nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-205-9-209-215nogr-2059Research ArticleОБЗОРREVIEWРоль микробиоты в развитии колоректального ракаThe role of microbiota in the development of colorectal cancerhttps://orcid.org/0000-0003-4461-316XМартиросянКристина АндраниковнаMartirosianK. A.christinamarrrrr@gmail.comЛялюковаЕлена АлександровнаLyalyukovaE. A.noemail@neicon.ruhttps://orcid.org/0000-0002-2463-8151ПриходаИгорь ВикторовичPrikhodaI. V.noemail@neicon.ruФГБОУ ВО «Омский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияOmsk State Medical UniversityRussian FederationЛуганский государственный университет имени Владимира ДаляРоссияLugansk State University named after Vladimir DahlRussian Federation20220710202209209215Copyright © Мартиросян К.А., Лялюкова Е.А., Прихода И.В., 20222022Мартиросян К.А., Лялюкова Е.А., Прихода И.В.Martirosian K.A., Lyalyukova E.A., Prikhoda I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2059

Колоректальный рак - глобальная проблема мирового здравоохранения, являющаяся экономическим и гуманистическим бременем как для пациентов, так и для государства. Растущее количество данных свидетельствует о том, что дисбактериоз кишечных бактерий может способствовать возникновению и развитию колоректального рака путем образования вредных метаболитов и изменения физиологических процессов хозяина. Цель обзора - обобщение исследований о свойствах кишечного микробиома и механизмов, связанных с колоректальным канцерогенезом, включая воспаление, факторы патогенности бактерий, образование биопленок, бактериальные метаболиты и генотоксины, а также окислительный стресс.

Colorectal cancer is a global health problem, which is an economic and humanistic burden for both patients and the state. A growing body of evidence suggests that dysbiosis of intestinal bacteria can contribute to the emergence and development of colorectal cancer by the formation of harmful metabolites and changes in the physiological processes of the host. The aim of the review is to summarize studies on the properties of the intestinal microbiome and mechanisms associated with colorectal carcinogenesis, including inflammation, bacterial pathogenicity factors, biofilm formation, bacterial metabolites and genotoxins, as well as oxidative stress.

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The authors declare that there are no conflicts of interest present.