nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-218-10-95-103nogr-2552Research ArticleОЖИРЕНИЕOBESITYМесто берберина в терапии метаболического синдромаThe place of berberine in the treatment of metabolic syndromehttps://orcid.org/0000-0003-3606-4068ШрайнерЕ. В.ShraynerE. V.sch704@icloud.comhttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinA. I.noemail@neicon.ruhttps://orcid.org/0000-0001-8364-6066НиколайчукК. М.NikolaychukK. M.noemail@neicon.ruhttps://orcid.org/0009-0008-7479-8277НовиковаМ. Ф.NovikovaM. F.noemail@neicon.ruhttps://orcid.org/0009-0002-9228-2350ВеременкоА. С.VeremenkoA. S.noemail@neicon.ruhttps://orcid.org/0009-0002-7317-6077ЛевченкоИ. Д.LevchenkoI. D.noemail@neicon.ruhttps://orcid.org/0009-0003-0793-4236ВергуноваЕ. Е.VergunovaE. E.noemail@neicon.ruhttps://orcid.org/0009-0004-1138-6049ТумасА. С.TumasA. S.noemail@neicon.ruhttps://orcid.org/0009-0004-1880-9585ПлатоноваП. Я.PlatonovaP. Ya.noemail@neicon.ruhttps://orcid.org/0009-0009-7816-5562ШаймардановаД. Р.ShaimardanovaD. R.noemail@neicon.ruhttps://orcid.org/0009-0009-7808-1000ПакИ. А.PakI. A.noemail@neicon.ruhttps://orcid.org/0000-0002-9494-4234ПокушаловЕ. А.PokushalovE. A.noemail@neicon.ruНовосибирский государственный университет; Институт химической биологии и фундаментальной медицины СО РАН; ГК Центр Новых медицинских технологий; “Soloways” лабораторияРоссияNovosibirsk State University; Institute of chemical, Institute of Chemical Biology and Fundamental Medicine of the SB RAS; Center for New Medical Technologies; “Soloways” laboratoryRussian FederationНаучно-исследовательский клинический институт детства Министерства здравоохранения Московской области; Белгородский государственный исследовательский университет Министерства науки и высшего образования Российской ФедерацииРоссияResearch Clinical Institute of Childhood, Ministry of Health of the Moscow Region; Belgorod State Research UniversityRussian FederationНовосибирский государственный университетРоссияNovosibirsk State UniversityRussian FederationГК Центр Новых медицинских технологий; “Soloways” лабораторияРоссияCenter for New Medical Technologies; “Soloways” laboratoryRussian Federation20231503202401095103Copyright © Шрайнер Е.В., Хавкин А.И., Николайчук К.М., Новикова М.Ф., Веременко А.С., Левченко И.Д., Вергунова Е.Е., Тумас А.С., Платонова П.Я., Шаймарданова Д.Р., Пак И.А., Покушалов Е.А., 20242024Шрайнер Е.В., Хавкин А.И., Николайчук К.М., Новикова М.Ф., Веременко А.С., Левченко И.Д., Вергунова Е.Е., Тумас А.С., Платонова П.Я., Шаймарданова Д.Р., Пак И.А., Покушалов Е.А.Shrayner E.V., Khavkin A.I., Nikolaychuk K.M., Novikova M.F., Veremenko A.S., Levchenko I.D., Vergunova E.E., Tumas A.S., Platonova P.Y., Shaimardanova D.R., Pak I.A., Pokushalov E.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2552

В данной статье освещается фармакологическая активность берберина, а также его место в лечение эпидемии нынешнего времени - метаболического синдрома. В обзоре подробно рассмотрены молекулярные механизмы, позволяющие достичь противовоспалительного, антимикробного и антиоксидантного эффектов. Такой фармакологический профиль действия берберина позволяет ему оказывать положительное воздействие на течение ожирения, неалкогольной жировой болезни печени, дислипопротеинемию, микробиом кишечника, а также инсулинорезистентность. В дополнении к этому настоящая статья рассматривает основные фармакокинетические параметры и побочные эффекты химически не модифицированного берберина.

The article highlights the pharmacological activity of berberine, as well as its place in the treatment of the current epidemic - metabolic syndrome. The review examines the molecular mechanisms that allows achieving anti-inflammatory, antimicrobial and antioxidant effects in detail. Berberine’s pharmacological profile makes it possible to have a positive effect on the pathway of obesity, non-alcoholic fatty liver disease, dyslipoproteinemia, the intestinal microbiome and insulin resistance. In addition, the article reviews the main pharmacokinetic parameters and side effects of chemically unmodified berberine.

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The authors declare that there are no conflicts of interest present.