nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-200-4-94-100nogr-1964Research ArticleКЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯCLINICAL GASTROENTEROLOGYПрименение пробиотиков в лечении дисбактериоза пищеварительного трактаGanzya Application of probiotics in treatment of digestive tract dysbacteriosishttps://orcid.org/0000-0001-9209-7839ЧервинецЮ. В.ChervinetsYu. V.

Чepвинeц Юлия Вячecлaвoвнa, д. м. н., пpoфeccop кaфeдpы микpoбиoлoгии и виpycoлoгии c кypcoм иммyнoлoгии

170100, Тверь, ул. Советская, д. 4

Yuliya V. Chervinets, MD, PhD of Department of Microbiology and Virology with the Course of Immunology

4, Sovetskaya St., Tver, 170100

julia_chervinec@mail.ruhttps://orcid.org/0000-0001-5304-1963ЧервинецВ. М.ChervinetsV. M.

Чepвинeц Вячecлaв Миxaйлoвич, д. м. н., пpoфeccop, зaвeдyющий кaфeдpы микpoбиoлoгии и виpycoлoгии c кypcoмиммyнoлoгии

170100, Тверь, ул. Советская, д. 4

Vyacheslav M. Chervinets, MD, PhD, Head of Department of Microbiology and Virology with the Course of Immunology

4, Sovetskaya St., Tver, 170100

https://orcid.org/0000-0002-3376-6585ГанзяД. В.GanzyaD. V.

Ганзя Денис Викторович, ассистент кафедры неврологии, реабилитации и нейрохирургии

170100, Тверь, ул. Советская, д. 4

Ganzya Denis Viktorovich, assistant at the Department of Neurology, Rehabilitation and Neurosurgery

4, Sovetskaya St., Tver, 170100

Федеральное государственное бюджетное образовательное учреждение высшего образования «Тверской государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияTver State Medical UniversityRussian Federation2022051020220494100Copyright © Червинец Ю.В., Червинец В.М., Ганзя Д.В., 20222022Червинец Ю.В., Червинец В.М., Ганзя Д.В.Chervinets Y.V., Chervinets V.M., Ganzya D.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1964

В данной работе проведен анализ чувствительности резидентной и факультативной микробиоты полости рта, желудка и 12-перстной кишки больных воспалительными и эрозивно- язвенными заболеваниями желудочно- кишечного тракта к пробиотическим препаратам с действующими веществами: Bacilus subtilis 534, Lactobacillus acidophilus, Bifi dobacterium bifi dum и Bifi dobacterium longum. Исследуемая микробиота показала разную степень чувствительности к Lactobacillus acidophilus и Bacilus subtilis 534, а также абсолютную резистентность к Bifi dobacterium bifi dum и Bifi dobacterium longum. Клиницистам необходимо учитывать, что в лечении дисбактериоза пищеварительного тракта эффективно использоваться могут не все пробиотические препараты.

This work analyzes the sensitivity of the resident and facultative microbiota of the oral cavity, stomach and duodenum of patients with infl ammatory and erosive — ulcerative diseases of the gastrointestinal tract to probiotic drugs with active ingredients: Bacilus subtilis 534, Lactobacillus acidophilus, Bifi dobacterium bifi dum and Bifi dobacterium longum. The studied microbiota showed a diff erent degree of sensitivity to the Lactobacillus acidophilus, and Bacilus subtilis 534, as well as absolute resistance to Bifi dobacterium bifi dum и Bifi dobacterium longum. Clinicians need to take into account that not all probiotic preparations can be eff ectively used in the treatment of dysbiosis of the digestive tract.

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The authors declare that there are no conflicts of interest present.