References

nogr

Экспериментальная и клиническая гастроэнтерология

Experimental and Clinical Gastroenterology

1682-8658

«Global Media Technologies»

10.31146/1682-8658-ecg-217-9-238-246

nogr-2474

Research Article

КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ

CLINICAL CASES

Болезнь Уиппла: этиология, патогенез, клиника, диагностика и лечение

Whipple’s disease: etiology, pathogenesis, clinic, diagnosis and treatment

https://orcid.org/0000-0002-9464-6560

Куприянова

И. Н.

Kupriyanova

I. N.

237380@mail.ru

Стафилова

М. В.

Stafilova

M. V.

noemail@neicon.ru

Федеральное государственное бюджетное образовательное учреждение высшего образования «Уральский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Educational Institution of Higher Education “Urals State Medical University” of the Ministry of Healthcare of the Russian FederationRussian Federation

2023

17012024

09238246

2024

Куприянова И.Н., Стафилова М.В.

Kupriyanova I.N., Stafilova M.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.nogr.org/jour/article/view/2474

Болезнь Уиппла представляет инфекционное, системное и рецидивирующее заболевание, вызываемое грамположительной бактерией Tropheryma whipplei. Заболевание протекает с гетерогенной клинической картиной, представляющей сложности своевременной диагностики и при отсутствии антибактериальной терапии может привести к летальному исходу. Данный обзор посвящен вопросам этиологии, патогенеза, эпидемиологии, клинической картины, современной диагностике и терапии болезни Уиппла.

Whipple’s disease is an infectious, systemic and recurrent disease caused by the gram-positive bacterium Tropheryma whipplei. The disease proceeds with a heterogeneous clinical picture, presenting difficulties of timely diagnosis and in the absence of antibacterial therapy can lethal outcome. This review is devoted to the etiology, pathogenesis, epidemiology, clinical picture, modern diagnosis and therapy of Whipple’s disease.

болезнь УипплаTropheryma whippleiPAS-положительные макрофагиПЦРантибиотикотерапия

Whipple’s diseaseTropheryma whippleiPAS-positive macrophagesPCRantibiotic therapy

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The authors declare that there are no conflicts of interest present.