nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-215-7-119-124nogr-2535Research ArticleОБЗОРREVIEWМикробиота кишечника у детей с ювенильным идиопатическим артритомGut microbiota and methotrexate in children with juvenile idiopathic arthritisЖуковС. С.ZhukovS. S.zhuksema@mail.ruhttps://orcid.org/0000-0003-0522-7442МалиевскийВ. А.MalievskyV. A.noemail@neicon.ruhttps://orcid.org/0000-0002-7408-5719НижевичА. А.NizhevichA. A.noemail@neicon.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Башкирский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияBashkir State Medical UniversityRussian Federation20230703202407119124Copyright © Жуков С.С., Малиевский В.А., Нижевич А.А., 20242024Жуков С.С., Малиевский В.А., Нижевич А.А.Zhukov S.S., Malievsky V.A., Nizhevich A.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2535

Ювенильный идиопатический артрит (ЮИА) - наиболее часто встречающееся ревматическое заболевание у детей [1]. Этиология заболевания в настоящее время неизвестна, однако существует множество работ, посвященных роли кишечной микробиоты при ЮИА и ее взаимодействию с противоревматическими препаратами (метотрексат). Имеется ряд данных, посвященных влиянию метотрексата на микробиоту кишечника. В статье приведен обзор литературы, посвященный возможному участию кишечной микробиоты в индукции аутовоспаления и антагонизм между микробиотой кишечника и метотрексатом.

Introduction. Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children [1]. The etiology of the disease is currently unknown, but there are many works on the role of the intestinal microbiota in JIA and its interaction with antirheumatic drugs (methotrexate). There are a number of data on the effect of methotrexate on the intestinal microbiota. The article provides a review of the literature on the involvement of the intestinal microbiota in the induction of autoinflammation and the possible antagonism between the intestinal microbiota and methotrexate.

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The authors declare that there are no conflicts of interest present.