nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»nogr-228Research ArticleПЕРЕДОВАЯ СТАТЬЯLEADING ARTICLEГЕПАТОЦЕЛЛЮЛЯРНЫЙ РАК. ГЕНДЕРНЫЕ АСПЕКТЫ КАНЦЕРОГЕНЕЗАHEPATOCELLULAR CARCINOMA. GENDER ASPECTS OF CARCINOGENESISШапошниковА. В.ShaposhnikovA. V.alexshap@donpac.ruФГБУ Ростовский научно-исследовательский онкологический институтРоссияFGBU Rostov Cancer Research InstituteRussian Federation20162007201607412Copyright © Шапошников А.В., 20162016Шапошников А.В.Shaposhnikov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/228

В обзоре представлены современные данные о роли циркулирующих и тканевых половых гормонов, а также их ядерных рецепторов в гепатоканцерогенезе. Обращается внимание на различные влияния гепатопротекторных средств на возникновение и развитие гепатоцеллюлярного рака у мужчин и женщин, что необходимо учитывать как в профилактике, так и в лечении рака печени.

The article reviews contemporary data about influences of sex hormons (androgenes, estrogenes) and their nuclear receptors on development of hepatocellular carcinoma. Use of hepatoprotective drugs for treatment of chronic liver diseases and prophylactic of hepatocellular carcinoma should be correlated with potential hormonal effects of the treatment.

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The authors declare that there are no conflicts of interest present.