<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-199-3-150-155</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-1970</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Хронический аспирационный бронхиолит у пациентки с дивертикулом пищевода и гастроэзофагеальной рефлюксной болезнью</article-title><trans-title-group xml:lang="en"><trans-title>Chronic aspiration bronchiolitis in a patient with esophageal diverticulum and gastroesophageal reﬂux disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6186-6746</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаповалова</surname><given-names>Т. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Shapovalova</surname><given-names>T. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шаповалова Татьяна Германовна -доктор медицинских наук, профессор, профессор кафедры терапии, гастроэнтерологии и пульмонологии. Scopus Author ID: 6603614978.</p><p>410012, Саратов, Большая Казачья ул.,112</p></bio><bio xml:lang="en"><p>Tatyana G. Shapovalova -Professor of the Department of Therapy, Gastroenterology and Pulmonology; Professor; Doctor of Medical Sciences; Scopus Author ID: 6603614978.</p><p>Bolshaya Sadovaya St., 137, Saratov, Saratov Region, 410000</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1469-0367</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рябова</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryabova</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рябова Анна Юрьевна -доктор медицинских наук, доцент, профессор, профессор кафедры терапии, гастроэнтерологии и пульмонологии. Scopus Author ID: 57213286335.</p><p>410012, Саратов, Большая Казачья ул.,112</p></bio><bio xml:lang="en"><p>Anna Yu. Ryabova -Professor of the Department of Therapy, Gastroenterology and Pulmonology; assistant professor; Doctor of Medical Sciences; Scopus Author ID: 57213286335.</p><p>Bolshaya Sadovaya St., 137, Saratov, Saratov Region, 410000</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4654-9344</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пахомова</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Pakhomova</surname><given-names>A. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пахомова Анна Леонидовна -кандидат медицинских наук, доцент кафедры терапии, гастроэнтерологии и пульмонологии, профессор. ResearcherID: AAD-9952–2021.</p><p>410012, Саратов, Большая Казачья ул.,112</p></bio><bio xml:lang="en"><p>Anna L. Pakhomova -Associate Professor at the Department of Therapy, Gastroenterology and Pulmonology; assistant professor; Candidate of Medical Sciences; ResearcherID: AAD-9952–2021.</p><p>Bolshaya Sadovaya St., 137, Saratov, Saratov Region, 410000</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0282-4359</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шашина</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Shashina</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шашина Марина Михайловна -кандидат медицинских наук, доцент кафедры терапии, гастроэнтерологии и пульмонологии.</p><p>410012, Саратов, Большая Казачья ул.,112</p></bio><bio xml:lang="en"><p>Marina M. Shashina -Associate Professor at the Department of Therapy, Gastroenterology and Pulmonology; assistant professor; Candidate of Medical Sciences.</p><p>Bolshaya Sadovaya St., 137, Saratov, Saratov Region, 410000</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО Саратовский государственный медицинский университет им. В.И. Разумовского МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Saratov State Medical University, Healthcare Ministry of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>05</day><month>10</month><year>2022</year></pub-date><volume>0</volume><issue>3</issue><fpage>150</fpage><lpage>155</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шаповалова Т.Г., Рябова А.Ю., Пахомова А.Л., Шашина М.М., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Шаповалова Т.Г., Рябова А.Ю., Пахомова А.Л., Шашина М.М.</copyright-holder><copyright-holder xml:lang="en">Shapovalova T.G., Ryabova A.Y., Pakhomova A.L., Shashina M.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/1970">https://www.nogr.org/jour/article/view/1970</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: представить описание клинического наблюдения хронического аспирационного бронхиолита у пациентки с дивертикулом верхней части пищевода больших размеров и гастроэзофагеальной рефлюксной болезнью (ГЭРБ).</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы: представлен краткий обзор литературы по современному представлению о внепищеводных респираторных проявлениях ГЭРБ и особенностях течения дивертикулов верхней части пищевода, клинико-радиологической симптоматики хронического аспирационного бронхиолита как одного из вариантов бронхолегочной патологии при этом заболевании, а также описание пациентки с данной патологией.</p></sec><sec><title>Результаты</title><p>Результаты: представлено развитие фиброзирующего интерстициального заболевания легких у пациентки с дивертикулом верхней части пищевода больших размеров и ГЭРБ.</p></sec><sec><title>Заключение</title><p>Заключение: показаны проблемы дифференциальной диагностики респираторных симптомов при патологии пищевода. Авторы надеются, что описанное наблюдение позволит насторожить врачей в плане возможного развития фиброзирующего интерстициального заболевания легких на фоне сочетанной патологии пищевода, требующего тщательного мониторирования с целью своевременного выявления прогрессирующего фиброзного фенотипа и определения показаний для антифибротической терапии.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose of the study</title><p>Purpose of the study: to present a description of the clinical observation of chronic aspiration bronchiolitis in a patient with a large diverticulum of the upper esophagus and gastroesophageal reﬂ ux disease (GERD).</p></sec><sec><title>Materials and methods</title><p>Materials and methods: a brief review of the literature on the modern concept of extraesophageal respiratory manifestations of GERD, the features of the course of upper esophageal diverticula, clinical and radiological symptoms of chronic aspiration bronchiolitis is presented. In the above clinical case, chronic aspiration bronchiolitis was a manifestation of gastroesophageal pathology.</p></sec><sec><title>Results</title><p>Results: The development of ﬁ brosing interstitial lung disease in a patient with a large upper esophageal diverticulum and GERD is presented.</p></sec><sec><title>Conclusion</title><p>Conclusion: the problems of diﬀerential diagnosis of respiratory symptoms in esophageal pathology are shown. The authors hope that the described observation will increase the attention of doctors regarding comorbid ﬁ brosing interstitial lung diseases in esophageal pathology; the need for timely detection of a progressive ﬁ brotic phenotype and determination of indications for antiﬁ brotic therapy.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хронический аспирационный бронхиолит</kwd><kwd>дивертикул пищевода</kwd><kwd>гастроэзофагеальная рефлюксная болезнь</kwd></kwd-group><kwd-group xml:lang="en"><kwd>сhronic aspiration bronchiolitis</kwd><kwd>esophageal diverticulum</kwd><kwd>gastroesophageal reﬂux disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Федорова С. О., Козлова Н. М. Гастроэзофагеальная рефлюксная болезнь, ассоциированная с заболеваниями дыхательных путей. Acta Biomedica Scientifi ca. 2018;3(3):103–107 doi https://doi.org/10.29413/ABS.2018–3.3.16</mixed-citation><mixed-citation xml:lang="en">Fedorova S. O., Kozlova N. M. Gastroesophageal refl ux disease associated with diseases of the respiratory tract. Acta biomedica scientifica (east siberian biomedical journal) 2018;3(3):103–107 с (in Russ.) doi https://doi.org/10.29413/ABS.2018–3.3.16</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Griffiths T.L, Nassar M, Soubani A. O. Pulmonary manifestations of gastroesophageal refl ux disease. Expert Rev Respir Med. 2020 Aug;14(8):767-775. doi:10.1080/174763 482020.1758068. PMID: 32308062</mixed-citation><mixed-citation xml:lang="en">Griffiths T.L, Nassar M, Soubani A. O. Pulmonary manifestations of gastroesophageal refl ux disease. Expert Rev Respir Med. 2020 Aug;14(8):767-775. doi:10.1080/174763 482020.1758068. PMID: 32308062</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Durazzo M., Lupi G., Cicerchia F., Ferro A., Barutta F., Beccuti G., Gruden G., Pellicano R. Extra-E sophageal Presentation of Gastroesophageal Refl ux Disease: 2020 Update. J Clin Med. 2020 Aug 7; 9(8):2559. doi: 10.3390/jcm9082559. PMID: 32784573. PMCID: PMC7465150.</mixed-citation><mixed-citation xml:lang="en">Durazzo M., Lupi G., Cicerchia F., Ferro A., Barutta F., Beccuti G., Gruden G., Pellicano R. Extra-E sophageal Presentation of Gastroesophageal Refl ux Disease: 2020 Update. J Clin Med. 2020 Aug 7; 9(8):2559. doi: 10.3390/jcm9082559. PMID: 32784573. PMCID: PMC7465150.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ахмедов В. А., Гаус О. В., Петров Д. В. Идиопатический легочный фиброз как возможное внепищеводное проявление гастроэзофагеальной рефлюксной болезни. Клин.медицина 2017; 95 (5):389–393. doi: 10.29413/ABS.2018–3.3.16</mixed-citation><mixed-citation xml:lang="en">Akhmedov VA, Gauss O V, Petrov D. V. Idiopathic pulmonary fi brosis as a possible extraesophageal manifestation of gastroesophageal refl ux disease. Klin. medicine 2017 95 (5):389–393. (in Russ.) doi: 10.29413/ABS.2018–3.3.16</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kost K., Parham K. Management decisions for Zenker diverticulum in the elderly. Ear Nose Throat J. 2017 Sep;96(9):363–364. doi:10.1177/014556131709600906. PMID:22931189.</mixed-citation><mixed-citation xml:lang="en">Kost K., Parham K. Management decisions for Zenker diverticulum in the elderly. Ear Nose Throat J. 2017 Sep;96(9):363–364. doi:10.1177/014556131709600906. PMID:22931189.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Uoti S., Andersson S. E., Robinson E., Räsänen J., Kytö V., Ilonen I. Epidemiology and Management of Zenker Diverticulum in a Low-Th reshold Single-payer Health Care System. JAMA Otolaryngol Head Neck Surg. 2021 Dec 16. doi:10.1001/jamaoto.2021.3671. PMID:34913965. PMCID: PMC8678895.</mixed-citation><mixed-citation xml:lang="en">Uoti S., Andersson S. E., Robinson E., Räsänen J., Kytö V., Ilonen I. Epidemiology and Management of Zenker Diverticulum in a Low-Threshold Single-payer Health Care System. JAMA Otolaryngol Head Neck Surg. 2021 Dec 16. doi:10.1001/jamaoto.2021.3671. PMID:34913965. PMCID: PMC8678895.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Карнаушкина М. А., Струтынская А. Д., Бабак С. Л., Горбунова М. В. КТ-признаки инфекционного бронхиолита. Руководство пользователя для клинициста. Архивъ внутренней медицины. 2021; 11(2):85–93 doi: 10.20514/2226–6704–2021–11–2–85–93</mixed-citation><mixed-citation xml:lang="en">Karnaushkina M.A., Strutynskaya A. D., Babak S. L., Gorbunova M. V. Characteristics Radiologic Signsof Infectious Bronchiolitis. A Practical Approach for the General Doctors Archives of Internal Medicine. 2021; 11(2): 85–93 (in Russ.) doi: 10.20514/2226–6704–2021–11–2–85–93</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Abigail V., Berniker., Travis S. Henry. Imaging of Small Airway Diseases. Radiol Clin North Am. 2016; 54(6): 1165–1181. doi: 10.1016/j.rcl.2016.05.009</mixed-citation><mixed-citation xml:lang="en">Abigail V., Berniker., Travis S. Henry. Imaging of Small Airway Diseases. Radiol Clin North Am. 2016; 54(6): 1165–1181. doi: 10.1016/j.rcl.2016.05.009</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Siboni S., Asti E., Sozzi M., Bonitta G., Melloni M., Bonavina L. RespiratorySymptoms and Complications of Zenker Diverticulum: Effect of Trans-O ral Septum Stapling. J Gastrointest Surg. 2017 Sep;21(9):1391–1395. doi: 10.1007/s11605–017-3435–9. Epub 2017 May 3. PMID: 28470561.</mixed-citation><mixed-citation xml:lang="en">Siboni S., Asti E., Sozzi M., Bonitta G., Melloni M., Bonavina L. RespiratorySymptoms and Complications of Zenker Diverticulum: Effect of Trans-O ral Septum Stapling. J Gastrointest Surg. 2017 Sep;21(9):1391–1395. doi: 10.1007/s11605–017-3435–9. Epub 2017 May 3. PMID: 28470561.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sato H., Takeuchi M., Hashimoto S., et al. Esophageal diverticulum: New perspectives in the era of minimallyinvasive endoscopic treatment. World J Gastroenterol. 2019 Mar28;25(12):1457-1464. doi: 10.3748/wjg.v25.i12.1457</mixed-citation><mixed-citation xml:lang="en">Sato H., Takeuchi M., Hashimoto S., et al. Esophageal diverticulum: New perspectives in the era of minimallyinvasive endoscopic treatment. World J Gastroenterol. 2019 Mar28;25(12):1457-1464. doi: 10.3748/wjg.v25.i12.1457</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
