nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-209-1-134-141QPBUMCnogr-2273Research ArticleОБЗОРREVIEWСаркопеническое ожирение у детейSarcopenic obesity in childrenhttps://orcid.org/0000-0002-9532-9698ЗавьяловаА. Н.Zav’yalovaA. N.

Завьялова Анна Никитична, к. м. н., доцент кафедры пропедевтики детских болезней с курсом общего ухода за детьми; доцент кафедры общей медицинской практики; врач диетолог Клиники 

 194100, Санкт-Петербург, ул. Литовская, д. 2, Россия 

Anna N. Zav’yalova, Candidate of Medical Sciences, Associate Professor of the Department of Propaedeutics of Children’s Diseases with a course of General Child Care; Associate Professor of the Department of General Medical Practice; dietitian of the Clinic

 2, Litovskaya str, Saint-Petersburg, 194100 Russia 

anzavjalova@mail.ruhttps://orcid.org/0000-0002-5431-0827ТрошкинаМ. Е.TroshkinaM. E.

 Трошкина Марина Евгеньевна, студентка 4 курса 

 194100, Санкт-Петербург, ул. Литовская, д. 2, Россия

Marina E. Troshkina, 4th year student

 2, Litovskaya str, Saint-Petersburg, 194100 Russia 

https://orcid.org/0000-0002-1798-8719ЩербакЛ. А.ShcherbakL. A.

 Щербак Лидия Аркадьевна, студентка 4 курса 

 194100, Санкт-Петербург, ул. Литовская, д. 2, Россия

Lidia A. Shcherbak 4th-year student

 2, Litovskaya str, Saint-Petersburg, 194100 Russia 

https://orcid.org/0000-0002-0992-1709НовиковаВ. П.NovikovaV. P.

Новикова Валерия Павловна, д. м. н., профессор, зав. кафедрой пропедевтики детских болезней с курсом общего ухода за детьми, зав. лабораторией «Медико- социальных проблем в педиатрии» 

 194100, Санкт-Петербург, ул. Литовская, д. 2, Россия

Valeria P. Novikova, Doctor of Medical Sciences, Professor, Head of the Department of Propaedeutics of Children’s Diseases with the course of general child care, Head of laboratory of “Medical and Social Problems in Pediatrics”

 2, Litovskaya str, Saint-Petersburg, 194100 Russia 

Федеральное государственное бюджетное образовательное учреждение высшего образования Санкт-Петербургский государственный педиатрический медицинский университет Министерства здравоохранения Российской ФедерацииРоссияSaint-Petersburg State Pediatric Medical UniversityRussian Federation20232405202311134141Copyright © Завьялова А.Н., Трошкина М.Е., Щербак Л.А., Новикова В.П., 20232023Завьялова А.Н., Трошкина М.Е., Щербак Л.А., Новикова В.П.Zav’yalova A.N., Troshkina M.E., Shcherbak L.A., Novikova V.P.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2273

В представленном обзоре литературы поднимается проблема саркопенического ожирения в педиатрической популяции. Ряд исследований показывает: при морбидном ожирении снижается уровень мышечной массы вплоть до развития саркопении. Саркопеническое ожирение тесно связано с ухудшением качества жизни и снижением активности человека. Несмотря на растущую актуальность вопроса, многие данные, такие как механизм развития, исходы и эпидемиология патологического состояния у детей, чётко не определены. В своей статье мы привели данные о методах исследования саркопении, преимущества одних методов над другими, связь рассматриваемого состояния с расстройствами других органов и систем, патогенез болезни у взрослого человека и возможный механизм развития саркопенического ожирения у детского населения.

The presented literature review raises the problem of sarcopenic obesity in the pediatric population. A number of studies show that with morbid obesity, the level of muscle mass decreases until the development of sarcopenia. Sarcopenic obesity is closely associated with a deterioration in the quality of life and a decrease in human activity. Despite the growing relevance of the issue, many data, such as the mechanism of development, outcomes and epidemiology of the pathological condition in children, are not clearly defi ned. In our article, we provided data on the methods of studying the disease, the advantages of some methods over others, the relationship of the condition in question with disorders of other organs and systems, the pathogenesis of the disease in an adult and a possible mechanism for the development of sarcopenic obesity in children. 

саркопеническое ожирениеожирениемышечная массамышечная силамышечная функциясаркопенияантропометрияпедиатрияsarcopenic obesityobesitymuscle massmuscle strengthmuscle functionsarcopeniaanthropometrypediatricsReferencesZembura Marcela, Paweł Matusik. Sarcopenic Obesity in Children and Adolescents: A Systematic Review. Frontiers in endocrinology vol. 2022;13:914740. doi:Zembura Marcela, Paweł Matusik. Sarcopenic Obesity in Children and Adolescents: A Systematic Review. Frontiers in endocrinology vol. 2022;13:914740. doi: 10.3389/fendo.2022.914740.3389/fendo.2022.914740.Donini L.M., Busetto L., Bischoff S. C., Cederholm T., Ballesteros-Pomar M.D., et al. Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement. Obesity Facts. 2022;15(3):321–335. doi: 10.1159/000521241.Donini L.M., Busetto L., Bischoff S. C., Cederholm T., Ballesteros-Pomar M.D., et al. Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement. Obesity Facts. 2022;15(3):321–335. doi: 10.1159/000521241.Polyzos S.A., Margioris A. N. Sarcopenic obesity. Hormones (Athens). 2018 Sep;17(3):321–331. doi: 10.1007/s42000-018-0049-x.Polyzos S.A., Margioris A. N. Sarcopenic obesity. Hormones (Athens). 2018 Sep;17(3):321–331. doi: 10.1007/s42000-018-0049-x.Koliaki C., Liatis S., Dalamaga M., Kokkinos A. Sarcopenic Obesity: Epidemiologic Evidence, Pathophysiology, and Therapeutic Perspectives. Current Obesity Reports. 2019;8(4):458–471. doi: 10.1007/s13679-019-00359-9.Koliaki C., Liatis S., Dalamaga M., Kokkinos A. Sarcopenic Obesity: Epidemiologic Evidence, Pathophysiology, and Therapeutic Perspectives. Current Obesity Reports. 2019;8(4):458–471. doi: 10.1007/s13679-019-00359-9.Safer U., Kaplan M., Binay Safer V. Evaluation of Sarcopenia in Children. J Surg Res. 2019 May;237:112. doi: 10.1016/j.jss.2018.03.008.Safer U., Kaplan M., Binay Safer V. Evaluation of Sarcopenia in Children. J Surg Res. 2019 May;237:112. doi: 10.1016/j.jss.2018.03.008.Woolfson J.P., Kamath B. M., Ng V. L. Reply. Liver Transpl. 2021 Jul;27(7):1073–1074. doi: 10.1002/lt.26051.Woolfson J.P., Kamath B. M., Ng V. L. Reply. Liver Transpl. 2021 Jul;27(7):1073–1074. doi: 10.1002/lt.26051.Carey E.J., Lai J. C., Sonnenday C., et al. A North American Expert Opinion Statement on Sarcopenia in Liver Transplantation. Hepatology. 2019;70(5):1816–1829. doi: 10.1002/hep.30828.Carey E.J., Lai J. C., Sonnenday C., et al. A North American Expert Opinion Statement on Sarcopenia in Liver Transplantation. Hepatology. 2019;70(5):1816–1829. doi: 10.1002/hep.30828.Zavyalova A.N., Khavkin A. I., Novikova V. P. Causes and prevention options for sarcopenia in children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2022;67(2):34–42. (In Russ.) doi: 10.21508/1027-4065-2022-67-2-34-42.Завьялова А. Н., Хавкин А. И., Новикова В. П. Причины и варианты профилактики саркопении у детей. Российский вестник перинатологии и педиатрии. – 2022. – Т. 67. – N 2. – С. 34–42. doi: 10.21508/1027-4065-2022-67-2-34-42Zavyalova A.N., Novikova V. P., Klikunova K. A. Juvenile sarcopenia in patients with cerebral palsy and predictors of its development. Forcipe. 2022;5(S2):207–208. (in Russ.)Завьялова А. Н., Новикова В. П., Кликунова К. А. Юношеская саркопения у пациентов с детским церебральным параличом и предикторы ее развития. Forcipe. – 2022. – Т. 5. – N S2. – С. 207–208.Benson A.C., Torode M. E., Singh M. A. Muscular strength and cardiorespiratory fitness is associated with higher insulin sensitivity in children and adolescents. International Journal of Pediatric Obesity. 2006;1(4):222–31. doi: 10.1080/17477160600962864.Benson A.C., Torode M. E., Singh M. A. Muscular strength and cardiorespiratory fitness is associated with higher insulin sensitivity in children and adolescents. International Journal of Pediatric Obesity. 2006;1(4):222–31. doi: 10.1080/17477160600962864.Choi K. M. Sarcopenia and sarcopenic obesity. Korean J Intern Med. 2016 Nov;31(6):1054–1060. doi: 10.3904/kjim.2016.193.Choi K. M. Sarcopenia and sarcopenic obesity. Korean J Intern Med. 2016 Nov;31(6):1054–1060. doi: 10.3904/kjim.2016.193.Cruz- Jentoft A.J., Baeyens J. P., Bauer J. M., et al. European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age and Ageing. 2010;39(4):412–23. doi: 10.1093/ageing/afq034.Cruz-Jentoft A.J., Baeyens J. P., Bauer J. M., et al. European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age and Ageing. 2010;39(4):412–23. doi: 10.1093/ageing/afq034.Cruz-Jentoft A.J., Bahat G., Bauer J., et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16–31. doi: 10.1093/ageing/afy169.Cruz-Jentoft A.J., Bahat G., Bauer J., et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16–31. doi: 10.1093/ageing/afy169.Petrenko Yu.V., Novikova V. P., Polunina A. V. Obesity in mothers and the health of children of different ages. Pediatrician. 2018;9(3):24–27. (in Russ.) doi: 10.17816/PED9324-27.Петренко Ю. В., Новикова В. П., Полунина А. В. Ожирение у матерей и здоровье детей разного возраста. // Педиатр. – 2018. – Т. 9. – N 3. – С. 24–27. doi: 10.17816/PED9324-27.Gritsinskaya V.L., Novikova V. P., Khavkin A. I. Epidemiology of obesity in children and adolescents (systematic review and meta-analysis of publications over a 15-year period). Vopr. prakt. pediatr. (Clinical Practice in Pediatrics). 2022; 17(2): 126–135. (In Russ.) doi: 10.20953/1817-7646-2022-2-126-135.Грицинская В. Л., Новикова В. П., Хавкин А. И. К вопросу об эпидемиологии ожирения у детей и подростков (систематический обзор и мета-анализ научных публикаций за 15-летний период. Вопросы практической педиатрии. – 2022. – Т. 17. – N 2. – С. 126–135. doi: 10.20953/1817-7646-2022-2-126-135.Gritsinskaya V.L., Novikova V. P. Obesity in children in the redions of Russia. Archives of Disease in Childhood. 2021;106(S2): A87. doi: 10.1136/archdischild-2021-europaediatrics.205Gritsinskaya V.L., Novikova V. P. Obesity in children in the redions of Russia. Archives of Disease in Childhood. 2021;106(S2): A87. doi: 10.1136/archdischild-2021-europaediatrics.205Novikova V.P., Gritsinskaya V. L., Klikunova K. A. Children overweight and obesity prevalence in the Russian Federation. Journal of Childhood Obesity. 2021;6(9): in Rrint/Novikova V.P., Gritsinskaya V. L., Klikunova K. A. Children overweight and obesity prevalence in the Russian Federation. Journal of Childhood Obesity. 2021;6(9): in Rrint/Gritsinskaya V.L., Novikova V. P., Gurova M. M. Prevalence of obesity among schoolchildren in St. Petersburg. Archives of Disease in Childhood. 2019;104(S3): A366.Gritsinskaya V.L., Novikova V. P., Gurova M. M. Prevalence of obesity among schoolchildren in St. Petersburg. Archives of Disease in Childhood. 2019;104(S3): A366.Gurova M. M. Epidemiology of obesity in children at the present stage. Questions of children’s dietetics. 2014;12(3):36–45. (in Russ.)Gurova M. M. Epidemiology of obesity in children at the present stage. Questions of children’s dietetics. 2014;12(3):36–45. (in Russ.) Гурова М. М. Эпидемиология ожирения у детей на современном этапе. Вопросы детской диетологии. – 2014. – Т. 12. – N 3. – С. 36–45.Nastusheva T.L., Boeva E. E., Volosovets G. G., Minakova O. V. Clinical and laboratory features and blood pressure in children of preschool and primary school age with obesity. Pediatrician. 2020;11(1):19–26. (in Russ.) doi: 10.17816/PED11119-26.Настаушева Т. Л., Боева Е. Е., Волосовец Г. Г., Минакова О. В. Клинико-лабораторные особенности и артериальное давление у детей дошкольного и младшего школьного возраста с ожирением. Педиатр. – 2020. – Т. 11. – N 1. – С. 19–26. doi: 10.17816/PED11119-26.Wagenaar C.A., Dekker L. H., Navis G. J. Prevalence of sarcopenic obesity and sarcopenic overweight in the general population: The lifelines cohort study. Clinical Nutrition. 2021;40(6):4422–4429. doi: 10.1016/j.clnu.2021.01.005.Wagenaar C.A., Dekker L. H., Navis G. J. Prevalence of sarcopenic obesity and sarcopenic overweight in the general population: The lifelines cohort study. Clinical Nutrition. 2021;40(6):4422–4429. doi: 10.1016/j.clnu.2021.01.005.Steffl M., Chrudimsky J., Tufano J. J. Using relative handgrip strength to identify children at risk of sarcopenic obesity. PLoS One. 2017;12(5): e0177006. doi: 10.1371/journal.pone.0177006.Steffl M., Chrudimsky J., Tufano J. J. Using relative handgrip strength to identify children at risk of sarcopenic obesity. PLoS One. 2017;12(5): e0177006. doi: 10.1371/journal.pone.0177006.Moon J.H., Kong M. H., Kim H. J. Low Muscle Mass and Depressed Mood in Korean Adolescents: a CrossSectional Analysis of the Fourth and Fifth Korea National Health and Nutrition Examination Surveys. Journal of Korean Medical Science. 2018;33(50): e320. doi: 10.3346/jkms.2018.33.e320.Moon J.H., Kong M. H., Kim H. J. Low Muscle Mass and Depressed Mood in Korean Adolescents: a CrossSectional Analysis of the Fourth and Fifth Korea National Health and Nutrition Examination Surveys. Journal of Korean Medical Science. 2018;33(50): e320. doi: 10.3346/jkms.2018.33.e320.Sack C., Ferrari N., Friesen D., et al. Health Risks of Sarcopenic Obesity in Overweight Children and Adolescents: Data from the CHILT III Programme (Cologne). Journal of Clinical Medicine. 2022;11(1):277. doi: 10.3390/jcm11010277.Sack C., Ferrari N., Friesen D., et al. Health Risks of Sarcopenic Obesity in Overweight Children and Adolescents: Data from the CHILT III Programme (Cologne). Journal of Clinical Medicine. 2022;11(1):277. doi: 10.3390/jcm11010277.Molino S., Dossena M., Buonocore D., Verri M. Sarcopenic Obesity: An Appraisal of the Current Status of Knowledge and Management in Elderly People. Journal of Nutrition, Health, Aging. 2016;20(7):780–8. doi: 10.1007/s12603-015-0631-8.Molino S., Dossena M., Buonocore D., Verri M. Sarcopenic Obesity: An Appraisal of the Current Status of Knowledge and Management in Elderly People. Journal of Nutrition, Health, Aging. 2016;20(7):780–8. doi: 10.1007/s12603-015-0631-8.Jensen G. L. Infl ammation: roles in aging and sarcopenia. Journal of Parenteral and Enteral Nutrition. 2008;32(6):656–9. doi: 10.1177/0148607108324585.Jensen G. L. Infl ammation: roles in aging and sarcopenia. Journal of Parenteral and Enteral Nutrition. 2008;32(6):656–9. doi: 10.1177/0148607108324585.Meng S.J., Yu L. J. Oxidative stress, molecular inflammation and sarcopenia. International Journal of Molecular Sciences. 2010;11(4):1509–26. doi: 10.3390/ijms11041509.Meng S.J., Yu L. J. Oxidative stress, molecular inflammation and sarcopenia. International Journal of Molecular Sciences. 2010;11(4):1509–26. doi: 10.3390/ijms11041509.Kalinkovich A., Livshits G. Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis. Ageing Res Rev. 2017 May;35:200–221. doi: 10.1016/j.arr.2016.09.008.Kalinkovich A., Livshits G. Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis. Ageing Res Rev. 2017 May;35:200–221. doi: 10.1016/j.arr.2016.09.008.Ooi P.H., Thompson- Hodgetts S., Pritchard- Wiart L., Gilmour S. M., Mager D. R. Pediatric Sarcopenia: A Paradigm in the Overall Definition of MalnutritionOoi P.H., Thompson- Hodgetts S., Pritchard- Wiart L., Gilmour S. M., Mager D. R. Pediatric Sarcopenia: A Paradigm in the Overall Definition of Malnutritionin Children? JPEN J Parenter Enteral Nutr. 2020 Mar;44(3):407–418. doi: 10.1002/jpen.1681.in Children? JPEN J Parenter Enteral Nutr. 2020 Mar;44(3):407–418. doi: 10.1002/jpen.1681.Lang T., Streeper T., Cawthon P., et al. Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos International. 2010;21(4):543–59. doi: 10.1007/s00198-009-1059-y.Lang T., Streeper T., Cawthon P., et al. Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos International. 2010;21(4):543–59. doi: 10.1007/s00198-009-1059-y.Polyzos S.A., Mathew H., Mantzoros C. S. Irisin: A true, circulating hormone. Metabolism journal. 2015;64(12):1611–8. doi: 10.1016/j.metabol.2015.09.001.Polyzos S.A., Mathew H., Mantzoros C. S. Irisin: A true, circulating hormone. Metabolism journal. 2015;64(12):1611–8. doi: 10.1016/j.metabol.2015.09.001.Bergen H.R. 3rd, Farr J. N., Vanderboom P. M., et al. Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry- based assay. Skeletal Muscle. 2015;5:21. doi: 10.1186/s13395-015-0047-5.Bergen H.R. 3rd, Farr J. N., Vanderboom P. M., et al. Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry- based assay. Skeletal Muscle. 2015;5:21. doi: 10.1186/s13395-015-0047-5.Tsoriev T.T., Belaya Zh.E., Rozhinskaya L. Ya., Melnichenko G. A., Grebennikova T. A., Nikankina L. V., Ilyin A. V., Dedov I. I. The content of myokines in blood serum in patients with endogenous hypercorticism and acromegaly: a single case-control study. Bulletin of the Russian Academy of Sciences. 2016;71(3):40–247. (in Russ.) doi: 10.15690/vramn659.Цориев Т. Т., Белая Ж. Е., Рожинская Л. Я., Мельниченко Г. А., Гребенникова Т. А., Никанкина Л. В., Ильин А. В., Дедов И. И. Содержание миокинов в сыворотке крови у пациентов с эндогенным гиперкортицизмом и акромегалией: одномоментное исследование «случай–контроль». Вестник РАМН. – 2016. – T. 71 – N. 3. – C.40–247. doi: 10.15690/vramn659.Chang J. S., Kim T. H., Nguyen T. T. Circulating irisin levels as a predictive biomarker for sarcopenia: A cross- sectional community- based study. Geriatric and Gerontology International. 2017;17(11):2266–2273. doi: 10.1111/ggi.13030.Chang J. S., Kim T. H., Nguyen T. T. Circulating irisin levels as a predictive biomarker for sarcopenia: A cross- sectional community- based study. Geriatric and Gerontology International. 2017;17(11):2266–2273. doi: 10.1111/ggi.13030.Wang C., Bai L. Sarcopenia in the elderly: basic and clinical issues. Geriatric and Gerontology International. 2012;12(3):388–96. doi: 10.1111/j.1447-0594.2012.00851.x.Wang C., Bai L. Sarcopenia in the elderly: basic and clinical issues. Geriatric and Gerontology International. 2012;12(3):388–96. doi: 10.1111/j.1447-0594.2012.00851.x.Choi K. M. Sarcopenia and sarcopenic obesity. Endocrinology and Metabolism. 2013;28(2):86–9. doi: 10.3803/EnM.2013.28.2.86.Choi K. M. Sarcopenia and sarcopenic obesity. Endocrinology and Metabolism. 2013;28(2):86–9. doi: 10.3803/EnM.2013.28.2.86.Kim T. N., Choi K. M. The implications of sarcopenia and sarcopenic obesity on cardiometabolic disease. Journal of Cellular Biochemistry. 2015;116(7):1171–8. doi: 10.1002/jcb.25077. PMID: 25545054.Kim T. N., Choi K. M. The implications of sarcopenia and sarcopenic obesity on cardiometabolic disease. Journal of Cellular Biochemistry. 2015;116(7):1171–8. doi: 10.1002/jcb.25077. PMID: 25545054.Zamboni M., Mazzali G., Fantin F., Rossi A., Di Francesco V. Sarcopenic obesity: a new category of obesity in the elderly. Nutrition, Metabolism and Cardiovascular Diseases. 2008;18(5):388–95. doi: 10.1016/j.numecd.2007.10.002.Zamboni M., Mazzali G., Fantin F., Rossi A., Di Francesco V. Sarcopenic obesity: a new category of obesity in the elderly. Nutrition, Metabolism and Cardiovascular Diseases. 2008;18(5):388–95. doi: 10.1016/j.numecd.2007.10.002.Gregor M. F., Hotamisligil G. S. Inf lammator y mechanisms in obesity. Annual Review of Immunology. 2011;29:415–45. doi: 10.1146/annurevimmunol-031210-101322.Gregor M. F., Hotamisligil G. S. Inf lammator y mechanisms in obesity. Annual Review of Immunology. 2011;29:415–45. doi: 10.1146/annurevimmunol-031210-101322.Kim K. M., Jang H. C., Lim S. Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia. The Korean Journal of International Medicine. 2016;31(4):643–50. doi: 10.3904/kjim.2016.015.Kim K. M., Jang H. C., Lim S. Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia. The Korean Journal of International Medicine. 2016;31(4):643–50. doi: 10.3904/kjim.2016.015.Al Snih S., Markides K. S., Ottenbacher K. J., Raji M. A. Hand grip strength and incident ADL disability in elderly Mexican Americans over a seven-year period. Aging Clinical and Experimental Research. 2004;16(6):481–6. doi: 10.1007/BF03327406.Al Snih S., Markides K. S., Ottenbacher K. J., Raji M. A. Hand grip strength and incident ADL disability in elderly Mexican Americans over a seven-year period. Aging Clinical and Experimental Research. 2004;16(6):481–6. doi: 10.1007/BF03327406.Šarabon N., Kozinc Ž., Perman M. Establishing Reference Values for Isometric Knee Extension and Flexion Strength. Frontiers in Physiology. 2021;12:767941. doi: 10.3389/fphys.2021.767941.Šarabon N., Kozinc Ž., Perman M. Establishing Reference Values for Isometric Knee Extension and Flexion Strength. Frontiers in Physiology. 2021;12:767941. doi: 10.3389/fphys.2021.767941.Guralnik J. M., Simonsick E. M., Ferrucci L., Glynn R. J., Berkman L. F., Blazer D. G., Scherr P. A., Wallace R. B. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. The Journal of Gerontology. 1994;49(2): M85–94. doi: 10.1093/geronj/49.2.m85.Guralnik J. M., Simonsick E. M., Ferrucci L., Glynn R. J., Berkman L. F., Blazer D. G., Scherr P. A., Wallace R. B. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. The Journal of Gerontology. 1994;49(2): M85–94. doi: 10.1093/geronj/49.2.m85.Peel N. M., Kuys S. S., Klein K. Gait speed as a measure in geriatric assessment in clinical settings: a systematic review. The Journal of Gerontology. Series A, Biological Sciences and Medical Sciences. 2013;68(1):39–46. doi: 10.1093/gerona/gls174.Peel N. M., Kuys S. S., Klein K. Gait speed as a measure in geriatric assessment in clinical settings: a systematic review. The Journal of Gerontology. Series A, Biological Sciences and Medical Sciences. 2013;68(1):39–46. doi: 10.1093/gerona/gls174.Griffiths A., Toovey R., Morgan P. E., Spittle A. J. Psychometric properties of gross motor assessment tools for children: a systematic review. BMJ Open. 2018;8(10): e021734. doi: 10.1136/bmjopen-2018-021734.Griffiths A., Toovey R., Morgan P. E., Spittle A. J. Psychometric properties of gross motor assessment tools for children: a systematic review. BMJ Open. 2018;8(10): e021734. doi: 10.1136/bmjopen-2018-021734.Dara N., Sayyari A. A., Imanzadeh F. Hepatic encephalopathy: early diagnosis in pediatric patients with cirrhosis. Iranian Journal of Child Neurology. 2014;8(1):1–11. PMID: 24665321; PMCID: PMC3943054.Dara N., Sayyari A. A., Imanzadeh F. Hepatic encephalopathy: early diagnosis in pediatric patients with cirrhosis. Iranian Journal of Child Neurology. 2014;8(1):1–11. PMID: 24665321; PMCID: PMC3943054.Chien M. Y., Huang T. Y., Wu Y. T. Prevalence of sarcopenia estimated using a bioelectrical impedance analysis prediction equation in community-dwelling elderly people in Taiwan. Journal of the American Geriatrics Society. 2008;56(9):1710–5. doi: 10.1111/j.1532-5415.2008.01854.x.Chien M. Y., Huang T. Y., Wu Y. T. Prevalence of sarcopenia estimated using a bioelectrical impedance analysis prediction equation in community-dwelling elderly people in Taiwan. Journal of the American Geriatrics Society. 2008;56(9):1710–5. doi: 10.1111/j.1532-5415.2008.01854.x.Sottier D., Petit J. M., Guiu S., Hamza S., Benhamiche H., Hillon P., Cercueil J. P., Krausé D., Guiu B. Quantification of the visceral and subcutaneous fat by computed tomography: interobserver correlation of a single slice technique. Diagnostic and Interventional Imaging. 2013;94(9):879–84. doi: 10.1016/j.diii.2013.04.006.Sottier D., Petit J. M., Guiu S., Hamza S., Benhamiche H., Hillon P., Cercueil J. P., Krausé D., Guiu B. Quantification of the visceral and subcutaneous fat by computed tomography: interobserver correlation of a single slice technique. Diagnostic and Interventional Imaging. 2013;94(9):879–84. doi: 10.1016/j.diii.2013.04.006.Edwards M. H., Buehring B. Novel Approaches to the Diagnosis of Sarcopenia. Journal of Clinical Densitometry. 2015;18(4):472–7. doi: 10.1016/j.jocd.2015.04.010.Edwards M. H., Buehring B. Novel Approaches to the Diagnosis of Sarcopenia. Journal of Clinical Densitometry. 2015;18(4):472–7. doi: 10.1016/j.jocd.2015.04.010.Safarova G., Milner E., Zavyalova A. Et al. Body Composition in Children with Morbid Obesity EAP2021 CONGRESS AND MASTERCOURSE. European Academy of Paediatrics (EAP). 2021:292–293.Safarova G., Milner E., Zavyalova A. Et al. Body Composition in Children with Morbid Obesity EAP2021 CONGRESS AND MASTERCOURSE. European Academy of Paediatrics (EAP). 2021:292–293.Alyoshina E. I., Andriyanov A. I., Bogdanova N. M., Edleeva A. G., et al. Methods of nutritional status research in children and adolescents. Saint Petersburg. SpecLit Publ., 2014. (In Russ.)Алешина Е. И., Андриянов А. И., Богданова Н. М., Эдлеева А. Г. и соавт. Методы исследования нутритивного статуса у детей и подростков. –Санкт-Петербург: СпецЛит, 2014.Ismail C., Zabal J., Hernandez H. J., et al. Diagnostic ultrasound estimates of muscle mass and muscle quality discriminate between women with and without sarcopenia. Frontiers in Physiology. 2015;6:302. doi: 10.3389/fphys.2015.00302.Ismail C., Zabal J., Hernandez H. J., et al. Diagnostic ultrasound estimates of muscle mass and muscle quality discriminate between women with and without sarcopenia. Frontiers in Physiology. 2015;6:302. doi: 10.3389/fphys.2015.00302.Horan M., Gibney E., Molloy E., McAuliffe F. Methodologies to assess paediatric adiposity. Irish Journal of Medical Science. 2015;184(1):53–68. doi: 10.1007/s11845-014-1124-1.Horan M., Gibney E., Molloy E., McAuliffe F. Methodologies to assess paediatric adiposity. Irish Journal of Medical Science. 2015;184(1):53–68. doi: 10.1007/s11845-014-1124-1.Lee S. Y., Gallagher D. Assessment methods in human body composition. Current Opinion Clinical Nutrition Metabolic Care. 2008;11(5):566–72. doi: 10.1097/MCO.0b013e32830b5f23.Lee S. Y., Gallagher D. Assessment methods in human body composition. Current Opinion Clinical Nutrition Metabolic Care. 2008;11(5):566–72. doi: 10.1097/MCO.0b013e32830b5f23.Wells J. C., Fewtrell M. S. Measuring body composition. Archives Disease in Childhood. 2006;91(7):612–7. doi: 10.1136/adc.2005.085522.Wells J. C., Fewtrell M. S. Measuring body composition. Archives Disease in Childhood. 2006;91(7):612–7. doi: 10.1136/adc.2005.085522.Loomba- Albrecht L.A., Styne D. M. Effect of puberty on body composition. Current Opinion in Endocrinology Diabetes and Obesity. 2009;16(1):10–5. doi: 10.1097/med.0b013e328320d54c.Loomba- Albrecht L.A., Styne D. M. Effect of puberty on body composition. Current Opinion in Endocrinology Diabetes and Obesity. 2009;16(1):10–5. doi: 10.1097/med.0b013e328320d54c.Hong H. C., Hwang S. Y., Choi H. Y., et al. Relationship between sarcopenia and nonalcoholic fatty liver disease: the Korean Sarcopenic Obesity Study. Hepatology. 2014;59(5):1772–8. doi: 10.1002/hep.26716.Hong H. C., Hwang S. Y., Choi H. Y., et al. Relationship between sarcopenia and nonalcoholic fatty liver disease: the Korean Sarcopenic Obesity Study. Hepatology. 2014;59(5):1772–8. doi: 10.1002/hep.26716.Novikova V. P., Gurova M. M., Komissarova M. Y. Multidisciplinary problems of obesity in children. Saint-Petersburg. SpetsLit Publ., 2018. (in Russ.)Новикова В. П., Гурова М. М., Комиссарова М. Ю. Мультидисциплинарные проблемы ожирения у детей. – Санкт- Петербург: СпецЛит, 2018.Srikanthan P., Hevener A. L., Karlamangla A. S. Sarcopenia exacerbates obesity-associated insulin resistance and dysglycemia: findings from the National Health and Nutrition Examination Survey III. PLoS One. 2010;5(5): e10805. doi: 10.1371/journal.pone.0010805.Srikanthan P., Hevener A. L., Karlamangla A. S. Sarcopenia exacerbates obesity-associated insulin resistance and dysglycemia: findings from the National Health and Nutrition Examination Survey III. PLoS One. 2010;5(5): e10805. doi: 10.1371/journal.pone.0010805.Han K., Park Y. M., Kwon H. S., et al. Sarcopenia as a determinant of blood pressure in older Koreans: findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008–2010. PLoS One. 2014;9(1): e86902. doi: 10.1371/journal.pone.0086902.Han K., Park Y. M., Kwon H. S., et al. Sarcopenia as a determinant of blood pressure in older Koreans: findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008–2010. PLoS One. 2014;9(1): e86902. doi: 10.1371/journal.pone.0086902.Snijder M. B., Henry R. M., Visser M., et al. Regional body composition as a determinant of arterial stiffness in the elderly: The Hoorn Study. Journal Hypertension. 20 04;22(12):2339– 47. doi: 10.1097/00004872-200412000-00016.Snijder M. B., Henry R. M., Visser M., et al. Regional body composition as a determinant of arterial stiffness in the elderly: The Hoorn Study. Journal Hypertension. 20 04;22(12):2339– 47. doi: 10.1097/00004872-200412000-00016.Wannamethee S. G., Atkins J. L. Muscle loss and obesity: the health implications of sarcopenia and sarcopenic obesity. Proceeding of Nutrition Society. 2015;74(4):405–12. doi: 10.1017/S002966511500169X.Wannamethee S. G., Atkins J. L. Muscle loss and obesity: the health implications of sarcopenia and sarcopenic obesity. Proceeding of Nutrition Society. 2015;74(4):405–12. doi: 10.1017/S002966511500169X.Mehta N. M., Corkins M. R., Lyman B., Malone A., Goday P. S., Carney L. N., Monczka J. L., Plogsted S. W., Schwenk W. F.; American Society for Parenteral and Enteral Nutrition Board of Directors. Defining pediatric malnutrition: a paradigm shift toward etiology-related definitions. Journal of Parenteral and Enteral Nutrition. 2013;37(4):460–81. doi: 10.1177/0148607113479972.Mehta N. M., Corkins M. R., Lyman B., Malone A., Goday P. S., Carney L. N., Monczka J. L., Plogsted S. W., Schwenk W. F.; American Society for Parenteral and Enteral Nutrition Board of Directors. Defining pediatric malnutrition: a paradigm shift toward etiology-related definitions. Journal of Parenteral and Enteral Nutrition. 2013;37(4):460–81. doi: 10.1177/0148607113479972.Mager D. R., Hager A., Ooi P. H., Siminoski K., Gilmour S. M., Yap J. Y.K. Persistence of Sarcopenia After Pediatric Liver Transplantation Is Associated With Poorer Growth and Recurrent Hospital Admissions. Journal of Parenteral and Enteral Nutrition. 2019;43(2):271–280. doi: 10.1002/jpen.1414.Mager D. R., Hager A., Ooi P. H., Siminoski K., Gilmour S. M., Yap J. Y.K. Persistence of Sarcopenia After Pediatric Liver Transplantation Is Associated With Poorer Growth and Recurrent Hospital Admissions. Journal of Parenteral and Enteral Nutrition. 2019;43(2):271–280. doi: 10.1002/jpen.1414.Wannamethee S. G., Shaper A. G., Lennon L., Whincup P. H. Decreased muscle mass and increased central adiposity are independently related to mortality in older men. The American Journal of Clinical Nutrition. 2007;86(5):1339–46. doi: 10.1093/ajcn/86.5.1339.Wannamethee S. G., Shaper A. G., Lennon L., Whincup P. H. Decreased muscle mass and increased central adiposity are independently related to mortality in older men. The American Journal of Clinical Nutrition. 2007;86(5):1339–46. doi: 10.1093/ajcn/86.5.1339.Wannamethee S. G., Shaper A. G., Lennon L., Whincup P. H. Decreased muscle mass and increased central adiposity are independently related to mortality in older men. The American Journal of Clinical Nutrition. 2007;86(5):1339–46. doi: 10.1093/ajcn/86.5.1339.

The authors declare that there are no conflicts of interest present.