosive and ulcerative defects, as well as in a small number of cases, the presence of adenoma. Thus, PP requires careful examination during endoscopic examination, if there is a suspicion of neoplasia or dysplasia in the PP tissue, biopsies must be taken for histological examination.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>воспалительные заболевания кишечника</kwd><kwd>псевдополипы</kwd><kwd>малигнизация</kwd><kwd>колоректальный рак</kwd></kwd-group><kwd-group xml:lang="en"><kwd>inflammatory bowel diseases</kwd><kwd>pseudopolypes</kwd><kwd>malignancy</kwd><kwd>colorectal cancer</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Recommendations of the Russian Gastroenterological Association and the Russian Association of Coloproctologists for the diagnosis and treatment of adult patients with ulcerative colitis. (In Russ.) Available at: http://cr.rosminzdrav.ru/schema/193_1#doc_a12020. 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