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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-199-3-156-160</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-1971</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Коморбидность неопределенного (недифференцированного) колита с целиакией и внекишечными проявлениями</article-title><trans-title-group xml:lang="en"><trans-title>Comorbidity of indeterminate colitis with celiac disease and extra-intestinal manifestations</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8361-3846</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудишина</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudishina</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кудишина Мария Михайловна -ассистент кафедры терапии, гастроэнтерологии и пульмонологии.</p><p>410012, Саратов, Большая Казачья ул.,112</p></bio><bio xml:lang="en"><p>Mariya M. Kudishina -assistant of department of therapy, gastroenterology and pulmonology; Scopus Author ID: 57219598105.</p><p>Saratov</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5056-4504</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Козлова Ирина Вадимовна -заведующий кафедрой терапии, гастроэнтерологии и пульмонологии, профессор, доктор медицинских наук.</p><p>410012, Саратов, Большая Казачья ул.,112</p></bio><bio xml:lang="en"><p>Irina V. Kozlova -chief of Department of therapy, gastroenterology and pulmonology, Professor, Ph. D of medical sciences; Scopus Author ID: 7102626490.</p><p>Saratov</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9421-5146</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Быкова</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Bykova</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Быкова Анна Павловна -доцент кафедры терапии, гастроэнтерологии и пульмонологии, кандидат медицинских наук.</p><p>410012, Саратов, Большая Казачья ул.,112</p></bio><bio xml:lang="en"><p>Anna P. Bykova -Assistant professor of the Department of Therapy, Gastroenterology and Pulmonology, Ph. D. of medical sciences; Scopus Author ID: 57190664726.</p><p>Saratov</p></bio><email xlink:type="simple">Vulpesruber@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО Саратовский государственный медицинский университет им. В.И. Разумовского» МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saratov State Medical University n. a. V.I. Razumovsky</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО Саратовский государственный медицинский университет им. В.И. Разумовского МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saratov State Medical University n. a. V.I. Razumovsky</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>05</day><month>10</month><year>2022</year></pub-date><volume>0</volume><issue>3</issue><fpage>156</fpage><lpage>160</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кудишина М.М., Козлова И.В., Быкова А.П., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Кудишина М.М., Козлова И.В., Быкова А.П.</copyright-holder><copyright-holder xml:lang="en">Kudishina M.M., Kozlova I.V., Bykova A.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/1971">https://www.nogr.org/jour/article/view/1971</self-uri><abstract><p>В статье представлен клинический случай сочетания целиакии с установлением диагноза во взрослом периоде и воспалительного заболевания кишечника, которое в дебюте имело фенотип язвенного колита и трансформировалось при наблюдении в неопределенный (недифференцированный) колит. Гастроэнтерологическая патология сопровождалась надпочечниковой недостаточностью и демиелинизирующим заболеванием центральной нервной системы, что, согласно литературным данным, может рассматриваться как внекишечные проявления аутоиммунных заболеваний кишечника.</p></abstract><trans-abstract xml:lang="en"><p>The article presents a clinical case of a combination of celiac disease with diagnosis in the adult period and inﬂ ammatory bowel disease, which had the phenotype of ulcerative colitis in its debut and transformed into indeterminate colitis during observation. Gastroenterological pathology was accompanied by adrenal insuﬃciency and demyelinating disease of the central nervous system, which can be considered as extra-intestinal manifestations of autoimmune intestinal diseases according to literature data.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Oxford E.C., Nguyen D. D., Sauk J., et al. Impact of coexistent celiac disease on phenotype and natural history of infl ammatory bowel diseases. Am J Gastroenterol. 2013;108(7):1123–1129. doi:10.1038/ajg.2013.20</mixed-citation><mixed-citation xml:lang="en">Oxford E.C., Nguyen D. D., Sauk J., et al. Impact of coexistent celiac disease on phenotype and natural history of infl ammatory bowel diseases. Am J Gastroenterol. 2013;108(7):1123–1129. doi:10.1038/ajg.2013.20</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Halling M.L., Kjeldsen J., Knudsen T., et al. Patients with infl ammatory bowel disease have increased risk of autoimmune and infl ammatory diseases. World Journal of gastroenterology. 2017;23:6137-6146. doi: 10.3748/wjg.v23.i33.6137</mixed-citation><mixed-citation xml:lang="en">Halling M.L., Kjeldsen J., Knudsen T., et al. Patients with infl ammatory bowel disease have increased risk of autoimmune and infl ammatory diseases. World Journal of gastroenterology. 2017;23:6137-6146. doi: 10.3748/wjg.v23.i33.6137</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Shah A., Walker M., Burger D., et al. Link between celiac disease and infl ammatory bowel disease. Journal of clinical gastroenterology. 2019;53:514–522. doi: 10.1097/MCG.0000000000001033</mixed-citation><mixed-citation xml:lang="en">Shah A., Walker M., Burger D., et al. Link between celiac disease and infl ammatory bowel disease. Journal of clinical gastroenterology. 2019;53:514–522. doi: 10.1097/MCG.0000000000001033</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bosca-Watts M.M., Minguez M., Planelles D., et al. HLADQ: Celiac disease vs infl ammatory bowel disease. World J Gastroenterol. 2018;24(1):96–103. doi:10.3748/wjg.v24.i1.96</mixed-citation><mixed-citation xml:lang="en">Bosca-Watts M.M., Minguez M., Planelles D., et al. HLADQ: Celiac disease vs infl ammatory bowel disease. World J Gastroenterol. 2018;24(1):96–103. doi:10.3748/wjg.v24.i1.96</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Yang A., Chen Y., Scherl E., et al. Infl ammatory bowel disease in patients with celiac disease. Infl amm Bowel Dis. 2005;11(6):528–532.</mixed-citation><mixed-citation xml:lang="en">Yang A., Chen Y., Scherl E., et al. Infl ammatory bowel disease in patients with celiac disease. Infl amm Bowel Dis. 2005;11(6):528–532.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Casella G., Di Bella C., Salemme M., Villanacci V., Antonelli E., Baldini V., Bassotti G. Celiac disease. non-celiac gluten sensitivity and infl ammatory bowel disease. Minevra Gastroenterol Dietol. 2015;61(4):267-71.</mixed-citation><mixed-citation xml:lang="en">Casella G., Di Bella C., Salemme M., Villanacci V., Antonelli E., Baldini V., Bassotti G. Celiac disease. non-celiac gluten sensitivity and infl ammatory bowel disease. Minevra Gastroenterol Dietol. 2015;61(4):267-71.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Schedel J., Rockmann F., Bongartz T., Woenckhaus M., Scholmerich J., Kullmann F. Association of Crohn’s disease and latent celiac disease: a case report and review of the literature. Int J Colorectal Dis. 2005;20:376–380.</mixed-citation><mixed-citation xml:lang="en">Schedel J., Rockmann F., Bongartz T., Woenckhaus M., Scholmerich J., Kullmann F. Association of Crohn’s disease and latent celiac disease: a case report and review of the literature. Int J Colorectal Dis. 2005;20:376–380.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Guindi M., Riddell R. H. Indeterminate colitis. J Clin Pathol. 2004;57(12):1233–1244. doi:10.1136/jcp.2003.015214</mixed-citation><mixed-citation xml:lang="en">Guindi M., Riddell R. H. Indeterminate colitis. J Clin Pathol. 2004;57(12):1233–1244. doi:10.1136/jcp.2003.015214</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Дуброва С. Э., Лунина С. М., Коростелева П. А. Мультидисциплинарная диагностика неопределенного колита. Экспериментальная и клиническая гастроэнтерология. 2021;(3):207-213. doi:10.31146/1682–8658-ecg-187-3–207-213</mixed-citation><mixed-citation xml:lang="en">Dubrova S. E., Lunina S. M., Korosteleva P. A. Difficulties of multidisciplinary diagnostics of indeterminate colitis. Experimental and Clinical Gastroenterology. 2021;(3):207-213. (In Russ.) doi:10.31146/1682–8658-ecg-187-3–207-213</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Durazzo M., Ferro A., Brascugli I., Mattivi S., Fagoonee S., Pellicano R. Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?. J Clin Med. 2022;11(1):258. doi:10.3390/jcm11010258</mixed-citation><mixed-citation xml:lang="en">Durazzo M., Ferro A., Brascugli I., Mattivi S., Fagoonee S., Pellicano R. Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?. J Clin Med. 2022;11(1):258. doi:10.3390/jcm11010258</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Дмитриева Ю. А., Захарова И. Н. Неврологические проявления у больных целиакией Медицинский совет. 2017;9:93–96.</mixed-citation><mixed-citation xml:lang="en">Dmitrieva Y.A., Zakharova I. N. Neurologic manifestations in coeliac disease patients. Meditsinskiy sovet. 2017;(9):93–96. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Freeman H. J. Endocrine manifestations in celiac disease. World J Gastroenterol. 2016 Oct 14;22(38):8472–8479. doi: 10.3748/wjg.v22.i38.8472.</mixed-citation><mixed-citation xml:lang="en">Freeman H. J. Endocrine manifestations in celiac disease. World J Gastroenterol. 2016 Oct 14;22(38):8472–8479. doi: 10.3748/wjg.v22.i38.8472.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Venkateswaran N., Weismiller S., Clarke K. Indeterminate Colitis – Update on Treatment Options. J Infl amm Res. 2021;14:6383–6395. Published 2021 Nov 30. doi:10.2147/JIR.S268262</mixed-citation><mixed-citation xml:lang="en">Venkateswaran N., Weismiller S., Clarke K. Indeterminate Colitis – Update on Treatment Options. J Infl amm Res. 2021;14:6383–6395. Published 2021 Nov 30. doi:10.2147/JIR.S268262</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
