nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-204-8-92-105nogr-2134Research ArticleКЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯCLINICAL GASTROENTEROLOGYСравнительный анализ показателей микробиома пациентов с психическими расстройствами и здоровых добровольцевComparative analysis of microbiome indicators in patients with mental disorders and in healthy volunteershttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.noemail@neicon.ruhttps://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.unesco.gromova@gmail.comВанчаковаН. П.VanchakovaN. P.noemail@neicon.ruСемёновВ. А.SemyonovV. A.noemail@neicon.ruФедеральный исследовательский центр «Информатика и управление» РАН (ФИЦ ИУ РАН), Институт ФармакоинформатикиРоссияFederal Research Center “Informatics and Management” RAS (FRC IU RAS), Institute of PharmacoinformaticRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования Первый Санкт-Петербургский государственный медицинский университет им. И. П. ПавловаРоссияFederal State Budgetary Educational Institution of Higher Education First St. I. P. PavlovaRussian FederationФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава РоссииРоссияFSBEI HE “Kemerovo State Medical University” of the Ministry of Health of RussiaRussian Federation2022180120230892105Copyright © Торшин И.Ю., Громова О.А., Ванчакова Н.П., Семёнов В.А., 20232023Торшин И.Ю., Громова О.А., Ванчакова Н.П., Семёнов В.А.Torshin I.Y., Gromova O.A., Vanchakova N.P., Semyonov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2134

Состояние микробиома тесно взаимосвязано с высшей нервной деятельностью. Исследования взаимосвязей между состоянием микробиома и формированием нервно-психических расстройств весьма перспективны. В настоящей работе представлены результаты сравнительного анализа профилей показателей микробиома пациентов 36±12 лет с психическими и поведенческими расстройствами (n=30) и здоровых добровольцев (n=10). Профили показателей, характеризующие состояние микробиома, измерялись на основании анализа крови методом масс-хроматоспектрометрии. Были найдены многочисленные достоверные отличия в паттернах микробиома между пациентами и контролями. На основании установленных различий предложены и верифицированы две балльные шкалы, которые можно рассматривать как своего рода индексы «психопатогенности микробиома». Данные шкалы позволяют не только отличать пациентов от контролей, но и ранжировать обследуемых по степени «психопатогенности» профиля микробиома.

The state of human microbiome is closely related to higher nervous activity. Studies of the relationship between the state of the microbiome and the formation of neuropsychiatric disorders represent a very promising field of research. This work presents the results of a comparative analysis of the profiles of microbiome indicators in 36 ± 12-year-old patients with mental and behavioral disorders (n = 30) and in healthy volunteers (n = 10). The profiles of microbiome indicators were measured on the basis of blood analysis by mass chromatospectrometry. Numerous significant differences were found in microbiome patterns between patients and controls. On the basis of the established differences, two point scales were proposed and verified, which can be regarded as a kind of indices of “psychopathogenicity of the microbiome”. These scales make it possible not only to distinguish patients from controls, but also to rank the subjects according to the degree of “psychopathogenicity” of the microbiome profile.

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The authors declare that there are no conflicts of interest present.