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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-205-9-196-200</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-2057</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Сердечно- сосудистые и онкологические заболевания: как разорвать поручный круг?</article-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular and oncological diseases: how to break the vicious circle?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2621-0068</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хакуашева</surname><given-names>Инара Аслановна</given-names></name><name name-style="western" xml:lang="en"><surname>Khakuasheva</surname><given-names>I. A.</given-names></name></name-alternatives><email xlink:type="simple">inara2333@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6575-3159</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Уметов</surname><given-names>Мурат Анатольевич</given-names></name><name name-style="western" xml:lang="en"><surname>Umetov</surname><given-names>Murat Anatolyevich</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хакулова</surname><given-names>Дарина Муратовна</given-names></name><name name-style="western" xml:lang="en"><surname>Khakulova</surname><given-names>D. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карданов</surname><given-names>Марат Алимович</given-names></name><name name-style="western" xml:lang="en"><surname>Kardanov</surname><given-names>M. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Кабардино-Балкарский государственный университет им. Х. М. Бербекова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kabardino-Balkarian State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>07</day><month>10</month><year>2022</year></pub-date><volume>0</volume><issue>9</issue><fpage>196</fpage><lpage>200</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хакуашева И.А., Уметов М.А., Хакулова Д.М., Карданов М.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Хакуашева И.А., Уметов М.А., Хакулова Д.М., Карданов М.А.</copyright-holder><copyright-holder xml:lang="en">Khakuasheva I.A., Umetov M.A., Khakulova D.M., Kardanov M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/2057">https://www.nogr.org/jour/article/view/2057</self-uri><abstract><p>Смертность от сердечно-сосудистых и онкологических заболеваний на протяжении многих лет остается рекордно высокой. Клиницисты обращают внимание на частое сочетание этих двух патологий. Естественно возникает вопрос, что объединяет, казалось бы, различные заболевания между собой? Современная терапия рака позволила достичь многим людям излечения или стойкой ремиссии, но при этом привела к появлению кардиальной патологии. Хорошо изучена взаимосвязь развития кардиотоксических явлений после проведенной противоопухолевой терапии, но незаслуженно мало отводится времени в реальной клинической практике на изучение васкулотоксичности у пациентов. Данный подход может рассматриваться как наиболее ранний предиктор повреждения микроциркуляторного русла в результате специфической терапии. Проведен анализ групп противоопухолевых препаратов вызывающих в наибольшей степени хроническую сердечную недостаточность и повреждение эндотелия сосудов. Рассмотрены основные подходы к стратификации риска у кардиоонкологических пациентов. Изучены принципы, использующиеся в профилактике и лечении кардио- и васкулотоксичности.</p></abstract><trans-abstract xml:lang="en"><p>Mortality from cardiovascular and oncological diseases has remained at record highs for many years. Clinicians pay attention to the frequent combination of these two pathologies. Naturally, the question arises, what unites seemingly different diseases among themselves? Modern cancer therapy has allowed many people to achieve a cure or a stable remission, but at the same time led to the appearance of cardiac pathology. The relationship between the development of cardiotoxic events after antitumor therapy has been well studied, but undeservedly little time is allocated in real clinical practice to study vasculotoxicity in patients. This approach can be considered as the earliest predictor of damage to the microvasculature as a result of specific therapy. The analysis of groups of anticancer drugs that cause chronic heart failure and damage to the vascular endothelium to the greatest extent was carried out. The main approaches to risk stratification in cardio-oncological patients are considered. The principles used in the prevention and treatment of cardio- and vasculotoxicity have been studied.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кардиоонкология</kwd><kwd>кардиотоксичность</kwd><kwd>васкулотоксичность</kwd><kwd>эндотелиальная дисфункция</kwd><kwd>противоопухолевая терапия</kwd><kwd>профилактика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardio-oncology</kwd><kwd>cardiotoxicity</kwd><kwd>vasculotoxicity</kwd><kwd>endothelial dysfunction</kwd><kwd>anticancer therapy</kwd><kwd>prevention</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Mohamad O., Tabuchi T., Nitta Y., et al. 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