References

nogr

Экспериментальная и клиническая гастроэнтерология

Experimental and Clinical Gastroenterology

1682-8658

«Global Media Technologies»

10.31146/1682-8658-ecg-211-3-134-143

nogr-2345

Research Article

ОБЗОР

REVIEW

Сигаретный дым и кишечная микробиота - что мы знаем?

Cigarette smoke and intestinal microbiota - what do we know?

https://orcid.org/0000-0001-6434-1267

Успенский

Ю. П.

Uspensky

Yu. P.

noemail@neicon.ru

https://orcid.org/0000-0002-2436-3813

Фоминых

Ю. А.

Fominykh

Yu. A.

noemail@neicon.ru

https://orcid.org/0000-0003-4168-4851

Башкина

О. А.

Bashkina

O. A.

noemail@neicon.ru

https://orcid.org/0000-0002-8419-0272

Наджафова

К. Н.

Nadzhafova

K. N.

kyamalyok@yandex.ru

https://orcid.org/0000-0002-0509-147X

Иманвердиева

Н. А.

Imanverdieva

N. A.

noemail@neicon.ru

Федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияSaint- Petersburg State Pediatric Medical University; Pavlov First Saint Petersburg State Medical UniversityRussian Federation

Федеральное государственное бюджетное образовательное учреждение высшего образования Астраханский государственный медицинский университет Министерства здравоохранения Российской ФедерацииРоссияAstrakhan State Medical UniversityRussian Federation

2023

25072023

03134143

2023

Успенский Ю.П., Фоминых Ю.А., Башкина О.А., Наджафова К.Н., Иманвердиева Н.А.

Uspensky Y.P., Fominykh Y.A., Bashkina O.A., Nadzhafova K.N., Imanverdieva N.A.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.nogr.org/jour/article/view/2345

Микробиота кишечника - это уникальная структура, в норме находящаяся в равновесном состоянии и выполняющая огромное число разнообразных функций. Сигаретный дым модифицирует микробиоту кишечника посредством множества механизмов и влияет на работу ферментов, связанных с окислительным стрессом, на слой муцина и экспрессию белков плотных контактов слизистой кишечника, на баланс кислот и оснований в толстой кишке. И это помимо прямого токсического воздействия множества компонентов табачного дыма и распространения бактерий непосредственно от сигарет. В статье рассматриваются данные современной литературы о сложных и неоднозначных механизмах влияния табачного дымы и его отдельных компонентов на микробиоту кишки.

The gut microbiota is a unique structure that is normally in an equilibrium state and performs a huge number of diverse functions. Cigarette smoke modifies the intestinal microbiota through a variety of mechanisms and affects the work of enzymes associated with oxidative stress, the mucin layer and the expression of proteins of dense contacts of the intestinal mucosa, the balance of acids and bases in the colon. And this is in addition to the direct toxic effects of many components of tobacco smoke and the spread of bacteria directly from cigarettes. The article examines the data of modern literature on the complex and ambiguous mechanisms of the influence of tobacco smoke and its individual components on the gut microbiota.

кишечная микробиотакурениесигаретный дым

intestinal microbiotasmokingcigarette smoke

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The authors declare that there are no conflicts of interest present.