nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-218-10-221-228nogr-2568Research ArticleЭКСПЕРИМЕНТАЛЬНАЯ ГАСТРОЭНТЕРОЛОГИЯEXPERIMENTAL GASTROENTEROLOGYФармакологические модели перегрузки печени железомPharmacological models of liver iron overloadБогачеваТ. Е.BogachevaT. E.tatiana.boga4iova@yandex.ruТоршинИ. Ю.TorshinI. Yu.noemail@neicon.ruГромоваО. А.GromovaO. A.unesco.gromova@gmail.comГришинаТ. Р.GrishinaT. R.noemail@neicon.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Ивановская государственная медицинская академия» Министерства здравоохранения Российской ФедерацииРоссияIvanovo State Medical AcademyRussian FederationФедеральный исследовательский центр «Информатика и управление» Российской академии наукРоссияFederal Research Center “Computer Science and Control”, Russian Academy of SciencesRussian Federation202315032024010221228Copyright © Богачева Т.Е., Торшин И.Ю., Громова О.А., Гришина Т.Р., 20242024Богачева Т.Е., Торшин И.Ю., Громова О.А., Гришина Т.Р.Bogacheva T.E., Torshin I.Y., Gromova O.A., Grishina T.R.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2568

Отложения железа в тканях (гемосидероз) сопровождает различные заболевания печени и поджелудочной железы. Перегрузка печени железом возникает вследствие (1) диеты с избытком насыщенных жиров, провоцирующих воспаление печени, (2) замедление и застой кровотока в области портальной вены (гиподинамия, ожирение, алкоголизм и др.), (3) бесконтрольный и длительный прием препаратов железа (прежде всего, на основе неорганических форм - сульфатов, оксидов, гидроксидов железа и др.), (4) наследственные заболевания (гемохроматоз). Пациенты с перегрузкой печени железом нуждаются не только в коррекции диеты и образа жизни (в т. ч. двигательной активности), но и в специальной терапии с использованием эффективных и безопасных препаратов. Для изучения влияния избытка железа на организм и поиска наиболее приемлемой терапии гемосидероза в фармакологии разработаны особые модели перегрузки печени железом. Степень перегрузки железом и скорость формирования гемосидероза в моделях могут быть замедлены посредством добавления микронутриентов с гепатопротекторными свойствами (витамины А, С) и ускорены посредством добавления в диету насыщенных жиров и/или фруктозы.

Iron deposits in tissues (hemosiderosis) accompany various diseases of the liver and pancreas. Overload of the liver with iron occurs due to (1) a diet with excess saturated fats, which provoke inflammation of the liver, (2) slowdown and stagnation of blood flow in the area of the portal vein (physical inactivity, obesity, alcoholism, etc), (3) uncontrolled and long-term use of iron supplements (primarily based on inorganic forms - sulfates, oxides, hydroxides of iron, etc.), (4) hereditary diseases (hemochromatosis). Patients with liver overload with iron require not only correction of diet and lifestyle (including physical activity), but also special therapy using effective and safe drugs. To study the effect of excess iron on the body and search for the most appropriate therapy for hemosiderosis, special models of liver overload with iron have been developed in pharmacology. The degree of iron overload and the rate of hemosiderosis formation in models can be slowed down by the addition of micronutrients with hepatoprotective properties (vitamins A, C) and accelerated by the addition of saturated fat and/or fructose to the diet.

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