nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-214-6-153-156nogr-2320Research ArticleЭКСПЕРИМЕНТАЛЬНАЯ ГАСТРОЭНТЕРОЛОГИЯEXPERIMENTAL GASTROENTEROLOGYЗначение морфологических исследований в диагностике билиарной интраэпителиальной неоплазии при непаразитарных кистах печениSignificance of morphological studies in the diagnostics of bilial intraepithelial neoplasia in nonparasitic liver cystsГромоваЕ. В.GromovaE. V.zhivaeva.e@bk.ruФрейндГ. Г.FreyndG. G.noemail@neicon.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Пермский государственный медицинский университет имени академика Е. А. Вагнера» Министерства здравоохранения Российской ФедерацииРоссияPerm State Medical University n. a. E. A. Wagner of the Ministry of Health of the Russian FederationRussian Federation20232507202306153156Copyright © Громова Е.В., Фрейнд Г.Г., 20232023Громова Е.В., Фрейнд Г.Г.Gromova E.V., Freynd G.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2320

Билиарная интраэпителиальная неоплазия (БилИН), по современным представлениям, рассматривается в качестве облигатного предрака желчных протоков. В ходе прогрессирования БилИН развивается холангиокарцинома, характеризующаяся низким процентом пятилетней выживаемости. Целью данной работы является описание морфологических характеристик БилИН в эпителии непаразитарных кист печени. Описан материал после первичных и повторныхв ряде случаев хирургических вмешательств у 99 пациентов. Изучены морфологические проявления интраэпителиальной неоплазии при непаразитарных дизонтогенетических кистах печени, установлена их роль в развитии холангиокарциномы печени.

Biliary intraepithelial neoplasia (BilIN) according to modern data is considered as an obligate precancer of the bile ducts. As BILIN progresses, cholangiocarcinoma often develops, characterized by a low five-year survival rate. The aim of this work is to describe the morphological characteristics of BilIN in the epithelium of nonparasitic liver cysts. The material is described after primary and repeated (15) surgical interventions in 99 patients. The morphological manifestations of intraepithelial neoplasia in non-parasitic dysontogenetic liver cysts were studied, their role in the development of liver cholangiocarcinoma was established.

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The authors declare that there are no conflicts of interest present.