nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-210-2-33-69nogr-2260Research ArticleКЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИCLINICAL GUIDELINESДивертикулярная болезнь толстой кишки: клиническая картина, диагностика, лечение и профилактикаColonic diverticular disease: clinical presentation, diagnosis, treatment, and prevention Clinical guidelines of the Russian Scientific Medical Society of Internal Medicine, the Gastroenterological Scientific Society of Russia, and the North- West Society of Gastroenterologists and Hepatologistshttps://orcid.org/0000-0002-4453-8430ДрапкинаО. М.DrapkinaO. M.

Оксана Михайловна Драпкина, д. м. н., профессор, академик РАН, директор, главный внештатный специалист Минздрава России по терапии и общей врачебной профилактике

101990

Петроверигский пер., 10, стр. 3

Москва

Oksana M. Drapkina, Corresponding Member RAS, Doctor of Medical Sciences, Professor, Director

101990

10/3 Petroverigsky Per.

Moscow

https://orcid.org/0000-0001-8736-5851ЛазебникЛ. Б.LazebnikL. B.

Леонид Борисович Лазебник, вице-президент РНМОТ, Президент НОГР, член президиума Общества врачей России, член президиума Национальной медицинской палаты, д. м. н., профессор, профессор кафедры

кафедра поликлинической терапии

127473

ул. Делегатская, 20/1

Москва

Scopus Author ID: 7005446863

Leonid B. Lazebnik, Vice President of the RSMST, President of the GSSR, Doctor of Medical Sciences, Professor

Department of Internal Medicine and Preventive Medicine

127473

20/1 Delegatskaya St.

Moscow

Scopus Author ID: 7005446863

https://orcid.org/0000-0002-6151-2021БакулинИ. Г.BakulinI. G.

Игорь Геннадьевич Бакулин, профессор, д. м. н., заведующий кафедрой, президент Общества гастроэнтерологов и гепатологов «Северо-Запад», главный внештатный специалист-терапевт СЗФО РФ

кафедра пропедевтики внутренних болезней, гастроэнтерологии и диетологии им. С. М. Рысса

191015

ул. Кирочная, 41

Санкт-Петербург

Igor G. Bakulin, Doctor of Medical Sciences, Professor, Head of the Dept.

Dept. of Propaedeutics of Internal Diseases, Gastroenterology and Dietetics n. a. S. M. Ryss

191015

41 Kirochnaya St.

St. Petersburg

https://orcid.org/0000-0002-8563-6870СказываеваЕ. В.SkazyvaevaE. V.

Екатерина Васильевна Сказываева, к. м. н., доцент

кафедра пропедевтики внутренних болезней, гастроэнтерологиии диетологии им. С. М. Рысса

191015

ул. Кирочная, 41

Санкт-Петербург

Ekaterina V. Skazyvaeva, MD, PhD, Assoc. Prof.Department of Propaedeutics of Internal Diseases, Gastroenterology and Dietetics named after S. M. Ryss19101541 Kirochnaya St.St. Petersburg

БакулинаН. В.BakulinaN. V.

Наталья Валерьевна Бакулина, д. м. н., проректор по науке и инновационной деятельности, заведующий кафедрой

кафедра внутренних болезней, клинической фармакологии и нефрологии

191015

ул. Кирочная, 41

Санкт-Петербург

Natalia V. Bakulina, Doctor of Medical Sciences, Professor, Head

Department of Internal Diseases, Clinical Pharmacology and Nephrology

191015

41 Kirochnaya St.

St. Petersburg

https://orcid.org/0000-0003-0331-0963СиткинС. И.SitkinS. I.

Станислав Игоревич Ситкин, к. м. н., доцент, зав. НИГ

кафедра пропедевтики внутренних болезней, гастроэнтерологии и диетологии им. С. М. Рысса

Институт перинатологии и педиатрии

НИГ эпигенетики и метагеномики

191015

ул. Кирочная, 41

197341

ул. Аккуратова, 2

Санкт-Петербург

Scopus Author ID: 6603071466

Stanislav I. Sitkin, Dr. med., Ph. D., Assoc. Prof., Head

Dept. of Propaedeutics of Internal Diseases, Gastroenterology and Dietetics n. a. S. M. Ryss

191015

41 Kirochnaya St.

Epigenetics & Metagenomics Research Group

197341

2 Akkuratova St.

St. Petersburg

Scopus Author ID: 6603071466

https://orcid.org/0000-0003-0769-8176СкалинскаяМ. И.SkalinskayaM. I.

Мария Игоревна Скалинская, к. м. н., доцент

кафедра пропедевтики внутренних болезней, гастроэнтерологиии диетологии им. С. М. Рысса

191015

ул. Кирочная, 41

Санкт-Петербург

Maria I. Skalinskaya, MD, PhD, Assoc. Prof.

Department of Propaedeutics of Internal Diseases, Gastroenterology andDietetics named after S. M. Ryss

191015

41 Kirochnaya St.

St. Petersburg

https://orcid.org/0000-0003-4838-5707ЖуравлеваМ. С.ZhuravlevaM. S.

Мария Сергеевна Журавлева, к. м. н., доцент

кафедра пропедевтики внутренних болезней, гастроэнтерологии и диетологии им. С. М. Рысса

191015

ул. Кирочная, 41

Санкт-Петербург

Mariia S. Zhuravleva, PhD, Ass. Prof.

Department of Propaedeutics of Internal Diseases, Gastroenterology and Dietetics named after S. M. Ryss

191015

41 Kirochnaya St.

St. Petersburg

https://orcid.org/0000-0003-0331-0963АвалуеваЕ. Б.AvaluevaE. B.

Елена Борисовна Авалуева, д. м. н., профессор

кафедра пропедевтики внутренних болезней, гастроэнтерологии и диетологии им. С. М. Рысса

191015

ул. Кирочная, 41

Санкт-Петербург

Elena B. Avalueva, MD, Doctor of Medical Sciences, professor

Department of Propaedeutics of Internal Diseases, Gastroenterology and Dietetics named after S. M. Ryss

191015

41 Kirochnaya St.

St. Petersburg

https://orcid.org/0000-0002-6581-7017ЛивзанМ. А.LivzanM. A.

Мария Анатольевна Ливзан, д. м. н., профессор, член-корреспондент РАН, ректор, заведующий кафедрой, главный внештатный специалист- терапевт СФО РФ

лечебный факультет

кафедра факультетской терапии с курсом профессиональных болезней 

644099

ул. Ленина,12

Омск

Researcher ID: AAA-1409–2019

Maria A. Livzan, gastroenterologist, chief freelance therapist in the Siberian Federal District, MD, professor, head of the department, rector

department of faculty therapy and gastroenterology

644099

12 Lenina St.

Omsk

Researcher ID: AAA-1409–2019

https://orcid.org/0000-0003-2815-3992БординД. С.BordinD. S.

Дмитрий Станиславович Бордин, д. м. н., профессор, заведующий отделом, профессор кафедры

отдел патологии поджелудочной железы, желчных путей и верхних отделов пищеварительного тракта

кафедра пропедевтики внутренних болезней и гастроэнтерологии

127473

ул. Делегатская, 20/1

111123

Шоссе Энтузиастов, 86

Москва

Department of Internal Medicine and Preventive Medicine

127473

20/1 Delegatskaya St.

111123

86 Shosse Entuziastov

Moscow

Scopus Author ID: 7005446863

https://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinA. I.

Анатолий Ильич Хавкин, д. м. н., профессор, руководитель центра

125412

ул. Островитянова, д. 1

Москва

Anatoly I. Khavkin, Doctor of Medical Sciences, Professor and Head; Chief Researcher, Professor

Clinical Institute of Pediatric named after academician Yu. E. Veltishev

Department of Gastroenterology Researcher

Department of Pediatrics with a Course in Pediatric Surgical Diseases

125412

1 Ostrovityanova St.

Moscow

Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр терапии и профилактической медицины» Министерства здравоохранения Российской ФедерацииРоссияNational Medical Research Center for Therapy and Preventive Medicine Russian FederationRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико- стоматологический университет им. А. И. Евдокимова» Министерства здравоохранения Российской ФедерацииРоссияA. I. Yevdokimov Moscow State University of Medicine and Dentistry Russian FederationRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Северо-Западный государственный медицинский университет им. И. И. Мечникова» Министерства здравоохранения Российской ФедерацииРоссияNorth-Western state medical University named after I. I. Mechnikov Russian FederationRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Северо-Западный государственный медицинский университет им. И. И. Мечникова» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияNorth-Western state medical University named after I. I. Mechnikov; Almazov National Medical Research CentreRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Омский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияOmsk State Medical UniversityRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико- стоматологический университет им. А. И. Евдокимова» Министерства здравоохранения Российской Федерации; Государственное бюджетное учреждение здравоохранения города Москвы «Московский клинический научный центр имени А. С. Логинова Департамента здравоохранения города Москвы»РоссияA. I. Yevdokimov Moscow State University of Medicine and Dentistry Russian Federation; Moscow Clinical Scientific Center named after LoginovRussian FederationНаучно-исследовательский клинический институт педиатрии им. Ю. Е. Вельтищева ФГБАУ ВО Российский национальный исследовательский медицинский университет им. Н. И. Пирогова МЗ РФ; Московский областной центр детской гастроэнтерологии и гепатологии «НИКИ детства» МЗ МОРоссияVeltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery, Pirogov Russian National Research Medical UniversityRussian Federation202321052023023369Copyright © Драпкина О.М., Лазебник Л.Б., Бакулин И.Г., Сказываева Е.В., Бакулина Н.В., Ситкин С.И., Скалинская М.И., Журавлева М.С., Авалуева Е.Б., Ливзан М.А., Бордин Д.С., Хавкин А.И., 20232023Драпкина О.М., Лазебник Л.Б., Бакулин И.Г., Сказываева Е.В., Бакулина Н.В., Ситкин С.И., Скалинская М.И., Журавлева М.С., Авалуева Е.Б., Ливзан М.А., Бордин Д.С., Хавкин А.И.Drapkina O.M., Lazebnik L.B., Bakulin I.G., Skazyvaeva E.V., Bakulina N.V., Sitkin S.I., Skalinskaya M.I., Zhuravleva M.S., Avalueva E.B., Livzan M.A., Bordin D.S., Khavkin A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2260

   Настоящие клинические рекомендации предназначены для гастроэнтерологов, терапевтов, врачей общей практики и делают акцент, прежде всего, на ведении пациентов с неосложненной клинически выраженной (симптоматической) дивертикулярной болезнью толстой кишки, а также на первичную и вторичную профилактику острого дивертикулита и других осложнений дивертикулярной болезни (ДБ). Клинические рекомендации разработаны Российским научным медицинским обществом терапевтов, Научным обществом гастроэнтерологов России и Обществом гастроэнтерологов и гепатологов «Северо-Запад». Одна из причин разработки новых клинических рекомендаций связана с тем, что текущие рекомендации «Дивертикулярная болезнь» (2021 г.) гораздо больше внимания уделяют осложненным формам дивертикулярной болезни, а также вопросам хирургического лечения острых и хронических осложнений данного заболевания.

   Clinical guidelines are intended for gastroenterologists, internists, and general practitioners and focus primarily on the management of patients with symptomatic uncomplicated diverticular disease, as well as on the primary and secondary prevention of acute diverticulitis and other complications of diverticular disease. Clinical guidelines were developed by the Russian Scientific Medical Society of Internal Medicine, the Gastroenterological Scientifi c Society of Russia, and the North-West Society of Gastroenterologists and Hepatologists. One of the reasons for creating new clinical guidelines is that the current guidelines on diverticular disease (2021) pay much more attention to complications of diverticular disease and surgical treatment of acute and chronic complications of the disease.

дивертикулярная болезнь толстой кишкидивертикулездивертикулитсимптоматическая неосложненная дивертикулярная болезньсимптоматическая осложненная дивертикулярная болезньдивертикулитпищевые волокнарифаксиминмесалазинпсиллиумcolonic diverticular diseasediverticulosissymptomatic uncomplicated diverticular diseasesymptomatic complicated diverticular diseasediverticulitisdietary fiberrifaximinmesalazinepsylliumReferencesСказываева Е. В. Дивертикулярная болезнь толстой кишки: этиопатогенез, диагностика, лечение и профилактика. – М.: Прима Принт, 2022. – 73 с. – ISBN 978–5–6046641–5–5.Skazyvaeva E. V., Sitkin S. I., Bakulin I. G., Avalueva E. B., Zhuravleva M. S., Skalinskaya M. I. [Diverticular disease of the colon: etiopathogenesis, diagnosis, treatment and prevention]. Moscow: Prima Print Publ., 2022. 73 p. (in Russ.) ISBN: 978–5–6046641–5–5.Yamamichi N., Shimamoto T., Takahashi Y., et al. Trend and risk factors of diverticulosis in Japan: age, gender, and lifestyle/metabolic- related factors may cooperatively affect on the colorectal diverticula formation. PLoS One. 2015 Apr 10;10(4): e0123688. doi: 10.1371/journal.pone.0123688.Yamamichi N., Shimamoto T., Takahashi Y., et al. Trend and risk factors of diverticulosis in Japan: age, gender, and lifestyle/metabolic- related factors may cooperatively affect on the colorectal diverticula formation. PLoS One. 2015 Apr 10;10(4): e0123688. doi: 10.1371/journal.pone.0123688.Gralnek I. M., Neeman Z., Strate L. L. Acute Lower Gastrointestinal Bleeding. N Engl J Med. 2017 Mar 16; 376 (11): 1054–1063. doi: 10.1056/NEJMcp1603455.Gralnek I. M., Neeman Z., Strate L. L. Acute Lower Gastrointestinal Bleeding. N Engl J Med. 2017 Mar 16; 376 (11): 1054–1063. doi: 10.1056/NEJMcp1603455.Boostrom S. Y., Wolff B. G., Cima R. R. et al. Uncomplicated diverticulitis, more complicated than we thought. J Gastrointest Surg. 2012 Sep; 16 (9): 1744–9. doi: 10.1007/s11605–012–1924–4.Boostrom S. Y., Wolff B. G., Cima R. R. et al. Uncomplicated diverticulitis, more complicated than we thought. J Gastrointest Surg. 2012 Sep; 16 (9): 1744–9. doi: 10.1007/s11605–012–1924–4.Bharucha A. E., Parthasarathy G., Ditah I. et al. Temporal Trends in the Incidence and Natural History of Diverticulitis: A Population-Based Study. Am J Gastroenterol. 2015 Nov; 110 (11): 1589–96. doi: 10.1038/ajg.2015.302.Bharucha A. E., Parthasarathy G., Ditah I. et al. Temporal Trends in the Incidence and Natural History of Diverticulitis: A Population-Based Study. Am J Gastroenterol. 2015 Nov; 110 (11): 1589–96. doi: 10.1038/ajg.2015.302.Strate L. L., Morris A. M. Epidemiology, Pathophysiology, and Treatment of Diverticulitis. Gastroenterology. 2019 Apr; 156 (5): 1282–1298.e1. doi: 10.1053/j.gastro.2018.12.033.Strate L. L., Morris A. M. Epidemiology, Pathophysiology, and Treatment of Diverticulitis. Gastroenterology. 2019 Apr; 156 (5): 1282–1298.e1. doi: 10.1053/j.gastro.2018.12.033.Tursi A. Current and Evolving Concepts on the Pathogenesis of Diverticular Disease. J Gastrointestin Liver Dis. 2019; 28: 225–223. doi: 10.15403/JGLD-184.Tursi A. Current and Evolving Concepts on the Pathogenesis of Diverticular Disease. J Gastrointestin Liver Dis. 2019; 28: 225–223. doi: 10.15403/JGLD-184.Strate L. L., Erichsen R., Baron J. A. et al. Heritability and familial aggregation of diverticular disease: a population-based study of twins and siblings. Gastroenterology. 2013; 144: 736–742. doi: 10.1053/j.gastro.2012.12.030.Strate L. L., Erichsen R., Baron J. A. et al. Heritability and familial aggregation of diverticular disease: a population-based study of twins and siblings. Gastroenterology. 2013; 144: 736–742. doi: 10.1053/j.gastro.2012.12.030.Granlund J., Svensson T., Olén O. et al. The genetic influence on diverticular disease - a twin study. Aliment Pharmacol Ther. 2012; 35: 1103–1107. doi: 10.1111/j.1365-2036.2012.05069.x.Granlund J., Svensson T., Olén O. et al. The genetic influence on diverticular disease - a twin study. Aliment Pharmacol Ther. 2012; 35: 1103–1107. doi: 10.1111/j.1365-2036.2012.05069.x.Sigurdsson S., Alexandersson, K. F., Sulem P. et al. Sequence variant in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis. Nat Commun. 2017; 8: 15789. doi:10.1038/ncomms15789.Sigurdsson S., Alexandersson, K. F., Sulem P. et al. Sequence variant in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis. Nat Commun. 2017; 8: 15789. doi:10.1038/ncomms15789.Maguire L. H., Handelman S. K., Du X. et al. Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease. Nat Genet. 2018; 50: 1359–1365. doi: 10.1038/s41588–018–0203-z.Maguire L. H., Handelman S. K., Du X. et al. Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease. Nat Genet. 2018; 50: 1359–1365. doi: 10.1038/s41588–018–0203-z.Schafmayer C., Harrison J. W., Buch S. et al. Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms. Gut. 2019; 68: 854–865. doi:10.1136/gutjnl-2018–317619.Schafmayer C., Harrison J. W., Buch S. et al. Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms. Gut. 2019; 68: 854–865. doi:10.1136/gutjnl-2018–317619.Painter N. S. Diverticular disease of the colon. Br Med J. 1968 Aug 24;3(5616):475–9. doi: 10.1136/bmj.3.5616.475.Painter N. S. Diverticular disease of the colon. Br Med J. 1968 Aug 24;3(5616):475–9. doi: 10.1136/bmj.3.5616.475.Golder M., Burleigh D. E., Ghali L. et al. Longitudinal muscle shows abnormal relaxation responses to nitric oxide and contains altered levels of NOS1 and elastin in uncomplicated diverticular disease. Colorectal Dis. 2007; 9: 218–228. doi: 10.1111/j.1463–1318.2006.01160.x.Golder M., Burleigh D. E., Ghali L. et al. Longitudinal muscle shows abnormal relaxation responses to nitric oxide and contains altered levels of NOS1 and elastin in uncomplicated diverticular disease. Colorectal Dis. 2007; 9: 218–228. doi: 10.1111/j.1463–1318.2006.01160.x.Parks T. G., Connell A. M. Motility studies in diverticular disease of the colon. Gut. 1969; 10: 534–542. doi: 10.1136/gut.10.7.534.Parks T. G., Connell A. M. Motility studies in diverticular disease of the colon. Gut. 1969; 10: 534–542. doi: 10.1136/gut.10.7.534.Bassotti G., Battaglia E., Bellone G. et al. Interstitial cells of Cajal, enteric nerves, and glial cells in colonic diverticular disease. J Clin Pathol. 2005; 58: 973–977. doi: 10.1136/jcp.2005.026112.Bassotti G., Battaglia E., Bellone G. et al. Interstitial cells of Cajal, enteric nerves, and glial cells in colonic diverticular disease. J Clin Pathol. 2005; 58: 973–977. doi: 10.1136/jcp.2005.026112.Rao M., Rastelli D., Dong L. et al. Enteric glia regulate gastrointestinal motility but are not required for maintenance of the epithelium in mice. Gastroenterology. 2017; 153: 1068–1081. e7. doi: 10.1053/j.gastro.2017.07.002.Rao M., Rastelli D., Dong L. et al. Enteric glia regulate gastrointestinal motility but are not required for maintenance of the epithelium in mice. Gastroenterology. 2017; 153: 1068–1081. e7. doi: 10.1053/j.gastro.2017.07.002.Böttner M., Barrenschee M., Hellwig I., et al. The enteric serotonergic system is altered in patients with iverticular disease. Gut. 2013; 62: 1753–1762. doi: 10.1136/gutjnl-2012–302660.Böttner M., Barrenschee M., Hellwig I., et al. The enteric serotonergic system is altered in patients with iverticular disease. Gut. 2013; 62: 1753–1762. doi: 10.1136/gutjnl-2012–302660.Egger B., Peter M. K., Candinas D. Persistent symptoms after elective sigmoid resection for diverticulitis. Dis Colon Rectum. 2008 Jul; 51 (7): 1044–8. doi: 10.1007/s10350–008–9234–3.Egger B., Peter M. K., Candinas D. Persistent symptoms after elective sigmoid resection for diverticulitis. Dis Colon Rectum. 2008 Jul; 51 (7): 1044–8. doi: 10.1007/s10350–008–9234–3.Humes D. J., Simpson J., Smith J., et al. Visceral hypersensitivity in symptomatic diverticular disease and the role of neuropeptides and low grade inflammation. Neurogastroenterol Motil. 2012 Apr; 24 (4): 318-e163. doi: 10.1111/j.1365–2982.2011.01863.x.Humes D. J., Simpson J., Smith J., et al. Visceral hypersensitivity in symptomatic diverticular disease and the role of neuropeptides and low grade inflammation. Neurogastroenterol Motil. 2012 Apr; 24 (4): 318-e163. doi: 10.1111/j.1365–2982.2011.01863.x.Bartho L., Benko R., Holzer-Petsche U., Holzer P., Undi S., Wolf M. Role of extrinsic afferent neurons in gastrointestinal motility. Eur Rev Med Pharmacol Sci. 2008 Aug; 12 Suppl 1: 21–31. PMID: 18924441.Bartho L., Benko R., Holzer-Petsche U., Holzer P., Undi S., Wolf M. Role of extrinsic afferent neurons in gastrointestinal motility. Eur Rev Med Pharmacol Sci. 2008 Aug; 12 Suppl 1: 21–31. PMID: 18924441.Bartho L., Benko R., Holzer-Petsche U., Holzer P., Undi S., Wolf M. Role of extrinsic afferent neurons in gastrointestinal motility. Eur Rev Med Pharmacol Sci. 2008 Aug; 12 Suppl 1: 21–31. PMID: 18924441.Bartho L., Benko R., Holzer-Petsche U., Holzer P., Undi S., Wolf M. Role of extrinsic afferent neurons in gastrointestinal motility. Eur Rev Med Pharmacol Sci. 2008 Aug; 12 Suppl 1: 21–31. PMID: 18924441.Clemens C. H., Samsom M., Roelofs J., van Berge Henegouwen G. P., Smout A. J. Colorectal visceral perception in diverticular disease. Gut. 2004 May; 53 (5): 717–22. doi: 10.1136/gut.2003.018093.Clemens C. H., Samsom M., Roelofs J., van Berge Henegouwen G. P., Smout A. J. Colorectal visceral perception in diverticular disease. Gut. 2004 May; 53 (5): 717–22. doi: 10.1136/gut.2003.018093.Pauza A. G., Rysevaite-Kyguoliene K., Malinauskas M. et al. Alterations in enteric calcitonin gene-related peptide in patients with colonic diverticular disease: CGRP in diverticular disease. Auton Neurosci. 2019 Jan; 216: 63–71. doi: 10.1016/j.autneu.2018.09.006.Pauza A. G., Rysevaite-Kyguoliene K., Malinauskas M. et al. Alterations in enteric calcitonin gene-related peptide in patients with colonic diverticular disease: CGRP in diverticular disease. Auton Neurosci. 2019 Jan; 216: 63–71. doi: 10.1016/j.autneu.2018.09.006.Spiller R. C., Humes D. J., Campbell E. et al. The Patient Health Questionnaire 12 Somatic Symptom scale as a predictor of symptom severity nd consulting behaviour in patients with irritable bowel syndrome and symptomatic diverticular disease. Aliment Pharmacol Ther. 2010 Sep; 32 (6): 811–20. doi: 10.1111/j.1365–2036.2010.04402.x.Spiller R. C., Humes D. J., Campbell E. et al. The Patient Health Questionnaire 12 Somatic Symptom scale as a predictor of symptom severity nd consulting behaviour in patients with irritable bowel syndrome and symptomatic diverticular disease. Aliment Pharmacol Ther. 2010 Sep; 32 (6): 811–20. doi: 10.1111/j.1365–2036.2010.04402.x.Humes D. J., Simpson J., Neal K. R. et al. Psychological and colonic factors in painful diverticulosis. Br J Surg. 2008 Feb; 95 (2): 195–8. doi: 10.1002/bjs.5962.Humes D. J., Simpson J., Neal K. R. et al. Psychological and colonic factors in painful diverticulosis. Br J Surg. 2008 Feb; 95 (2): 195–8. doi: 10.1002/bjs.5962.Painter N. S., Burkitt D. P. Diverticular disease of the colon: a deficiency disease of western civilization. Br Med J. 1971 May 22; 2 (5759):450–4. doi: 10.1136/bmj.2.5759.450.Painter N. S., Burkitt D. P. Diverticular disease of the colon: a deficiency disease of western civilization. Br Med J. 1971 May 22; 2 (5759):450–4. doi: 10.1136/bmj.2.5759.450.Aldoori W. H., Giovannucci E. L., Rockett H. R., et al. A prospective study of dietary fiber types and symptomatic diverticular disease in men. J Nutr. 1998 Apr; 128 (4): 714–9. doi: 10.1093/jn/128.4.714.Aldoori W. H., Giovannucci E. L., Rockett H. R., et al. A prospective study of dietary fiber types and symptomatic diverticular disease in men. J Nutr. 1998 Apr; 128 (4): 714–9. doi: 10.1093/jn/128.4.714.Crowe F. L., Appleby P. N., Allen N. E., et al. Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians. BMJ. 2011 Jul 19; 343: d4131. doi: 10.1136/bmj.d4131.Crowe F. L., Appleby P. N., Allen N. E., et al. Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians. BMJ. 2011 Jul 19; 343: d4131. doi: 10.1136/bmj.d4131.Aune D., Sen A., Norat T., Riboli E. Dietary fi bre intake and the risk of diverticular disease: a systematic review and meta-analysis of prospective studies. Eur J Nutr. 2020 Mar; 59 (2): 421–432. doi: 10.1007/s00394–019–01967-w.Aune D., Sen A., Norat T., Riboli E. Dietary fi bre intake and the risk of diverticular disease: a systematic review and meta-analysis of prospective studies. Eur J Nutr. 2020 Mar; 59 (2): 421–432. doi: 10.1007/s00394–019–01967-w.Strate L. L., Liu Y. L., Syngal S. et al. Nut, corn, and popcorn consumption and the incidence of diverticular disease. JAMA. 2008 Aug 27; 300 (8): 907–14. doi: 10.1001/jama.300.8.907.Strate L. L., Liu Y. L., Syngal S. et al. Nut, corn, and popcorn consumption and the incidence of diverticular disease. JAMA. 2008 Aug 27; 300 (8): 907–14. doi: 10.1001/jama.300.8.907.Maguire L. H., Song M., Strate L. E., Giovannucci E. L., Chan A. T. Higher serum levels of vitamin D are associated with a reduced risk of diverticulitis. Clin Gastroenterol Hepatol. 2013 Dec; 11 (12): 1631–5. doi: 10.1016/j.cgh.2013.07.035.Maguire L. H., Song M., Strate L. E., Giovannucci E. L., Chan A. T. Higher serum levels of vitamin D are associated with a reduced risk of diverticulitis. Clin Gastroenterol Hepatol. 2013 Dec; 11 (12): 1631–5. doi: 10.1016/j.cgh.2013.07.035.Maguire L. H., Song M., Strate L. L. et al. Association of geographic and seasonal variation with diverticulitis admissions. JAMA Surg. 2015 Jan; 150 (1): 74–7. doi: 10.1001/jamasurg.2014.2049.Maguire L. H., Song M., Strate L. L. et al. Association of geographic and seasonal variation with diverticulitis admissions. JAMA Surg. 2015 Jan; 150 (1): 74–7. doi: 10.1001/jamasurg.2014.2049.Tursi A. Current and Evolving Concepts on the Pathogenesis of Diverticular Disease. J Gastrointestin Liver Dis. 2019; 28: 225–223. doi:10.15403/JGLD-184.Tursi A. Current and Evolving Concepts on the Pathogenesis of Diverticular Disease. J Gastrointestin Liver Dis. 2019; 28: 225–223. doi:10.15403/JGLD-184.Maguire L. H., Song M., Strate L. L. et al. Association of geographic and seasonal variation with diverticulitis admissions. JAMA Surg. 2015 Jan; 150 (1): 74–7. doi: 10.1001/jamasurg.2014.2049.Maguire L. H., Song M., Strate L. L. et al. Association of geographic and seasonal variation with diverticulitis admissions. JAMA Surg. 2015 Jan; 150 (1): 74–7. doi: 10.1001/jamasurg.2014.2049.Strate L. L., Liu Y. L., Syngal S. et al. Nut, corn, and popcorn consumption and the incidence of diverticular disease. JAMA. 2008 Aug 27; 300 (8): 907–14. doi: 10.1001/jama.300.8.907.Strate L. L., Liu Y. L., Syngal S. et al. Nut, corn, and popcorn consumption and the incidence of diverticular disease. JAMA. 2008 Aug 27; 300 (8): 907–14. doi: 10.1001/jama.300.8.907.Strate L. L., Liu Y. L., Huang E. S. et al. Use of aspirin or non-steroidal anti-inflammatory drugs increases risk for diverticulitis and diverticular bleeding. Gastroenterology. 2011 May; 140 (5): 1427–33. doi: 10.1053/j.gastro.2011.02.004.Strate L. L., Liu Y. L., Huang E. S. et al. Use of aspirin or non-steroidal anti-inflammatory drugs increases risk for diverticulitis and diverticular bleeding. Gastroenterology. 2011 May; 140 (5): 1427–33. doi: 10.1053/j.gastro.2011.02.004.Humes D. J., Fleming K. M., Spiller R. C. et al. Concurrent drug use and the risk of perforated colonic diverticular disease: a population- based case-control study. Gut. 2011 Feb; 60 (2): 219–24. doi: 10.1136/gut.2010.217281.Humes D. J., Fleming K. M., Spiller R. C. et al. Concurrent drug use and the risk of perforated colonic diverticular disease: a population- based case-control study. Gut. 2011 Feb; 60 (2): 219–24. doi: 10.1136/gut.2010.217281.Strate L. L., Modi R., Cohen E. et al. Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights. Am J Gastroenterol. 2012 Oct; 107 (10): 1486–93. doi: 10.1038/ajg.2012.194.Strate L. L., Modi R., Cohen E. et al. Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights. Am J Gastroenterol. 2012 Oct; 107 (10): 1486–93. doi: 10.1038/ajg.2012.194.Barbara G., Cremon C., Barbaro M. R. et al. Treatment of Diverticular Disease With Aminosalicylates: The Evidence. J Clin Gastroenterol. 2016 Oct; 50 Suppl 1: S60–3. doi: 10.1097/MCG.0000000000000611.Barbara G., Cremon C., Barbaro M. R. et al. Treatment of Diverticular Disease With Aminosalicylates: The Evidence. J Clin Gastroenterol. 2016 Oct; 50 Suppl 1: S60–3. doi: 10.1097/MCG.0000000000000611.Laghi L., Mastromarino P., Elisei W. et al. Impact of treatments on fecal microbiota and fecal metabolome in symptomatic uncomplicated diverticular disease of the colon: a pilot study. J Biol Regul Homeost Agents. 2018 Nov-Dec; 32 (5): 1421–1432.Laghi L., Mastromarino P., Elisei W. et al. Impact of treatments on fecal microbiota and fecal metabolome in symptomatic uncomplicated diverticular disease of the colon: a pilot study. J Biol Regul Homeost Agents. 2018 Nov-Dec; 32 (5): 1421–1432.Derrien M., Vaughan E. E., Plugge C. M., de Vos W. M. Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. Int J Syst Evol Microbiol. 2004 Sep; 54 (Pt 5): 1469–1476. doi: 10.1099/ijs.0.02873–0.Derrien M., Vaughan E. E., Plugge C. M., de Vos W. M. Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. Int J Syst Evol Microbiol. 2004 Sep; 54 (Pt 5): 1469–1476. doi: 10.1099/ijs.0.02873–0.Biagi E., Nylund L., Candela M., et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One. 2010 May 17; 5 (5): e10667. doi: 10.1371/journal.pone.0010667.Biagi E., Nylund L., Candela M., et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One. 2010 May 17; 5 (5): e10667. doi: 10.1371/journal.pone.0010667.Daniels L., Budding A. E., de Korte N. et al. Fecal microbiome analysis as a diagnostic test for diverticulitis. Eur J Clin Microbiol Infect Dis. 2014 Nov; 33 (11): 1927–36. doi: 10.1007/s10096–014–2162–3.Daniels L., Budding A. E., de Korte N. et al. Fecal microbiome analysis as a diagnostic test for diverticulitis. Eur J Clin Microbiol Infect Dis. 2014 Nov; 33 (11): 1927–36. doi: 10.1007/s10096–014–2162–3.Schieffer K. M., Sabey K., Wright J. R. et al. The microbial ecosystem distinguishes chronically diseased tissue from adjacent tissue in the sigmoid colon of chronic, recurrent diverticulitis patients. Sci Rep. 2017 Aug 16; 7 (1): 8467. doi: 10.1038/s41598–017–06787–8.Schieffer K. M., Sabey K., Wright J. R. et al. The microbial ecosystem distinguishes chronically diseased tissue from adjacent tissue in the sigmoid colon of chronic, recurrent diverticulitis patients. Sci Rep. 2017 Aug 16; 7 (1): 8467. doi: 10.1038/s41598–017–06787–8.Kvasnovsky C. L., Leong L. E. X., Choo J. M., Abell G. C. J., Papagrigoriadis S., Bruce K. D., Rogers G. B. Clinical and symptom scores are signifi cantly correlated with fecal microbiota features in patients with symptomatic uncomplicated diverticular disease: a pilot study. Eur J Gastroenterol Hepatol. 2018 Jan; 30 (1): 107–112. doi: 10.1097/MEG.0000000000000995.Kvasnovsky C. L., Leong L. E. X., Choo J. M., Abell G. C. J., Papagrigoriadis S., Bruce K. D., Rogers G. B. Clinical and symptom scores are signifi cantly correlated with fecal microbiota features in patients with symptomatic uncomplicated diverticular disease: a pilot study. Eur J Gastroenterol Hepatol. 2018 Jan; 30 (1): 107–112. doi: 10.1097/MEG.0000000000000995.Peery A. F., Crockett S. D., Barritt A. S. Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States. Gastroenterology. 2015 Dec; 149 (7): 1731–1741.e3. doi: 10.1053/j.gastro.2015.08.045.Peery A. F., Crockett S. D., Barritt A. S. Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States. Gastroenterology. 2015 Dec; 149 (7): 1731–1741.e3. doi: 10.1053/j.gastro.2015.08.045.Everhart J. E., Ruhl C. E. Burden of digestive diseases in the United States part II: lower gastrointestinal diseases. Gastroenterology. 2009 Mar; 136 (3): 741–54. doi: 10.1053/j.gastro.2009.01.015.Everhart J. E., Ruhl C. E. Burden of digestive diseases in the United States part II: lower gastrointestinal diseases. Gastroenterology. 2009 Mar; 136 (3): 741–54. doi: 10.1053/j.gastro.2009.01.015.Tursi A. Diverticulosis today: unfashionable and still under-researched. Therap Adv Gastroenterol. 2016 Mar; 9 (2): 213–28. doi: 10.1177/1756283X15621228.Tursi A. Diverticulosis today: unfashionable and still under-researched. Therap Adv Gastroenterol. 2016 Mar; 9 (2): 213–28. doi: 10.1177/1756283X15621228.Peery A. F., Crockett S. D., Barritt A. S. Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States. Gastroenterology. 2015 Dec; 149 (7): 1731–1741.e3. doi: 10.1053/j.gastro.2015.08.045.Peery A. F., Crockett S. D., Barritt A. S. Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States. Gastroenterology. 2015 Dec; 149 (7): 1731–1741.e3. doi: 10.1053/j.gastro.2015.08.045.Peery A. F. Colonic Diverticula and Diverticular Disease: 10 Facts Clinicians Should Know. N C Med J. 2016 May-Jun; 77 (3): 220–2. doi: 10.18043/ncm.77.3.220.Peery A. F. Colonic Diverticula and Diverticular Disease: 10 Facts Clinicians Should Know. N C Med J. 2016 May-Jun; 77 (3): 220–2. doi: 10.18043/ncm.77.3.220.Shahedi K., Fuller G., Bolus R., et al. Long-term risk of acute diverticulitis among patients with incidental diverticulosis found during colonoscopy. Clin Gastroenterol Hepatol. 2013 Dec; 11 (12): 1609–13. doi: 10.1016/j.cgh.2013.06.020.Shahedi K., Fuller G., Bolus R., et al. Long-term risk of acute diverticulitis among patients with incidental diverticulosis found during colonoscopy. Clin Gastroenterol Hepatol. 2013 Dec; 11 (12): 1609–13. doi: 10.1016/j.cgh.2013.06.020.Jeyarajah S., Faiz O., Bottle A., Aylin P., Bjarnason I., Tekkis P. P., Papagrigoriadis S. Diverticular disease hospital admissions are increasing, with poor outcomes in the elderly and emergency admissions. Aliment Pharma col Ther. 2009 Dec 1; 30 (11–12): 1171–82. doi: 10.1111/j.1365–2036.2009.04098.x.Jeyarajah S., Faiz O., Bottle A., Aylin P., Bjarnason I., Tekkis P. P., Papagrigoriadis S. Diverticular disease hospital admissions are increasing, with poor outcomes in the elderly and emergency admissions. Aliment Pharma col Ther. 2009 Dec 1; 30 (11–12): 1171–82. doi: 10.1111/j.1365–2036.2009.04098.x.Binda G. A., Mataloni F., Bruzzone M., et al. Trends in hospital admission for acute diverticulitis in Italy from 2008 to 2015. Tech Coloproctol. 2018 Aug; 22 (8): 597–604. doi: 10.1007/s10151–018–1840-z.Binda G. A., Mataloni F., Bruzzone M., et al. Trends in hospital admission for acute diverticulitis in Italy from 2008 to 2015. Tech Coloproctol. 2018 Aug; 22 (8): 597–604. doi: 10.1007/s10151–018–1840-z.Клинические рекомендации. Дивертикулярная болезнь. – 2021. – Утверждены Минздравом РФ. Дата размещения: 25. 06. 2021. Режим доступа: https://cr.minzdrav.gov.ru/recomend/179_2Clinical guidelines. diverticular disease. 2021. Approved by the Ministry of Health of the Russian Federation. (in Russ.) Available at: https://cr.minzdrav.gov.ru/recomend/179_2 Accessed: 06/ 25/ 2021.Schieffer K. M., Kline B. P., Yochum G. S., Koltun W. A. Pathophysiology of diverticular disease. Expert Rev Gastroenterol Hepatol. 2018 Jul; 12 (7): 683–692. doi: 10.1080/17474124.2018.1481746.Schieffer K. M., Kline B. P., Yochum G. S., Koltun W. A. Pathophysiology of diverticular disease. Expert Rev Gastroenterol Hepatol. 2018 Jul; 12 (7): 683–692. doi: 10.1080/17474124.2018.1481746.Сказываева Е. В. Дивертикулярная болезнь толстой кишки / Е. В. Сказываева [и др.] // Фарматека. – 2017. –(S5): 22–30.Skazyvaeva E. V., Avalueva E. B., Sitkin S. I., Bakulin I. G., Skalinskaya M. I. Diverticular disease of the colon. Farmateka. 2017; (S5): 22–30. (in Russ.)Böhm S. K, Kruis W. Lifestyle and other risk factors for diverticulitis. Minerva Gastroenterol Dietol. 2017 Jun; 63 (2): 110–118. URL: https://pubmed.ncbi.nlm.nih.gov/28150481/Böhm S. K, Kruis W. Lifestyle and other risk factors for diverticulitis. Minerva Gastroenterol Dietol. 2017 Jun; 63 (2): 110–118. doi: URL: https://pubmed.ncbi.nlm.nih.gov/28150481/Aune D., Sen A., Leitzmann M. F. et al. Tobacco smoking and the risk of diverticular disease – a systematic review and meta-analysis of prospective studies. Colorectal Dis. 2017 Jul; 19 (7): 621–633. doi: 10.1111/codi.13748.Aune D., Sen A., Leitzmann M. F. et al. Tobacco smoking and the risk of diverticular disease – a systematic review and meta-analysis of prospective studies. Colorectal Dis. 2017 Jul; 19 (7): 621–633. doi: 10.1111/codi.13748.Hjern F., Johansson C., Mellgren A. et al. Diverticular disease and migration – the influence of acculturation to a Western lifestyle on diverticular disease. Aliment Pharmacol Ther. 2006 Mar 15; 23 (6): 797–805. doi: 10.1111/j.1365–2036.2006.02805.x.Hjern F., Johansson C., Mellgren A. et al. Diverticular disease and migration – the influence of acculturation to a Western lifestyle on diverticular disease. Aliment Pharmacol Ther. 2006 Mar 15; 23 (6): 797–805. doi: 10.1111/j.1365–2036.2006.02805.x.Liu P. H., Cao Y., Keeley B. R. et al. Adherence to a Healthy Lifestyle is Associated With a Lower Risk of Diverticulitis among Men. Am J Gastroenterol. 2017 Dec; 112 (12): 1868–1876. doi: 10.1038/ajg.2017.398.Liu P. H., Cao Y., Keeley B. R. et al. Adherence to a Healthy Lifestyle is Associated With a Lower Risk of Diverticulitis among Men. Am J Gastroenterol. 2017 Dec; 112 (12): 1868–1876. doi: 10.1038/ajg.2017.398.Tursi A. Current and Evolving Concepts on the Pathogenesis of Diverticular Disease. J Gastrointestin Liver Dis. 2019; 28: 225–223. doi:10.15403/JGLD-184.Tursi A. Current and Evolving Concepts on the Pathogenesis of Diverticular Disease. J Gastrointestin Liver Dis. 2019; 28: 225–223. doi:10.15403/JGLD-184.Kechagias A., Sofi anidis A., Zografos G. et al. Index C-reactive protein predicts increased severity in acute sigmoid diverticulitis. Ther Clin Risk Manag. 2018 Oct 2;14:1847–1853. doi: 10.2147/TCRM.S160113.Kechagias A., Sofi anidis A., Zografos G. et al. Index C-reactive protein predicts increased severity in acute sigmoid diverticulitis. Ther Clin Risk Manag. 2018 Oct 2;14:1847–1853. doi: 10.2147/TCRM.S160113.Tursi A. Biomarkers in diverticular diseases of the colon. Dig Dis. 2012; 30 (1): 12–8. doi: 10.1159/000335695.Tursi A. Biomarkers in diverticular diseases of the colon. Dig Dis. 2012; 30 (1): 12–8. doi: 10.1159/000335695.Tursi A., Brandimarte G., Elisei W. et al. Faecal calprotectin in colonic diverticular disease: a case-control study. Int J Colorectal Dis. 2009 Jan; 24 (1): 49–55. doi: 10.1007/s00384–008–0595–9.Tursi A., Brandimarte G., Elisei W. et al. Faecal calprotectin in colonic diverticular disease: a case-control study. Int J Colorectal Dis. 2009 Jan; 24 (1): 49–55. doi: 10.1007/s00384–008–0595–9.Jeger V., Pop R., Forudastan F., Barras J. P., Zuber M., Piso R. J. Correction to: Jeger V., et al. Is there a role for procalcitonin in differentiating uncomplicated and complicated diverticulitis in order to reduce antibiotic therapy? Swiss Med Wkly. 2018 Sep 24; 148: w14673. doi: 10.4414/smw.2018.14673.Jeger V., Pop R., Forudastan F., Barras J. P., Zuber M., Piso R. J. Correction to: Jeger V., et al. Is there a role for procalcitonin in differentiating uncomplicated and complicated diverticulitis in order to reduce antibiotic therapy? Swiss Med Wkly. 2018 Sep 24; 148: w14673. doi: 10.4414/smw.2018.14673.Tursi A., Scarpignato C., Strate L. L. et al. Colonic diverticular disease. Nat Rev Dis Primers. 2020 Mar 26; 6 (1): 20. doi: 10.1038/s41572–020–0153–5.Tursi A., Scarpignato C., Strate L. L. et al. Colonic diverticular disease. Nat Rev Dis Primers. 2020 Mar 26; 6 (1): 20. doi: 10.1038/s41572–020–0153–5.Niikura R., Nagata N., Shimbo T. et al. Colonoscopy can miss diverticula of the left colon identifi ed by barium enema. World J Gastroenterol. 2013 Apr 21; 19 (15): 2362–7. doi: 10.3748/wjg.v19.i15.2362.Niikura R., Nagata N., Shimbo T. et al. Colonoscopy can miss diverticula of the left colon identifi ed by barium enema. World J Gastroenterol. 2013 Apr 21; 19 (15): 2362–7. doi: 10.3748/wjg.v19.i15.2362.Andeweg C. S., Wegdam J. A., Groenewoud J., et al. Toward an evidence- based step-up approach in diagnosing diverticulitis. Scand J Gastroenterol. 2014 Jul; 49 (7): 775–84. doi: 10.3109/00365521.2014.908475.Andeweg C. S., Wegdam J. A., Groenewoud J., et al. Toward an evidence- based step-up approach in diagnosing diverticulitis. Scand J Gastroenterol. 2014 Jul; 49 (7): 775–84. doi: 10.3109/00365521.2014.908475.Bor R., Fábián A., Szepes Z. Role of ultrasound in colorectal diseases. World J Gastroenterol. 2016 Nov 21; 22 (43): 9477–9487.Bor R., Fábián A., Szepes Z. Role of ultrasound in colorectal diseases. World J Gastroenterol. 2016 Nov 21; 22 (43): 9477–9487.Kruis W., Germer C. T., Leifeld L.; German Society for Gastroenterology, Digestive and Metabolic Diseases and The German Society for General and Visceral Surgery. Diverticular disease: guidelines of the german society for gastroenterology, digestive and metabolic diseases and the german society for general and visceral surgery. Digestion. 2014; 90 (3): 190–207. doi: 10.1159/000367625.Kruis W., Germer C. T., Leifeld L.; German Society for Gastroenterology, Digestive and Metabolic Diseases and The German Society for General and Visceral Surgery. Diverticular disease: guidelines of the german society for gastroenterology, digestive and metabolic diseases and the german society for general and visceral surgery. Digestion. 2014; 90 (3): 190–207. doi: 10.1159/000367625.Min J. H., Kim H. C., Kim S. W. et al. Th e value of initial sonography compared to supplementary CT for diagnosing right-sided colonic diverticulitis. Jpn J Radiol. 2017 Jul; 35 (7): 358–365. doi: 10.1007/s11604–017–0646–7.Min J. H., Kim H. C., Kim S. W. et al. Th e value of initial sonography compared to supplementary CT for diagnosing right-sided colonic diverticulitis. Jpn J Radiol. 2017 Jul; 35 (7): 358–365. doi: 10.1007/s11604–017–0646–7.Farag Soliman M., Wüstner M., Sturm J., Werner A., Diehl S. J., Düber C., Post S. Primärdiagnostik der akuten Sigmadivertikulitis. Sonografie versus Computer-tomografie, eine prospektive Studie [Primary diagnostics of acute diverticulitis of the sigmoid]. Ultraschall Med. 2004 Sep; 25 (5): 342–7. German. doi: 10.1055/s-2004–813381.Farag Soliman M., Wüstner M., Sturm J., Werner A., Diehl S. J., Düber C., Post S. Primärdiagnostik der akuten Sigmadivertikulitis. Sonografie versus Computer-tomografie, eine prospektive Studie [Primary diagnostics of acute diverticulitis of the sigmoid]. Ultraschall Med. 2004 Sep; 25 (5): 342–7. German. doi: 10.1055/s-2004–813381.Puylaert J. B. Ultrasound of colon diverticulitis. Dig Dis. 2012; 30 (1): 56–9. doi: 10.1159/000336620.Puylaert J. B. Ultrasound of colon diverticulitis. Dig Dis. 2012; 30 (1): 56–9. doi: 10.1159/000336620.Nielsen K. et al. The Limited Role of Ultrasound in the Diagnostic Process of Colonic Diverticulitis. World J Surg. 2014 Jul; 38 (7): 1814–8. doi: 10.1007/s00268–013–2423–9.Nielsen K. et al. The Limited Role of Ultrasound in the Diagnostic Process of Colonic Diverticulitis. World J Surg. 2014 Jul; 38 (7): 1814–8. doi: 10.1007/s00268–013–2423–9.Dickerson E. C., Chong S. T., Ellis J. H. et al. Recurrence of Colonic Diverticulitis: Identifying Predictive CT Findings-Retrospective Cohort Study. Radiology. 2017 Dec; 285 (3): 850–858. doi: 10.1148/radiol.2017161374.Dickerson E. C., Chong S. T., Ellis J. H. et al. Recurrence of Colonic Diverticulitis: Identifying Predictive CT Findings-Retrospective Cohort Study. Radiology. 2017 Dec; 285 (3): 850–858. doi: 10.1148/radiol.2017161374.Lembcke B. J., Strobel D., Dirks K. et al. Statement of the section internal medicine of the DEGUM – ultrasound obtains pole position for clinical imaging in acute diverticulitis. Ultraschall Med. 2015 Apr; 36 (2): 191–5. doi: 10.1055/s-0034–1369761.Lembcke B. J., Strobel D., Dirks K. et al. Statement of the section internal medicine of the DEGUM – ultrasound obtains pole position for clinical imaging in acute diverticulitis. Ultraschall Med. 2015 Apr; 36 (2): 191–5. doi: 10.1055/s-0034–1369761.Mounce L. T. A., Price S., Valderas J. M. et al. Comorbid conditions delay diagnosis of colorectal cancer: a cohort study using electronic primary care records. Br J Cancer. 2017 Jun 6; 116 (12): 1536–1543. doi: 10.1038/bjc.2017.127.Mounce L. T. A., Price S., Valderas J. M. et al. Comorbid conditions delay diagnosis of colorectal cancer: a cohort study using electronic primary care records. Br J Cancer. 2017 Jun 6; 116 (12): 1536–1543. doi: 10.1038/bjc.2017.127.Papi C., Ciaco A., Koch M. et al. Efficacy of rifaximin in the treatment of symptomatic diverticular disease of the colon. A multicentre dou-ble-blind placebo-controlled trial. Aliment Pharmacol Ther. 1995 Feb; 9 (1): 33–9. doi: 10.1111/j.1365–2036.1995.tb00348.x.Papi C., Ciaco A., Koch M. et al. Efficacy of rifaximin in the treatment of symptomatic diverticular disease of the colon. A multicentre dou-ble-blind placebo-controlled trial. Aliment Pharmacol Ther. 1995 Feb; 9 (1): 33–9. doi: 10.1111/j.1365–2036.1995.tb00348.x.Schieffer K. M., Sabey K., Wright J. R. et al. The microbial ecosystem distinguishes chronically diseased tissue from adjacent tissue in the sigmoid colon of chronic, recurrent diverticulitis patients. Sci Rep. 2017 Aug 16; 7 (1): 8467. doi: 10.1038/s41598–017–06787–8.Schieffer K. M., Sabey K., Wright J. R. et al. The microbial ecosystem distinguishes chronically diseased tissue from adjacent tissue in the sigmoid colon of chronic, recurrent diverticulitis patients. Sci Rep. 2017 Aug 16; 7 (1): 8467. doi: 10.1038/s41598–017–06787–8.Barbara G., Scaioli E., Barbaro M. R. et al. Gut microbiota, metabolome and immune signatures in patients with uncomplicated diverticular disease. Gut. 2017 Jul; 66 (7): 1252–1261. doi: 10.1136/gutjnl-2016–312377.Barbara G., Scaioli E., Barbaro M. R. et al. Gut microbiota, metabolome and immune signatures in patients with uncomplicated diverticular disease. Gut. 2017 Jul; 66 (7): 1252–1261. doi: 10.1136/gutjnl-2016–312377.Kurpad A. V., Shetty P. S. Effects of antimicrobial therapy on faecal bulking. Gut. 1986 Jan; 27 (1): 55–8. doi: 10.1136/gut.27.1.55.Kurpad A. V., Shetty P. S. Effects of antimicrobial therapy on faecal bulking. Gut. 1986 Jan; 27 (1): 55–8. doi: 10.1136/gut.27.1.55.Frieri G., Pimpo M. T., Scarpignato C. Management of colonic diverticular disease. Digestion. 2006;73 Suppl 1: 58–66. doi: 10.1159/000089780.Frieri G., Pimpo M. T., Scarpignato C. Management of colonic diverticular disease. Digestion. 2006;73 Suppl 1: 58–66. doi: 10.1159/000089780.Ponziani F. R., Zocco M. A., D’Aversa F., Pompili M., Gasbarrini A. Eubiotic properties of rifaximin: Disruption of the traditional concepts in gut microbiota modulation. World J Gastroenterol. 2017 Jul 7; 23 (25): 4491–4499. doi: 10.3748/wjg.v23.i25.4491.Ponziani F. R., Zocco M. A., D’Aversa F., Pompili M., Gasbarrini A. Eubiotic properties of rifaximin: Disruption of the traditional concepts in gut microbiota modulation. World J Gastroenterol. 2017 Jul 7; 23 (25): 4491–4499. doi: 10.3748/wjg.v23.i25.4491.Gatta L., Scarpignato C. Systematic review with meta-analysis: rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth. Aliment Pharmacol Ther. 2017 Mar; 45 (5): 604–616. doi: 10.1111/apt.13928.Gatta L., Scarpignato C. Systematic review with meta-analysis: rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth. Aliment Pharmacol Ther. 2017 Mar; 45 (5): 604–616. doi: 10.1111/apt.13928.Stallinger S., Eller N., Högenauer C. Non-interventional study evaluating efficacy and tolerability of rifaximin for treatment of uncomplicated diverticular disease. Wien Klin Wochenschr. 2014 Jan; 126 (1–2): 9–14. doi: 10.1007/s00508–013–0447–7.Stallinger S., Eller N., Högenauer C. Non-interventional study evaluating efficacy and tolerability of rifaximin for treatment of uncomplicated diverticular disease. Wien Klin Wochenschr. 2014 Jan; 126 (1–2): 9–14. doi: 10.1007/s00508–013–0447–7.Latella G., Scarpignato C. Rifaximin in the management of colonic diverticular disease. Expert Rev Gastroenterol Hepatol. 2009 Dec; 3 (6): 585–98. doi: 10.1586/egh.09.63.Latella G., Scarpignato C. Rifaximin in the management of colonic diverticular disease. Expert Rev Gastroenterol Hepatol. 2009 Dec; 3 (6): 585–98. doi: 10.1586/egh.09.63.Bianchi M., Festa V., Moretti A. et al. Meta-analysis: long-term therapy with rifaximin in the management of uncomplicated diverticular disease. Aliment Pharmacol Ther. 2011 Apr; 33 (8): 902–10. doi: 10.1111/j.1365–2036.2011.04606.x.Bianchi M., Festa V., Moretti A. et al. Meta-analysis: long-term therapy with rifaximin in the management of uncomplicated diverticular disease. Aliment Pharmacol Ther. 2011 Apr; 33 (8): 902–10. doi: 10.1111/j.1365–2036.2011.04606.x.Copaci I., Constantinescu G., Mihăilă M. et al. Efficacy of Rifaximin-a vs Dietary Fiber on the Evolution of Uncomplicated Colonic Diverticular Disease. Surg Gastroenterol Oncol. 2019; 24: 233–240. doi: 10.21614/sgo-24–5–233.Copaci I., Constantinescu G., Mihăilă M. et al. Efficacy of Rifaximin-a vs Dietary Fiber on the Evolution of Uncomplicated Colonic Diverticular Disease. Surg Gastroenterol Oncol. 2019; 24: 233–240. doi: 10.21614/sgo-24–5–233.Moniuszko A., Rydzewska G. The effect of cyclic rifaximin therapy on symptoms of diverticular disease from the perspective of the gastroenterology outpatient clinic: a “real-life” study. Prz Gastroenterol. 2017; 12 (2): 145–151. doi: 10.5114/pg.2017.68167.Moniuszko A., Rydzewska G. The effect of cyclic rifaximin therapy on symptoms of diverticular disease from the perspective of the gastroenterology outpatient clinic: a “real-life” study. Prz Gastroenterol. 2017; 12 (2): 145–151. doi: 10.5114/pg.2017.68167.Picchio M., Elisei W., Brandimarte G. et al. Mesalazine for the Treatment of Symptomatic Uncomplicated Diverticular Disease of the Colon and for Primary Prevention of Diverticulitis: A Systematic Review of Randomized Clinical Trials. J Clin Gastroenterol. 2016 Oct; 50 Suppl 1: S64–69. doi: 10.1097/MCG.0000000000000669.Picchio M., Elisei W., Brandimarte G. et al. Mesalazine for the Treatment of Symptomatic Uncomplicated Diverticular Disease of the Colon and for Primary Prevention of Diverticulitis: A Systematic Review of Randomized Clinical Trials. J Clin Gastroenterol. 2016 Oct; 50 Suppl 1: S64–69. doi: 10.1097/MCG.0000000000000669.Krokowicz L., Stojcev Z., Kaczmarek B. F., et al. Microencapsulated sodium butyrate administered to patients with diverticulosis decreases incidence of diverticulitis – a prospective randomized study. Int J Colorectal Dis. 2014 Mar; 29 (3): 387–93. doi: 10.1007/s00384–013–1807–5.Krokowicz L., Stojcev Z., Kaczmarek B. F., et al. Microencapsulated sodium butyrate administered to patients with diverticulosis decreases incidence of diverticulitis – a prospective randomized study. Int J Colorectal Dis. 2014 Mar; 29 (3): 387–93. doi: 10.1007/s00384–013–1807–5.Scarpignato C., Bertelé A., Tursi A. Probiotics for the Treatment of Symptomatic Uncomplicated Diverticular Disease: Rationale and Current Evidence. J Clin Gastroenterol. 2016 Oct; 50 Suppl 1: S70–3. doi: 10.1097/MCG.0000000000000641.Scarpignato C., Bertelé A., Tursi A. Probiotics for the Treatment of Symptomatic Uncomplicated Diverticular Disease: Rationale and Current Evidence. J Clin Gastroenterol. 2016 Oct; 50 Suppl 1: S70–3. doi: 10.1097/MCG.0000000000000641.Lahner E., Bellisario C., Hassan C. et al. Probiotics in the Treatment of Diverticular Disease. A Systematic Review. J Gastrointestin Liver Dis. 2016 Mar; 25 (1): 79–86. doi: 10.15403/jgld.2014.1121.251.srw.Lahner E., Bellisario C., Hassan C. et al. Probiotics in the Treatment of Diverticular Disease. A Systematic Review. J Gastrointestin Liver Dis. 2016 Mar; 25 (1): 79–86. doi: 10.15403/jgld.2014.1121.251.srw.Tursi A., Brandimarte G., Elisei W., et al. Randomised clinical trial: mesalazine and / or probiotics in maintaining remission of symptomatic uncomplicated diverticular disease – a double- blind, randomised, placebo-controlled study. Aliment Pharmacol Ther. 2013 Oct; 38 (7): 741–51. doi: 10.1111/apt.12463.Tursi A., Brandimarte G., Elisei W., et al. Randomised clinical trial: mesalazine and / or probiotics in maintaining remission of symptomatic uncomplicated diverticular disease – a double- blind, randomised, placebo-controlled study. Aliment Pharmacol Ther. 2013 Oct; 38 (7): 741–51. doi: 10.1111/apt.12463.Turco F., Andreozzi P., Palumbo I., et al. Bacterial stimuli activate nitric oxide colonic mucosal production in diverticular disease. Protective effects of L. casei DG® (Lactobacillus paracasei CNCM I-1572). United European Gastroenterol J. 2017; 5 (5): 715-724. doi: 10.1177/2050640616684398.Turco F., Andreozzi P., Palumbo I., et al. Bacterial stimuli activate nitric oxide colonic mucosal production in diverticular disease. Protective effects of L. casei DG® (Lactobacillus paracasei CNCM I-1572). United European Gastroenterol J. 2017; 5 (5): 715-724. doi: 10.1177/2050640616684398.Cirocchi R., Randolph J. J., Binda G. A. Is the outpatient management of acute diverticulitis safe and eff ective? A systematic review and meta-analysis. Tech Coloproctol. 2019 Feb; 23 (2): 87–100. doi: 10.1007/s10151–018–1919–6.Cirocchi R., Randolph J. J., Binda G. A. Is the outpatient management of acute diverticulitis safe and eff ective? A systematic review and meta-analysis. Tech Coloproctol. 2019 Feb; 23 (2): 87–100. doi: 10.1007/s10151–018–1919–6.Stam M. A., Draaisma W. A., van de Wall B. J. et al. An unrestricted diet for uncomplicated diverticulitis is safe: results of a prospective diverticulitis diet study. Colorectal Dis. 2017 Apr; 19 (4): 372–377. doi: 10.1111/codi.13505.Stam M. A., Draaisma W. A., van de Wall B. J. et al. An unrestricted diet for uncomplicated diverticulitis is safe: results of a prospective diverticulitis diet study. Colorectal Dis. 2017 Apr; 19 (4): 372–377. doi: 10.1111/codi.13505.Van de Wall B. J., Draaisma W. A., van Iersel J. J. et al. Dietary restrictions for acute diverticulitis: evidence-based or expert opinion? Int J Colorectal Dis. 2013 Sep; 28 (9): 1287–93. doi: 10.1007/s00384–013–1694–9.Van de Wall B. J., Draaisma W. A., van Iersel J. J. et al. Dietary restrictions for acute diverticulitis: evidence-based or expert opinion? Int J Colorectal Dis. 2013 Sep; 28 (9): 1287–93. doi: 10.1007/s00384–013–1694–9.Chabok A., Påhlman L., Hjern F. et al. Randomized clinical trial of antibiotics in acute uncomplicated diverticulitis. Br J Surg. 2012 Apr; 99 (4): 532–9. doi: 10.1002/bjs.8688.Chabok A., Påhlman L., Hjern F. et al. Randomized clinical trial of antibiotics in acute uncomplicated diverticulitis. Br J Surg. 2012 Apr; 99 (4): 532–9. doi: 10.1002/bjs.8688.Daniels L., Ünlü Ç., de Korte N. et al. Randomized clinical trial of observational versus antibiotic treatment for a first episode of CT-proven uncomplicated acute diverticulitis. Dutch Diverticular Disease (3D) Collaborative Study Group. Br J Surg. 2017 Jan; 104 (1): 52–61. doi: 10.1002/bjs.10309.Daniels L., Ünlü Ç., de Korte N. et al. Randomized clinical trial of observational versus antibiotic treatment for a first episode of CT-proven uncomplicated acute diverticulitis. Dutch Diverticular Disease (3D) Collaborative Study Group. Br J Surg. 2017 Jan; 104 (1): 52–61. doi: 10.1002/bjs.10309.Tandon A., Fretwell V. L., Nunes Q. M., et al. Antibiotics versus no antibiotics in the treatment of acute uncomplicated diverticulitis – a systematic review and meta-analysis. Colorectal Dis. 2018 Jan 11. doi: 10.1111/codi.14013.Tandon A., Fretwell V. L., Nunes Q. M., et al. Antibiotics versus no antibiotics in the treatment of acute uncomplicated diverticulitis – a systematic review and meta-analysis. Colorectal Dis. 2018 Jan 11. doi: 10.1111/codi.14013.Emile S. H., Elfeki H., Sakr A. et al. Management of acute uncomplicated diverticulitis without antibiotics: a systematic review, meta-analysis, and meta-regression of predictors of treatment. Tech Coloproctol. 2018 Jul; 22 (7): 499–509. doi: 10.1007/s10151–018–1817-y.Emile S. H., Elfeki H., Sakr A. et al. Management of acute uncomplicated diverticulitis without antibiotics: a systematic review, meta-analysis, and meta-regression of predictors of treatment. Tech Coloproctol. 2018 Jul; 22 (7): 499–509. doi: 10.1007/s10151–018–1817-y.van Dijk S. T., Daniels L., Ünlü Ç., de Korte N., van Dieren S., Stockmann H. B., Vrouenraets B. C., Consten E. C., van der Hoeven J. A., Eijsbouts Q. A., Faneyte I. F., Bemelman W. A., Dijkgraaf M. G., Boermeester M. A.; Dutch Diverticular Disease (3D) Collaborative Study Group. Long-Term Effects of Omitting Antibiotics in Uncomplicated Acute Diverticulitis. Am J Gastroenterol. 2018 Jul; 113 (7): 1045–1052. doi: 10.1038/s41395–018–0030-y.van Dijk S. T., Daniels L., Ünlü Ç., de Korte N., van Dieren S., Stockmann H. B., Vrouenraets B. C., Consten E. C., van der Hoeven J. A., Eijsbouts Q. A., Faneyte I. F., Bemelman W. A., Dijkgraaf M. G., Boermeester M. A.; Dutch Diverticular Disease (3D) Collaborative Study Group. Long-Term Effects of Omitting Antibiotics in Uncomplicated Acute Diverticulitis. Am J Gastroenterol. 2018 Jul; 113 (7): 1045–1052. doi: 10.1038/s41395–018–0030-y.Slim K., Joris J., Beyer-Berjot L. The end of antibiotics in the management of uncomplicated acute diverticulitis. J Visc Surg. 2019 Oct; 156 (5): 373–375. doi: 10.1016/j.jviscsurg.2019.10.001.Slim K., Joris J., Beyer-Berjot L. The end of antibiotics in the management of uncomplicated acute diverticulitis. J Visc Surg. 2019 Oct; 156 (5): 373–375. doi: 10.1016/j.jviscsurg.2019.10.001.Rottier S. J., van Dijk S. T., Ünlü Ç., van Geloven A. A. W., Schreurs W. H., Boermeester M. A. Complicated Disease Course in Initially Computed Tomography-Proven Uncomplicated Acute Diverticulitis. Surg Infect (Larchmt). 2019 Sep; 20 (6): 453–459. doi: 10.1089/sur.2018.289.Rottier S. J., van Dijk S. T., Ünlü Ç., van Geloven A. A. W., Schreurs W. H., Boermeester M. A. Complicated Disease Course in Initially Computed Tomography-Proven Uncomplicated Acute Diverticulitis. Surg Infect (Larchmt). 2019 Sep; 20 (6): 453–459. doi: 10.1089/sur.2018.289.Stollman N., Smalley W., Hirano I.; AGA Institute Clinical Guidelines Committee. American Gastroenterological Association Institute Guideline on the Management of Acute Diverticulitis. Gastroenterology. 2015 Dec; 149 (7): 1944–9. doi: 10.1053/j.gastro.2015.10.003.Stollman N., Smalley W., Hirano I.; AGA Institute Clinical Guidelines Committee. American Gastroenterological Association Institute Guideline on the Management of Acute Diverticulitis. Gastroenterology. 2015 Dec; 149 (7): 1944–9. doi: 10.1053/j.gastro.2015.10.003.Bolkenstein H. E., Consten E. C. J., van der Palen J., van de Wall B. J. M., Broeders I. A. M. J., Bemelman W. A., Lange J. F., Boermeester M. A., Draaisma W. A.; Dutch Diverticular Disease (3D) Collaborative Study Group. Long-term Outcome of Surgery Versus Conservative Management for Recurrent and Ongoing Complaints After an Episode of Diverticulitis: 5-year Follow-up Results of a Multicenter Randomized Controlled Trial (DIRECT-Trial). Ann Surg. 2019 Apr; 269 (4): 612–620. doi: 10.1097/SLA.0000000000003033.Bolkenstein H. E., Consten E. C. J., van der Palen J., van de Wall B. J. M., Broeders I. A. M. J., Bemelman W. A., Lange J. F., Boermeester M. A., Draaisma W. A.; Dutch Diverticular Disease (3D) Collaborative Study Group. Long-term Outcome of Surgery Versus Conservative Management for Recurrent and Ongoing Complaints After an Episode of Diverticulitis: 5-year Follow-up Results of a Multicenter Randomized Controlled Trial (DIRECT-Trial). Ann Surg. 2019 Apr; 269 (4): 612–620. doi: 10.1097/SLA.0000000000003033.Jaung R., Kularatna M., Robertson J. P., Vather R., Rowbotham D., MacCormick A. D., Bissett I. P. Uncomplicated Acute Diverticulitis: Identifying Risk Factors for Severe Outcomes. World J Surg. 2017 Sep; 41 (9): 2258–2265. doi: 10.1007/s00268–017–4012–9.Jaung R., Kularatna M., Robertson J. P., Vather R., Rowbotham D., MacCormick A. D., Bissett I. P. Uncomplicated Acute Diverticulitis: Identifying Risk Factors for Severe Outcomes. World J Surg. 2017 Sep; 41 (9): 2258–2265. doi: 10.1007/s00268–017–4012–9.Shabanzadeh D. M., Wille-Jørgensen P. Antibiotics for uncomplicated diverticulitis. Cochrane Database Syst Rev. 2012 Nov 14; 11: CD009092. doi: 10.1002/14651858. CD009092.pub2.Shabanzadeh D. M., Wille-Jørgensen P. Antibiotics for uncomplicated diverticulitis. Cochrane Database Syst Rev. 2012 Nov 14; 11: CD009092. doi: 10.1002/14651858. CD009092.pub2.Schug-Pass C., Geers P., Hügel O., Lippert H., Köckerling F. Prospective randomized trial comparing short-term antibiotic therapy versus standard therapy for acute uncomplicated sigmoid diverticulitis. Int J Colorectal Dis. 2010 Jun; 25 (6): 751–9. doi: 10.1007/s00384–010–0899–4.Schug-Pass C., Geers P., Hügel O., Lippert H., Köckerling F. Prospective randomized trial comparing short-term antibiotic therapy versus standard therapy for acute uncomplicated sigmoid diverticulitis. Int J Colorectal Dis. 2010 Jun; 25 (6): 751–9. doi: 10.1007/s00384–010–0899–4.Evans J., Kozol R., Frederick W., Voytavich A., Pennoyer W., Lukianoff A., Lardner J. Does a 48-hour rule predict outcomes in patients with acute sigmoid diverticulitis? J Gastrointest Surg. 2008 Mar; 12 (3): 577–82. doi: 10.1007/s11605–007–0405–7.Evans J., Kozol R., Frederick W., Voytavich A., Pennoyer W., Lukianoff A., Lardner J. Does a 48-hour rule predict outcomes in patients with acute sigmoid diverticulitis? J Gastrointest Surg. 2008 Mar; 12 (3): 577–82. doi: 10.1007/s11605–007–0405–7.Gregersen R., Mortensen L. Q., Burcharth J., Pom mergaard H. C., Rosenberg J. Treatment of patients with acute colonic diverticulitis complicated by abscess formation: A systematic review. Int J Surg. 2016 Nov; 35: 201–208. doi: 10.1016/j.ijsu.2016.10.006.Gregersen R., Mortensen L. Q., Burcharth J., Pom mergaard H. C., Rosenberg J. Treatment of patients with acute colonic diverticulitis complicated by abscess formation: A systematic review. Int J Surg. 2016 Nov; 35: 201–208. doi: 10.1016/j.ijsu.2016.10.006.Young-Fadok T. M. Diverticulitis. N Engl J Med. 2018 Oct 25; 379 (17): 1635–1642. doi: 10.1056/NEJMcp1800468.Young-Fadok T. M. Diverticulitis. N Engl J Med. 2018 Oct 25; 379 (17): 1635–1642. doi: 10.1056/NEJMcp1800468.Galetin T., Galetin A., Vestweber K. H., Rink A. D. Systematic review and comparison of national and international guidelines on diverticular disease. Int J Colorectal Dis. 2018 Mar; 33 (3): 261–272. doi: 10.1007/s00384–017–2960-z.Galetin T., Galetin A., Vestweber K. H., Rink A. D. Systematic review and comparison of national and international guidelines on diverticular disease. Int J Colorectal Dis. 2018 Mar; 33 (3): 261–272. doi: 10.1007/s00384–017–2960-z.Cirocchi R., Afshar S., Di Saverio S., et al. A historical review of surgery for peritonitis secondary to acute colonic diverticulitis: from Lockhart- Mummery to evidence-based medicine. World J Emerg Surg. 2017 Mar 9; 12:14. doi: 10.1186/s13017–017–0120-y.Cirocchi R., Afshar S., Di Saverio S., et al. A historical review of surgery for peritonitis secondary to acute colonic diverticulitis: from Lockhart- Mummery to evidence-based medicine. World J Emerg Surg. 2017 Mar 9; 12:14. doi: 10.1186/s13017–017–0120-y.Biondo S. The diminishing role of surgery for acute diverticulitis. Br J Surg. 2019 Mar; 106 (4): 308–309. doi: 10.1002/bjs.11133.Biondo S. The diminishing role of surgery for acute diverticulitis. Br J Surg. 2019 Mar; 106 (4): 308–309. doi: 10.1002/bjs.11133.Vaghiri S., Prassas D., Knoefel W. T., Krieg A. The optimal timing of elective surgery in sigmoid diverticular disease: a meta-analysis. Langenbecks Arch Surg. 2022 Dec; 407 (8): 3259–3274. doi: 10.1007/s00423–022–02698-z.Vaghiri S., Prassas D., Knoefel W. T., Krieg A. The optimal timing of elective surgery in sigmoid diverticular disease: a meta-analysis. Langenbecks Arch Surg. 2022 Dec; 407 (8): 3259–3274. doi: 10.1007/s00423–022–02698-z.Stollman N., Magowan S., Shanahan F. et al. A randomized controlled study of mesalamine aft er acute diverticulitis: results of the DIVA trial. J Clin Gastroenterol. 2013 Aug; 47 (7): 621–9. doi: 10.1097/MCG.0b013e31828003f6.Stollman N., Magowan S., Shanahan F. et al. A randomized controlled study of mesalamine aft er acute diverticulitis: results of the DIVA trial. J Clin Gastroenterol. 2013 Aug; 47 (7): 621–9. doi: 10.1097/MCG.0b013e31828003f6.Khan R. M. A., Ali B., Hajibandeh S. et al. Effect of mesalazine on recurrence of diverticulitis in patients with symptomatic uncomplicated diverticular disease: a meta-analysis with trial sequential analysis of randomized controlled trials. Colorectal Dis. 2018 Jun; 20 (6): 469–478. doi: 10.1111/codi.14064.Khan R. M. A., Ali B., Hajibandeh S. et al. Effect of mesalazine on recurrence of diverticulitis in patients with symptomatic uncomplicated diverticular disease: a meta-analysis with trial sequential analysis of randomized controlled trials. Colorectal Dis. 2018 Jun; 20 (6): 469–478. doi: 10.1111/codi.14064.Nespoli L., Lo Bianco G., Uggeri F. et al. Effect of oral mesalamine on inflammatory response in acute uncomplicated diverticulitis. World J Gastroenterol. 2015 Jul 21; 21 (27): 8366–72. doi: 10.3748/wjg.v21.i27.8366.Nespoli L., Lo Bianco G., Uggeri F. et al. Effect of oral mesalamine on inflammatory response in acute uncomplicated diverticulitis. World J Gastroenterol. 2015 Jul 21; 21 (27): 8366–72. doi: 10.3748/wjg.v21.i27.8366.Lanas A., Ponce J., Bignamini A. et al. One year intermittent rifaximin plus fibre supplementation vs. fibre supplementation alone to prevent diverticulitis recurrence: a proof-of-concept study. Dig Liver Dis. 2013 Feb; 45 (2): 104–9. doi: 10.1016/j.dld.2012.09.006.Lanas A., Ponce J., Bignamini A. et al. One year intermittent rifaximin plus fibre supplementation vs. fibre supplementation alone to prevent diverticulitis recurrence: a proof-of-concept study. Dig Liver Dis. 2013 Feb; 45 (2): 104–9. doi: 10.1016/j.dld.2012.09.006.Festa V., Spila Alegiani S., Chiesara F., Moretti A., Bianchi M., Dezi A., Traversa G., Koch M. Retrospective comparison of long-term ten-day / month rifaximin or mesalazine in prevention of relapse in acute diverticulitis. Eur Rev Med Pharmacol Sci. 2017 Mar; 21 (6): 1397–1404. PMID: 28387885.Festa V., Spila Alegiani S., Chiesara F., Moretti A., Bianchi M., Dezi A., Traversa G., Koch M. Retrospective comparison of long-term ten-day / month rifaximin or mesalazine in prevention of relapse in acute diverticulitis. Eur Rev Med Pharmacol Sci. 2017 Mar; 21 (6): 1397–1404. PMID: 28387885.Tursi A., Brandimarte G., Daffinà R. Long-term treatment with mesalazine and rifaximin versus rifaximin alone for patients with recurrent attacks of acute diverticulitis of colon. Dig Liver Dis. 2002 Jul; 34 (7): 510–5. doi: 10.1016/s1590–8658(02)80110–4.Tursi A., Brandimarte G., Daffinà R. Long-term treatment with mesalazine and rifaximin versus rifaximin alone for patients with recurrent attacks of acute diverticulitis of colon. Dig Liver Dis. 2002 Jul; 34 (7): 510–5. doi: 10.1016/s1590–8658(02)80110–4.Инновации в питании для взрослых : Ежегодное издание с каталогом : Выпуск 1 / Под ред. В. А. Тутельяна [и др.] – Москва: ООО «Медицинское информационное агентсво», 2021. – 176 с.Tutelyan V. A., Nikityuk D. B., Pogozheva A. V., Shestopalova A. E., Popova T. S. [Adult Nutrition Innovation: An annual publication with a catalog]. Issue 1. Moscow: Medical Information Agency LLC Publ., 2021. 176 p. (in Russ.)Смолянский Б. Л. Диетология : Новейший справочник для врачей / Б. Л. Смолянский, В. Г. Лифляндский. – М.: ЭКСМО, 2003. – 816 c.Smolyansky B. L., Liflyandsky V. G. Dietology. [The newest guide for doctors]. Moscow: EKSMO Publ. 2003, 816 p.Пищевые волокна – важный компонент здорового питания. [Электронный ресурс]. Режим доступа: https://77.rospotrebnadzor.ru/index.php/doc/infdoc/9031pishchevye-volokna-vazhnyj-komponent-zdorovogo-pitaniya[Dietary fiber is an important component of a healthy diet]. (in Russ.) Available at: https://77.rospotrebnadzor.ru/index.php/doc/infdoc/9031pishchevye- volokna-vazhnyj-komponent-zdorovogo-pitaniya Access: 05. 05. 2022.Буторова Л. И. Дивертикулярная болезнь толстой кишки: клинические формы, диагностика и лечение : пособие для врачей / Л. И. Буторова. – М.: 4 ТЕ Арт, 2011. – 48 с.Butorova L.I. [Diverticular disease of the colon: clinical forms, diagnosis and treatment: a guide for doctors]. Moscow: 4 TE Art Publ., 2011. 48 p. (in Russ.)Ардатская М. Д. Дивертикулярная болезнь толстой кишки: решенные и нерешенные вопросы / М. Д. Ардатская // Медицинский совет. – 2017. – (15): 68–75. doi: 10.21518/2079–701X-2017–15–68–75.Ardatskaya M. D. Diverticular disease of the colon: resolved and unresolved issues. Meditsinskiy sovet = Medical Council. 2017; (15): 68–75. (In Russ.) doi: 10.21518/2079–701X-2017–15–68–75.Радченко В. Г. Пищевые волокна в клинической практике / В. Г. Радченко [и др.] // Клинические перспективы гастроэнтерологии, гепатологии. – 2010. – (1): 20–27.Radchenko V. G., Safronenkova I. G., Seliverstov P. V., Sitkin S. I., Teterina L. A. [Dietary fiber in clinical practice]. Clinical perspectives of gastroenterology, hepatology. 2010; (1): 20–27. (in Russ.)Пилат Т. Л. Исследование эффективности детоксицирующего влияния комплексной программы питания DETOX на функциональные показатели организма / Т. Л. Пилат [и др.] // Терапия. – 2020. – 6 (2): 156–163. doi: 10.18565/therapy.2020.2.156–163.Pilat T. L., Bezrukavnikova L. M., Kolyaskina M. M., Bessonov V. V., Anvarul N. A., Khanferyan R. A. Study of effectiveness of detoxing impact of the complex detox nutrition program on functional parameters of the organism. Therapy. 2020; 6 (2): 156–163. (in Russ.) doi: 10.18565/therapy.2020.2.156–163.Пилат Т. Л. Детоксикационное питание / Т. Л. Пилат, Л. П. Кузьмина, И. И. Измерова ; под ред. Т. Л. Пилат. – М.: ГЭОТАР-Медиа, 2012. – 688 с.Pilat T. L., Kuzmina L. P., Izmerova I. I. [Detox nutrition]. Moscow: GEOTAR-Media Publ., 2012. 688 p. (in Russ.)Пилат Т. Л. Специализированные диетические продукты как факторы повышения эффективности фармакотерапии желудочно-кишечных заболеваний / Т. Л. Пилат, Р. А. Ханферьян // Терапия. – 2020. – 6 (6): 212–218. doi: 10.18565/therapy.2020.6.212–218.Pilat T. L., Khanferian R. A. Specialized dietary preventive and therapeutic products as a means of increasing the efficiency of gastrointestinal diseases pharmacotherapy. Therapy. 2020; 6 (6): 212–218. (in Russ.) doi: 10.18565/therapy.2020.6.212–218.Пилат Т. Л. Опыт применения специализированного пищевого продукта диетического лечебного и диетического профилактического питания при воспалительных заболеваниях желудочно- кишечного тракта / Т. Л. Пилат [и др.] // Медицинский совет. – 2020. – (4): 107–113. doi: 10.21518/2079–701X-2020–4–107–113.Pilat T. L., Kuzmina L. P., Lashina E. L., Kolyaskina M. M., Bezrukavnikova L. M., Bessonov V. V., Korosteleva M. M., Gurevich K. G., Lagutina N. P., Khanferyan R. A. Experience of application of specialized food product of dietary therapeutic and dietary preventive nutrition in case of inflammatory diseases of gastrointestinal tract. Meditsinskiy sovet = Medical Council. 2020; (4): 107–113. (In Russ.) doi: 10.21518/2079–701X-2020–4–107–113.Srivastava G. S., Smith A. N., Painter N. S. Sterculia bulk-forming agent with smooth- muscle relaxant versus bran in diverticular disease. Br Med J. 1976 Feb 7; 1 (6005): 315–8. doi: 10.1136/bmj.1.6005.315.Srivastava G. S., Smith A. N., Painter N. S. Sterculia bulk-forming agent with smooth- muscle relaxant versus bran in diverticular disease. Br Med J. 1976 Feb 7; 1 (6005): 315–8. doi: 10.1136/bmj.1.6005.315.

The authors declare that there are no conflicts of interest present.