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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-203-7-185-191</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-2028</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Метаболические основы обоснования терапии питанием при хронических заболеваниях печени</article-title><trans-title-group xml:lang="en"><trans-title>Metabolic basis for substantiation of nutrition therapy in chronic liver diseases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Першко</surname><given-names>Анатолий Михайлович</given-names></name><name name-style="western" xml:lang="en"><surname>Pershko</surname><given-names>Anatoli M.</given-names></name></name-alternatives><email xlink:type="simple">pershkoam@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яровенко</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Yarovenko</surname><given-names>I. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Першко</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pershko</surname><given-names>V. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБВОУ ВО «Военно-медицинская академия имени С. М. Кирова» МО РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Military Medical Academy named after S. M. Kirov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>07</day><month>10</month><year>2022</year></pub-date><volume>0</volume><issue>7</issue><fpage>185</fpage><lpage>191</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Першко А.М., Яровенко И.И., Першко В.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Першко А.М., Яровенко И.И., Першко В.А.</copyright-holder><copyright-holder xml:lang="en">Pershko A.M., Yarovenko I.I., Pershko V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/2028">https://www.nogr.org/jour/article/view/2028</self-uri><abstract><p>В последние 10 лет углубленное изучение процессов метаболизма при хронических заболеваниях печени и бурное развития новых технологий в производстве макро- и микронутриентов, фармаконутриентов в клинической диетологии и нутрициологии привели к созданию принципиально новых подходов в терапии питанием при этих заболеваниях. Признается тот факт, что диетические вмешательства при хронических заболеваниях печени должны следовать не только общим рекомендациям, указанным как потребность в энергии и белке, но и способствовать нормализации аминокислотного состава крови, обмена макро- и микроэлементов, витаминов и др. Особое значение приобретают методы диетической коррекции печеночной энцефалопатии, а также использования с лечебной целью микро- и фармаконутриентов.</p></abstract><trans-abstract xml:lang="en"><p>Over the past 10 years, an in-depth study of metabolic processes in chronic liver diseases and the rapid development of new technologies in the production of macro- and nutrients, pharmacological nutrients in clinical dietetics and nutritional science have led to the creation of fundamentally new approaches in nutritional therapy for these diseases. It is recognized that dietary interventions for chronic liver diseases should not only follow the general recommendations indicated as the need for energy and protein, but also contribute to the normalization of the amino acid composition of the blood, the metabolism of macro- and microelements, vitamins, etc. Methods of dietary correction are of particular importance hepatic encephalopathy, as well as the use of micro- and pharmacological nutrients for therapeutic purposes.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хронические заболевания печени</kwd><kwd>цирроз печени</kwd><kwd>гепатит</kwd><kwd>жировой гепатоз</kwd><kwd>клиническая диетология</kwd><kwd>нутрициология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>liver diseases</kwd><kwd>hepatic cirrhosis</kwd><kwd>hepatitis</kwd><kwd>steatohepatosis</kwd><kwd>clinical dietetics</kwd><kwd>nutriciology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bogush L.S. Diagnostics algorithm of iron dysbolism in patients with chronic diffusive liver desease. Health and Ecology Issues. 2008;(3):142-148. (In Russ.) @@Богуш Л. С. Алгоритм диагностики нарушений обмена железом у больных хроническими диффузными заболеваниями печени. // Проблемы здоровья и экологии. 2008, № 3. - С. 142-148.</mixed-citation><mixed-citation xml:lang="en">Bogush L.S. Diagnostics algorithm of iron dysbolism in patients with chronic diffusive liver desease. Health and Ecology Issues. 2008;(3):142-148. (In Russ.) @@Богуш Л. С. Алгоритм диагностики нарушений обмена железом у больных хроническими диффузными заболеваниями печени. // Проблемы здоровья и экологии. 2008, № 3. - С. 142-148.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Диетология. Руководство для врачей / Под редакцией А. Ю. Барановского. - 4-е издание. СПб, из-во «Питер», 2012. - 504 с.</mixed-citation><mixed-citation xml:lang="en">Диетология. Руководство для врачей / Под редакцией А. Ю. Барановского. - 4-е издание. СПб, из-во «Питер», 2012. - 504 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Mikhtiev S.N., Mikhtieva O. A. Iron overload syndrome in chronic liver disease: focus on non-alcoholic fatty liver disease. Lechaschi Vrach Journal. 2017(17):2-7. (in Russ.) @@Михтиев С. Н., Михтиева О. А. Синдром перегрузки железом при хронических заболеваниях печени: фокус на неалкогольную жировую болезнь печени. // Лечащий врач. 2017, № 17. - С. 2-7.</mixed-citation><mixed-citation xml:lang="en">Mikhtiev S.N., Mikhtieva O. A. Iron overload syndrome in chronic liver disease: focus on non-alcoholic fatty liver disease. Lechaschi Vrach Journal. 2017(17):2-7. (in Russ.) @@Михтиев С. Н., Михтиева О. А. Синдром перегрузки железом при хронических заболеваниях печени: фокус на неалкогольную жировую болезнь печени. // Лечащий врач. 2017, № 17. - С. 2-7.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Pershko A.M., Grinevich V. B., Ivanyuk E. S. Nutritional support in a multidisciplinary hospital. St. Petersburg, 2020. 32 p. (in Russ.) @@Першко А. М., Гриневич В. Б., Иванюк Е. С. Нутриционная поддержка в многопрофильном стационаре. - СПб, 2020. - 32 с.</mixed-citation><mixed-citation xml:lang="en">Pershko A.M., Grinevich V. B., Ivanyuk E. S. Nutritional support in a multidisciplinary hospital. St. Petersburg, 2020. 32 p. (in Russ.) @@Першко А. М., Гриневич В. Б., Иванюк Е. С. Нутриционная поддержка в многопрофильном стационаре. - СПб, 2020. - 32 с.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Polunina TE, Maev IV. [Diagnosis of iron overload syndrome]. Eksp Klin Gastroenterol. 2010;(5):61-8.Russian. PMID: 20731136. @@Полунина Т. Е., Маев И. В. Диагностика синдрома перегрузки железом. // Экспериментальная и клиническая гастроэнтерология. - 2010, № 5. - С. 61-68.</mixed-citation><mixed-citation xml:lang="en">Polunina TE, Maev IV. [Diagnosis of iron overload syndrome]. Eksp Klin Gastroenterol. 2010;(5):61-8.Russian. PMID: 20731136. @@Полунина Т. Е., Маев И. В. Диагностика синдрома перегрузки железом. // Экспериментальная и клиническая гастроэнтерология. - 2010, № 5. - С. 61-68.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Als-Nielsen B., Koretz R. L., Kjaergard L. L., et al. Branched-chain amino acids for hepatic encephalopathy. Cochrane Database Syst. Rev. 2003;(2): CD001939. doi: 10.1002/14651858.CD001939. Update in: Cochrane Database Syst Rev. 2015;2: CD001939. PMID: 12804416.</mixed-citation><mixed-citation xml:lang="en">Als-Nielsen B., Koretz R. L., Kjaergard L. L., et al. Branched-chain amino acids for hepatic encephalopathy. Cochrane Database Syst. Rev. 2003;(2): CD001939. doi: 10.1002/14651858.CD001939. Update in: Cochrane Database Syst Rev. 2015;2: CD001939. PMID: 12804416.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bravi F., Tavani A., Bosetti C., et al. Coffee and the risk of hepatocellular carcinoma and chronic liver disease: a systematic review and meta-analysis of prospective studies. Eur J Cancer Prev. 2017 Sep;26(5):368-377. doi: 10.1097/CEJ.0000000000000252</mixed-citation><mixed-citation xml:lang="en">Bravi F., Tavani A., Bosetti C., et al. Coffee and the risk of hepatocellular carcinoma and chronic liver disease: a systematic review and meta-analysis of prospective studies. Eur J Cancer Prev. 2017 Sep;26(5):368-377. doi: 10.1097/CEJ.0000000000000252</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bresci G., Parisi G., Banti S. Management of hepatic encephalopathy with oral zinc supplementation: a long-term treatment. Eur J Med. 1993 Aug-Sep;2(7):414-6. PMID: 8258031.</mixed-citation><mixed-citation xml:lang="en">Bresci G., Parisi G., Banti S. Management of hepatic encephalopathy with oral zinc supplementation: a long-term treatment. Eur J Med. 1993 Aug-Sep;2(7):414-6. PMID: 8258031.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Carey E.J., Lai J. C., Wang C. W., et al. A multicenter study to define sarcopenia in patients with end-stage liver disease. Liver Transpl. 2017 May;23(5):625-633. doi: 10.1002/lt.24750</mixed-citation><mixed-citation xml:lang="en">Carey E.J., Lai J. C., Wang C. W., et al. A multicenter study to define sarcopenia in patients with end-stage liver disease. Liver Transpl. 2017 May;23(5):625-633. doi: 10.1002/lt.24750</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Chen P., Torralba M., Tan J., et al. Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice. Gastroenterology. 2015 Jan;148(1):203-214.e16. doi: 10.1053/j.gastro.2014.09.014</mixed-citation><mixed-citation xml:lang="en">Chen P., Torralba M., Tan J., et al. Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice. Gastroenterology. 2015 Jan;148(1):203-214.e16. doi: 10.1053/j.gastro.2014.09.014</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Córdoba J., López-Hellín J., Planas M., et al. Normal protein diet for episodic hepatic encephalopathy: results of a randomized study. J Hepatol. 2004 Jul;41(1):38-43. doi: 10.1016/j.jhep.2004.03.023</mixed-citation><mixed-citation xml:lang="en">Córdoba J., López-Hellín J., Planas M., et al. Normal protein diet for episodic hepatic encephalopathy: results of a randomized study. J Hepatol. 2004 Jul;41(1):38-43. doi: 10.1016/j.jhep.2004.03.023</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Dasarathy J., McCullough A.J., Dasarathy S. Sarcopenia in alcoholic liver disease: clinical and molecular advances. Alcohol Clin Exp Res. 2017 Aug;41(8):1419-1431. doi: 10.1111/acer.13425</mixed-citation><mixed-citation xml:lang="en">Dasarathy J., McCullough A.J., Dasarathy S. Sarcopenia in alcoholic liver disease: clinical and molecular advances. Alcohol Clin Exp Res. 2017 Aug;41(8):1419-1431. doi: 10.1111/acer.13425</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">DiCecco S.R., Wieners E. J., Wiesner R. H., Southorn P. A., et al. Assessment of nutritional status of patients with end-stage liver disease undergoing liver transplantation. Mayo Clin Proc. 1989 Jan;64(1):95-102. doi: 10.1016/s0025-6196(12)65308-7</mixed-citation><mixed-citation xml:lang="en">DiCecco S.R., Wieners E. J., Wiesner R. H., Southorn P. A., et al. Assessment of nutritional status of patients with end-stage liver disease undergoing liver transplantation. Mayo Clin Proc. 1989 Jan;64(1):95-102. doi: 10.1016/s0025-6196(12)65308-7</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Dolz C., Raurich J. M., Ibanez J., et al. Ascites increases the resting energy expenditure in liver cirrhosis. Gastroenterology. 1991 Mar;100(3):738-44. doi: 10.1016/0016-5085(91)80019-6</mixed-citation><mixed-citation xml:lang="en">Dolz C., Raurich J. M., Ibanez J., et al. Ascites increases the resting energy expenditure in liver cirrhosis. Gastroenterology. 1991 Mar;100(3):738-44. doi: 10.1016/0016-5085(91)80019-6</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver. EASL Clinical Practice Guidelines on nutrition in chronic liver disease. J Hepatol. 2019 Jan;70(1):172-193. doi: 10.1016/j.jhep.2018.06.024</mixed-citation><mixed-citation xml:lang="en">European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver. EASL Clinical Practice Guidelines on nutrition in chronic liver disease. J Hepatol. 2019 Jan;70(1):172-193. doi: 10.1016/j.jhep.2018.06.024</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">European Association For The Study Of The Liver. EASL clinical practice guidelines for HFE hemochromatosis. J Hepatol. 2010 Jul;53(1):3-22. doi: 10.1016/j.jhep.2010.03.001</mixed-citation><mixed-citation xml:lang="en">European Association For The Study Of The Liver. EASL clinical practice guidelines for HFE hemochromatosis. J Hepatol. 2010 Jul;53(1):3-22. doi: 10.1016/j.jhep.2010.03.001</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Gheorghe L., Iacob R., Vadan R., et al. Improvement of hepatic encephalopathy using a modified high-calorie high-protein diet. Rom J Gastroenterol. 2005 Sep;14(3):231-8. PMID: 16200232.</mixed-citation><mixed-citation xml:lang="en">Gheorghe L., Iacob R., Vadan R., et al. Improvement of hepatic encephalopathy using a modified high-calorie high-protein diet. Rom J Gastroenterol. 2005 Sep;14(3):231-8. PMID: 16200232.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Gluud L.L., Dam G., Borre M., et al. Oral branched chain amino acids have a beneficial effect on manifestations of hepatic encephalopathy in a systematic review with meta-analyses of randomized controlled trials. J Nutr. 2013 Aug;143(8):1263-8. doi: 10.3945/jn.113.174375</mixed-citation><mixed-citation xml:lang="en">Gluud L.L., Dam G., Borre M., et al. Oral branched chain amino acids have a beneficial effect on manifestations of hepatic encephalopathy in a systematic review with meta-analyses of randomized controlled trials. J Nutr. 2013 Aug;143(8):1263-8. doi: 10.3945/jn.113.174375</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Goh G.B., Chow W. C., Wang R., et al. Coffee, alcohol and other beverages in relation to cirrhosis mortality: the Singapore Chinese Health Study. Hepatology. 2014 Aug;60(2):661-9. doi: 10.1002/hep.27054</mixed-citation><mixed-citation xml:lang="en">Goh G.B., Chow W. C., Wang R., et al. Coffee, alcohol and other beverages in relation to cirrhosis mortality: the Singapore Chinese Health Study. Hepatology. 2014 Aug;60(2):661-9. doi: 10.1002/hep.27054</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Gow P., Spelman T., Gardner S., et al. Estimates of the Global Reduction in Liver Disease-related Mortality With Increased Coffee Consumption. Aliment Pharmacol Ther. 2020 Oct;52(7):1195-1203. doi: 10.1111/apt.16020</mixed-citation><mixed-citation xml:lang="en">Gow P., Spelman T., Gardner S., et al. Estimates of the Global Reduction in Liver Disease-related Mortality With Increased Coffee Consumption. Aliment Pharmacol Ther. 2020 Oct;52(7):1195-1203. doi: 10.1111/apt.16020</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Greco A.V., Mingrone G., Benedetti G., et al. Daily energy and substrate metabolism in patients with cirrhosis. Hepatology. 1998 Feb;27(2):346-50. doi: 10.1002/hep.510270205</mixed-citation><mixed-citation xml:lang="en">Greco A.V., Mingrone G., Benedetti G., et al. Daily energy and substrate metabolism in patients with cirrhosis. Hepatology. 1998 Feb;27(2):346-50. doi: 10.1002/hep.510270205</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Guglielmi F.W., Panella C., Buda A., et al. Nutritional state and energy balance in cirrhotic patients with or without hypermetabolism. Multicentre prospective study by the ‘Nutritional Problems in Gastroenterology’ Section of the Italian Society of Gastroenterology (SIGE). Dig Liver Dis. 2005 Sep;37(9):681-8. doi: 10.1016/j.dld.2005.03.010</mixed-citation><mixed-citation xml:lang="en">Guglielmi F.W., Panella C., Buda A., et al. Nutritional state and energy balance in cirrhotic patients with or without hypermetabolism. Multicentre prospective study by the ‘Nutritional Problems in Gastroenterology’ Section of the Italian Society of Gastroenterology (SIGE). Dig Liver Dis. 2005 Sep;37(9):681-8. doi: 10.1016/j.dld.2005.03.010</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Henkel A.S., Buchman A. L. Nutritional support in patients with chronic liver disease. Nat Clin Pract Gastroenterol Hepatol. 2006 Apr;3(4):202-9. doi: 10.1038/ncpgasthep0443</mixed-citation><mixed-citation xml:lang="en">Henkel A.S., Buchman A. L. Nutritional support in patients with chronic liver disease. Nat Clin Pract Gastroenterol Hepatol. 2006 Apr;3(4):202-9. doi: 10.1038/ncpgasthep0443</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">American Association for the Study of Liver Diseases; European Association for the Study of the Liver. Hepatic encephalopathy in chronic liver disease: 2014 practice guideline by the European Association for the Study of the Liver and the American Association for the Study of Liver Diseases. J Hepatol. 2014 Sep;61(3):642-59. doi: 10.1016/j.jhep.2014.05.042</mixed-citation><mixed-citation xml:lang="en">American Association for the Study of Liver Diseases; European Association for the Study of the Liver. Hepatic encephalopathy in chronic liver disease: 2014 practice guideline by the European Association for the Study of the Liver and the American Association for the Study of Liver Diseases. J Hepatol. 2014 Sep;61(3):642-59. doi: 10.1016/j.jhep.2014.05.042</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Himoto T., Yoneyama H., Kurokohchi K., et al. Selenium deficiency is associated with insulin resistance in patients with hepatitis C virus-related chronic liver disease. Nutr Res. 2011 Nov;31(11):829-35. doi: 10.1016/j.nutres.2011.09.021</mixed-citation><mixed-citation xml:lang="en">Himoto T., Yoneyama H., Kurokohchi K., et al. Selenium deficiency is associated with insulin resistance in patients with hepatitis C virus-related chronic liver disease. Nutr Res. 2011 Nov;31(11):829-35. doi: 10.1016/j.nutres.2011.09.021</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Holecek M. Branched-chain amino acid supplementation in treatment of liver cirrhosis: Updated views on how to attenuate their harmful effects on cataplerosis and ammonia formation. Nutrition. 2017 Sep;41:80-85. doi: 10.1016/j.nut.2017.04.003</mixed-citation><mixed-citation xml:lang="en">Holecek M. Branched-chain amino acid supplementation in treatment of liver cirrhosis: Updated views on how to attenuate their harmful effects on cataplerosis and ammonia formation. Nutrition. 2017 Sep;41:80-85. doi: 10.1016/j.nut.2017.04.003</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Holecek M. Three targets of branched-chain amino acid supplementation in the treatment of liver disease. Nutrition. 2010 May;26(5):482-90. doi: 10.1016/j.nut.2009.06.027</mixed-citation><mixed-citation xml:lang="en">Holecek M. Three targets of branched-chain amino acid supplementation in the treatment of liver disease. Nutrition. 2010 May;26(5):482-90. doi: 10.1016/j.nut.2009.06.027</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Inoue E., Hori S., Narumi Y.et al. Portalsystemic encephalopathy: presence of basal ganglia lesions with high signal intensity on MR images. Radiology. 1991 May;179(2):551-5. doi: 10.1148/radiology.179.2.2014310</mixed-citation><mixed-citation xml:lang="en">Inoue E., Hori S., Narumi Y.et al. Portalsystemic encephalopathy: presence of basal ganglia lesions with high signal intensity on MR images. Radiology. 1991 May;179(2):551-5. doi: 10.1148/radiology.179.2.2014310</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kang Y.J., Zhou Z. Zinc prevention and treatment of alcoholic liver disease. Mol Aspects Med. 2005 Aug-Oct;26(4-5):391-404. doi: 10.1016/j.mam.2005.07.002</mixed-citation><mixed-citation xml:lang="en">Kang Y.J., Zhou Z. Zinc prevention and treatment of alcoholic liver disease. Mol Aspects Med. 2005 Aug-Oct;26(4-5):391-404. doi: 10.1016/j.mam.2005.07.002</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Katayama K., Saito M., Kawaguchi T., et al. Effect of zinc on liver cirrhosis with hyperammonemia: a preliminary randomized, placebo-controlled double-blind trial. Nutrition. 2014 Nov-Dec;30(11-12):1409-14. doi: 10.1016/j.nut.2014.04.018</mixed-citation><mixed-citation xml:lang="en">Katayama K., Saito M., Kawaguchi T., et al. Effect of zinc on liver cirrhosis with hyperammonemia: a preliminary randomized, placebo-controlled double-blind trial. Nutrition. 2014 Nov-Dec;30(11-12):1409-14. doi: 10.1016/j.nut.2014.04.018</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kawaguchi T., Izumi N., Charlton M. R., Sata M. Branched-chain amino acids as pharmacological nutrients in chronic liver disease. Hepatology. 2011 Sep 2;54(3):1063-70. doi: 10.1002/hep.24412</mixed-citation><mixed-citation xml:lang="en">Kawaguchi T., Izumi N., Charlton M. R., Sata M. Branched-chain amino acids as pharmacological nutrients in chronic liver disease. Hepatology. 2011 Sep 2;54(3):1063-70. doi: 10.1002/hep.24412</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Naylor C.D., O’Rourke K., Detsky A. S., Baker J. P. Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. A meta-analysis. Gastroenterology. 1989 Oct;97(4):1033-42. doi: 10.1016/0016-5085(89)91517-5</mixed-citation><mixed-citation xml:lang="en">Naylor C.D., O’Rourke K., Detsky A. S., Baker J. P. Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. A meta-analysis. Gastroenterology. 1989 Oct;97(4):1033-42. doi: 10.1016/0016-5085(89)91517-5</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ndraha S., Hasan I., Simadibrata M. The effect of L-ornithine L-aspartate and branch chain amino acids on encephalopathy and nutritional status in liver cirrhosis with malnutrition. Acta Med Indones. 2011 Jan;43(1):18-22. PMID: 21339541.</mixed-citation><mixed-citation xml:lang="en">Ndraha S., Hasan I., Simadibrata M. The effect of L-ornithine L-aspartate and branch chain amino acids on encephalopathy and nutritional status in liver cirrhosis with malnutrition. Acta Med Indones. 2011 Jan;43(1):18-22. PMID: 21339541.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Nicoletti A., Ponziani F. R., Biolato M., et al.Intestinal permeability in the pathogenesis of liver damage: from non-alcoholic fatty liver disease to liver transplantation. World J Gastroenterol. 2019 Sep 7;25(33):4814-4834. doi: 10.3748/wjg.v25.i33.4814</mixed-citation><mixed-citation xml:lang="en">Nicoletti A., Ponziani F. R., Biolato M., et al.Intestinal permeability in the pathogenesis of liver damage: from non-alcoholic fatty liver disease to liver transplantation. World J Gastroenterol. 2019 Sep 7;25(33):4814-4834. doi: 10.3748/wjg.v25.i33.4814</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Nishikawa H., Enomoto H., Ishii A.et al. Elevated serum myostatin level is associated with worse survival in patients with liver cirrhosis. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):915-925. doi: 10.1002/jcsm.12212</mixed-citation><mixed-citation xml:lang="en">Nishikawa H., Enomoto H., Ishii A.et al. Elevated serum myostatin level is associated with worse survival in patients with liver cirrhosis. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):915-925. doi: 10.1002/jcsm.12212</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Owen O. E. Nature and quantity of fuels consumed in patients with alcoholic cirrhosis. J Clin Invest. 1983 Nov;72(5):1821-32. doi: 10.1172/JCI111142</mixed-citation><mixed-citation xml:lang="en">Owen O. E. Nature and quantity of fuels consumed in patients with alcoholic cirrhosis. J Clin Invest. 1983 Nov;72(5):1821-32. doi: 10.1172/JCI111142</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Pace A., de Weerth A., Berna M., et al. Pancreas and liver injury are associated in individuals with increased alcohol consumption. Clin. Gastroenterol. Clin Gastroenterol Hepatol. 2009 Nov;7(11):1241-6. doi: 10.1016/j.cgh.2009.06.010</mixed-citation><mixed-citation xml:lang="en">Pace A., de Weerth A., Berna M., et al. Pancreas and liver injury are associated in individuals with increased alcohol consumption. Clin. Gastroenterol. Clin Gastroenterol Hepatol. 2009 Nov;7(11):1241-6. doi: 10.1016/j.cgh.2009.06.010</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Periyalwar P., Dasarathy S. Malnutrition in cirrhosis: contribution and consequences of sarcopenia on metabolic and clinical responses. Clin Liver Dis. 2012 Feb;16(1):95-131. doi: 10.1016/j.cld.2011.12.009</mixed-citation><mixed-citation xml:lang="en">Periyalwar P., Dasarathy S. Malnutrition in cirrhosis: contribution and consequences of sarcopenia on metabolic and clinical responses. Clin Liver Dis. 2012 Feb;16(1):95-131. doi: 10.1016/j.cld.2011.12.009</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Plauth M., Cabré E., Campillo B., et al. ESPEN Guidelines on Parenteral Nutrition: Hepatology. Clin Nutr. 2009 Aug;28(4):436-44. doi: 10.1016/j.clnu.2009.04.019</mixed-citation><mixed-citation xml:lang="en">Plauth M., Cabré E., Campillo B., et al. ESPEN Guidelines on Parenteral Nutrition: Hepatology. Clin Nutr. 2009 Aug;28(4):436-44. doi: 10.1016/j.clnu.2009.04.019</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Poole R., Kennedy O. J., Roderick P., et al. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ. 2017 Nov 22;359: j5024. doi: 10.1136/bmj.j5024. Erratum in: BMJ. 2018 Jan 12;360: k194. PMID: 29167102; PMCID: PMC5696634.</mixed-citation><mixed-citation xml:lang="en">Poole R., Kennedy O. J., Roderick P., et al. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ. 2017 Nov 22;359: j5024. doi: 10.1136/bmj.j5024. Erratum in: BMJ. 2018 Jan 12;360: k194. PMID: 29167102; PMCID: PMC5696634.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Qiu J., Tsien C., Thapalaya S.et al. Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis. Am J Physiol Endocrinol Metab. 2012 Oct 15;303(8): E983-93. doi: 10.1152/ajpendo.00183.2012</mixed-citation><mixed-citation xml:lang="en">Qiu J., Tsien C., Thapalaya S.et al. Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis. Am J Physiol Endocrinol Metab. 2012 Oct 15;303(8): E983-93. doi: 10.1152/ajpendo.00183.2012</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Ruhl C.E., Everhart J. E. Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States. Gastroenterology. 2005 Jan;128(1):24-32. doi: 10.1053/j.gastro.2004.09.075</mixed-citation><mixed-citation xml:lang="en">Ruhl C.E., Everhart J. E. Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States. Gastroenterology. 2005 Jan;128(1):24-32. doi: 10.1053/j.gastro.2004.09.075</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Setiawan V.W., Wilkens L. R., Lu S. C., Hernandez B. Y., Le Marchand L, Henderson B. E. Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort. Gastroenterology. 2015 Jan;148(1):118-25; quiz e15. doi: 10.1053/j.gastro.2014.10.005</mixed-citation><mixed-citation xml:lang="en">Setiawan V.W., Wilkens L. R., Lu S. C., Hernandez B. Y., Le Marchand L, Henderson B. E. Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort. Gastroenterology. 2015 Jan;148(1):118-25; quiz e15. doi: 10.1053/j.gastro.2014.10.005</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Shergill R., Syed W., Rizvi S.A, Singh I. Nutritional support in chronic liver disease and cirrhotics. World J Hepatol. 2018 Oct 27;10(10):685-694. doi: 10.4254/wjh.v10.i10.685</mixed-citation><mixed-citation xml:lang="en">Shergill R., Syed W., Rizvi S.A, Singh I. Nutritional support in chronic liver disease and cirrhotics. World J Hepatol. 2018 Oct 27;10(10):685-694. doi: 10.4254/wjh.v10.i10.685</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Sinclair M., Grossmann M., Hoermann R., et al. Testosterone therapy increases muscle mass in men with cirrhosis and low testosterone: a randomised controlled trial. J Hepatol. 2016 Nov;65(5):906-913. doi: 10.1016/j.jhep.2016.06.007</mixed-citation><mixed-citation xml:lang="en">Sinclair M., Grossmann M., Hoermann R., et al. Testosterone therapy increases muscle mass in men with cirrhosis and low testosterone: a randomised controlled trial. J Hepatol. 2016 Nov;65(5):906-913. doi: 10.1016/j.jhep.2016.06.007</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Takuma Y., Nouso K., Makino Y., Hayashi M., Takahashi H. Clinical trial: oral zinc in hepatic encephalopathy. Aliment Pharmacol Ther. 2010 Nov;32(9):1080-90. doi: 10.1111/j.1365-2036.2010.04448.x</mixed-citation><mixed-citation xml:lang="en">Takuma Y., Nouso K., Makino Y., Hayashi M., Takahashi H. Clinical trial: oral zinc in hepatic encephalopathy. Aliment Pharmacol Ther. 2010 Nov;32(9):1080-90. doi: 10.1111/j.1365-2036.2010.04448.x</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Tanaka K., Tokunaga S., Kono S., et al. Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkers.Int J Epidemiol. 1998 Jun;27(3):438-43. doi: 10.1093/ije/27.3.438</mixed-citation><mixed-citation xml:lang="en">Tanaka K., Tokunaga S., Kono S., et al. Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkers.Int J Epidemiol. 1998 Jun;27(3):438-43. doi: 10.1093/ije/27.3.438</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Torres D.M., Harrison SA. Is it time to write a prescription for coffee? Coffee and liver disease. Gastroenterology. 2013 Apr;144(4):670-2. doi: 10.1053/j.gastro.2013.02.015</mixed-citation><mixed-citation xml:lang="en">Torres D.M., Harrison SA. Is it time to write a prescription for coffee? Coffee and liver disease. Gastroenterology. 2013 Apr;144(4):670-2. doi: 10.1053/j.gastro.2013.02.015</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Tsien C., Davuluri G., Singh D et al. Metabolic and molecular responses to leucine-enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis. Hepatology. 2015 Jun;61(6):2018-29. doi: 10.1002/hep.27717</mixed-citation><mixed-citation xml:lang="en">Tsien C., Davuluri G., Singh D et al. Metabolic and molecular responses to leucine-enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis. Hepatology. 2015 Jun;61(6):2018-29. doi: 10.1002/hep.27717</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Tverdal A., Skurtveit S. Coffee intake and mortality from liver cirrhosis. Ann Epidemiol. 2003 Jul;13(6):419-23. doi: 10.1016/s1047-2797(02)00462-3</mixed-citation><mixed-citation xml:lang="en">Tverdal A., Skurtveit S. Coffee intake and mortality from liver cirrhosis. Ann Epidemiol. 2003 Jul;13(6):419-23. doi: 10.1016/s1047-2797(02)00462-3</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
