nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-220-12-148-163nogr-2662Research ArticleОБЗОРREVIEWСовременные представления об этиологии и патогенезе воспалительных заболеваний кишечника (Часть 1): роль иммунной системы, генетических и эпигенетических факторовCurrent understanding of the aetiology and pathogenesis of inflammatory bowel diseases (Part 1): the role of the immune system, genetic and epigenetic factorshttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinA. I.khavkin@nikid.ruhttps://orcid.org/0000-0001-8364-6066НиколайчукК. М.NikolaychukK. M.noemail@neicon.ruhttps://orcid.org/0000-0003-3606-4068ШрайнерЕ. В.ShraynerE. V.noemail@neicon.ruhttps://orcid.org/0009-0009-7816-5562ШаймардановаД. Р.ShaimardanovaD. R.noemail@neicon.ruhttps://orcid.org/0009-0002-9228-2350ВеременкоА. С.VeremenkoA. S.noemail@neicon.ruhttps://orcid.org/0009-0002-7317-6077ЛевченкоИ. Д.LevchenkoI. D.noemail@neicon.ruhttps://orcid.org/0009-0004-1880-9585ПлатоноваП. Я.PlatonovaP. Ya.noemail@neicon.ruhttps://orcid.org/0009-0008-7479-8277НовиковаМ. Ф.NovikovaM. F.noemail@neicon.ruhttps://orcid.org/0000-0002-6271-5218ДудуричВ. В.DudurichV. V.noemail@neicon.ruНаучно-исследовательский клинический институт детства Министерства здравоохранения Московской области; Белгородский государственный исследовательский университет Министерства науки и высшего образования Российской ФедерацииРоссияResearch Clinical Institute of Childhood, Ministry of Health of the Moscow Region; Belgorod State Research UniversityRussian FederationНовосибирский государственный университетРоссияNovosibirsk State UniversityRussian FederationНовосибирский государственный университет; Институт химической биологии и фундаментальной медицины СО РАНРоссияNovosibirsk State University; Institute of Chemical Biology and Fundamental Medicine of the SB RASRussian FederationФедеральное государственное автономное образовательное учреждение высшего образования «Национальный исследовательский университет ИТМО»; «Сербалаб» генетическая лабораторияРоссияITMO National Research University; “Сerbalab” laboratoryRussian Federation202318122023012148163Copyright © Хавкин А.И., Николайчук К.М., Шрайнер Е.В., Шаймарданова Д.Р., Веременко А.С., Левченко И.Д., Платонова П.Я., Новикова М.Ф., Дудурич В.В., 20232023Хавкин А.И., Николайчук К.М., Шрайнер Е.В., Шаймарданова Д.Р., Веременко А.С., Левченко И.Д., Платонова П.Я., Новикова М.Ф., Дудурич В.В.Khavkin A.I., Nikolaychuk K.M., Shrayner E.V., Shaimardanova D.R., Veremenko A.S., Levchenko I.D., Platonova P.Y., Novikova M.F., Dudurich V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2662

Воспалительные заболевания кишечника (ВЗК) в последние годы в клинической практике и становятся предметом многочисленных научных исследований. Настоящий обзор подробно рассматривает ключевые аспекты патогенеза ВЗК, включая роль иммунной системы, стромальных компонентов и генетических факторов. Особое внимание уделяется взаимодействию этих факторов и их влиянию на развитие и течение заболевания. Данный обзор стремится предоставить комплексное понимание механизмов развития ВЗК и выявить потенциальные направления для диагностики, терапии и профилактики. Основное содержание статьи охватывает последние научные данные и клинические наблюдения в области гастроэнтерологии, делая акцент на интеграции различных дисциплин в понимании и лечении ВЗК.

Inflammatory bowel diseases (IBD) have become the subject of numerous scientific studies in clinical practice in recent years. The review is examines in detail key aspects of IBD pathogenesis, including the role of the immune system, stromal components and genetic factors. Particular attention have been paid to the interaction of these factors and influence on the development and course of the disease. The review’s aims to provide a comprehensive understanding of the mechanisms of IBD development and identify potential avenues for diagnosis, therapy and prevention. The main content of the article covers the latest scientific data and clinical observations in the field of gastroenterology, emphasizing the integration of various disciplines in the understanding and treatment of IBD.

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The authors declare that there are no conflicts of interest present.