nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-222-2-75-88nogr-2584Research ArticleОБЗОРREVIEWПротивовоспалительные и антимикробные свойства некоторых метаболитов солодкиAnti-inflammatory and antimicrobial properties of some licorice metaboliteshttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinA. I.khavkin@nikid.ruhttps://orcid.org/0000-0001-8364-6066НиколайчукК. М.NikolaychukK. M.noemail@neicon.ruhttps://orcid.org/0000-0003-3606-4068ШрайнерЕ. В.ShreinerE. V.noemail@neicon.ruhttps://orcid.org/0009-0008-7479-8277НовиковаМ. Ф.NovikovaM. F.noemail@neicon.ruhttps://orcid.org/0009-0002-9228-2350ВеременкоА. С.VeremenkoA. S.noemail@neicon.ruhttps://orcid.org/0009-0002-7317-6077ЛевченкоИ. Д.LevchenkoI. D.noemail@neicon.ruhttps://orcid.org/0009-0003-0793-4236ВергуноваЕ. Е.VergunovaE. E.noemail@neicon.ruhttps://orcid.org/0009-0004-1138-6049ТумасА. С.TumasA. S.noemail@neicon.ruhttps://orcid.org/0009-0004-1880-9585ПлатоноваП. Я.PlatonovaP. Ya.noemail@neicon.ruhttps://orcid.org/0000-0002-5468-9961ПономаренкоА. В.PonomarenkoA. V.noemail@neicon.ruhttps://orcid.org/0009-0009-7808-1000ПакИ. А.PakI. A.noemail@neicon.ruhttps://orcid.org/0000-0002-9494-4234ПокушаловЕ. А.PokushalovE. A.noemail@neicon.ruНаучно-исследовательский клинический институт детства Министерства здравоохранения Московской области; Белгородский государственный исследовательский университет Министерства науки и высшего образования Российской ФедерацииРоссияResearch Clinical Institute of Childhood, Ministry of Health of the Moscow Region; Belgorod State Research UniversityRussian FederationНовосибирский государственный университетРоссияNovosibirsk State UniversityRussian FederationНовосибирский государственный университет; Институт химической биологии и фундаментальной медицины СО РАН; ГК Центр Новых медицинских технологий; “Soloways” лабораторияРоссияNovosibirsk State University; Institute of chemical, Institute of Chemical Biology and Fundamental Medicine of the SB RAS; Group of companies “Center for new medical technologies” Russia; “Soloways” laboratoryRussian FederationИнститут химической биологии и фундаментальной медицины СО РАН; ГК Центр Новых медицинских технологий; “Soloways” лабораторияРоссияInstitute of chemical, Institute of Chemical Biology and Fundamental Medicine of the SB RAS; Group of companies “Center for new medical technologies” Russia; “Soloways” laboratoryRussian FederationГК Центр Новых медицинских технологий; “Soloways” лабораторияРоссияGroup of companies “Center for new medical technologies” Russia; “Soloways” laboratoryRussian Federation202426032024027588Copyright © Хавкин А.И., Николайчук К.М., Шрайнер Е.В., Новикова М.Ф., Веременко А.С., Левченко И.Д., Вергунова Е.Е., Тумас А.С., Платонова П.Я., Пономаренко А.В., Пак И.А., Покушалов Е.А., 20242024Хавкин А.И., Николайчук К.М., Шрайнер Е.В., Новикова М.Ф., Веременко А.С., Левченко И.Д., Вергунова Е.Е., Тумас А.С., Платонова П.Я., Пономаренко А.В., Пак И.А., Покушалов Е.А.Khavkin A.I., Nikolaychuk K.M., Shreiner E.V., Novikova M.F., Veremenko A.S., Levchenko I.D., Vergunova E.E., Tumas A.S., Platonova P.Y., Ponomarenko A.V., Pak I.A., Pokushalov E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2584

В данной статье освещается фармакологическая активность метаболитов солодки, представляющих собой значимый интерес в контексте лечения онкологических, сердечно-сосудистых, респираторных заболеваний. В обзоре подробно рассмотрены многообразие и эффективность лихалокона, изоликвиритигенина, ликвиритигенина и других метаболитов солодки, которые демонстрируют противовоспалительные, антимикробные, антиоксидантные. В основе данных эффектов лежит способность метаболитов солодки регулировать молекулярные каскады, обуславливающие апоптоз, клеточный цикл, пролиферацию клеток и многие другие процессы. В статье подробно рассматриваются перспективы использования метаболитов солодки в онкологии, кардиологии их потенциал в создании новых лекарственных препаратов и необходимость дальнейших исследований для определения их полного терапевтического потенциала.

This article highlights the pharmacological activity of licorice metabolites of significant interest in the context of the treatment of cancer, cardiovascular, and respiratory diseases. The review details the diversity and efficacy of lichalocone, isoliquiritigenin, liquiritigenin, and other licorice metabolites that exhibit anti-inflammatory, antimicrobial, and antioxidant effects. These effects are based on the ability of licorice metabolites to regulate molecular cascades responsible for apoptosis, cell cycle, cell proliferation and many other processes. The article discusses in detail the prospects for the use of licorice metabolites in oncology, cardiology, their potential in the development of new drugs and the need for further research to determine their full therapeutic potential.

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The authors declare that there are no conflicts of interest present.