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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-211-3-22-27</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-2331</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕРЕДОВАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LEADING ARTICLE</subject></subj-group></article-categories><title-group><article-title>Метастатический колоректальный рак</article-title><trans-title-group xml:lang="en"><trans-title>Metastatic colorectal cancer</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4424-0850</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цыганкова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsygankova</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">tsygankovva98@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6375-8335</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткаченко</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkachenko</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Петрова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N. N. Petrov National Medical Research Center of Oncology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>25</day><month>07</month><year>2023</year></pub-date><volume>0</volume><issue>3</issue><fpage>22</fpage><lpage>27</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Цыганкова М.В., Ткаченко Е.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Цыганкова М.В., Ткаченко Е.В.</copyright-holder><copyright-holder xml:lang="en">Tsygankova M.V., Tkachenko E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/2331">https://www.nogr.org/jour/article/view/2331</self-uri><abstract><p>В данной статье представлен клинический случай пациента с колоректальным раком (КРР), который был диагностирован на этапе метастатического генерализованного процесса, в связи с длительным бессимптомным течением, неспецифичностью симптомов и трудностью первичной диагностики. Рассматриваются особенности ведения, а также возможности лечения пациента с метастатическим колоректальным раком (мКРР) на современном этапе. Данное клиническое наблюдение демонстрирует актуальность поиска новых методов диагностики, схем лечения и принципов профилактики КРР.</p></abstract><trans-abstract xml:lang="en"><p>This article presents a clinical case of a patient with colorectal cancer (CRC), who was diagnosed at the stage of a metastatic generalized process, due to a long asymptomatic course, non-specific symptoms and the difficulty of primary diagnosis. The features of management, as well as the possibilities of treating a patient with metastatic colorectal cancer (mCRC) at the present stage, are considered. This clinical observation demonstrates the relevance of the search for new diagnostic methods, treatment regimens and principles for the prevention of CRC.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>метастатический колоректальный рак</kwd><kwd>лекарственная терапия</kwd><kwd>КРР</kwd><kwd>мКРР</kwd><kwd>клинический случай</kwd></kwd-group><kwd-group xml:lang="en"><kwd>metastatic colorectal cancer</kwd><kwd>drug therapy</kwd><kwd>CRR</kwd><kwd>mCRC</kwd><kwd>clinical case</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sung H., Ferlay J., Siegel R. L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660.</mixed-citation><mixed-citation xml:lang="en">Sung H., Ferlay J., Siegel R. 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