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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-204-8-190-194</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-2145</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Рецидивирующий кандидоз ротоглотки и пищевода у пациента с иммунной дисфункцией после тимусэктомии</article-title><trans-title-group xml:lang="en"><trans-title>Recurrent candidiasis of the oropharynx and esophagus in a patient with immune dysfunction after thymusectomy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шевяков</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shevyakov</surname><given-names>M. A.</given-names></name></name-alternatives><email xlink:type="simple">shevyakov@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Парамонова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Paramonova</surname><given-names>O. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Котрехова</surname><given-names>Л. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kotrekhova</surname><given-names>L. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мирзоян</surname><given-names>В. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Mirzoyan</surname><given-names>V. L.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шурпицкая</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shurpitskaya</surname><given-names>O. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фролова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Frolova</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Митрофанов</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Mitrofanov</surname><given-names>V. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И. И. Мечникова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-Western State Medical University named after I. I. Mechnikov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>18</day><month>01</month><year>2023</year></pub-date><volume>0</volume><issue>8</issue><fpage>190</fpage><lpage>194</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шевяков М.А., Парамонова О.В., Котрехова Л.П., Мирзоян В.Л., Шурпицкая О.А., Фролова Е.В., Митрофанов В.С., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Шевяков М.А., Парамонова О.В., Котрехова Л.П., Мирзоян В.Л., Шурпицкая О.А., Фролова Е.В., Митрофанов В.С.</copyright-holder><copyright-holder xml:lang="en">Shevyakov M.A., Paramonova O.V., Kotrekhova L.P., Mirzoyan V.L., Shurpitskaya O.A., Frolova E.V., Mitrofanov V.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/2145">https://www.nogr.org/jour/article/view/2145</self-uri><abstract><p>Представлен клинический случай пациента, перенесшего в возрасте 50 лет тимусэктомию по поводу тимомы. В последствии у пациента развилась иммунная дисфункция с рецидивирующим кандидозом пищевода и орофарингеальным кандидозом, вызванным Candida albicans. Так же пациент страдает упорным распространенным микозом кожи и ногтевых пластин, вызванным Trichophyton rubrum, аутоиммунным гастритом и доброкачественными новообразованиями полости рта и кишечника. Повторные курсы лечения флуконазолом привели к возникновению резистентности Candida albicans к азоловым антимикотическим средствам. Лечение орошениями раствора Амфотерицина. В ротоглотки и пищевода было эффективным.</p></abstract><trans-abstract xml:lang="en"><p>A clinical case of a patient who underwent a thymusectomy for thymoma at the age of 50 is presented. Subsequently, the patient developed immune dysfunction with recurrent esophageal candidiasis and oropharyngeal candidiasis caused by Candida albicans. The patient also suffers from persistent widespread mycosis of the skin and nail plates caused by Trichophyton rubrum, autoimmune gastritis and benign neoplasms of the oral cavity and intestines. Repeated courses of treatment with fluconazole led to the emergence of Candida albicans resistance to azole antimycotics. Treatment with irrigation of Amphotericin solution B in the oropharynx and in the esophagus was effective.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>тимома</kwd><kwd>тимусэктомия</kwd><kwd>кандидоз пищевода</kwd><kwd>кандидоз ротоглотки</kwd><kwd>онихомикоз</kwd><kwd>аутоиммунный гастрит</kwd><kwd>Candida</kwd></kwd-group><kwd-group xml:lang="en"><kwd>thymoma</kwd><kwd>thymusectomy</kwd><kwd>esophageal candidiasis</kwd><kwd>oropharyngeal candidiasis</kwd><kwd>onychomycosis</kwd><kwd>autoimmune gastritis</kwd><kwd>Candida</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Venuta F., Rendina E. A., Coloni G. F. Multimodality treatment of thymic tumors. Thorac Surg Clin. 2009 Feb;19(1):71-81. doi: 10.1016/j.thorsurg.2008.09.008</mixed-citation><mixed-citation xml:lang="en">Venuta F., Rendina E. A., Coloni G. F. Multimodality treatment of thymic tumors. 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