nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-216-8-151-166nogr-2417Research ArticleОБЗОРREVIEWВитамин D: генетическая регуляция воспаления на примере аутоиммунной, метаболической и микробной моделейVitamin D: genetic regulation of inflammation in autoimmune, metabolic and microbial modelshttps://orcid.org/0000-0002-3043-8674ЛошковаЕ. В.LoshkovaE. V.loshkova@rambler.ruhttps://orcid.org/0000-0001-6395-0407КондратьеваЕ. И.KondratyevaE. I.noemail@neicon.ruhttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinA. I.noemail@neicon.ruhttps://orcid.org/0000-0001-5013-3360ЖекайтеЕ. К.ZhekaiteE. K.noemail@neicon.ruКотоваЮ. В.KotovaYu. V.noemail@neicon.ruhttps://orcid.org/0000-0002-8814-5532МельяновскаяЮ. Л.MelyanovskayaYu. L.noemail@neicon.ruhttps://orcid.org/0000-0003-3441-4626ЕрохинаМ. И.ErokhinaM. I.noemail@neicon.ruhttps://orcid.org/0000-0003-3364-610XЯблоковаЕ. А.YablokovaE. A.noemail@neicon.ruЖелевВ. А.ZhelevV. A.noemail@neicon.ruНаучно-исследовательский клинический институт детства Министерства здравоохранения Московской области; Сибирский государственный медицинский университет Министерства здравоохранения Российской ФедерацииРоссияResearch Clinical Institute of Childhood of the Ministry of Health of the Moscow Region; Siberian state medical UniversityRussian FederationНаучно-исследовательский клинический институт детства Министерства здравоохранения Московской области; Медико-генетический научный центр им. академика Н. П. БочковаРоссияResearch Clinical Institute of Childhood of the Ministry of Health of the Moscow Region; Federal state budgetary scientific institution “Research Centre for Medical Genetics”Russian FederationНаучно-исследовательский клинический институт детства Министерства здравоохранения Московской областиРоссияResearch Clinical Institute of Childhood of the Ministry of Health of the Moscow RegionRussian FederationСибирский государственный медицинский университет Министерства здравоохранения Российской ФедерацииРоссияSiberian state medical UniversityRussian Federation20230910202308151166Copyright © Лошкова Е.В., Кондратьева Е.И., Хавкин А.И., Жекайте Е.К., Котова Ю.В., Мельяновская Ю.Л., Ерохина М.И., Яблокова Е.А., Желев В.А., 20232023Лошкова Е.В., Кондратьева Е.И., Хавкин А.И., Жекайте Е.К., Котова Ю.В., Мельяновская Ю.Л., Ерохина М.И., Яблокова Е.А., Желев В.А.Loshkova E.V., Kondratyeva E.I., Khavkin A.I., Zhekaite E.K., Kotova Y.V., Melyanovskaya Y.L., Erokhina M.I., Yablokova E.A., Zhelev V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2417

Изучение цитокиновой продукции и ее генетической регуляции при различных по патогенезу заболеваниях в детском возрасте, которые включают несколько механизмов воспаления - это аутоиммунный на фоне целиакии, СД 1 типа и ХАИТ, лимфопролиферативный на фоне онкогематологических заболеваний, микробно-воспалительный на фоне хронического пиелонефрита и муковисцидоза и метаболический на фоне ожирения и снижения минеральной плотности кости необходимо для расширения представлений о патогенезе, прогнозировании вариантов клинического течения заболеваний (клинических фенотипов) и осложнений, а также ответа на терапию. Обзор литературы посвящен анализу и интерпретации данных о влиянии обеспеченности витамином D и его генетической регуляции на течение заболеваний, объединенных по ведущему патогенетическому механизму воспаления в аутоиммунную, микробную и лимфопролиферативную модели.

The study of cytokine production and its genetic regulation in diseases of various pathogenesis in childhood, which include several mechanisms of inflammation - this is autoimmune against the background of celiac disease, type 1 diabetes and CAI, lymphoproliferative against the background of oncohematological diseases, microbial-inflammatory against the background of chronic pyelonephritis and cystic fibrosis and metabolic against the background of obesity and a decrease in bone mineral density is necessary to expand understanding of pathogenesis, predict variants of the clinical course of diseases (clinical phenotypes) and complications, as well as response to therapy. The literature review is devoted to the analysis and interpretation of data on the effect of vitamin D supply and its genetic regulation on the course of diseases, combined according to the leading pathogenetic mechanism of inflammation into autoimmune, microbial, and lymphoproliferative models.

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The authors declare that there are no conflicts of interest present.