nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-205-9-216-221nogr-2060Research ArticleОБЗОРREVIEWОсобенности молекулярного патогенеза гастроэнтерита, вызванного нетифоидными сероварами сальмонеллSome peculiarities of the molecular pathogenesis of gastroenteritis caused by non-typhoidal Salmonellahttps://orcid.org/0000-0002-9706-2691БойченкоМарина НиколаевнаBoichenkoM. N.noemail@neicon.ruhttps://orcid.org/0000-0003-4789-4964БошьянРоман ЕвгеньевичBosh’IanR. E.rbrm@mail.ruhttps://orcid.org/0000-0003-1864-5635БудановаЕлена ВячеславовнаBudanovaE. V.noemail@neicon.ruhttps://orcid.org/0000-0002-8955-3570УсатоваГалина НиколаевнаUsatovaG. N.noemail@neicon.ruФедеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И. М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияFederal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University, Ministry of Healthcare of the Russian Federation (Sechenov University)Russian Federation20220710202209216221Copyright © Бойченко М.Н., Бошьян Р.Е., Буданова Е.В., Усатова Г.Н., 20222022Бойченко М.Н., Бошьян Р.Е., Буданова Е.В., Усатова Г.Н.Boichenko M.N., Bosh’Ian R.E., Budanova E.V., Usatova G.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2060

Развитие гастроэнтеритов, вызванных нетифоидной группой сальмонелл (НТС) Salmonella enterica, связано с действием эффекторных молекул секреторных систем третьего типа (Т3СС-1 и Т3СС-2), экспрессируемых 1 и 2 островами патогенности генома S. enterica. Эффекторы, секретируемые Т3СС-1, обеспечивают проникновение НТС в клетку хозяина, участвуют в развитии воспалительной диареи, а некоторые из их являются предрасполагающими факторами в развитии колоректального рака (КРР). С другой стороны, эффекторы, секретируемые Т3СС-2, обеспечивают внутриклеточное существование НТС и способствуют «побегу» микроба от иммунного ответа организма хозяина и развития адаптивного иммунитета, что способствует персистенции сальмонелл

The development of gastroenteritis caused by non-typhoidal Salmonella (NTS) is mediated by the action of effectors that belong to the Type three secretory systems (T3SS) of Salmonella enterica. These effectors are expressed by Salmonella pathogenicity islands 1 and 2 located in the genome. The effectors of T3SS-1 provide invasion of salmonella into host cell, take part in the development of inflammatory diarrhea some and may act as a predisposing factor in oncogenesis leading to the development of colorectal cancer (CRC). The T3SS-2 effectors provide intracellular survival of bacteria in the host cell and evading from the host adaptive immune response that may lead to the prolonged persistence.

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The authors declare that there are no conflicts of interest present.