References

nogr

Экспериментальная и клиническая гастроэнтерология

Experimental and Clinical Gastroenterology

1682-8658

«Global Media Technologies»

10.31146/1682-8658-ecg-218-10-202-215

nogr-2566

Research Article

ХИРУРГИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯ

SURGICAL GASTROENTEROLOGY

Хирургическое лечение хронического панкреатита у детей

Surgical treatment of chronic pancreatitis in children

Кисленко

А. А.

Kislenko

A. A.

lina.kislenko@mail.ru

Разумовский

А. Ю.

Razumovsky

A. Yu.

noemail@neicon.ru

Холостова

В. В.

Kholostova

V. V.

noemail@neicon.ru

Митупов

З. Б.

Mitupov

Z. B.

noemail@neicon.ru

Задвернюк

А. С.

Zadvernyuk

A. S.

noemail@neicon.ru

Чумакова

Г. Ю.

Chumakova

G. Yu.

noemail@neicon.ru

ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И Пирогова» Минздрава России; ГБУЗ «ДГКБ № 13 им. Н.Ф Филатова» Департамента здравоохранения города МосквыРоссияFederal State Autonomous Educational Institution of Higher Education “Russian National Research Medical University named after. N. I. Pirogov” of the Ministry of Health of Russia; GBUZ “DGKB No. 13 named after. N. F. Filatova” Department of Health of the City of MoscowRussian Federation

2023

15032024

010202215

2024

Кисленко А.А., Разумовский А.Ю., Холостова В.В., Митупов З.Б., Задвернюк А.С., Чумакова Г.Ю.

Kislenko A.A., Razumovsky A.Y., Kholostova V.V., Mitupov Z.B., Zadvernyuk A.S., Chumakova G.Y.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.nogr.org/jour/article/view/2566

Хронический панкреатит у детей - это непрерывное или рецидивирующее заболевание, характеризующееся необратимыми воспалительными и деструктивными изменениями поджелудочной железы (ПЖ), прогрессирующим фиброзом, сопровождающимся постепенным снижением её экзокринной и эндокринной функций. В последние десятилетия отмечается значительный рост больных ХП, заболеваемость у детей оценивается в 2 случая на 100 000 человек. По данным литературы рак поджелудочной железы в исходе хронического панкреатита в детском возрасте составляет 6,2%. Показатели смертности при ХП в разных исследованиях различаются: 15-20% детей с ХП погибают от осложнений, вторичных нарушений. Цель исследования - изучить современные проблемы и определить перспективы лечения хронического панкреатита у детей на основании обзора современной литературы. Материалы и методы. В рамках подготовки был проведён систематический обзор мировой и отечественной литературы по вопросам хирургического лечения хронического панкреатита у детей. Результаты. Проведённый поиск литературы подтвердил отсутствие единого мнения в отношении хирургического лечения ХП у детей. Малое количество наблюдений не позволяет проводить анализ отдалённых результатов хирургического лечения детей с ХП. Особую сложность представляют пациенты с наследственным панкреатитом, в литературе не описаны алгоритмы лечения данной группы пациентов. Также в литературе встречаются единичные описания осложнений при ХП у детей, нет достоверных результатов эффективности оперативного вмешательства при эндокринной и экзокринной недостаточности у детей. Необходимо проведение научно-практических исследований для разработки показаний к хирургическому лечению детей с ХП, верификации специфических осложнений.

Chronic pancreatitis in children is a continuous or recurrent disease characterized by irreversible inflammatory and destructive changes in the pancreas (PG), progressive fibrosis, accompanied by a gradual decrease in its exocrine and endocrine functions. In recent decades, there has been a significant increase in patients with CP; the incidence in children is estimated at 2 cases per 100,000 people. According to the literature, pancreatic cancer in the outcome of chronic pancreatitis in childhood is 6.2%. Mortality rates for CP vary in different studies: 15-20% of children with CP die from complications and secondary disorders. The purpose of the study is to study current problems and determine the prospects for the treatment of chronic pancreatitis in children based on a review of modern literature. Materials and methods. As part of the preparation, a systematic review of the world and domestic literature on the surgical treatment of chronic pancreatitis in children was carried out. Results. A literature search confirmed the lack of consensus regarding the surgical treatment of CP in children. The small number of observations does not allow us to analyze the long-term results of surgical treatment of children with CP. Patients with hereditary pancreatitis pose a particular challenge; treatment algorithms for this group of patients are not described in the literature. Also in the literature there are isolated descriptions of complications with CP in children; there are no reliable results of the effectiveness of surgical intervention for endocrine and exocrine insufficiency in children. It is necessary to conduct scientific and practical research to develop indications for surgical treatment of children with CP and to verify specific complications.

хронический панкреатит у детейнаследственный панкреатитпанкреатогенный сахарный диабетэндоскопическое лечение хронического панкреатитаосложнения хронического панкреатита

chronic pancreatitis in childrenhereditary pancreatitispancreatogenic diabetes mellitusendoscopic treatment of chronic pancreatitiscomplications of chronic pancreatitis

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The authors declare that there are no conflicts of interest present.