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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-213-5-81-91</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-2491</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Актуальная проблема - послеоперационный илеус</article-title><trans-title-group xml:lang="en"><trans-title>Current problem - postoperative ileus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1597-1876</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трухан</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Trukhan</surname><given-names>D. I.</given-names></name></name-alternatives><email xlink:type="simple">dmitry_trukhan@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0385-8232</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Деговцов</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Degovtsov</surname><given-names>E. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карасев</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Karasev</surname><given-names>V. E.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Омский государственный медицинский университет» Министерства здравоохранения России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Omsk state medical university</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Омский государственный медицинский университет» Министерства здравоохранения России; БУЗ Омской области «Клинический онкологический диспансер»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Omsk state medical university; Clinical Oncological Dispensary</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>25</day><month>05</month><year>2023</year></pub-date><volume>0</volume><issue>5</issue><fpage>81</fpage><lpage>91</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Трухан Д.И., Деговцов Е.Н., Карасев В.Е., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Трухан Д.И., Деговцов Е.Н., Карасев В.Е.</copyright-holder><copyright-holder xml:lang="en">Trukhan D.I., Degovtsov E.N., Karasev V.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/2491">https://www.nogr.org/jour/article/view/2491</self-uri><abstract><p>В абдоминальной хирургии после операций на брюшной полости возможно развитие нарушений нормальной согласованной пропульсивной моторики желудочно-кишечного тракта (ЖКТ). Этот эпизод желудочно-кишечной гипомоторики или состояние динамической кишечной непроходимости обозначается как послеоперационный илеус (ПОИ) или послеоперационный парез ЖКТ. Частота развития ПОИ в клинике абдоминальной хирургии составляет от 10 до 30%. Жевательная резинка используется в хирургии для уменьшения послеоперационной кишечной непроходимости с начала XXI века. В рамках представленного обзора рассмотрены основные рандомизированные клинические исследования, обзоры и мета-анализы, посвященные изучению эффекта жевательной резинки в абдоминальной хирургии для профилактики послеоперационного илеуса. Приведенные в обзоре данные свидетельствуют об эффективности и безопасности применения жевательной резинки в послеоперационном периоде для профилактики ПОИ в абдоминальной хирургии и оперативных вмешательствах в смежных областях.</p></abstract><trans-abstract xml:lang="en"><p>In abdominal surgery, after operations on the abdominal cavity, it is possible to develop disturbances in the normal coordinated propulsive motility of the gastrointestinal tract. This episode of gastrointestinal hypomotility or the state of dynamic ileus is referred to as postoperative ileus (POI) or postoperative gastrointestinal tract paresis. The incidence of POI in the clinic of abdominal surgery ranges from 10 to 30%. Chewing gum has been used in surgery to relieve postoperative intestinal obstruction since the early 21st century. The present review considers the main randomized clinical trials, reviews and meta-analyses on the study of the effect of chewing gum in abdominal surgery for the prevention of postoperative ileus. The data presented in the review indicate the effectiveness and safety of the use of chewing gum in the postoperative period for the prevention of POI in abdominal surgery and surgical interventions in related areas.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>абдоминальная хирургия</kwd><kwd>колоректальная хирургия</kwd><kwd>послеоперационный парез ЖКТ</kwd><kwd>послеоперационный илеус</kwd><kwd>профилактика</kwd><kwd>жевательная резинка</kwd><kwd>флатус</kwd><kwd>дефекация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>abdominal surgery</kwd><kwd>colorectal surgery</kwd><kwd>postoperative gastrointestinal paresis</kwd><kwd>postoperative ileus</kwd><kwd>prevention</kwd><kwd>chewing gum</kwd><kwd>flatus</kwd><kwd>defecation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">van den Heijkant T. C., Costes L. M., van der Lee D. G., et al. Randomized clinical trial of the effect of gum chewing on postoperative ileus and inflammation in colorectal surgery. Br J Surg. 2015 Feb;102(3):202-211. doi: 10.1002/bjs.9691.</mixed-citation><mixed-citation xml:lang="en">van den Heijkant T. C., Costes L. M., van der Lee D. G., et al. Randomized clinical trial of the effect of gum chewing on postoperative ileus and inflammation in colorectal surgery. Br J Surg. 2015 Feb;102(3):202-211. doi: 10.1002/bjs.9691.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Khomyakov E. A., Rybakov E. G. Postoperative paresis of the gastrointestinal tract. Pirogov Russian Journal of Surgery. 2017;3:76-85. (in Russ.) doi: 10.17116/hirurgia2017376-85.@@ Хомяков Е. А., Рыбаков Е. Г. Послеоперационный парез желудочно-кишечного тракта. Хирургия. Журнал им. Н. И. Пирогова. 2017;3: 76-85. doi: 10.17116/hirurgia2017376-85.</mixed-citation><mixed-citation xml:lang="en">Khomyakov E. A., Rybakov E. G. Postoperative paresis of the gastrointestinal tract. Pirogov Russian Journal of Surgery. 2017;3:76-85. (in Russ.) doi: 10.17116/hirurgia2017376-85.@@ Хомяков Е. А., Рыбаков Е. Г. Послеоперационный парез желудочно-кишечного тракта. Хирургия. Журнал им. Н. И. Пирогова. 2017;3: 76-85. doi: 10.17116/hirurgia2017376-85.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Fomin V. S. Postoperative dynamic intestinal obstruction: prevention and treatment. Pharmateka. 2018;(7):97-101. (in Russ.)@@ Фомин В. С. Послеоперационная динамическая кишечная непроходимость: профилактика и лечение. Фарматека. 2018;7: 97-101.</mixed-citation><mixed-citation xml:lang="en">Fomin V. S. Postoperative dynamic intestinal obstruction: prevention and treatment. Pharmateka. 2018;(7):97-101. (in Russ.)@@ Фомин В. С. Послеоперационная динамическая кишечная непроходимость: профилактика и лечение. Фарматека. 2018;7: 97-101.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Venara A., Neunlist M., Slim K. et al. Postoperative ileus: Pathophysiology, incidence, and prevention. J Visc Surg. 2016 Dec;153(6):439-446. doi: 10.1016/j.jviscsurg.2016.08.010.</mixed-citation><mixed-citation xml:lang="en">Venara A., Neunlist M., Slim K. et al. Postoperative ileus: Pathophysiology, incidence, and prevention. J Visc Surg. 2016 Dec;153(6):439-446. doi: 10.1016/j.jviscsurg.2016.08.010.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Harnsberger C. R., Maykel J. A., Alavi K. Postoperative Ileus. Clin Colon Rectal Surg. 2019 May;32(3):166-170. doi: 10.1055/s-0038-1677003.</mixed-citation><mixed-citation xml:lang="en">Harnsberger C. R., Maykel J. A., Alavi K. Postoperative Ileus. Clin Colon Rectal Surg. 2019 May;32(3):166-170. doi: 10.1055/s-0038-1677003.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Wattchow D., Heitmann P., Smolilo D. et al. Postoperative ileus-An ongoing conundrum. Neurogastroenterol Motil. 2021 May;33(5): e14046. doi: 10.1111/nmo.14046.</mixed-citation><mixed-citation xml:lang="en">Wattchow D., Heitmann P., Smolilo D. et al. Postoperative ileus-An ongoing conundrum. Neurogastroenterol Motil. 2021 May;33(5): e14046. doi: 10.1111/nmo.14046.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Yeh Y. C., Klinger E. V., Reddy P. Pharmacologic options to prevent postoperative ileus. Ann Pharmacother. 2009 Sep;43(9):1474-1485. doi: 10.1345/aph.1M121.</mixed-citation><mixed-citation xml:lang="en">Yeh Y. C., Klinger E. V., Reddy P. Pharmacologic options to prevent postoperative ileus. Ann Pharmacother. 2009 Sep;43(9):1474-1485. doi: 10.1345/aph.1M121.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sanfilippo F., Spoletini G. Perspectives on the importance of postoperative ileus. Curr Med Res Opin. 2015 Apr;31(4):675-6. doi: 10.1185/03007995.2015.1027184.</mixed-citation><mixed-citation xml:lang="en">Sanfilippo F., Spoletini G. Perspectives on the importance of postoperative ileus. Curr Med Res Opin. 2015 Apr;31(4):675-6. doi: 10.1185/03007995.2015.1027184.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Becker G., Blum H. E. Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus. Lancet. 2009 Apr 4;373(9670):1198-1206. doi: 10.1016/S0140-6736(09)60139-2.</mixed-citation><mixed-citation xml:lang="en">Becker G., Blum H. E. Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus. Lancet. 2009 Apr 4;373(9670):1198-1206. doi: 10.1016/S0140-6736(09)60139-2.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Shtoyko A. N., Cwikla G. M., Feldman E. A. et al. Trust your gut: Effect of a pharmacist-driven pilot project to decrease alvimopan use past gastrointestinal recovery in postsurgical patients. Am J Health Syst Pharm. 2021 May 24: zxab221. doi: 10.1093/ajhp/zxab221.</mixed-citation><mixed-citation xml:lang="en">Shtoyko A. N., Cwikla G. M., Feldman E. A. et al. Trust your gut: Effect of a pharmacist-driven pilot project to decrease alvimopan use past gastrointestinal recovery in postsurgical patients. Am J Health Syst Pharm. 2021 May 24: zxab221. doi: 10.1093/ajhp/zxab221.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Li S., Liu Y., Peng Q. et al. Chewing gum reduces postoperative ileus following abdominal surgery: a meta-analysis of 17 randomized controlled trials. J Gastroenterol Hepatol. 2013 Jul;28(7):1122-1132. doi: 10.1111/jgh.12206.</mixed-citation><mixed-citation xml:lang="en">Li S., Liu Y., Peng Q. et al. Chewing gum reduces postoperative ileus following abdominal surgery: a meta-analysis of 17 randomized controlled trials. J Gastroenterol Hepatol. 2013 Jul;28(7):1122-1132. doi: 10.1111/jgh.12206.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Q., Zhao P. Influence of gum chewing on return of gastrointestinal function after gastric abdominal surgery in children. Eur J Pediatr Surg. 2008 Feb;18(1):44-46. doi: 10.1055/s-2007-989273.</mixed-citation><mixed-citation xml:lang="en">Zhang Q., Zhao P. Influence of gum chewing on return of gastrointestinal function after gastric abdominal surgery in children. Eur J Pediatr Surg. 2008 Feb;18(1):44-46. doi: 10.1055/s-2007-989273.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Noble E. J., Harris R., Hosie K. B., et al. Gum chewing reduces postoperative ileus? A systematic review and meta-analysis.Int J Surg. 2009 Apr;7(2):100-105. doi: 10.1016/j.ijsu.2009.01.006.</mixed-citation><mixed-citation xml:lang="en">Noble E. J., Harris R., Hosie K. B., et al. Gum chewing reduces postoperative ileus? A systematic review and meta-analysis.Int J Surg. 2009 Apr;7(2):100-105. doi: 10.1016/j.ijsu.2009.01.006.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Tandeter H. Hypothesis: hexitols in chewing gum may play a role in reducing postoperative ileus. Med Hypotheses. 2009 Jan;72(1):39-40. doi: 10.1016/j.mehy.2008.06.044.</mixed-citation><mixed-citation xml:lang="en">Tandeter H. Hypothesis: hexitols in chewing gum may play a role in reducing postoperative ileus. Med Hypotheses. 2009 Jan;72(1):39-40. doi: 10.1016/j.mehy.2008.06.044.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Lepore M., Fitzgerald J. E. Gum chewing is associated with early recovery of bowel motility and shorter length of hospital stay for women after caesarean section. Evid Based Med. 2015 Feb;20(1):22. doi: 10.1136/ebmed-2014-110058.</mixed-citation><mixed-citation xml:lang="en">Lepore M., Fitzgerald J. E. Gum chewing is associated with early recovery of bowel motility and shorter length of hospital stay for women after caesarean section. Evid Based Med. 2015 Feb;20(1):22. doi: 10.1136/ebmed-2014-110058.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Asao T., Kuwano H., Nakamura J. et al. Gum chewing enhances early recovery from postoperative ileus after laparoscopic colectomy. J Am Coll Surg. 2002 Jul;195(1):30-32. doi: 10.1016/s1072-7515(02)01179-1.</mixed-citation><mixed-citation xml:lang="en">Asao T., Kuwano H., Nakamura J. et al. Gum chewing enhances early recovery from postoperative ileus after laparoscopic colectomy. J Am Coll Surg. 2002 Jul;195(1):30-32. doi: 10.1016/s1072-7515(02)01179-1.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Schuster R., Grewal N., Greaney G. C., Waxman K. Gum chewing reduces ileus after elective open sigmoid colectomy. Arch Surg. 2006 Feb;141(2):174-176. doi: 10.1001/archsurg.141.2.174.</mixed-citation><mixed-citation xml:lang="en">Schuster R., Grewal N., Greaney G. C., Waxman K. Gum chewing reduces ileus after elective open sigmoid colectomy. Arch Surg. 2006 Feb;141(2):174-176. doi: 10.1001/archsurg.141.2.174.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Cavuşoğlu Y. H., Azili M. N., Karaman A. et al. Does gum chewing reduce postoperative ileus after intestinal resection in children? A prospective randomized controlled trial. Eur J Pediatr Surg. 2009 Jun;19(3):171-173. doi: 10.1055/s-0029-1202776.</mixed-citation><mixed-citation xml:lang="en">Cavuşoğlu Y. H., Azili M. N., Karaman A. et al. Does gum chewing reduce postoperative ileus after intestinal resection in children? A prospective randomized controlled trial. Eur J Pediatr Surg. 2009 Jun;19(3):171-173. doi: 10.1055/s-0029-1202776.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ngowe M. N., Eyenga V. C., Kengne B. H. et al. Chewing gum reduces postoperative ileus after open appendectomy. Acta Chir Belg. 2010 Mar-Apr;110(2):195-199. doi: 10.1080/00015458.2010.11680596.</mixed-citation><mixed-citation xml:lang="en">Ngowe M. N., Eyenga V. C., Kengne B. H. et al. Chewing gum reduces postoperative ileus after open appendectomy. Acta Chir Belg. 2010 Mar-Apr;110(2):195-199. doi: 10.1080/00015458.2010.11680596.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Bahena-Aponte J.A., Cárdenas-Lailson E., Chávez-Tapia N., Flores-Gama F. Usefulness of chewing gum for the resolution of postoperative ileus in left colon resections. Rev Gastroenterol Mex. 2010 Oct-Dec;75(4):369-373.</mixed-citation><mixed-citation xml:lang="en">Bahena-Aponte J.A., Cárdenas-Lailson E., Chávez-Tapia N., Flores-Gama F. Usefulness of chewing gum for the resolution of postoperative ileus in left colon resections. Rev Gastroenterol Mex. 2010 Oct-Dec;75(4):369-373.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Marwah S., Singla S., Tinna P. Role of gum chewing on the duration of postoperative ileus following ileostomy closure done for typhoid ileal perforation: a prospective randomized trial. Saudi J Gastroenterol. 2012 Mar-Apr;18(2):111-117. doi: 10.4103/1319-3767.93812.</mixed-citation><mixed-citation xml:lang="en">Marwah S., Singla S., Tinna P. Role of gum chewing on the duration of postoperative ileus following ileostomy closure done for typhoid ileal perforation: a prospective randomized trial. Saudi J Gastroenterol. 2012 Mar-Apr;18(2):111-117. doi: 10.4103/1319-3767.93812.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Andersson T., Bjerså K., Falk K., Olsén M. F. Effects of chewing gum against postoperative ileus after pancreaticoduodenectomy - a randomized controlled trial. BMC Res Notes. 2015 Feb 10;8:37. doi: 10.1186/s13104-015-0996-0.</mixed-citation><mixed-citation xml:lang="en">Andersson T., Bjerså K., Falk K., Olsén M. F. Effects of chewing gum against postoperative ileus after pancreaticoduodenectomy - a randomized controlled trial. BMC Res Notes. 2015 Feb 10;8:37. doi: 10.1186/s13104-015-0996-0.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">López-Jaimez G., Cuello-García C. A. Use of chewing gum in children undergoing an appendectomy: A randomized clinical controlled trial.Int J Surg. 2016 Aug;32: 38-42. doi: 10.1016/j.ijsu.2016.06.003.</mixed-citation><mixed-citation xml:lang="en">López-Jaimez G., Cuello-García C. A. Use of chewing gum in children undergoing an appendectomy: A randomized clinical controlled trial.Int J Surg. 2016 Aug;32: 38-42. doi: 10.1016/j.ijsu.2016.06.003.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Takagi K., Teshima H., Arinaga K., et al. Gum chewing enhances early recovery of bowel function following transperitoneal abdominal aortic surgery. Surg Today. 2012 Aug;42(8):759-764. doi: 10.1007/s00595-012-0180-2.</mixed-citation><mixed-citation xml:lang="en">Takagi K., Teshima H., Arinaga K., et al. Gum chewing enhances early recovery of bowel function following transperitoneal abdominal aortic surgery. Surg Today. 2012 Aug;42(8):759-764. doi: 10.1007/s00595-012-0180-2.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kobayashi T., Masaki T., Kogawa K. et al. Efficacy of Gum Chewing on Bowel Movement After Open Colectomy for Left-Sided Colorectal Cancer: A Randomized Clinical Trial. Dis Colon Rectum. 2015 Nov;58(11):1058-1063. doi: 10.1097/DCR.0000000000000452.</mixed-citation><mixed-citation xml:lang="en">Kobayashi T., Masaki T., Kogawa K. et al. Efficacy of Gum Chewing on Bowel Movement After Open Colectomy for Left-Sided Colorectal Cancer: A Randomized Clinical Trial. Dis Colon Rectum. 2015 Nov;58(11):1058-1063. doi: 10.1097/DCR.0000000000000452.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Topcu S. Y., Oztekin S. D. Effect of gum chewing on reducing postoperative ileus and recovery after colorectal surgery: A randomised controlled trial.Complement Ther Clin Pract. 2016 May;23:21-25. doi: 10.1016/j.ctcp.2016.02.001.</mixed-citation><mixed-citation xml:lang="en">Topcu S. Y., Oztekin S. D. Effect of gum chewing on reducing postoperative ileus and recovery after colorectal surgery: A randomised controlled trial.Complement Ther Clin Pract. 2016 May;23:21-25. doi: 10.1016/j.ctcp.2016.02.001.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Shum N. F., Choi H. K., Mak J. C. et al. Randomized clinical trial of chewing gum after laparoscopic colorectal resection. Br J Surg. 2016 Oct;103(11):1447-1452. doi: 10.1002/bjs.10277.</mixed-citation><mixed-citation xml:lang="en">Shum N. F., Choi H. K., Mak J. C. et al. Randomized clinical trial of chewing gum after laparoscopic colorectal resection. Br J Surg. 2016 Oct;103(11):1447-1452. doi: 10.1002/bjs.10277.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Vergara-Fernandez O., Gonzalez-Vargas A.P., Castellanos-Juarez J.C. et al. Usefulness of Gum Chewing to Decrease Postoperative Ileus in Colorectal Surgery with Primary Anastomosis: A Randomized Controlled Trial. Rev Invest Clin. 2016 Nov-Dec;68(6):314-318.</mixed-citation><mixed-citation xml:lang="en">Vergara-Fernandez O., Gonzalez-Vargas A.P., Castellanos-Juarez J.C. et al. Usefulness of Gum Chewing to Decrease Postoperative Ileus in Colorectal Surgery with Primary Anastomosis: A Randomized Controlled Trial. Rev Invest Clin. 2016 Nov-Dec;68(6):314-318.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Z., Boersema G. S., Jeekel J., Lange J. F. Nicotine gum chewing: a novel strategy to shorten duration of postoperative ileus via vagus nerve activation. Med Hypotheses. 2014 Sep;83(3):352-354. doi: 10.1016/j.mehy.2014.06.011.</mixed-citation><mixed-citation xml:lang="en">Wu Z., Boersema G. S., Jeekel J., Lange J. F. Nicotine gum chewing: a novel strategy to shorten duration of postoperative ileus via vagus nerve activation. Med Hypotheses. 2014 Sep;83(3):352-354. doi: 10.1016/j.mehy.2014.06.011.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Lambrichts D. P.V., Boersema G. S.A., Tas B. et al. Nicotine chewing gum for the prevention of postoperative ileus after colorectal surgery: a multicenter, double-blind, randomised, controlled pilot study.Int J Colorectal Dis. 2017 Sep;32(9):1267-1275. doi: 10.1007/s00384-017-2839-z.</mixed-citation><mixed-citation xml:lang="en">Lambrichts D. P.V., Boersema G. S.A., Tas B. et al. Nicotine chewing gum for the prevention of postoperative ileus after colorectal surgery: a multicenter, double-blind, randomised, controlled pilot study.Int J Colorectal Dis. 2017 Sep;32(9):1267-1275. doi: 10.1007/s00384-017-2839-z.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Yang P., Long W. J., Wei L. Chewing Xylitol Gum could Accelerate Bowel motility Recovery after Elective Open Proctectomy for Rectal Cancer. Rev Invest Clin. 2018; 70(1):53-58. doi: 10.24875/RIC.18002428.</mixed-citation><mixed-citation xml:lang="en">Yang P., Long W. J., Wei L. Chewing Xylitol Gum could Accelerate Bowel motility Recovery after Elective Open Proctectomy for Rectal Cancer. Rev Invest Clin. 2018; 70(1):53-58. doi: 10.24875/RIC.18002428.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Bhatti S., Malik Y. J., Changazi S. H. et al. Role of Chewing Gum in Reducing Postoperative Ileus after Reversal of Ileostomy: A Randomized Controlled Trial. World J Surg. 2021 Apr;45(4):1066-1070. doi: 10.1007/s00268-020-05897-1.</mixed-citation><mixed-citation xml:lang="en">Bhatti S., Malik Y. J., Changazi S. H. et al. Role of Chewing Gum in Reducing Postoperative Ileus after Reversal of Ileostomy: A Randomized Controlled Trial. World J Surg. 2021 Apr;45(4):1066-1070. doi: 10.1007/s00268-020-05897-1.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Hsu Y. C., Szu S. Y. Effects of Gum Chewing on Recovery From Postoperative Ileus: A Randomized Clinical Trail. J Nurs Res. 2022 Oct 1;30(5): e233. doi: 10.1097/jnr.0000000000000510.</mixed-citation><mixed-citation xml:lang="en">Hsu Y. C., Szu S. Y. Effects of Gum Chewing on Recovery From Postoperative Ileus: A Randomized Clinical Trail. J Nurs Res. 2022 Oct 1;30(5): e233. doi: 10.1097/jnr.0000000000000510.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Pattamatta M., Smeets B. J.J., Evers S. M.A.A. et al. Health-related quality of life and cost-effectiveness analysis of gum chewing in patients undergoing colorectal surgery: results of a randomized controlled trial. Acta Chir Belg. 2018 Oct;118(5):299-306. doi: 10.1080/00015458.2018.1432742.</mixed-citation><mixed-citation xml:lang="en">Pattamatta M., Smeets B. J.J., Evers S. M.A.A. et al. Health-related quality of life and cost-effectiveness analysis of gum chewing in patients undergoing colorectal surgery: results of a randomized controlled trial. Acta Chir Belg. 2018 Oct;118(5):299-306. doi: 10.1080/00015458.2018.1432742.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Quah H. M., Samad A., Neathey A. J. et al. Does gum chewing reduce postoperative ileus following open colectomy for left-sided colon and rectal cancer? A prospective randomized controlled trial. Colorectal Dis. 2006 Jan;8(1):64-70. doi: 10.1111/j.1463-1318.2005.00884.x.</mixed-citation><mixed-citation xml:lang="en">Quah H. M., Samad A., Neathey A. J. et al. Does gum chewing reduce postoperative ileus following open colectomy for left-sided colon and rectal cancer? A prospective randomized controlled trial. Colorectal Dis. 2006 Jan;8(1):64-70. doi: 10.1111/j.1463-1318.2005.00884.x.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Niloff P. H. Does gum chewing ameliorate postoperative ileus? Results of a prospective randomized, placebo-controlled trial. J Am Coll Surg. 2006 Sep;203(3):405. doi: 10.1016/j.jamcollsurg.2006.06.006.</mixed-citation><mixed-citation xml:lang="en">Niloff P. H. Does gum chewing ameliorate postoperative ileus? Results of a prospective randomized, placebo-controlled trial. J Am Coll Surg. 2006 Sep;203(3):405. doi: 10.1016/j.jamcollsurg.2006.06.006.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Matros E., Rocha F., Zinner M. et al. Does gum chewing ameliorate postoperative ileus? Results of a prospective, randomized, placebo-controlled trial. J Am Coll Surg. 2006 May;202(5):773-778. doi: 10.1016/j.jamcollsurg.2006.02.009.</mixed-citation><mixed-citation xml:lang="en">Matros E., Rocha F., Zinner M. et al. Does gum chewing ameliorate postoperative ileus? Results of a prospective, randomized, placebo-controlled trial. J Am Coll Surg. 2006 May;202(5):773-778. doi: 10.1016/j.jamcollsurg.2006.02.009.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Zaghiyan K., Felder S., Ovsepyan G. et al. A prospective randomized controlled trial of sugared chewing gum on gastrointestinal recovery after major colorectal surgery in patients managed with early enteral feeding. Dis. Colon. Rectum. 2013;56(3):328-335. doi: 10.1097/DCR.0b013e31827e4971.</mixed-citation><mixed-citation xml:lang="en">Zaghiyan K., Felder S., Ovsepyan G. et al. A prospective randomized controlled trial of sugared chewing gum on gastrointestinal recovery after major colorectal surgery in patients managed with early enteral feeding. Dis. Colon. Rectum. 2013;56(3):328-335. doi: 10.1097/DCR.0b013e31827e4971.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Lim P., Morris O. J., Nolan G. et al. Sham feeding with chewing gum after elective colorectal resectional surgery: a randomized clinical trial. Ann Surg. 2013 Jun;257(6):1016-1024. doi: 10.1097/SLA.0b013e318286504a.</mixed-citation><mixed-citation xml:lang="en">Lim P., Morris O. J., Nolan G. et al. Sham feeding with chewing gum after elective colorectal resectional surgery: a randomized clinical trial. Ann Surg. 2013 Jun;257(6):1016-1024. doi: 10.1097/SLA.0b013e318286504a.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">You X. M., Mo X. S., Ma L. et al. Randomized Clinical Trial Comparing Efficacy of Simo Decoction and Acupuncture or Chewing Gum Alone on Postoperative Ileus in Patients With Hepatocellular Carcinoma After Hepatectomy. Medicine (Baltimore). 2015 Nov;94(45): e1968. doi: 10.1097/MD.0000000000001968.</mixed-citation><mixed-citation xml:lang="en">You X. M., Mo X. S., Ma L. et al. Randomized Clinical Trial Comparing Efficacy of Simo Decoction and Acupuncture or Chewing Gum Alone on Postoperative Ileus in Patients With Hepatocellular Carcinoma After Hepatectomy. Medicine (Baltimore). 2015 Nov;94(45): e1968. doi: 10.1097/MD.0000000000001968.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Ge B., Zhao H., Lin R., et al. Influence of gum-chewing on postoperative bowel activity after laparoscopic surgery for gastric cancer: A randomized controlled trial. Medicine (Baltimore). 2017 Mar;96(13): e6501. doi: 10.1097/MD.0000000000006501.</mixed-citation><mixed-citation xml:lang="en">Ge B., Zhao H., Lin R., et al. Influence of gum-chewing on postoperative bowel activity after laparoscopic surgery for gastric cancer: A randomized controlled trial. Medicine (Baltimore). 2017 Mar;96(13): e6501. doi: 10.1097/MD.0000000000006501.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">de Leede E. M., van Leersum N. J., Kroon H. M. Multicentre randomized clinical trial of the effect of chewing gum after abdominal surgery. Br J Surg. 2018 Jun;105(7):820-828. doi: 10.1002/bjs.10828.</mixed-citation><mixed-citation xml:lang="en">de Leede E. M., van Leersum N. J., Kroon H. M. Multicentre randomized clinical trial of the effect of chewing gum after abdominal surgery. Br J Surg. 2018 Jun;105(7):820-828. doi: 10.1002/bjs.10828.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Leier H. Does gum chewing help prevent impaired gastric motility in the postoperative period? J Am Acad Nurse Pract. 2007 Mar;19(3):133-136. doi: 1111/j.1745-7599.2006.00209.x.</mixed-citation><mixed-citation xml:lang="en">Leier H. Does gum chewing help prevent impaired gastric motility in the postoperative period? J Am Acad Nurse Pract. 2007 Mar;19(3):133-136. doi: 1111/j.1745-7599.2006.00209.x.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Chan M. K., Law W. L. Use of chewing gum in reducing postoperative ileus after elective colorectal resection: a systematic review. Dis Colon Rectum. 2007 Dec;50(12):2149-2157. doi: 10.1007/s10350-007-9039-9.</mixed-citation><mixed-citation xml:lang="en">Chan M. K., Law W. L. Use of chewing gum in reducing postoperative ileus after elective colorectal resection: a systematic review. Dis Colon Rectum. 2007 Dec;50(12):2149-2157. doi: 10.1007/s10350-007-9039-9.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Purkayastha S., Tilney H. S., Darzi A. W., Tekkis P. P. Meta-analysis of randomized studies evaluating chewing gum to enhance postoperative recovery following colectomy. Arch Surg. 2008 Aug;143(8):788-793. doi: 10.1001/archsurg.143.8.788.</mixed-citation><mixed-citation xml:lang="en">Purkayastha S., Tilney H. S., Darzi A. W., Tekkis P. P. Meta-analysis of randomized studies evaluating chewing gum to enhance postoperative recovery following colectomy. Arch Surg. 2008 Aug;143(8):788-793. doi: 10.1001/archsurg.143.8.788.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">de Castro S. M., van den Esschert J. W., van Heek N. T. et al. A systematic review of the efficacy of gum chewing for the amelioration of postoperative ileus. Dig Surg. 2008;25(1):39-45. doi: 10.1159/000117822.</mixed-citation><mixed-citation xml:lang="en">de Castro S. M., van den Esschert J. W., van Heek N. T. et al. A systematic review of the efficacy of gum chewing for the amelioration of postoperative ileus. Dig Surg. 2008;25(1):39-45. doi: 10.1159/000117822.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Kristensen S. D., Lind K., Rosenberg J. Gum chewing reduces duration of postoperative ileus. Ugeskr Laeger. 2008 Sep 22;170(39):3062-3065.</mixed-citation><mixed-citation xml:lang="en">Kristensen S. D., Lind K., Rosenberg J. Gum chewing reduces duration of postoperative ileus. Ugeskr Laeger. 2008 Sep 22;170(39):3062-3065.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Vásquez W., Hernández A. V., Garcia-Sabrido J. L. Is gum chewing useful for ileus after elective colorectal surgery? A systematic review and meta-analysis of randomized clinical trials. J Gastrointest Surg. 2009 Apr;13(4):649-656. doi: 10.1007/s11605-008-0756-8.</mixed-citation><mixed-citation xml:lang="en">Vásquez W., Hernández A. V., Garcia-Sabrido J. L. Is gum chewing useful for ileus after elective colorectal surgery? A systematic review and meta-analysis of randomized clinical trials. J Gastrointest Surg. 2009 Apr;13(4):649-656. doi: 10.1007/s11605-008-0756-8.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Fitzgerald J. E., Ahmed I. Systematic review and meta-analysis of chewing-gum therapy in the reduction of postoperative paralytic ileus following gastrointestinal surgery. World J Surg. 2009 Dec;33(12):2557-2566. doi: 10.1007/s00268-009-0104-5.</mixed-citation><mixed-citation xml:lang="en">Fitzgerald J. E., Ahmed I. Systematic review and meta-analysis of chewing-gum therapy in the reduction of postoperative paralytic ileus following gastrointestinal surgery. World J Surg. 2009 Dec;33(12):2557-2566. doi: 10.1007/s00268-009-0104-5.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Hocevar B. J., Robinson B., Gray M. Does chewing gum shorten the duration of postoperative ileus in patients undergoing abdominal surgery and creation of a stoma? J Wound Ostomy Continence Nurs. 2010 Mar-Apr;37(2):140-146. doi: 10.1097/WON.0b013e3181d0b92b.</mixed-citation><mixed-citation xml:lang="en">Hocevar B. J., Robinson B., Gray M. Does chewing gum shorten the duration of postoperative ileus in patients undergoing abdominal surgery and creation of a stoma? J Wound Ostomy Continence Nurs. 2010 Mar-Apr;37(2):140-146. doi: 10.1097/WON.0b013e3181d0b92b.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Wang X. J., Chi P. Effect of chewing gum on the promotion of intestinal function recovery after colorectal surgery: a meta-analysis. Zhonghua Wei Chang Wai Ke Za Zhi. 2013 Nov;16(11):1078-1083.</mixed-citation><mixed-citation xml:lang="en">Wang X. J., Chi P. Effect of chewing gum on the promotion of intestinal function recovery after colorectal surgery: a meta-analysis. Zhonghua Wei Chang Wai Ke Za Zhi. 2013 Nov;16(11):1078-1083.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Yin Z, Sun J., Liu T. et al. Gum chewing: another simple potential method for more rapid improvement of postoperative gastrointestinal function. Digestion. 2013;87(2):67-74. doi: 10.1159/000342637.</mixed-citation><mixed-citation xml:lang="en">Yin Z, Sun J., Liu T. et al. Gum chewing: another simple potential method for more rapid improvement of postoperative gastrointestinal function. Digestion. 2013;87(2):67-74. doi: 10.1159/000342637.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Wronski S. Chew on this: reducing postoperative ileus with chewing gum. Nursing. 2014 Aug;44(8):19-23. doi: 10.1097/01.NURSE.0000451535.63211.a8.</mixed-citation><mixed-citation xml:lang="en">Wronski S. Chew on this: reducing postoperative ileus with chewing gum. Nursing. 2014 Aug;44(8):19-23. doi: 10.1097/01.NURSE.0000451535.63211.a8.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Ho Y. M., Smith S. R., Pockney P. et al. A meta-analysis on the effect of sham feeding following colectomy: should gum chewing be included in enhanced recovery after surgery protocols? Dis Colon Rectum. 2014 Jan;57(1):115-126. doi: 10.1097/DCR.0b013e3182a665be.</mixed-citation><mixed-citation xml:lang="en">Ho Y. M., Smith S. R., Pockney P. et al. A meta-analysis on the effect of sham feeding following colectomy: should gum chewing be included in enhanced recovery after surgery protocols? Dis Colon Rectum. 2014 Jan;57(1):115-126. doi: 10.1097/DCR.0b013e3182a665be.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Su’a B.U., Pollock T. T., Lemanu D. P. et al. Chewing gum and postoperative ileus in adults: a systematic literature review and meta-analysis.Int J Surg. 2015 Feb;14:49-55. doi: 10.1016/j.ijsu.2014.12.032.</mixed-citation><mixed-citation xml:lang="en">Su’a B.U., Pollock T. T., Lemanu D. P. et al. Chewing gum and postoperative ileus in adults: a systematic literature review and meta-analysis.Int J Surg. 2015 Feb;14:49-55. doi: 10.1016/j.ijsu.2014.12.032.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Song G. M., Deng Y. H., Jin Y. H. et al. Meta-analysis comparing chewing gum versus standard postoperative care after colorectal resection. Oncotarget. 2016 Oct 25;7(43):70066-70079. doi: 10.18632/oncotarget.11735.</mixed-citation><mixed-citation xml:lang="en">Song G. M., Deng Y. H., Jin Y. H. et al. Meta-analysis comparing chewing gum versus standard postoperative care after colorectal resection. Oncotarget. 2016 Oct 25;7(43):70066-70079. doi: 10.18632/oncotarget.11735.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Q., Jiang H., Xu D., Jin J. Effect of gum chewing on ameliorating ileus following colorectal surgery: A meta-analysis of 18 randomized controlled trials.Int J Surg. 2017 Nov;47:107-115. doi: 10.1016/j.ijsu.2017.07.107.</mixed-citation><mixed-citation xml:lang="en">Liu Q., Jiang H., Xu D., Jin J. Effect of gum chewing on ameliorating ileus following colorectal surgery: A meta-analysis of 18 randomized controlled trials.Int J Surg. 2017 Nov;47:107-115. doi: 10.1016/j.ijsu.2017.07.107.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Mei B., Wang W., Cui F. et al. Chewing Gum for Intestinal Function Recovery after Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis. Gastroenterol Res Pract. 2017;2017:3087904. doi: 10.1155/2017/3087904.</mixed-citation><mixed-citation xml:lang="en">Mei B., Wang W., Cui F. et al. Chewing Gum for Intestinal Function Recovery after Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis. Gastroenterol Res Pract. 2017;2017:3087904. doi: 10.1155/2017/3087904.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Roslan F., Kushairi A., Cappuyns L., et al. The Impact of Sham Feeding with Chewing Gum on Postoperative Ileus Following Colorectal Surgery: a Meta-Analysis of Randomised Controlled Trials. J Gastrointest Surg. 2020 Nov;24(11):2643-2653. doi: 10.1007/s11605-019-04507-3.</mixed-citation><mixed-citation xml:lang="en">Roslan F., Kushairi A., Cappuyns L., et al. The Impact of Sham Feeding with Chewing Gum on Postoperative Ileus Following Colorectal Surgery: a Meta-Analysis of Randomised Controlled Trials. J Gastrointest Surg. 2020 Nov;24(11):2643-2653. doi: 10.1007/s11605-019-04507-3.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Sammut R., Trapani J., Deguara J., Ravasi V. The effect of gum chewing on postoperative ileus in open colorectal surgery patients: A review. J Perioper Pract. 2021 Apr;31(4):132-139. doi: 10.1177/1750458920917015.</mixed-citation><mixed-citation xml:lang="en">Sammut R., Trapani J., Deguara J., Ravasi V. The effect of gum chewing on postoperative ileus in open colorectal surgery patients: A review. J Perioper Pract. 2021 Apr;31(4):132-139. doi: 10.1177/1750458920917015.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Zhu Y. P., Wang W. J., Zhang S. L. et al. Effects of gum chewing on postoperative bowel motility after caesarean section: a meta-analysis of randomised controlled trials. BJOG. 2014 Jun;121(7):787-792. doi: 10.1111/1471-0528.12662.</mixed-citation><mixed-citation xml:lang="en">Zhu Y. P., Wang W. J., Zhang S. L. et al. Effects of gum chewing on postoperative bowel motility after caesarean section: a meta-analysis of randomised controlled trials. BJOG. 2014 Jun;121(7):787-792. doi: 10.1111/1471-0528.12662.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Craciunas L., Sajid M. S., Ahmed A. S. Chewing gum in preventing postoperative ileus in women undergoing caesarean section: a systematic review and meta-analysis of randomised controlled trials. BJOG. 2014 Jun;121(7):793-799; discussion 799. doi: 10.1111/1471-0528.12696.</mixed-citation><mixed-citation xml:lang="en">Craciunas L., Sajid M. S., Ahmed A. S. Chewing gum in preventing postoperative ileus in women undergoing caesarean section: a systematic review and meta-analysis of randomised controlled trials. BJOG. 2014 Jun;121(7):793-799; discussion 799. doi: 10.1111/1471-0528.12696.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Huang H-P, He M. Usefulness of chewing gum for recovering intestinal function after cesarean delivery: A systematic review and meta-analysis of randomized controlled trials. Taiwan J Obstet Gynecol. 2015 Apr;54(2):116-121. doi: 10.1016/j.tjog.2014.10.004.</mixed-citation><mixed-citation xml:lang="en">Huang H-P, He M. Usefulness of chewing gum for recovering intestinal function after cesarean delivery: A systematic review and meta-analysis of randomized controlled trials. Taiwan J Obstet Gynecol. 2015 Apr;54(2):116-121. doi: 10.1016/j.tjog.2014.10.004.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Hochner H., Tenfelde S. M., Abu Ahmad W., Liebergall-Wischnitzer M. Gum chewing and gastrointestinal function following caesarean delivery: a systematic review and meta-analysis. J Clin Nurs. 2015 Jul;24(13-14):1795-1804. doi: 10.1111/jocn.12836.</mixed-citation><mixed-citation xml:lang="en">Hochner H., Tenfelde S. M., Abu Ahmad W., Liebergall-Wischnitzer M. Gum chewing and gastrointestinal function following caesarean delivery: a systematic review and meta-analysis. J Clin Nurs. 2015 Jul;24(13-14):1795-1804. doi: 10.1111/jocn.12836.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Wen Z., Shen M., Wu C. et al. Chewing gum for intestinal function recovery after caesarean section: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2017 Apr 18;17(1):105. doi: 10.1186/s12884-017-1286-8.</mixed-citation><mixed-citation xml:lang="en">Wen Z., Shen M., Wu C. et al. Chewing gum for intestinal function recovery after caesarean section: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2017 Apr 18;17(1):105. doi: 10.1186/s12884-017-1286-8.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Wilson A. Does Chewing Gum Promote Bowel Function After Cesarean Section? Am J Nurs. 2017 Jul;117(7):21. doi: 10.1097/01.NAJ.0000520940.23976.94.</mixed-citation><mixed-citation xml:lang="en">Wilson A. Does Chewing Gum Promote Bowel Function After Cesarean Section? Am J Nurs. 2017 Jul;117(7):21. doi: 10.1097/01.NAJ.0000520940.23976.94.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Ciardulli A., Saccone G., Di Mascio D. et al. Chewing gum improves postoperative recovery of gastrointestinal function after cesarean delivery: a systematic review and meta-analysis of randomized trials. J Matern Fetal Neonatal Med. 2018 Jul;31(14):1924-1932. doi: 10.1080/14767058.2017.1330883.</mixed-citation><mixed-citation xml:lang="en">Ciardulli A., Saccone G., Di Mascio D. et al. Chewing gum improves postoperative recovery of gastrointestinal function after cesarean delivery: a systematic review and meta-analysis of randomized trials. J Matern Fetal Neonatal Med. 2018 Jul;31(14):1924-1932. doi: 10.1080/14767058.2017.1330883.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Xu C., Peng J., Liu S., Qi D. Y. Effect of chewing gum on gastrointestinal function after gynecological surgery: A systematic literature review and meta-analysis. J Obstet Gynaecol Res. 2018 May;44(5):936-943. doi: 10.1111/jog.13602.</mixed-citation><mixed-citation xml:lang="en">Xu C., Peng J., Liu S., Qi D. Y. Effect of chewing gum on gastrointestinal function after gynecological surgery: A systematic literature review and meta-analysis. J Obstet Gynaecol Res. 2018 May;44(5):936-943. doi: 10.1111/jog.13602.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Yin Y. N., Xie H., Ren J. H. et al. The impact of gum-chewing on postoperative ileus following gynecological cancer surgery: A systematic review and meta-analysis of randomized controlled trials. Front Oncol. 2023 Jan 17;12:1059924. doi: 10.3389/fonc.2022.1059924.</mixed-citation><mixed-citation xml:lang="en">Yin Y. N., Xie H., Ren J. H. et al. The impact of gum-chewing on postoperative ileus following gynecological cancer surgery: A systematic review and meta-analysis of randomized controlled trials. Front Oncol. 2023 Jan 17;12:1059924. doi: 10.3389/fonc.2022.1059924.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Pereira Gomes Morais E., Riera R., Porfírio G. J. et al. Chewing gum for enhancing early recovery of bowel function after caesarean section. Cochrane Database Syst Rev. 2016 Oct 17;10(10): CD011562. doi: 10.1002/14651858.CD011562.pub2.</mixed-citation><mixed-citation xml:lang="en">Pereira Gomes Morais E., Riera R., Porfírio G. J. et al. Chewing gum for enhancing early recovery of bowel function after caesarean section. Cochrane Database Syst Rev. 2016 Oct 17;10(10): CD011562. doi: 10.1002/14651858.CD011562.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Kouba E. J., Wallen E. M., Pruthi R. S. Gum chewing stimulates bowel motility in patients undergoing radical cystectomy with urinary diversion. Urology. 2007 Dec;70(6):1053-1056. doi: 10.1016/j.urology.2007.07.048.</mixed-citation><mixed-citation xml:lang="en">Kouba E. J., Wallen E. M., Pruthi R. S. Gum chewing stimulates bowel motility in patients undergoing radical cystectomy with urinary diversion. Urology. 2007 Dec;70(6):1053-1056. doi: 10.1016/j.urology.2007.07.048.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Choi H., Kang S. H., Yoon D. K. et al. Chewing gum has a stimulatory effect on bowel motility in patients after open or robotic radical cystectomy for bladder cancer: a prospective randomized comparative study. Urology. 2011 Apr;77(4):884-890. doi: 10.1016/j.urology.2010.06.042.</mixed-citation><mixed-citation xml:lang="en">Choi H., Kang S. H., Yoon D. K. et al. Chewing gum has a stimulatory effect on bowel motility in patients after open or robotic radical cystectomy for bladder cancer: a prospective randomized comparative study. Urology. 2011 Apr;77(4):884-890. doi: 10.1016/j.urology.2010.06.042.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Choi H., Kim J. H., Park J. Y. et al. Gum chewing promotes bowel motility after a radical retropubic prostatectomy. Asia Pac J Clin Oncol. 2014 Mar;10(1):53-59. doi: 10.1111/ajco.12113.</mixed-citation><mixed-citation xml:lang="en">Choi H., Kim J. H., Park J. Y. et al. Gum chewing promotes bowel motility after a radical retropubic prostatectomy. Asia Pac J Clin Oncol. 2014 Mar;10(1):53-59. doi: 10.1111/ajco.12113.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y., Meng Y. S., Fan Y. et al. Effect of gum chewing on bowel function recovery in patients after radical cystectomy with urinary diversion. Beijing Da Xue Xue Bao Yi Xue Ban. 2016 Oct 18;48(5):822-824.</mixed-citation><mixed-citation xml:lang="en">Wang Y., Meng Y. S., Fan Y. et al. Effect of gum chewing on bowel function recovery in patients after radical cystectomy with urinary diversion. Beijing Da Xue Xue Bao Yi Xue Ban. 2016 Oct 18;48(5):822-824.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Park J. S., Kim J., Jang W. S. et al. Management of postoperative ileus after robot-assisted laparoscopic prostatectomy. Medicine (Baltimore). 2018 Nov;97(44): e13036. doi: 10.1097/MD.0000000000013036.</mixed-citation><mixed-citation xml:lang="en">Park J. S., Kim J., Jang W. S. et al. Management of postoperative ileus after robot-assisted laparoscopic prostatectomy. Medicine (Baltimore). 2018 Nov;97(44): e13036. doi: 10.1097/MD.0000000000013036.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Ziouziou I., Ammani A., Karmouni T. et al. Does chewing gum improve postoperative results in patients undergoing radical cystectomy? A systematic review of literature and meta-analysis. Prog Urol. 2017 Sep;27(10):513-520. doi: 10.1016/j.purol.2017.06.005.</mixed-citation><mixed-citation xml:lang="en">Ziouziou I., Ammani A., Karmouni T. et al. Does chewing gum improve postoperative results in patients undergoing radical cystectomy? A systematic review of literature and meta-analysis. Prog Urol. 2017 Sep;27(10):513-520. doi: 10.1016/j.purol.2017.06.005.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Atkins C. S., Tubog T. D., Schaffer S. K. Chewing Gum After Radical Cystectomy With Urinary Diversion for Recovery of Intestinal Function: A Systematic Review and Meta-Analysis. J Perianesth Nurs. 2022 Aug;37(4):467-473. doi: 10.1016/j.jopan.2021.10.003.</mixed-citation><mixed-citation xml:lang="en">Atkins C. S., Tubog T. D., Schaffer S. K. Chewing Gum After Radical Cystectomy With Urinary Diversion for Recovery of Intestinal Function: A Systematic Review and Meta-Analysis. J Perianesth Nurs. 2022 Aug;37(4):467-473. doi: 10.1016/j.jopan.2021.10.003.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Cha Y. H., Nam D. C., Song S.Y, Yoo J. I. A prospective randomized controlled trial to evaluate effect of chewing gum on postoperative ileus in elderly patient after hip fracture. Medicine (Baltimore). 2021 Apr 2;100(13): e25321. doi: 10.1097/MD.0000000000025321.</mixed-citation><mixed-citation xml:lang="en">Cha Y. H., Nam D. C., Song S.Y, Yoo J. I. A prospective randomized controlled trial to evaluate effect of chewing gum on postoperative ileus in elderly patient after hip fracture. Medicine (Baltimore). 2021 Apr 2;100(13): e25321. doi: 10.1097/MD.0000000000025321.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Du X., Ou Y., Jiang G. et al. Chewing gum promotes bowel function recovery in elderly patients after lumbar spinal surgery: a retrospective single-center cohort study. Ann Palliat Med. 2021 Feb;10(2):1216-1223. doi: 10.21037/apm-20-1077.</mixed-citation><mixed-citation xml:lang="en">Du X., Ou Y., Jiang G. et al. Chewing gum promotes bowel function recovery in elderly patients after lumbar spinal surgery: a retrospective single-center cohort study. Ann Palliat Med. 2021 Feb;10(2):1216-1223. doi: 10.21037/apm-20-1077.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Liao X. Q., Li S. L., Peng Y. C. et al. Effects of chewing gum on gastrointestinal function in patients following spinal surgery: a meta-analysis and systematic review. Eur Spine J. 2022 Oct;31(10):2536-2546. doi: 10.1007/s00586-022-07304-w.</mixed-citation><mixed-citation xml:lang="en">Liao X. Q., Li S. L., Peng Y. C. et al. Effects of chewing gum on gastrointestinal function in patients following spinal surgery: a meta-analysis and systematic review. Eur Spine J. 2022 Oct;31(10):2536-2546. doi: 10.1007/s00586-022-07304-w.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Short V., Herbert G., Perry R. et al. Chewing gum for postoperative recovery of gastrointestinal function. Cochrane Database Syst Rev. 2015 Feb 20;2015(2): CD006506. doi: 10.1002/14651858.CD006506.pub3.</mixed-citation><mixed-citation xml:lang="en">Short V., Herbert G., Perry R. et al. Chewing gum for postoperative recovery of gastrointestinal function. Cochrane Database Syst Rev. 2015 Feb 20;2015(2): CD006506. doi: 10.1002/14651858.CD006506.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Dudi-Venkata N.N., Kroon H. M., Bedrikovetski S. et al. Systematic scoping review of enhanced recovery protocol recommendations targeting return of gastrointestinal function after colorectal surgery. ANZ J Surg. 2020 Jan;90(1-2):41-47. doi: 10.1111/ans.15319.</mixed-citation><mixed-citation xml:lang="en">Dudi-Venkata N.N., Kroon H. M., Bedrikovetski S. et al. Systematic scoping review of enhanced recovery protocol recommendations targeting return of gastrointestinal function after colorectal surgery. ANZ J Surg. 2020 Jan;90(1-2):41-47. doi: 10.1111/ans.15319.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Alfonsi P., Slim K., Chauvin M. et al. French guidelines for enhanced recovery after elective colorectal surgery. J Visc Surg. 2014 Feb;151(1):65-79. doi: 10.1016/j.jviscsurg.2013.10.006.</mixed-citation><mixed-citation xml:lang="en">Alfonsi P., Slim K., Chauvin M. et al. French guidelines for enhanced recovery after elective colorectal surgery. J Visc Surg. 2014 Feb;151(1):65-79. doi: 10.1016/j.jviscsurg.2013.10.006.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Alfonsi P., Slim K., Chauvin M. et al. Guidelines for enhanced recovery after elective colorectal surgery. Ann Fr Anesth Reanim. 2014 May;33(5):370-384. doi: 10.1016/j.annfar.2014.03.007.</mixed-citation><mixed-citation xml:lang="en">Alfonsi P., Slim K., Chauvin M. et al. Guidelines for enhanced recovery after elective colorectal surgery. Ann Fr Anesth Reanim. 2014 May;33(5):370-384. doi: 10.1016/j.annfar.2014.03.007.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Latthe P., Panza J., Marquini G. V. et al. AUGS-IUGA Joint Clinical Consensus Statement on Enhanced Recovery After Urogynecologic Surgery: Developed by the Joint Writing Group of the International Urogynecological Association and the American Urogynecologic Society. Individual writing group members are noted in the Acknowledgements section. Urogynecology (Hagerstown). 2022 Nov 1; 28(11):716-734. doi: 10.1097/SPV.0000000000001252.</mixed-citation><mixed-citation xml:lang="en">Latthe P., Panza J., Marquini G. V. et al. AUGS-IUGA Joint Clinical Consensus Statement on Enhanced Recovery After Urogynecologic Surgery: Developed by the Joint Writing Group of the International Urogynecological Association and the American Urogynecologic Society. Individual writing group members are noted in the Acknowledgements section. Urogynecology (Hagerstown). 2022 Nov 1; 28(11):716-734. doi: 10.1097/SPV.0000000000001252.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
