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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-201-5-5-11</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-1951</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕРЕДОВАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LEADING ARTICLE</subject></subj-group></article-categories><title-group><article-title>Частота эрозивно-язвенных дефектов и язвенных кровотечений гастродуоденальной зоны у больных с инфекцией COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>The frequency of ulcerative-erosive defects and ulcerative bleeding of the gastroduodenal zone in patients with coronavirus infection COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Буторин</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Butorin</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Буторин Николай Николаевич, к. м. н., заведующий эндоскопическим отделением</p><p>655019, г. Абакан, ул. Крылова, 72</p></bio><bio xml:lang="en"><p>Nikolay N. Butorin, candidate of medical sciences, head of endoscopy department</p><p>655019, Abakan, Krylova street, build.72</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9980-2294</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цуканов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsukanov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Цуканов Владислав Владимирович, д. м. н., профессор, заведующий клиническим отделением патологии пищеварительной системы у взрослых и детейResearch ID: E-6638–2015Scopus ID: 7004057447</p><p>660022, г. Красноярск, ул. Партизана Железняка 3-г</p></bio><bio xml:lang="en"><p>Vladislav V. Tsukanov, habilitated doctor of medical sciences, professor, head of the clinical department of the digestive system pathology of adults and childrenResearch ID: E-6638–2015Scopus ID: 7004057447</p><p>660022, Krasnoyarsk, Partizan Zheleznyak street, build.3-G</p></bio><email xlink:type="simple">gastro@impn.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Асяев</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Asyayev</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Асяев Роман Витальевич, врач-эндоскопист, эндоскопическое отделение</p><p>655019, г. Абакан, ул. Крылова, 72</p></bio><bio xml:lang="en"><p>Roman V. Asyayev, endoscopist of endoscopy department</p><p>655019, Abakan, Krylova street, build.72</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Буторина</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Butorina</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Буторина Мария Николаевна, врач-гастроэнтеролог, терапевтическое отделение</p><p>655019, г. Абакан, ул. Крылова, 72</p></bio><bio xml:lang="en"><p>Maria N. Butorina, gastroenterologist of therapeutic department</p><p>655019, Abakan, Krylova street, build.72</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6481-3196</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васютин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasyutin</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Васютин Александр Викторович, к. м. н., старший научный сотрудник клинического отделения патологии пищеварительной системы у взрослых и детейResearch ID: E-6657–2015Scopus ID: 55891923200</p><p>660022, г. Красноярск, ул. Партизана Железняка 3-г</p></bio><bio xml:lang="en"><p>Alexander V. Vasyutin, candidate of medical sciences, senior research fellow of the clinical department of the digestive system pathology of adults and childrenResearch ID: E-6657–2015Scopus ID: 55891923200</p><p>660022, Krasnoyarsk, Partizan Zheleznyak street, build.3-G</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7518-1895</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тонких</surname><given-names>Ю. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Tonkikh</surname><given-names>J. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тонких Юлия Леонгардовна, к. м. н., ведущий научный сотрудник клинического отделения патологии пищеварительной системы взрослых и детейResearch ID: S-5608–2016Scopus ID: 37033139400</p><p>660022, г. Красноярск, ул. Партизана Железняка 3-г</p></bio><bio xml:lang="en"><p>Julia L. Tonkikh, candidate of medical sciences, leading research fellow of the clinical department of the digestive system pathology of adults and childrenResearch ID: S-5608–2016Scopus ID: 37033139400</p><p>660022, Krasnoyarsk, Partizan Zheleznyak street, build.3-G</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ РХ «Республиканская клиническая больница им. Г. Я. Ремишевской»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Republican Clinical Hospital named after G. Y. Remishevskaya</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр «Красноярский научный центр» Сибирского отделения Российской академии наук» (ФИЦ КНЦ СО РАН), обособленное подразделение «Научно- исследовательский институт медицинских проблем Севера» (НИИ МПС)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science”, a separate subdivision “Scientifi c Research Institute of medical problems of the North”</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>05</day><month>10</month><year>2022</year></pub-date><volume>0</volume><issue>5</issue><fpage>5</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Буторин Н.Н., Цуканов В.В., Асяев Р.В., Буторина М.Н., Васютин А.В., Тонких Ю.Л., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Буторин Н.Н., Цуканов В.В., Асяев Р.В., Буторина М.Н., Васютин А.В., Тонких Ю.Л.</copyright-holder><copyright-holder xml:lang="en">Butorin N.N., Tsukanov V.V., Asyayev R.V., Butorina M.N., Vasyutin A.V., Tonkikh J.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/1951">https://www.nogr.org/jour/article/view/1951</self-uri><abstract><p>Цель исследования: определить частоту эрозивно-язвенных дефектов и язвенных кровотечений гастродуоденальной зоны у больных с инфекцией COVID-19.Материалы и методы. У пациентов, находящихся на лечении в ковидном госпитале для лечения инфекции COVID-19, при наличии изжоги, диспепсии или признаков желудочно- кишечного кровотечения проводилась фиброэзофагога стродуоденоскопия. Всего эндоскопическое исследование было сделано 387 пациентам (116 мужчин и 271 женщин, средний возраст 65,4 лет). Оценка эрозивного эзофагита выполнялась по Лос- Анджелесской классификации (1994), кандидозного эзофагита по классификации Kodsi (1976), варикозного расширения вен пищевода по K. J. Paquet (1983), классификация язвенных кровотечений по J. A. Forrest (1974).Результаты. Эрозии в  пищеводе были обнаружены у  25,3% обследованных пациентов, эрозии желудка и двенадцатиперстной кишки — у 44,4% лиц, язвы желудка и двенадцатиперстной кишки — у 10,1% больных. Гастродуоденальные кровотечения определялись у 5,7% обследованных пациентов и были ассоциированы с язвенными дефектами в 81,8% случаях. Мужской пол являлся выраженным фактором риска эрозий, язв и кровотечений из верхнего отдела пищеварительного тракта.Заключение. У больных с COVID-19 осложнения со стороны желудочно- кишечного тракта, проявляющиеся в виде образования язвенных дефектов и кровотечений из гастродуоденальной зоны, являются значимой проблемой. Рациональным выглядит предложение относиться к пациентам с инфекцией COVID-19, получающих массивную противовоспалительную, антромбоцитарную, антикоагулянтную терапию так, как это принято в тактике ведения кардиологических и ревматологических пациентов для профилактики НПВП-гастропатий.</p></abstract><trans-abstract xml:lang="en"><p>Aim: to determine the frequency of erosive and ulcerative defects and ulcerative bleeding of the gastroduodenal zone in patients with COVID-19 infection.Materials and methods. Fibroesophagogastroduodenoscopy was performed in patients in the hospital for the COVID-19 infection treatment when they had heartburn, dyspepsia, or signs of gastrointestinal bleeding among patients. In total, endoscopy was performed in 387 patients (116 men and 271 women, mean age 65.4 years). Erosive esophagitis was assessed according to the Los Angeles classification (1994), candidiasis esophagitis according to the Kodsi classification (1976), esophageal varices according to K. J. Paquet (1983), classification of ulcerative bleeding according to J. A. Forrest (1974).Results. Erosions in the esophagus was found in 25.3% of the examined patients, gastric and duodenal erosions—in 44.4% of persons, gastric and duodenal ulcers — in 10.1% of patients. Gastroduodenal bleeding was determined in 5.7% of the examined patients and was associated with ulcerative defects in 81.8% of cases. Male gender was a strong risk factor for erosions, ulcers, and bleeding from the upper gastrointestinal tract.Conclusion. In patients with COVID-19, complications from the gastrointestinal tract, manifested by ulcerative defects and bleeding from the gastroduodenal zone, are a significant problem. It seems rational to propose to treat patients with COVID-19 infection receiving massive anti-inflammatory, anthrombocytic, anticoagulant therapy in the same way as is customary in the management of cardiological and rheumatological patients for the prevention of NSAID-gastropathy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>язвенные кровотечения</kwd><kwd>язва желудка</kwd><kwd>язва ДПК</kwd><kwd>эзофагит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>ulcerative bleeding</kwd><kwd>gastric ulcer</kwd><kwd>duodenal ulcer</kwd><kwd>esophagitis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Tang J.W., Tambyah P. A., Hui D. S.C. Emergence of a novel coronavirus causing respiratory illness from Wuhan, China. 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