<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-220-12-4-18</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-2646</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕРЕДОВАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LEADING ARTICLE</subject></subj-group></article-categories><title-group><article-title>Метабиотики - новое направление эффективной профилактики и лечения заболеваний</article-title><trans-title-group xml:lang="en"><trans-title>Metabiotics - a new direction in the effectiveness of disease prevention and treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткаченко</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkachenko</surname><given-names>E. I.</given-names></name></name-alternatives><email xlink:type="simple">tkachenkoe@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дадали</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dadali</surname><given-names>V. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБВОУ ВО «Военно-медицинская академия имени С. М. Кирова» МО РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Military Medical Academy named after S. M. Kirov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И. И. Мечникова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-Western State Medical University named after I. I. Mechnikov, Ministry of Health of Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>18</day><month>12</month><year>2023</year></pub-date><volume>0</volume><issue>12</issue><fpage>4</fpage><lpage>18</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ткаченко Е.И., Дадали В.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Ткаченко Е.И., Дадали В.А.</copyright-holder><copyright-holder xml:lang="en">Tkachenko E.I., Dadali V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/2646">https://www.nogr.org/jour/article/view/2646</self-uri><abstract><p>Авторы рассматривают симбиотическую микробиоту организма человека как ведущий фактор здоровья всего организма, которым следует управлять в целях профилактики и лечения различных заболеваний и возможности применяемых для этой цели метабиотиков и таргетных метабиотиков как наиболее перспективного направления лечения и профилактики заболеваний различных органов. Отмечено, что Россия - одна из первых стран, оценивших биотехнологические перспективы и важность создания метабиотиков различного назначения, способных предотвращать, восстанавливать и регулировать физиологические функции, биохимические и поведенческие реакции, сигнальные внутри- и межклеточные коммуникации, эпигенетическую регуляцию экспрессии генов и посттрансляционную модификацию их конечных продуктов.</p></abstract><trans-abstract xml:lang="en"><p>The authors consider the symbiotic microbiota of the human body as a leading factor in the health of the entire body, which should be managed in order to prevent and treat various diseases and possibilities of metabiotics and targeted metabiotics used for this purpose as the most promising direction for the treatment and prevention of diseases of various organs. It was noted that Russia is one of the first countries to assess biotechnological prospects and the importance of creating metabiotics for various purposes, capable of preventing, restoring and regulating physiological functions, biochemical and behavioral responses, signaling intra and intercellular communications, epigenetic regulation of gene expression and post-translational modification of their final products.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>микробиота</kwd><kwd>дисбиоз</kwd><kwd>метабиотики</kwd><kwd>таргетные метабиотики</kwd><kwd>пребиотики</kwd><kwd>пробиотики</kwd><kwd>межклеточные коммуникации</kwd><kwd>иммунитет</kwd><kwd>ноосфера</kwd></kwd-group><kwd-group xml:lang="en"><kwd>microbiota</kwd><kwd>dysbiosis</kwd><kwd>metabiotics</kwd><kwd>targeted metabiotics</kwd><kwd>prebiotics</kwd><kwd>probiotics</kwd><kwd>intercellular communications</kwd><kwd>immunity</kwd><kwd>noosphere</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Vernadsky V. I. Biosphere and noosphere. Мoscow. Ayris-Press. 2013. 569 Р. (In Russ.)@@ Вернадский В. И. Биосфера и ноосфера. М.: Айрис-Пресс; 2013. - 569 С.</mixed-citation><mixed-citation xml:lang="en">Vernadsky V. I. Biosphere and noosphere. Мoscow. Ayris-Press. 2013. 569 Р. (In Russ.)@@ Вернадский В. И. Биосфера и ноосфера. М.: Айрис-Пресс; 2013. - 569 С.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kondrat’ev K. Ya., Krapivin V. F., Savinykh V. P. Prospects for the development of civilization: a multivariate analysis. Мoscow. Logos. 2003. 573 Р. (InRuss.)@@ Кондратьев К. Я., Крапивин В. Ф., Савиных В. П. Перспективы развития цивилизации. Многомерный анализ. М.: Логос; 2003. - 573 С.</mixed-citation><mixed-citation xml:lang="en">Kondrat’ev K. Ya., Krapivin V. F., Savinykh V. P. Prospects for the development of civilization: a multivariate analysis. Мoscow. Logos. 2003. 573 Р. (InRuss.)@@ Кондратьев К. Я., Крапивин В. Ф., Савиных В. П. Перспективы развития цивилизации. Многомерный анализ. М.: Логос; 2003. - 573 С.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Yuval Noah Harari. Sapiens. A Brief History of Humancind. Moscow. Sindbad. 2020. 512 Р.</mixed-citation><mixed-citation xml:lang="en">Yuval Noah Harari. Sapiens. A Brief History of Humancind. Moscow. Sindbad. 2020. 512 Р.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Stefen Hawking. Briff Answers To The Big Questions. Moscow. Bombora. 2019. 256 P.</mixed-citation><mixed-citation xml:lang="en">Stefen Hawking. Briff Answers To The Big Questions. Moscow. Bombora. 2019. 256 P.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ugolev A. M. Trophology is a new interdisciinteplinary science. Vestnik AN SSSR. 1980; 1: 50-61. (In Russ.)@@ Уголев.A.M. Трофология - новая междисциплинарная наука Вестник АН СССР. 1980; 1: 50-61.</mixed-citation><mixed-citation xml:lang="en">Ugolev A. M. Trophology is a new interdisciinteplinary science. Vestnik AN SSSR. 1980; 1: 50-61. (In Russ.)@@ Уголев.A.M. Трофология - новая междисциплинарная наука Вестник АН СССР. 1980; 1: 50-61.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ugolev A. M. Theory of adequate nutrition and tropholoqy. SPb. Nauka publishing Hause. 1991. 271 P. (InRuss.)@@ Уголев А. М. Теория адекватного питания и трофология. СПб.: Наука. -1991. -271 С.</mixed-citation><mixed-citation xml:lang="en">Ugolev A. M. Theory of adequate nutrition and tropholoqy. SPb. Nauka publishing Hause. 1991. 271 P. (InRuss.)@@ Уголев А. М. Теория адекватного питания и трофология. СПб.: Наука. -1991. -271 С.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Shenderov B. A., Tkachenko E. I., Lazebnik L. B., Ardatskaya M. D., Sinitsa A. V., Zakharchenko M. M. Metabiotics - noveltechnology of protective and treatment of diseases associated with microecological imbalance in human being. Experimental and Clinical Gastroenterology. 2018;151(3):83-92. (In Russ.)@@ Шендеров Б. А., Ткаченко Е. И., Лазебник Л. Б., Ардатская М. Д., Синица А. В., Захарченко М. М. Метабиотики - новая технология профилактики и лечения заболеваний, связанных с микроэкологическими нарушениями в организме человека. Экспериментальная и клиническая гастроэнтерология. 2018;151(3):83-92.</mixed-citation><mixed-citation xml:lang="en">Shenderov B. A., Tkachenko E. I., Lazebnik L. B., Ardatskaya M. D., Sinitsa A. V., Zakharchenko M. M. Metabiotics - noveltechnology of protective and treatment of diseases associated with microecological imbalance in human being. Experimental and Clinical Gastroenterology. 2018;151(3):83-92. (In Russ.)@@ Шендеров Б. А., Ткаченко Е. И., Лазебник Л. Б., Ардатская М. Д., Синица А. В., Захарченко М. М. Метабиотики - новая технология профилактики и лечения заболеваний, связанных с микроэкологическими нарушениями в организме человека. Экспериментальная и клиническая гастроэнтерология. 2018;151(3):83-92.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Oleskin A. V., Shenderov B. A., Rogovsky V. S. Sociality of microorganisms and relationships in the microbiota-host system. The role of neurotransmitters. Moscow. publishing house of Moscow state University. 2020. 286 P. (In Russ.)@@ Олескин А. В., Шендеров Б. А., Роговский В. С. Социальность микроорганизмов и взаимоотношения в системе микробиота-хозяин. Роль нейромедиаторов. М., изд МГУ. - 2020. -286 С.</mixed-citation><mixed-citation xml:lang="en">Oleskin A. V., Shenderov B. A., Rogovsky V. S. Sociality of microorganisms and relationships in the microbiota-host system. The role of neurotransmitters. Moscow. publishing house of Moscow state University. 2020. 286 P. (In Russ.)@@ Олескин А. В., Шендеров Б. А., Роговский В. С. Социальность микроорганизмов и взаимоотношения в системе микробиота-хозяин. Роль нейромедиаторов. М., изд МГУ. - 2020. -286 С.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012 Jun 13;486(7402):207-14. doi: 10.1038/nature11234.</mixed-citation><mixed-citation xml:lang="en">Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012 Jun 13;486(7402):207-14. doi: 10.1038/nature11234.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Syromyatnikov M., Nesterova E., Gladkikh M. et al. Characteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions. Microorganisms. 2022;10:1866. doi: 10.3390/microorganisms10091866.</mixed-citation><mixed-citation xml:lang="en">Syromyatnikov M., Nesterova E., Gladkikh M. et al. Characteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions. Microorganisms. 2022;10:1866. doi: 10.3390/microorganisms10091866.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Petersen C., Round J. L. Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol. 2014 Jul;16(7):1024-33. doi: 10.1111/cmi.12308.@@ Руш К., Петерс У. Кишечник -центр управления иммунной системы. Биологическая медицина 2003. - Март. - С. 4-8.</mixed-citation><mixed-citation xml:lang="en">Petersen C., Round J. L. Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol. 2014 Jul;16(7):1024-33. doi: 10.1111/cmi.12308.@@ Руш К., Петерс У. Кишечник -центр управления иммунной системы. Биологическая медицина 2003. - Март. - С. 4-8.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Rusch K., Peters U.Intestines - the control center of the immune system. Bio. med. 2003: 4-8. (in Russ.)</mixed-citation><mixed-citation xml:lang="en">Rusch K., Peters U.Intestines - the control center of the immune system. Bio. med. 2003: 4-8. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Shenderov B. A. Functional nutrition and its rolе of the prevrntionofmetabolic diseases. Moscow. DeLhiprint. 2008. 319 Р. (In Russ.)@@ Шендеров Б. А. Функциональное питание и его роль в профилактике метаболических заболеваний. - М., ДеЛипринт. - 2008. - 319 С.</mixed-citation><mixed-citation xml:lang="en">Shenderov B. A. Functional nutrition and its rolе of the prevrntionofmetabolic diseases. Moscow. DeLhiprint. 2008. 319 Р. (In Russ.)@@ Шендеров Б. А. Функциональное питание и его роль в профилактике метаболических заболеваний. - М., ДеЛипринт. - 2008. - 319 С.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Shenderov B. A., Sinitca A. V., Zacharhenko M. M. Modern methods and technologies for restoring eating disorders and nutritional imbalances in humans. Donosologic and healthy lifestyle. 2018;1(22):76-87. (In Russ.)@@ Шендеров Б. А., Синица А. В., Захарченко М. М. Приемы и технологии восстановления нарушений пищевого поведения и дисбаланса питания у современного человека. // Донозология и здоровый образ жизни.-2018. - № 1(22). - С. 76-87.</mixed-citation><mixed-citation xml:lang="en">Shenderov B. A., Sinitca A. V., Zacharhenko M. M. Modern methods and technologies for restoring eating disorders and nutritional imbalances in humans. Donosologic and healthy lifestyle. 2018;1(22):76-87. (In Russ.)@@ Шендеров Б. А., Синица А. В., Захарченко М. М. Приемы и технологии восстановления нарушений пищевого поведения и дисбаланса питания у современного человека. // Донозология и здоровый образ жизни.-2018. - № 1(22). - С. 76-87.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ocovityy S. V., Shulenin S. N., Smirnov A. V. Clinical pharmacology of antihypoxants and antioxidants. SPb., Pharmindex. 2005. 72 Р. (InRuss.)@@ Оковитый С. В., Шуленин С. Н., Смирнов А. В., Клиническая фармакология антигипоксантов и антиоксидантов. СПб., Фарминдекс. 2005. 72 С.</mixed-citation><mixed-citation xml:lang="en">Ocovityy S. V., Shulenin S. N., Smirnov A. V. Clinical pharmacology of antihypoxants and antioxidants. SPb., Pharmindex. 2005. 72 Р. (InRuss.)@@ Оковитый С. В., Шуленин С. Н., Смирнов А. В., Клиническая фармакология антигипоксантов и антиоксидантов. СПб., Фарминдекс. 2005. 72 С.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Sitkin S. I., Tkachenko E. I., Vachitov T Ya. Metabolic intestinal dysbiosis and its biomarkers. Exp. Kiln. gastroenterol. 2015;124(12):6-29. (In Russ.)@@ Ситкин С. И., Ткаченко Е. И., Вахитов Т. Я. Метаболический дисбиоз кишечника и его биомаркеры. Экспериментальная и клиническая гастроэнтерология. 2015; 124 (12): 6-29.</mixed-citation><mixed-citation xml:lang="en">Sitkin S. I., Tkachenko E. I., Vachitov T Ya. Metabolic intestinal dysbiosis and its biomarkers. Exp. Kiln. gastroenterol. 2015;124(12):6-29. (In Russ.)@@ Ситкин С. И., Ткаченко Е. И., Вахитов Т. Я. Метаболический дисбиоз кишечника и его биомаркеры. Экспериментальная и клиническая гастроэнтерология. 2015; 124 (12): 6-29.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Sitkin S. I., Tkachenko E. I., Vakhitov T. Ya. Phylometabolic core of intestinal microbiota. Almanac of Clinical Medicine. 2015; 40:12-34 (in Russ.)@@ Ситкин С. И., Ткаченко Е. И., Вахитов Т. Я. Филометаболическое ядро микробиоты кишечника. Альманах клинической медицины. 2015; 40:12-34.</mixed-citation><mixed-citation xml:lang="en">Sitkin S. I., Tkachenko E. I., Vakhitov T. Ya. Phylometabolic core of intestinal microbiota. Almanac of Clinical Medicine. 2015; 40:12-34 (in Russ.)@@ Ситкин С. И., Ткаченко Е. И., Вахитов Т. Я. Филометаболическое ядро микробиоты кишечника. Альманах клинической медицины. 2015; 40:12-34.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Sitkin S. I., Vachitov T Ya. Dyachova E. V. Microbiome, colon dysbiosis and inflammatore bovel disorder. When function is more impotent than taxonomy. Almanach of clinical medicine. 2018;46(5):396-425. (In Russ.)@@ Ситкин С. И., Вахитов Т. Я., Дьякова Е. В. Микробиом, дисбиоз толстой кишки и воспалительныезаболевания кишечника: когда функция важнее таксономии. Альманах клинической медицины. -2018. -46(5). - С. 396-425.</mixed-citation><mixed-citation xml:lang="en">Sitkin S. I., Vachitov T Ya. Dyachova E. V. Microbiome, colon dysbiosis and inflammatore bovel disorder. When function is more impotent than taxonomy. Almanach of clinical medicine. 2018;46(5):396-425. (In Russ.)@@ Ситкин С. И., Вахитов Т. Я., Дьякова Е. В. Микробиом, дисбиоз толстой кишки и воспалительныезаболевания кишечника: когда функция важнее таксономии. Альманах клинической медицины. -2018. -46(5). - С. 396-425.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ardatskaya M. D. Probiotics, prebiotics and metabiotics in the correction of microecological disorders of the intestine. Medical Advice. 2015;13:94-99. (In Russ.)@@ Ардатская М. Д. Пробиотики, пребиотики и метабиотики в коррекции микроэкологических нарушений кишечника. Медицинский совет. -2015. - № 13. - С. 94-99.</mixed-citation><mixed-citation xml:lang="en">Ardatskaya M. D. Probiotics, prebiotics and metabiotics in the correction of microecological disorders of the intestine. Medical Advice. 2015;13:94-99. (In Russ.)@@ Ардатская М. Д. Пробиотики, пребиотики и метабиотики в коррекции микроэкологических нарушений кишечника. Медицинский совет. -2015. - № 13. - С. 94-99.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Shenderov B. A. Normal microflora and its role in maintaining human health.Russian Journal of Gastroenterology, Hepatology, Coloproctology. 1998;(1):61-65.(In Russ.)@@ Шендеров Б. А. Нормальная микрофлора и ее роль в поддержании здоровья человека. // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. -1998. - № 1. - C. 61-65.</mixed-citation><mixed-citation xml:lang="en">Shenderov B. A. Normal microflora and its role in maintaining human health.Russian Journal of Gastroenterology, Hepatology, Coloproctology. 1998;(1):61-65.(In Russ.)@@ Шендеров Б. А. Нормальная микрофлора и ее роль в поддержании здоровья человека. // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. -1998. - № 1. - C. 61-65.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Frank D. N., St Amand A. L., Feldman R. A., Boedeker E. C., Harpaz N., Pace N. R. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13780-5. doi: 10.1073/pnas.0706625104.</mixed-citation><mixed-citation xml:lang="en">Frank D. N., St Amand A. L., Feldman R. A., Boedeker E. C., Harpaz N., Pace N. R. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13780-5. doi: 10.1073/pnas.0706625104.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Karlsson F. H., Tremaroli V., Nookaew I., Bergström G., Behre C. J., Fagerberg B., Nielsen J., Bäckhed F. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature. 2013 Jun 6;498(7452):99-103. doi: 10.1038/nature12198.</mixed-citation><mixed-citation xml:lang="en">Karlsson F. H., Tremaroli V., Nookaew I., Bergström G., Behre C. J., Fagerberg B., Nielsen J., Bäckhed F. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature. 2013 Jun 6;498(7452):99-103. doi: 10.1038/nature12198.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Abrahamsson T. R., Jakobsson H. E., Andersson A. F., Björkstén B., Engstrand L., Jenmalm M. C. Low gut microbiota diversity in early infancy precedes asthma at school age. Clin Exp Allergy. 2014 Jun;44(6):842-50. doi: 10.1111/cea.12253.</mixed-citation><mixed-citation xml:lang="en">Abrahamsson T. R., Jakobsson H. E., Andersson A. F., Björkstén B., Engstrand L., Jenmalm M. C. Low gut microbiota diversity in early infancy precedes asthma at school age. Clin Exp Allergy. 2014 Jun;44(6):842-50. doi: 10.1111/cea.12253.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Parracho H. M., Bingham M. O., Gibson G. R., McCartney A. L. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J Med Microbiol. 2005 Oct;54(Pt 10):987-991. doi: 10.1099/jmm.0.46101-0.</mixed-citation><mixed-citation xml:lang="en">Parracho H. M., Bingham M. O., Gibson G. R., McCartney A. L. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J Med Microbiol. 2005 Oct;54(Pt 10):987-991. doi: 10.1099/jmm.0.46101-0.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmed I., Roy B. C., Khan S. A., Septer S., Umar S. Microbiome, Metabolome and Inflammatory Bowel Disease. Microorganisms. 2016 Jun 15;4(2):20. doi: 10.3390/microorganisms4020020.</mixed-citation><mixed-citation xml:lang="en">Ahmed I., Roy B. C., Khan S. A., Septer S., Umar S. Microbiome, Metabolome and Inflammatory Bowel Disease. Microorganisms. 2016 Jun 15;4(2):20. doi: 10.3390/microorganisms4020020.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Jamshidi P., Hasanzadeh S., Tahvildari A., Farsi Y., Arbabi M., Mota J. F., Sechi L. A., Nasiri M. J. Is there any association between gut microbiota and type 1 diabetes? A systematic review. Gut Pathog. 2019 Oct 14;11:49. doi: 10.1186/s13099-019-0332-7.</mixed-citation><mixed-citation xml:lang="en">Jamshidi P., Hasanzadeh S., Tahvildari A., Farsi Y., Arbabi M., Mota J. F., Sechi L. A., Nasiri M. J. Is there any association between gut microbiota and type 1 diabetes? A systematic review. Gut Pathog. 2019 Oct 14;11:49. doi: 10.1186/s13099-019-0332-7.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Mizutani T., Ishizaka A., Koga M., Tsutsumi T., Yotsuyanagi H. Role of Microbiota in Viral Infections and Pathological Progression. Viruses. 2022 May 1;14(5):950. doi: 10.3390/v14050950.</mixed-citation><mixed-citation xml:lang="en">Mizutani T., Ishizaka A., Koga M., Tsutsumi T., Yotsuyanagi H. Role of Microbiota in Viral Infections and Pathological Progression. Viruses. 2022 May 1;14(5):950. doi: 10.3390/v14050950.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Shenderov B.A., Sinitca A. V., Zacharhenko M.M, Lang C. Metabiotics. Present State, Challenges and Perspectives. Springer Nature Switzerland AG. 2020. 123Р. doi: 10.1007/978-3-030-34167-1.</mixed-citation><mixed-citation xml:lang="en">Shenderov B.A., Sinitca A. V., Zacharhenko M.M, Lang C. Metabiotics. Present State, Challenges and Perspectives. Springer Nature Switzerland AG. 2020. 123Р. doi: 10.1007/978-3-030-34167-1.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Budden K. F., Gellatly S. L., Wood D. L., Cooper M. A., Morrison M., Hugenholtz P., Hansbro P. M. Emerging pathogenic links between microbiota and the gut-lung axis. Nat Rev Microbiol. 2017 Jan;15(1):55-63. doi: 10.1038/nrmicro.2016.142.</mixed-citation><mixed-citation xml:lang="en">Budden K. F., Gellatly S. L., Wood D. L., Cooper M. A., Morrison M., Hugenholtz P., Hansbro P. M. Emerging pathogenic links between microbiota and the gut-lung axis. Nat Rev Microbiol. 2017 Jan;15(1):55-63. doi: 10.1038/nrmicro.2016.142.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Sonnenburg J. L., Bäckhed F. Diet-microbiota interactions as moderators of human metabolism. Nature. 2016 Jul 7;535(7610):56-64. doi: 10.1038/nature18846.</mixed-citation><mixed-citation xml:lang="en">Sonnenburg J. L., Bäckhed F. Diet-microbiota interactions as moderators of human metabolism. Nature. 2016 Jul 7;535(7610):56-64. doi: 10.1038/nature18846.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Beloborodova N. V., Osipov G. A. Small molecules originating from microbes (SMOM) and their role in microbes-host relationship. Microbial Ecologyin Health and Disease. 2000; 12: 12-21. doi: 10.1080/089106000435545.</mixed-citation><mixed-citation xml:lang="en">Beloborodova N. V., Osipov G. A. Small molecules originating from microbes (SMOM) and their role in microbes-host relationship. Microbial Ecologyin Health and Disease. 2000; 12: 12-21. doi: 10.1080/089106000435545.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Galland L. The gut microbiome and the brain. J Med Food. 2014 Dec;17(12):1261-72. doi: 10.1089/jmf.2014.7000.</mixed-citation><mixed-citation xml:lang="en">Galland L. The gut microbiome and the brain. J Med Food. 2014 Dec;17(12):1261-72. doi: 10.1089/jmf.2014.7000.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Mills S., Stanton C., Lane J. A., Smith G. J., Ross R. P. Precision Nutrition and the Microbiome, Part I: Current State of the Science. Nutrients. 2019 Apr 24;11(4):923. doi: 10.3390/nu11040923.</mixed-citation><mixed-citation xml:lang="en">Mills S., Stanton C., Lane J. A., Smith G. J., Ross R. P. Precision Nutrition and the Microbiome, Part I: Current State of the Science. Nutrients. 2019 Apr 24;11(4):923. doi: 10.3390/nu11040923.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Shenderov B. A. Medical microbial ecology and functional nutrition. Vol.3. Probiotics and functional nutrition. Moscow. Grant Publishing House. 2001. 287 p. (In Russ.) ISBN 5-89135-177-3.@@ Шендеров Б. А. Медицинская микробная экология и функциональное питание. Т. 3. Пробиотики и функциональное питание. М. - 2001. - Изд-во Грантъ, - 287 с. ISBN 5-89135-177.</mixed-citation><mixed-citation xml:lang="en">Shenderov B. A. Medical microbial ecology and functional nutrition. Vol.3. Probiotics and functional nutrition. Moscow. Grant Publishing House. 2001. 287 p. (In Russ.) ISBN 5-89135-177-3.@@ Шендеров Б. А. Медицинская микробная экология и функциональное питание. Т. 3. Пробиотики и функциональное питание. М. - 2001. - Изд-во Грантъ, - 287 с. ISBN 5-89135-177.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Holzapfel W.H., Shillinger U.Introduction to pre- and probiotics. Food Research International. 2002; 35: 109-116. doi: 10.1016/S0963-9969(01)00171-5.</mixed-citation><mixed-citation xml:lang="en">Holzapfel W.H., Shillinger U.Introduction to pre- and probiotics. Food Research International. 2002; 35: 109-116. doi: 10.1016/S0963-9969(01)00171-5.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Hill C., Guarner F., Reid G. et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14. doi: 10.1038/nrgastro.2014.66.</mixed-citation><mixed-citation xml:lang="en">Hill C., Guarner F., Reid G. et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14. doi: 10.1038/nrgastro.2014.66.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Zhernakova A., Kurilshikov A., Bonder M. J. et al. Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science. 2016 Apr 29;352(6285):565-9. doi: 10.1126/science.aad3369.</mixed-citation><mixed-citation xml:lang="en">Zhernakova A., Kurilshikov A., Bonder M. J. et al. Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science. 2016 Apr 29;352(6285):565-9. doi: 10.1126/science.aad3369.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Salminen S., Collado M. C., Endo A. et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol. 2021 Sep;18(9):649-667. doi: 10.1038/s41575-021-00440-6.</mixed-citation><mixed-citation xml:lang="en">Salminen S., Collado M. C., Endo A. et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol. 2021 Sep;18(9):649-667. doi: 10.1038/s41575-021-00440-6.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Martyniak A., Medyńska-Przęczek A., Wędrychowicz A., Skoczeń S., Tomasik P. J. Prebiotics, Probiotics, Synbiotics, Paraprobiotics and Postbiotic Compounds in IBD. Biomolecules. 2021 Dec 18;11(12):1903. doi: 10.3390/biom11121903.</mixed-citation><mixed-citation xml:lang="en">Martyniak A., Medyńska-Przęczek A., Wędrychowicz A., Skoczeń S., Tomasik P. J. Prebiotics, Probiotics, Synbiotics, Paraprobiotics and Postbiotic Compounds in IBD. Biomolecules. 2021 Dec 18;11(12):1903. doi: 10.3390/biom11121903.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Gibson G. R., Hutkins R., Sanders M. E. et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017 Aug;14(8):491-502. doi: 10.1038/nrgastro.2017.75.</mixed-citation><mixed-citation xml:lang="en">Gibson G. R., Hutkins R., Sanders M. E. et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017 Aug;14(8):491-502. doi: 10.1038/nrgastro.2017.75.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Shenderov B. A. Microbial ecology of man and its role in maintaining health / B. A. Shenderov. METAMORPHOSES. 2014, No. 5, pp. 72-80. (In Russ.)@@ Шендеров, Б. А. Микробная экология человека и ее роль в поддержании здоровья. МЕТАМОРФОЗЫ. - 2014. - № 5. - С. 72-80.</mixed-citation><mixed-citation xml:lang="en">Shenderov B. A. Microbial ecology of man and its role in maintaining health / B. A. Shenderov. METAMORPHOSES. 2014, No. 5, pp. 72-80. (In Russ.)@@ Шендеров, Б. А. Микробная экология человека и ее роль в поддержании здоровья. МЕТАМОРФОЗЫ. - 2014. - № 5. - С. 72-80.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Roberfroid M., Gibson G. R., Hoyles L. et al. Prebiotic effects: metabolic and health benefits. Br J Nutr. 2010 Aug;104 Suppl 2: S1-63. doi: 10.1017/S0007114510003363.</mixed-citation><mixed-citation xml:lang="en">Roberfroid M., Gibson G. R., Hoyles L. et al. Prebiotic effects: metabolic and health benefits. Br J Nutr. 2010 Aug;104 Suppl 2: S1-63. doi: 10.1017/S0007114510003363.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Swanson K. S., Gibson G. R., Hutkins R., Reimer R. A., Reid G., Verbeke K., Scott K. P., Holscher H. D., Azad M. B., Delzenne N. M., Sanders M. E. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat Rev Gastroenterol Hepatol. 2020 Nov;17(11):687-701. doi: 10.1038/s41575-020-0344-2.</mixed-citation><mixed-citation xml:lang="en">Swanson K. S., Gibson G. R., Hutkins R., Reimer R. A., Reid G., Verbeke K., Scott K. P., Holscher H. D., Azad M. B., Delzenne N. M., Sanders M. E. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat Rev Gastroenterol Hepatol. 2020 Nov;17(11):687-701. doi: 10.1038/s41575-020-0344-2.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Mikhailova E. A., Lokoshko D. V., Bolshakova E. M. Review of modern scientific data on the possibilities and effectiveness of the use of metabiotics in the correction of dysbiotic conditions. Priority directions of development of Russian science: materials of the VIII All-Russian Scientific and Practical Conference. Ed. Zaraisky A. A. Publishing House of the CPM “Academy of Business”, Saratov. 2021. 28 P. (InRuss.)@@ Михайлова Е. А., Локошко Д. В., Большакова Е. М. Обзор современных научных данных, посвященных возможностям и эффективности использования метабиотиков в коррекции дисбиотических состояний //Приоритетные направления развития российской науки: материалы VIII всероссийской научно-практической конференции. Отв. ред. Зарайский А. А. - ИздательствоЦПМ «Академия Бизнеса». -Саратов. - 2021. - C. 28.</mixed-citation><mixed-citation xml:lang="en">Mikhailova E. A., Lokoshko D. V., Bolshakova E. M. Review of modern scientific data on the possibilities and effectiveness of the use of metabiotics in the correction of dysbiotic conditions. Priority directions of development of Russian science: materials of the VIII All-Russian Scientific and Practical Conference. Ed. Zaraisky A. A. Publishing House of the CPM “Academy of Business”, Saratov. 2021. 28 P. (InRuss.)@@ Михайлова Е. А., Локошко Д. В., Большакова Е. М. Обзор современных научных данных, посвященных возможностям и эффективности использования метабиотиков в коррекции дисбиотических состояний //Приоритетные направления развития российской науки: материалы VIII всероссийской научно-практической конференции. Отв. ред. Зарайский А. А. - ИздательствоЦПМ «Академия Бизнеса». -Саратов. - 2021. - C. 28.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Ardatskaya M. D. et al. Metabiotics as a natural development of the probiotic concept. Recipe. 2019;22 (2). (In Russ.)@@ Ардатская М. Д. и соавт. Метабиотики как естественное развитие пробиотической концепции. Рецепт. 2019;22 (2).</mixed-citation><mixed-citation xml:lang="en">Ardatskaya M. D. et al. Metabiotics as a natural development of the probiotic concept. Recipe. 2019;22 (2). (In Russ.)@@ Ардатская М. Д. и соавт. Метабиотики как естественное развитие пробиотической концепции. Рецепт. 2019;22 (2).</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Ansari J. M., Colasacco C., Emmanouil E., Kohlhepp S., Harriott O. Strain-level diversity of commercial probiotic isolates of Bacillus, Lactobacillus, and Saccharomyces species illustrated by molecular identification and phenotypic profiling. PLoS One. 2019 Mar 22;14(3): e0213841. doi: 10.1371/journal.pone.0213841.</mixed-citation><mixed-citation xml:lang="en">Ansari J. M., Colasacco C., Emmanouil E., Kohlhepp S., Harriott O. Strain-level diversity of commercial probiotic isolates of Bacillus, Lactobacillus, and Saccharomyces species illustrated by molecular identification and phenotypic profiling. PLoS One. 2019 Mar 22;14(3): e0213841. doi: 10.1371/journal.pone.0213841.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Meyer H., Weidmann H., Mäder U., Hecker M., Völker U., Lalk M. A time resolved metabolomics study: the influence of different carbon sources during growth and starvation of Bacillus subtilis. Mol Biosyst. 2014 Jul;10(7):1812-23. doi: 10.1039/c4mb00112e.</mixed-citation><mixed-citation xml:lang="en">Meyer H., Weidmann H., Mäder U., Hecker M., Völker U., Lalk M. A time resolved metabolomics study: the influence of different carbon sources during growth and starvation of Bacillus subtilis. Mol Biosyst. 2014 Jul;10(7):1812-23. doi: 10.1039/c4mb00112e.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Khatri I., Sharma S., Ramya T. N., Subramanian S.Complete Genomes of Bacillus coagulans S-lac and Bacillus subtilis TO-A JPC, Two Phylogenetically Distinct Probiotics. PLoS One. 2016 Jun 3;11(6): e0156745. doi: 10.1371/journal.pone.0156745.</mixed-citation><mixed-citation xml:lang="en">Khatri I., Sharma S., Ramya T. N., Subramanian S.Complete Genomes of Bacillus coagulans S-lac and Bacillus subtilis TO-A JPC, Two Phylogenetically Distinct Probiotics. PLoS One. 2016 Jun 3;11(6): e0156745. doi: 10.1371/journal.pone.0156745.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Sorokulova I. Modern status and perspectives of bacillus bacteria as probiotics. Journa lof Probiotics&amp;Health. 2013; 1(4): P. e106. doi: 10.4172/2329-8901.1000e106.</mixed-citation><mixed-citation xml:lang="en">Sorokulova I. Modern status and perspectives of bacillus bacteria as probiotics. Journa lof Probiotics&amp;Health. 2013; 1(4): P. e106. doi: 10.4172/2329-8901.1000e106.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Ilinskaya O. N., Ulyanova V. V., Yarullina D. R., Gataullin I. G. Secretome of Intestinal Bacilli: A Natural Guard against Pathologies. Front Microbiol. 2017 Sep 1;8:1666. doi: 10.3389/fmicb.2017.01666.</mixed-citation><mixed-citation xml:lang="en">Ilinskaya O. N., Ulyanova V. V., Yarullina D. R., Gataullin I. G. Secretome of Intestinal Bacilli: A Natural Guard against Pathologies. Front Microbiol. 2017 Sep 1;8:1666. doi: 10.3389/fmicb.2017.01666.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Plotnikova E. Yu. Effects of active metabolites of Bacillus subtilis in a probiotic product of a new generation. RMJ. Medical Review. 2018;(3):39-44. (in Russ.)@@ Плотникова Е. Ю. Эффекты активных метаболитов Bacillussubtilis в пробиотическом продукте нового поколения. РМЖ. Медицинское обозрение. - 2018. - № 3. - С. 39-44.</mixed-citation><mixed-citation xml:lang="en">Plotnikova E. Yu. Effects of active metabolites of Bacillus subtilis in a probiotic product of a new generation. RMJ. Medical Review. 2018;(3):39-44. (in Russ.)@@ Плотникова Е. Ю. Эффекты активных метаболитов Bacillussubtilis в пробиотическом продукте нового поколения. РМЖ. Медицинское обозрение. - 2018. - № 3. - С. 39-44.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Dou Y., Yu X., Luo Y., Chen B., Ma D., Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients. 2022 Aug 12;14(16):3298. doi: 10.3390/nu14163298.</mixed-citation><mixed-citation xml:lang="en">Dou Y., Yu X., Luo Y., Chen B., Ma D., Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients. 2022 Aug 12;14(16):3298. doi: 10.3390/nu14163298.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Wierdsma N. J., van Bodegraven A. A., Uitdehaag B. M., Arjaans W., Savelkoul P. H., Kruizenga H. M., van Bokhorst-de van der Schueren M. A. Fructo-oligosaccharides and fibre in enteral nutrition has a beneficial influence on microbiota and gastrointestinal quality of life. Scand J Gastroenterol. 2009;44(7):804-12. doi: 10.1080/00365520902839675.</mixed-citation><mixed-citation xml:lang="en">Wierdsma N. J., van Bodegraven A. A., Uitdehaag B. M., Arjaans W., Savelkoul P. H., Kruizenga H. M., van Bokhorst-de van der Schueren M. A. Fructo-oligosaccharides and fibre in enteral nutrition has a beneficial influence on microbiota and gastrointestinal quality of life. Scand J Gastroenterol. 2009;44(7):804-12. doi: 10.1080/00365520902839675.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Bouhnik Y., Raskine L., Simoneau G., Paineau D., Bornet F. The capacity of short-chain fructo-oligosaccharides to stimulate faecal bifidobacteria: a dose-response relationship study in healthy humans. Nutr J. 2006 Mar 28;5:8. doi: 10.1186/1475-2891-5-8.</mixed-citation><mixed-citation xml:lang="en">Bouhnik Y., Raskine L., Simoneau G., Paineau D., Bornet F. The capacity of short-chain fructo-oligosaccharides to stimulate faecal bifidobacteria: a dose-response relationship study in healthy humans. Nutr J. 2006 Mar 28;5:8. doi: 10.1186/1475-2891-5-8.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Costa G., Vasconcelos Q., Abreu G., Albuquerque A., Vilarejo J., Aragão G. Changes in nutrient absorption in children and adolescents caused by fructans, especially fructooligosaccharides and inulin. Arch Pediatr. 2020 Apr;27(3):166-169. doi: 10.1016/j.arcped.2020.01.004.</mixed-citation><mixed-citation xml:lang="en">Costa G., Vasconcelos Q., Abreu G., Albuquerque A., Vilarejo J., Aragão G. Changes in nutrient absorption in children and adolescents caused by fructans, especially fructooligosaccharides and inulin. Arch Pediatr. 2020 Apr;27(3):166-169. doi: 10.1016/j.arcped.2020.01.004.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">LapinskyI V., Serkova M. Yu., BakulinI G., Skalinskaya M. I., Avalueva E. B. Metabiotic based on metabolites of Bacillus subtilis for correction of gastrointestinal symptoms in patients with post-COVID syndrome. Medical alphabet. 2022;35(4):8-14. (In Russ.) doi: 10.33667/20785631202235814.@@ Лапинский И. В., Серкова М. Ю., Бакулин И. Г., Скалинская М. И., Авалуева Е. Б. Возможности использования метабиотика на основе метаболитов Bacillus subtilis для коррекции гастроинтестинальных симптомов у пациентов с постковидным синдромом. Медицинский алфавит. 2022;35(4):8-14. doi: 10.33667/20785631202235814.</mixed-citation><mixed-citation xml:lang="en">LapinskyI V., Serkova M. Yu., BakulinI G., Skalinskaya M. I., Avalueva E. B. Metabiotic based on metabolites of Bacillus subtilis for correction of gastrointestinal symptoms in patients with post-COVID syndrome. Medical alphabet. 2022;35(4):8-14. (In Russ.) doi: 10.33667/20785631202235814.@@ Лапинский И. В., Серкова М. Ю., Бакулин И. Г., Скалинская М. И., Авалуева Е. Б. Возможности использования метабиотика на основе метаболитов Bacillus subtilis для коррекции гастроинтестинальных симптомов у пациентов с постковидным синдромом. Медицинский алфавит. 2022;35(4):8-14. doi: 10.33667/20785631202235814.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Mehling H., Busjahn A. Non-viable Lactobacillus reuteri DSMZ 17648 (Pylopass™) as a new approach to Helicobacter pylori control in humans. Nutrients. 2013 Aug 2;5(8):3062-73. doi: 10.3390/nu5083062.</mixed-citation><mixed-citation xml:lang="en">Mehling H., Busjahn A. Non-viable Lactobacillus reuteri DSMZ 17648 (Pylopass™) as a new approach to Helicobacter pylori control in humans. Nutrients. 2013 Aug 2;5(8):3062-73. doi: 10.3390/nu5083062.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Holz C., Busjahn A., Mehling H., Arya S., Boettner M., Habibi H., Lang C. Significant Reduction in Helicobacter pylori Load in Humans with Non-viable Lactobacillus reuteri DSM17648: A Pilot Study. Probiotics Antimicrob Proteins. 2015 Jun;7(2):91-100. doi: 10.1007/s12602-014-9181-3.</mixed-citation><mixed-citation xml:lang="en">Holz C., Busjahn A., Mehling H., Arya S., Boettner M., Habibi H., Lang C. Significant Reduction in Helicobacter pylori Load in Humans with Non-viable Lactobacillus reuteri DSM17648: A Pilot Study. Probiotics Antimicrob Proteins. 2015 Jun;7(2):91-100. doi: 10.1007/s12602-014-9181-3.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Bordin D. S. et al. Efficacy and safety of probiotic bacteria Lactobacillus reuteri DSMZ17648 in infected Helicobacter pylori without absolute indications for eradication therapy: results of the study. Lechaschi Vrach. 2015;8:22-25. (In Russ.)@@ Бордин Д. С. и соавт. Эффективность и безопасность пробиотических бактерий Lactobacillus reuteri DSMZ17648 у инфицированных Helicobacter pylori, не имеющих абсолютных показаний для эрадикационной терапии: результаты исследования. ЛЕЧАЩИЙ ВРАЧ. - 2015. - 8. - 22-25.</mixed-citation><mixed-citation xml:lang="en">Bordin D. S. et al. Efficacy and safety of probiotic bacteria Lactobacillus reuteri DSMZ17648 in infected Helicobacter pylori without absolute indications for eradication therapy: results of the study. Lechaschi Vrach. 2015;8:22-25. (In Russ.)@@ Бордин Д. С. и соавт. Эффективность и безопасность пробиотических бактерий Lactobacillus reuteri DSMZ17648 у инфицированных Helicobacter pylori, не имеющих абсолютных показаний для эрадикационной терапии: результаты исследования. ЛЕЧАЩИЙ ВРАЧ. - 2015. - 8. - 22-25.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Bordin D. S. et al. Efficacy and safety of probiotic bacteria Lactobacillus reuteri DSMZ17648 in infected Helicobacter pylori without absolute indications for eradication therapy: results of the study. Lechaschi Vrach. 2016;5:1-6. (In Russ.)@@ Бордин Д. С. и соавт. Эффективность и безопасность пробиотических бактерий Lactobacillus reuteri DSMZ17648 уинфицированных Helicobacter pylori, не имеющих абсолютных показаний для эрадикационной терапии: результаты исследования. ЛЕЧАЩИЙ ВРАЧ. - 2016. - 5. - 1-6.</mixed-citation><mixed-citation xml:lang="en">Bordin D. S. et al. Efficacy and safety of probiotic bacteria Lactobacillus reuteri DSMZ17648 in infected Helicobacter pylori without absolute indications for eradication therapy: results of the study. Lechaschi Vrach. 2016;5:1-6. (In Russ.)@@ Бордин Д. С. и соавт. Эффективность и безопасность пробиотических бактерий Lactobacillus reuteri DSMZ17648 уинфицированных Helicobacter pylori, не имеющих абсолютных показаний для эрадикационной терапии: результаты исследования. ЛЕЧАЩИЙ ВРАЧ. - 2016. - 5. - 1-6.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Kornienko E. A., Parolova N. I., Ivanov S. V. et al. Possibilities of using probiotics in Helicobacter pylori eradication. RMJ. Medical Review. 2018;7(II):51-58. (in Russ.)@@ Корниенко Е. А., Паролова Н. И., Иванов С. В. и др. Возможности использования пробиотиков в эрадикации Helicobacter pylori. РМЖ. Медицинское обозрение. 2018. № 7(II). С. 51-58.</mixed-citation><mixed-citation xml:lang="en">Kornienko E. A., Parolova N. I., Ivanov S. V. et al. Possibilities of using probiotics in Helicobacter pylori eradication. RMJ. Medical Review. 2018;7(II):51-58. (in Russ.)@@ Корниенко Е. А., Паролова Н. И., Иванов С. В. и др. Возможности использования пробиотиков в эрадикации Helicobacter pylori. РМЖ. Медицинское обозрение. 2018. № 7(II). С. 51-58.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Yang C., Liang L., Lv P., Liu L., Wang S., Wang Z., Chen Y. Effects of non-viable Lactobacillus reuteri combining with 14-day standard triple therapy on Helicobacter pylori eradication: A randomized double-blind placebo-controlled trial. Helicobacter. 2021 Dec;26(6): e12856. doi: 10.1111/hel.12856.</mixed-citation><mixed-citation xml:lang="en">Yang C., Liang L., Lv P., Liu L., Wang S., Wang Z., Chen Y. Effects of non-viable Lactobacillus reuteri combining with 14-day standard triple therapy on Helicobacter pylori eradication: A randomized double-blind placebo-controlled trial. Helicobacter. 2021 Dec;26(6): e12856. doi: 10.1111/hel.12856.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Parth K., Prudhivi R., Palatheeya S., Abbas S. K., Varsha K., Niharika B. V., Lyngkhoi B. Efficacy of Lactobacillus reuteri Supplementation in Eradication of H. pylori: A Comparison Study with Triple Drug Therapy. Journal of Pharmaceutical Research International. 2021;33(52B):151-159. doi: 10.9734/jpri/2021/v33i52B33611.</mixed-citation><mixed-citation xml:lang="en">Parth K., Prudhivi R., Palatheeya S., Abbas S. K., Varsha K., Niharika B. V., Lyngkhoi B. Efficacy of Lactobacillus reuteri Supplementation in Eradication of H. pylori: A Comparison Study with Triple Drug Therapy. Journal of Pharmaceutical Research International. 2021;33(52B):151-159. doi: 10.9734/jpri/2021/v33i52B33611.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Lazebnik L. B., Sarsenbaeva A. S., Avalueva E. B., Oreshko L. S., Sitkin S. I., Golovanova E. V., Turkina S. V., Khlynova O. V., Sagalova O. I., Mironchev O. V. Clinical guidelines “Chronic diarrhea in adults”. Experimental and Clinical Gastroenterology. 2021;(4):7-67. (In Russ.) doi: 10.31146/1682-8658-ecg-188-4-7-67.@@ Лазебник Л. Б., Сарсенбаева А. С., Авалуева Е. Б., Орешко С. Л., Ситкин С. И., Голованова Е. В., Туркина С. В., Хлынова О. В., Сагалова О. И., Мирончев О. В. Клинические рекомендации «Хронические диареи у взрослых». Экспериментальная и клиническая гастроэнтерология. 2021;(4):7-67. doi: 10.31146/1682-8658-ecg-188-4-7-67.</mixed-citation><mixed-citation xml:lang="en">Lazebnik L. B., Sarsenbaeva A. S., Avalueva E. B., Oreshko L. S., Sitkin S. I., Golovanova E. V., Turkina S. V., Khlynova O. V., Sagalova O. I., Mironchev O. V. Clinical guidelines “Chronic diarrhea in adults”. Experimental and Clinical Gastroenterology. 2021;(4):7-67. (In Russ.) doi: 10.31146/1682-8658-ecg-188-4-7-67.@@ Лазебник Л. Б., Сарсенбаева А. С., Авалуева Е. Б., Орешко С. Л., Ситкин С. И., Голованова Е. В., Туркина С. В., Хлынова О. В., Сагалова О. И., Мирончев О. В. Клинические рекомендации «Хронические диареи у взрослых». Экспериментальная и клиническая гастроэнтерология. 2021;(4):7-67. doi: 10.31146/1682-8658-ecg-188-4-7-67.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Shenderov B. A., Sinitsa A. V., Zakharchenko M. M. Metabiotics: yesterday, today, tomorrow. St. Petersburg. Kraft. 2017. 80 p. (In Russ.)@@ Шендеров Б. А., Синица А. В., Захарченко М. М. Метабиотики: вчера, сегодня, завтра. СПб.: Крафт, 2017. - 80 с.</mixed-citation><mixed-citation xml:lang="en">Shenderov B. A., Sinitsa A. V., Zakharchenko M. M. Metabiotics: yesterday, today, tomorrow. St. Petersburg. Kraft. 2017. 80 p. (In Russ.)@@ Шендеров Б. А., Синица А. В., Захарченко М. М. Метабиотики: вчера, сегодня, завтра. СПб.: Крафт, 2017. - 80 с.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao W., Peng C., Sakandar H. A., Kwok L. Y., Zhang W. Meta-Analysis: Randomized Trials of Lactobacillus plantarum on Immune Regulation Over the Last Decades. Front Immunol. 2021 Mar 22;12:643420. doi: 10.3389/fimmu.2021.643420.</mixed-citation><mixed-citation xml:lang="en">Zhao W., Peng C., Sakandar H. A., Kwok L. Y., Zhang W. Meta-Analysis: Randomized Trials of Lactobacillus plantarum on Immune Regulation Over the Last Decades. Front Immunol. 2021 Mar 22;12:643420. doi: 10.3389/fimmu.2021.643420.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Guo L., Xiao P., Zhang X., Yang Y., Yang M., Wang T., Lu H., Tian H., Wang H., Liu J. Inulin ameliorates schizophrenia via modulation of the gut microbiota and anti-inflammation in mice. Food Funct. 2021 Feb 15;12(3):1156-1175. doi: 10.1039/d0fo02778b.</mixed-citation><mixed-citation xml:lang="en">Guo L., Xiao P., Zhang X., Yang Y., Yang M., Wang T., Lu H., Tian H., Wang H., Liu J. Inulin ameliorates schizophrenia via modulation of the gut microbiota and anti-inflammation in mice. Food Funct. 2021 Feb 15;12(3):1156-1175. doi: 10.1039/d0fo02778b.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Bian Y., Zhao C., Lee S. M. Neuroprotective Potency of Saffron Against Neuropsychiatric Diseases, Neurodegenerative Diseases, and Other Brain Disorders: From Bench to Bedside. Front Pharmacol. 2020 Oct 6;11:579052. doi: 10.3389/fphar.2020.579052.</mixed-citation><mixed-citation xml:lang="en">Bian Y., Zhao C., Lee S. M. Neuroprotective Potency of Saffron Against Neuropsychiatric Diseases, Neurodegenerative Diseases, and Other Brain Disorders: From Bench to Bedside. Front Pharmacol. 2020 Oct 6;11:579052. doi: 10.3389/fphar.2020.579052.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Presnyakova M. V., Kostina O. V., Albitskaya Zh. V. The biological role of zinc and its significance in the pathogenesis of autism spectrum disorders. Social and clinical psychiatry. 2019;29(3):63-70. (In Russ.)@@ Преснякова М. В., Костина О. В., Альбицкая Ж. В. Биологическая роль цинка и его значимость в патогенезе расстройств аутистического спектра. Социальная и клиническая психиатрия. - 2019. - т. 29. - № 3. - С. 63-70.</mixed-citation><mixed-citation xml:lang="en">Presnyakova M. V., Kostina O. V., Albitskaya Zh. V. The biological role of zinc and its significance in the pathogenesis of autism spectrum disorders. Social and clinical psychiatry. 2019;29(3):63-70. (In Russ.)@@ Преснякова М. В., Костина О. В., Альбицкая Ж. В. Биологическая роль цинка и его значимость в патогенезе расстройств аутистического спектра. Социальная и клиническая психиатрия. - 2019. - т. 29. - № 3. - С. 63-70.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou G., Yu R., Ahmed T., Jiang H., Zhang M., Lv L., Alhumaydhi F. A., Allemailem K. S., Li B. Biosynthesis and Characterization of Zinc Oxide Nanoparticles and Their Impact on the Composition of Gut Microbiota in Healthy and Attention-Deficit Hyperactivity Disorder Children. Front Microbiol. 2021 Aug 5;12:700707. doi: 10.3389/fmicb.2021.700707.</mixed-citation><mixed-citation xml:lang="en">Zhou G., Yu R., Ahmed T., Jiang H., Zhang M., Lv L., Alhumaydhi F. A., Allemailem K. S., Li B. Biosynthesis and Characterization of Zinc Oxide Nanoparticles and Their Impact on the Composition of Gut Microbiota in Healthy and Attention-Deficit Hyperactivity Disorder Children. Front Microbiol. 2021 Aug 5;12:700707. doi: 10.3389/fmicb.2021.700707.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Kaybysheva V. O., Baranskaya Ye. K. Carbohydrate intolerance.Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2017;27(5):94-104. (In Russ.) doi: 10.22416/1382-4376-2017-27-5-94-104.@@ Кайбышева В. О., Баранская Е. К. Непереносимость углеводов. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2017;27(5):94-104. doi: 10.22416/1382-4376-2017-27-5-94-104.</mixed-citation><mixed-citation xml:lang="en">Kaybysheva V. O., Baranskaya Ye. K. Carbohydrate intolerance.Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2017;27(5):94-104. (In Russ.) doi: 10.22416/1382-4376-2017-27-5-94-104.@@ Кайбышева В. О., Баранская Е. К. Непереносимость углеводов. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2017;27(5):94-104. doi: 10.22416/1382-4376-2017-27-5-94-104.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Razzaq A., Shamsi S., Ali A., Ali Q., Sajjad M., Malik A., Ashraf M. Microbial Proteases Applications. Front Bioeng Biotechnol. 2019 Jun 12;7:110. doi: 10.3389/fbioe.2019.00110.</mixed-citation><mixed-citation xml:lang="en">Razzaq A., Shamsi S., Ali A., Ali Q., Sajjad M., Malik A., Ashraf M. Microbial Proteases Applications. Front Bioeng Biotechnol. 2019 Jun 12;7:110. doi: 10.3389/fbioe.2019.00110.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Maurer H. R. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001 Aug;58(9):1234-45. doi: 10.1007/PL00000936.</mixed-citation><mixed-citation xml:lang="en">Maurer H. R. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001 Aug;58(9):1234-45. doi: 10.1007/PL00000936.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Pavan R., Jain S., Shraddha, Kumar A. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. doi: 10.1155/2012/976203.</mixed-citation><mixed-citation xml:lang="en">Pavan R., Jain S., Shraddha, Kumar A. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. doi: 10.1155/2012/976203.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Casas-Godoy L., Gasteazoro F., Duquesne S., Bordes F., Marty A., Sandoval G. Lipases: An Overview. Methods Mol Biol. 2018;1835:3-38. doi: 10.1007/978-1-4939-8672-9_1.</mixed-citation><mixed-citation xml:lang="en">Casas-Godoy L., Gasteazoro F., Duquesne S., Bordes F., Marty A., Sandoval G. Lipases: An Overview. Methods Mol Biol. 2018;1835:3-38. doi: 10.1007/978-1-4939-8672-9_1.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">The pancreas: an integrated textbook of basic science, medicine and surgery / Eds.: H. G. Beger., Malden: Blackwell Publishing. 2008;1006 p.</mixed-citation><mixed-citation xml:lang="en">The pancreas: an integrated textbook of basic science, medicine and surgery / Eds.: H. G. Beger., Malden: Blackwell Publishing. 2008;1006 p.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Plotnikova E. Y. The role of non-animal enzymes in digestive disorders of various etiologies. (In Russ.) Available at: https://www.lvrach.ru/2019/01/15437193 (accessed: 07/28/2023).@@ Плотникова Е. Ю. Роль энзимов неживотного происхождения при нарушениях пищеварения различной этиологии. URL: https://www.lvrach.ru/2019/01/15437193 (дата обращения: 28.07.2023)</mixed-citation><mixed-citation xml:lang="en">Plotnikova E. Y. The role of non-animal enzymes in digestive disorders of various etiologies. (In Russ.) Available at: https://www.lvrach.ru/2019/01/15437193 (accessed: 07/28/2023).@@ Плотникова Е. Ю. Роль энзимов неживотного происхождения при нарушениях пищеварения различной этиологии. URL: https://www.lvrach.ru/2019/01/15437193 (дата обращения: 28.07.2023)</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Tarasenko S. V., Katola V. M., Komogortseva V. E. Effect of oral microbiota on the development of inflammation and somatic diseases. Rossiyskii stomatologicheskii zhurnal. 2018; 22(3): 162-165. doi: 10.18821/1728-2802-2018-22-3-162-165.@@ Тарасенко С. В., Кетола В. М., Комогорцев В. Е. Влияние микробиоты полости рта на развитие воспаления и соматических заболеваний. Российский стоматологический журнал. 2018; 22(3): 162-165. doi: 10.18821/1728-2802-2018-22-3-162-165.</mixed-citation><mixed-citation xml:lang="en">Tarasenko S. V., Katola V. M., Komogortseva V. E. Effect of oral microbiota on the development of inflammation and somatic diseases. Rossiyskii stomatologicheskii zhurnal. 2018; 22(3): 162-165. doi: 10.18821/1728-2802-2018-22-3-162-165.@@ Тарасенко С. В., Кетола В. М., Комогорцев В. Е. Влияние микробиоты полости рта на развитие воспаления и соматических заболеваний. Российский стоматологический журнал. 2018; 22(3): 162-165. doi: 10.18821/1728-2802-2018-22-3-162-165.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Dang A. T., Marsland B. J. Microbes, metabolites, and the gut-lung axis. Mucosal Immunol. 2019 Jul;12(4):843-850. doi: 10.1038/s41385-019-0160-6.</mixed-citation><mixed-citation xml:lang="en">Dang A. T., Marsland B. J. Microbes, metabolites, and the gut-lung axis. Mucosal Immunol. 2019 Jul;12(4):843-850. doi: 10.1038/s41385-019-0160-6.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Villena J, Alvarez S. Probiotics for everyone! The novel immunobiotic Lactobacillus rhamnosus CRL1505и and the beginning of social probiotic programs in Argentina.Int. J Biotechnol Wellness Industr. 2012; 1:189-198. doi: 10.6000/1927-3037/2012.01.03.05.</mixed-citation><mixed-citation xml:lang="en">Villena J, Alvarez S. Probiotics for everyone! The novel immunobiotic Lactobacillus rhamnosus CRL1505и and the beginning of social probiotic programs in Argentina.Int. J Biotechnol Wellness Industr. 2012; 1:189-198. doi: 10.6000/1927-3037/2012.01.03.05.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Albarracin L., Garcia-Castillo V., Masumizu Y. et al. Efficient Selection of New Immunobiotic Strains With Antiviral Effects in Local and Distal Mucosal Sites by Using Porcine Intestinal Epitheliocytes. Front Immunol. 2020 Apr 8;11:543. doi: 10.3389/fimmu.2020.00543.</mixed-citation><mixed-citation xml:lang="en">Albarracin L., Garcia-Castillo V., Masumizu Y. et al. Efficient Selection of New Immunobiotic Strains With Antiviral Effects in Local and Distal Mucosal Sites by Using Porcine Intestinal Epitheliocytes. Front Immunol. 2020 Apr 8;11:543. doi: 10.3389/fimmu.2020.00543.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Correa Deza M. A., Rodríguez de Olmos A., Suárez N. E., Font de Valdez G., Salva S., Gerez C. L. Inorganic polyphosphate from the immunobiotic Lactobacillus rhamnosus CRL1505 prevents inflammatory response in the respiratory tract. Saudi J Biol Sci. 2021 Oct;28(10):5684-5692. doi: 10.1016/j.sjbs.2021.06.010.</mixed-citation><mixed-citation xml:lang="en">Correa Deza M. A., Rodríguez de Olmos A., Suárez N. E., Font de Valdez G., Salva S., Gerez C. L. Inorganic polyphosphate from the immunobiotic Lactobacillus rhamnosus CRL1505 prevents inflammatory response in the respiratory tract. Saudi J Biol Sci. 2021 Oct;28(10):5684-5692. doi: 10.1016/j.sjbs.2021.06.010.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Villena J., Kitazawa H. The Modulation of Mucosal Antiviral Immunity by Immunobiotics: Could They Offer Any Benefit in the SARS-CoV-2 Pandemic? Front Physiol. 2020 Jun 16;11:699. doi: 10.3389/fphys.2020.00699.</mixed-citation><mixed-citation xml:lang="en">Villena J., Kitazawa H. The Modulation of Mucosal Antiviral Immunity by Immunobiotics: Could They Offer Any Benefit in the SARS-CoV-2 Pandemic? Front Physiol. 2020 Jun 16;11:699. doi: 10.3389/fphys.2020.00699.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Mindt B. C., DiGiandomenico A. Microbiome Modulation as a Novel Strategy to Treat and Prevent Respiratory Infections. Antibiotics (Basel). 2022 Apr 1;11(4):474. doi: 10.3390/antibiotics11040474.</mixed-citation><mixed-citation xml:lang="en">Mindt B. C., DiGiandomenico A. Microbiome Modulation as a Novel Strategy to Treat and Prevent Respiratory Infections. Antibiotics (Basel). 2022 Apr 1;11(4):474. doi: 10.3390/antibiotics11040474.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Oliviero M., Romilde I., Beatrice M. M., Matteo V., Giovanna N., Consuelo A., Claudio C., Giorgio S., Filippo M., Massimo N. Evaluations of thyme extract effects in human normal bronchial and tracheal epithelial cell lines and in human lung cancer cell line. Chem Biol Interact. 2016 Aug 25;256:125-33. doi: 10.1016/j.cbi.2016.06.024.</mixed-citation><mixed-citation xml:lang="en">Oliviero M., Romilde I., Beatrice M. M., Matteo V., Giovanna N., Consuelo A., Claudio C., Giorgio S., Filippo M., Massimo N. Evaluations of thyme extract effects in human normal bronchial and tracheal epithelial cell lines and in human lung cancer cell line. Chem Biol Interact. 2016 Aug 25;256:125-33. doi: 10.1016/j.cbi.2016.06.024.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Minernitsky Yu.L., Sulaymanov Sh. A. Modern combined plant remedies in pulmonologist’s practice. Meditsinskiy sovet = Medical Council. 2019;(11):82-88. (In Russ.) doi: 10.21518/2079-701X-2019-11-82-88.@@ Мизерницкий Ю. Л., Сулайманов Ш. А. Современные комбинированные растительные препараты в практике пульмонолога. Медицинский Совет. 2019;(11):82-88. doi: 10.21518/2079-701X-2019-11-82-88.</mixed-citation><mixed-citation xml:lang="en">Minernitsky Yu.L., Sulaymanov Sh. A. Modern combined plant remedies in pulmonologist’s practice. Meditsinskiy sovet = Medical Council. 2019;(11):82-88. (In Russ.) doi: 10.21518/2079-701X-2019-11-82-88.@@ Мизерницкий Ю. Л., Сулайманов Ш. А. Современные комбинированные растительные препараты в практике пульмонолога. Медицинский Совет. 2019;(11):82-88. doi: 10.21518/2079-701X-2019-11-82-88.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Tkachenko E. I. The theory of noospheric-anthropogenic harmony as methodological basis for the prevention and treatment of diseases. New St. Petersburg medical records. 2018;2(84):13-19. (In Russ.)@@ Ткаченко Е. И. Теория ноосферно-антропогенной гармонии как методологическая основа профилактики и лечения заболеваний. Новые Санкт-Петербургские врачебные ведомости. 2018;2 (84):13-19.</mixed-citation><mixed-citation xml:lang="en">Tkachenko E. I. The theory of noospheric-anthropogenic harmony as methodological basis for the prevention and treatment of diseases. New St. Petersburg medical records. 2018;2(84):13-19. (In Russ.)@@ Ткаченко Е. И. Теория ноосферно-антропогенной гармонии как методологическая основа профилактики и лечения заболеваний. Новые Санкт-Петербургские врачебные ведомости. 2018;2 (84):13-19.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
