References

nogr

Экспериментальная и клиническая гастроэнтерология

Experimental and Clinical Gastroenterology

1682-8658

«Global Media Technologies»

10.31146/1682-8658-ecg-212-4-37-48

nogr-2360

Research Article

КЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯ

CLINICAL GASTROENTEROLOGY

При синдроме раздраженной кишки уровень зонулина ассоциирован с уровнями кортизола, дофамина и серотонина

Zonulin levels are associated with cortisol, dopamine, and serotonin levels in irritable bowel syndrome

https://orcid.org/0000-0001-9370-4768

Гаус

О. В.

Gaus

O. V.

gaus_olga@bk.ru

https://orcid.org/0000-0002-6581-7017

Ливзан

М. А.

Livzan

M. A.

noemail@neicon.ru

Федеральное государственное бюджетное образовательное учреждение высшего образования «Омский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияOmsk State Medical UniversityRussian Federation

2023

26072023

043748

2023

Гаус О.В., Ливзан М.А.

Gaus O.V., Livzan M.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.nogr.org/jour/article/view/2360

Синдром повышенной эпителиальной проницаемости (СПЭП) является одним из основных механизмов развития синдрома раздраженного кишечника (СРК). В качестве ключевых модифицируемых факторов, способствующих развитию СПЭП, рассматривается роль факторов стресса и питания. Цель исследования: оценить содержание маркера повышенной кишечной проницаемости (зонулин в кале) во взаимосвязи с пищевыми привычками, уровнем тревоги и депрессии, уровнем гормонов стресса (кортизол в слюне) и нейромедиаторов (серотонин в сыворотке крови, дофамин в плазме крови) у пациентов с СРК. Материал и методы: проведено открытое когортное проспективное исследование с включением 263 пациентов с установленным диагнозом СРК. Контрольную группу составили 40 здоровых добровольцев. Всем включенным в исследование лицам проводилась оценка рациона питания и пищевых привычек, выраженности тревоги и депрессии, в том числе, уровня специфической тревоги в отношении гастроинтестинальных симптомов, качества жизни. Кроме того, проводилась оценка уровней кортизола в утренней и вечерней порциях слюны, серотонина в сыворотке крови, дофамина в плазме крови и зонулина в кале. Результаты: у пациентов с СРК маркер повышенной кишечной проницаемости (зонулин в кале) находится в тесной взаимосвязи с характером питания, уровнем тревоги, секрецией кортизола и серотонина, а также ассоциирован с развитием абдоминальной боли, диареи и степенью тяжести заболевания.

Increase intestinal permeability is one of the main mechanisms for the development of irritable bowel syndrome (IBS). The role of stress and nutrition factors is considered as key modifiable factors contributing to the development of increase intestinal permeability. Purpose of the study: to evaluate the content of a marker of increased intestinal permeability (zonulin in feces) in relation to dietary habits, levels of anxiety and depression, levels of stress hormones (cortisol in saliva) and neurotransmitters (serotonin in blood serum, dopamine in blood plasma) in patients with IBS. Materials and methods: an open cohort prospective study was conducted with the inclusion of 263 patients with an established diagnosis of IBS. The control group consisted of 40 healthy volunteers. All individuals included in the study were assessed for diet and eating habits, the severity of anxiety and depression, including the level of specific anxiety in relation to gastrointestinal symptoms, and quality of life. In addition, the levels of cortisol in the morning and evening portions of saliva, serum serotonin, plasma dopamine and fecal zonulin were assessed. Results: in patients with IBS, the marker of increased intestinal permeability (zonulin in feces) is closely related to the nature of nutrition, anxiety levels, cortisol and serotonin secretion, and is also associated with the development of abdominal pain, diarrhea, and the severity of the disease.

синдром раздраженного кишечникаповышенная кишечная проницаемостьзонулинкортизолсеротониндофаминтревогадепрессияпищевые привычки

irritable bowel syndromeincreased intestinal permeabilityzonulincortisolserotonindopamineanxietydepressioneating habits

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The authors declare that there are no conflicts of interest present.