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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/16828658-ecg-199-3-26-36</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-1939</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Гастроэзофагеальная рефлюксная болезнь и бронхообструктивный синдром у детей — «порочный круг» или коморбидность?</article-title><trans-title-group xml:lang="en"><trans-title>Gastroesophageal reﬂ ux disease and broncho- obstructive syndrome in children — a “vicious circle” or comorbidity?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8121-7396</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воротникова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorotnikova</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воротникова Наталия Анатольевна - кандидат медицинских наук, ассистент кафедры госпитальной педиатрии и неонатологии педиатрического факультета.</p><p>410012, Саратов, Большая Казачья ул.,112</p></bio><bio xml:lang="en"><p>Nataliya A. Vorotnikova - Candidate of Medical Sciences, Assistant of the Department of Hospital Pediatrics and Neonatology, Faculty of Pediatrics.</p><p>410012, Saratov, Bolshaya Kazachya, 112</p></bio><email xlink:type="simple">ocean8765@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6896-7563</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черненков</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernenkov</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черненков Юрий Валентинович - доктор медицинских наук, директор клиники госпитальной педиатрии Университетской клинической больницы № 1 им. С. Р. Миротворцева; заведующий кафедрой, профессор кафедры госпитальной педиатрии и неонатологии педиатрического факультета.</p><p>410012, Саратов, Большая Казачья ул.,112</p></bio><bio xml:lang="en"><p>Yuri V. Chernenkov - MD, DSc, Director of the Hospital Pediatrics Clinic, University Clinical Hospital № 1 n. a. S. R. Mirotvortseva; head of department, Professor of the Department of Hospital Pediatrics and Neonatology, Faculty of Pediatrics.</p><p>410012, Saratov, Bolshaya Kazachya, 112</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5663-9220</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эйберман</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Eiberman</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эйберман Александр Семенович - доктор медицинских наук, профессор кафедры госпитальной педиатрии и неонатологии педиатрического факультета.</p><p>410012, Саратов, Большая Казачья ул.,112</p></bio><bio xml:lang="en"><p>Alexander S. Eiberman - MD, DSc, Professor of the Department of Hospital Pediatrics and Neonatology, Faculty of Pediatrics.</p><p>410012, Saratov, Bolshaya Kazachya, 112</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО Саратовский государственный медицинский университет им. В.И. Разумовского МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saratov State University named after V.I. Razumovsky</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>04</day><month>10</month><year>2022</year></pub-date><volume>0</volume><issue>3</issue><fpage>26</fpage><lpage>36</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Воротникова Н.А., Черненков Ю.В., Эйберман А.С., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Воротникова Н.А., Черненков Ю.В., Эйберман А.С.</copyright-holder><copyright-holder xml:lang="en">Vorotnikova N.A., Chernenkov Y.V., Eiberman A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/1939">https://www.nogr.org/jour/article/view/1939</self-uri><abstract><p>Настоящая статья посвящена коморбидности заболеваний органов пищеварительного тракта и дыхательной системы у детей. Коморбидность (полиморбидность) при патологии желудочно-кишечного тракта достаточно широко описывается в современной научной литературе, однако, менее изученными представляются взаимоотношения пищеварительной и дыхательной систем.</p><p>Цель исследования — провести анализ эндоскопических признаков рефлюксной патологии пищеварительного тракта у детей при коморбидном состоянии — ГЭРБ и заболеваниях органов дыхания, протекающих с бронхообструктивным синдромом (БОС).</p><sec><title>Материалы и методы</title><p>Материалы и методы. Проведено углубленное обследование 180 детей от 6 до 16 лет с коморбидной патологией (заболевания органов дыхания с БОС и ГЭРБ). Выполнено: рентгенографическое исследование, спирометрия, внутриполостная рH — метрия, ЭФГДС и УЗИ органов ЖКТ. Для изучения морфологических особенностей слизистой пищевода при данной сочетанной патологии исследованы биоптаты на 1 см выше Z-линии; одновременно проведена биопсия слизистой антрального отдела препилорической части желудка.</p></sec><sec><title>Результаты</title><p>Результаты. Заболевания органов дыхания с БОС в обследованных группах больных наиболее часто (43,9%) сочетались с ГЭРБ в возрасте 12–14 лет. Преобладание эндоскопически- позитивного варианта ГЭРБ 1 степени характерно для пациентов с бронхообструктивным синдромом, обусловленного средне- тяжелым и тяжелым персистирующим течением БА, острым и затяжным течением пневмонии, рецидивирующим бронхитом. Воспалительные заболевания органов пищеварения (хронический гастрит, хронический гастродуоденит) при БА выявлены у 40,6% больных, при пневмонии — у 45,7%, при рецидивирующем бронхите — у 33,3% пациентов. На основании данных общеморфологического исследования биоптатов, независимо от возраста и вида бронхо- легочной патологии, выявлено два варианта воспаления, встречающихся чаще других — с преобладанием изменений дистрофического характера и с преобладанием собственно воспаления, что в большей степени зависело от длительности заболевания. У пациентов, страдающих как БА, так и пневмонией с БОС, морфологические изменения со стороны слизистой пищевода соответствовали катаральному характеру воспаления.</p></sec></abstract><trans-abstract xml:lang="en"><p>This article is devoted to the comorbidity of diseases of the digestive tract and respiratory system in children. Comorbidity (polymorbidity) in the pathology of the gastrointestinal tract is widely described in modern scientiﬁc literature, however, the relationship between the digestive and respiratory systems seems to be less studied.</p><p>The purpose of the study was to analyze the endoscopic signs of reﬂ ux pathology of the digestive tract in children with a comorbid condition — GERD and respiratory diseases occurring with broncho-o bstructive syndrome (BOS).</p><sec><title>Materials and methods</title><p>Materials and methods. An in-depth examination of 180 children from 6 to 16 years old with comorbid pathology (respiratory diseases with BOS and GERD) was carried out. Performed: X-ray examination, spirometry, intracavitary pH-metry, EFGDS and ultrasound of the gastrointestinal tract. To study the morphological features of the esophageal mucosa in this comorbidity, biopsies were examined 1 cm above the Z-line; at the same time, a biopsy of the mucosa of the antrum of the prepyloric part of the stomach was performed.</p></sec><sec><title>Results</title><p>Results. Respiratory diseases with biofeedback in the examined groups of patients were most often (43.9%) combined with GERD at the age of 12–14 years. The predominance of endoscopically positive grade 1 GERD is typical for patients with broncho- obstructive syndrome caused by moderate and severe persistent BA, acute and prolonged pneumonia, and recurrent bronchitis. Inﬂ ammatory diseases of the digestive system (chronic gastritis, chronic gastroduodenitis) in BA were detected in 40.6% of patients, in pneumonia — in 45.7%, in recurrent bronchitis — in 33.3% of patients. Based on the data of a general morphological study of biopsy specimens, regardless of age and type of bronchopulmonary pathology, two variants of inﬂ ammation were identiﬁ ed, which are more common than others — with a predominance of dystrophic changes and with a predominance of inﬂ ammation itself, which largely depended on the duration of the disease. In patients suﬀ ering from both BA and pneumonia with biofeedback, morphological changes in the esophageal mucosa corresponded to the catarrhal nature of the inﬂ ammation.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>гастроэзофагеальная рефлюксная болезнь</kwd><kwd>коморбидность</kwd><kwd>бронхиальная астма</kwd><kwd>бронхообструктивный синдром</kwd><kwd>рН-метрия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>gastroesophageal reﬂ ux disease</kwd><kwd>comorbidity</kwd><kwd>bronchial asthma</kwd><kwd>broncho-o bstructive syndrome</kwd><kwd>pH-metry</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Заболеваемость детского населения России (0–14 лет) в 2020 году с диагнозом, установленным впервые в жизни: статистические материалы / Е. Г. Котова, О. С. Кобякова, В. И. Стародубов, Г. А. Александрова и др.-М.: ЦНИИОИЗ Минздрава России, 2021. – 147 с. doi: 10.21045/978–25–94116–042–6</mixed-citation><mixed-citation xml:lang="en">Kotova E. G., Kobyakova O. S., Starodubov V. I., Alexandrova G. A., et al. Th e incidence of the child population of Russia (0–14 years) in 2020 with a diagnosis established for the fi rst time in life: statistical materials. 2021. 147 P. (in Russ.) doi: 10.21045/978–25–94116–042–6</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Щербаков П. Л., Лобанов Ю. Ф. Детская гастроэнтерология- настоящее и будущее. Экспериментальная и клиническая гастроэнтерология, 2011; 1:3–8.</mixed-citation><mixed-citation xml:lang="en">Shcherbakov P.L., Lobanov Yu. F. Pediatric gastroenterology – present and future. Experimental and Clinical Gastroenterology, 2011;1: 3–8. (in Russ)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Баранов А. А. Федеральные клинические рекомендации по диагностике и лечению гастроэзофагеальной рефлюксной болезни у детей / А. А. Баранов, 2015. – 27 c.</mixed-citation><mixed-citation xml:lang="en">Baranov A. A. Federal clinical guidelines for the diagnosis and treatment of gastroesophageal refl ux disease in children. 2015. 27 P. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Приворотский В. Ф., Луппова Н. Е. Гастроэзофагеа льная рефлюксная болезнь у детей. В кн.: Детская гастроэнтерология, практическое руководство. Под ред. И.Ю Мельниковой. – М.: ГЭОТАР-Медиа, 2018. – C. 184–203.</mixed-citation><mixed-citation xml:lang="en">Privorotsky V.F., Luppova N. E. Gastroesophageal refl ux disease in children. In: Children’s gastroenterology, a practical guide. Ed. I. Yu Melnikova. Moscow. GEOTAR-Media Publ., 2018. 184–203. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Федеральные клинические рекомендации по диагностике и лечению гастроэзофагеальной рефлюксной болезни у детей / Союз педиатров России, 2016.</mixed-citation><mixed-citation xml:lang="en">Russian Union of Pediatricians. Federal clinical guidelines for the diagnosis and treatment of gastroesophageal refl ux disease in children. 2016. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Система поддержки принятия врачебных решений. Гастроэнтерология: Клинические протоколы лечения / Составители: Д. С. Бородин, К. А. Никольская, И. Г. Бакулин и др. – М.: ГБУ «НИИОЗММ ДЗМ», 2021. С. 25–41.</mixed-citation><mixed-citation xml:lang="en">Borodin D. S., Nikolskaya K. A., Bakulin I. G. et al. Medical decision support system. Gastroenterology: Clinical treatment protocols. Moscow. GBU «NIIOZMM DZM» Publ., 2021. pp. 25–41. ( in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Тарасова Г. Н., Смирнова Е. А. Патогенетические особенности повреждения слизистой оболочки пищевода при гастроэзофагеальной рефлюксной болезни. Consilium Medicum, 2017; 8; Гастроэнтерология (19):7–12.</mixed-citation><mixed-citation xml:lang="en">Tarasova G.N., Smirnova E. A. Pathogenetic features of damage to the mucous membrane of the esophagus in gastroesophageal refl ux disease. Consilium Medicum, 2017; 8. Gastroenterology (19): 7–12. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Корняк Б. С., Кубышкин В. А., Чернова Т. Г., Азимов Р. Х. Бронхопульмональные и ларингеальные симптомы гастроэзофагеальной рефлюксной болезни: диагностика и лечение. Экспериментальная и клиническая гастроэнтерология, 2003; 1: 33–37.</mixed-citation><mixed-citation xml:lang="en">Kornyak B.S., Kubyshkin V. A., Chernova T. G., Azimov R. Kh. Bronchopulmonary and laryngeal symptoms of gastroesophageal refl ux disease: diagnosis and treatment. Experimental and clinical gastroenterology, 2003; 1: 33–37. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Звягинцева Т.Д, Чернобай А. И. «Гастроэзофагеальная рефлюксная болезнь в сочетании с бронхиальной астмой: общность патогенеза и тактика лечения». Харьков. – Газета «Новости медицины и фармации» Гастроэнтерология (323), 2010 (тематический номер).</mixed-citation><mixed-citation xml:lang="en">Zvyagintseva T.D., Chernobay A. I. “Gastroesophageal reflux disease in combination with bronchial asthma: common pathogenesis and treatment tactics”. Kharkov. – Newspaper “Medicine and Pharmacy News” Gastroenterology (323), 2010 (thematic issue). (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Асманов А. И., Ханакаева З. К., Пивнева Н. Д. Внепищеводные проявления гастроэзофагеальной рефлюксной болезни в практике детского оториноларинголога. Российский вестник перинатологии и педиатрии, 2017; 62 (6): 87–91.</mixed-citation><mixed-citation xml:lang="en">Asmanov A. I., Khanakaeva Z. K., Pivneva N. D. Extraesophageal manifestations of gastroesophageal refl ux disease in the practice of a pediatric otorhinolaryngologist. Russian Bulletin of Perinatology and Pediatrics, 2017; 62(6): 87–91. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Белялов Ф. И. Лечение внутренних болезней в условиях коморбидности. – Москва: ГЕОТАР – Медиа, 2019. 305 с.</mixed-citation><mixed-citation xml:lang="en">Belyalov F. I. Treatment of internal diseases in conditions of comorbidity. Moscow. GEOTAR – Media Publ., 2019. 305 p. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Апенченко Ю. С., Гнусаев С. Ф., Розов Д. Н., и др. Течение бронхиальной астмы в сочетании с гастроэзофагеальной рефлюксной болезнью у детей. Вестник новых медицинских технологий, 2018; 25(3): 7–14. (in Russ.) doi: 10.24411/1609–2163–2018–16057</mixed-citation><mixed-citation xml:lang="en">Apenchenko Yu.S., Gnusaev S. F., Rozov D. N., et al. Th e course of bronchial asthma in combination with gastroesophageal refl ux disease in children. Bulletin of new medical technologies, 2018; 25(3): 7–14. (in Russ.) doi: 10.24411/1609–2163–2018–16057</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Косарев С. С., Лопакова Н. Н. Внепищеводные проявления гастроэзофагеальной рефлюксной болезни у детей. Современные проблемы науки и образования. 2019; 5:117.</mixed-citation><mixed-citation xml:lang="en">Kosarev S.S., Lopakova N. N. Extraesophageal manifestations of gastroesophageal refl ux disease in children. Modern problems of science and education. 2019; 5: 117. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Alagha K., Bourdin A., Vernisse C., Garulli C., Tummino C., Charriot J., Gras D. Goblet Cell Hyperplasia as a feature of neutrophilic asthma. Clinical &amp; Experimental Allergу, 2019; 49 (6): 781–788. doi: 10.1111/cea.13359</mixed-citation><mixed-citation xml:lang="en">Alagha K., Bourdin A., Vernisse C., Garulli C., Tummino C., Charriot J., Gras D. Goblet Cell Hyperplasia as a feature of neutrophilic asthma. Clinical &amp; Experimental Allergу, 2019; 49 (6): 781–788. doi: 10.1111/cea.13359</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Chang A., Oppenheimer J., Kahrilas P., et al. On behalf of the CHEST Expert Cough Panel. Chronic cough and gastroesophageal refl ux in children – CHEST Guideline and Expert Panel Report, CHEST. 2019, pp. 131–140.</mixed-citation><mixed-citation xml:lang="en">Chang A., Oppenheimer J., Kahrilas P., et al. On behalf of the CHEST Expert Cough Panel. Chronic cough and gastroesophageal refl ux in children – CHEST Guideline and Expert Panel Report, CHEST. 2019, pp. 131–140.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Abdallah A., El- Desoky T., Fathi K., Fawzi Elkashef W., Zaki A. Evaluation of gastro- oesophageal refl ux disease in wheezy infants using 24-h oesophageal combined impedance and pH monitoring. Arab J. Gastroenterol. Pan-A rab Association of Gastroenterology, 2017; 18 (2): 68–73. doi: 10.1016/|j.ajg.2017.05.009</mixed-citation><mixed-citation xml:lang="en">Abdallah A., El- Desoky T., Fathi K., Fawzi Elkashef W., Zaki A. Evaluation of gastro-oesophageal refl ux disease in wheezy infants using 24-h oesophageal combined impedance and pH monitoring. Arab J. Gastroenterol. Pan-A rab Association of Gastroenterology, 2017; 18 (2): 68–73. doi: 10.1016/|j.ajg.2017.05.009</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Barfield E., Parker M. W. Management of Pediatric Gastroesophageal Refl ux Disease. JAMA Pediatrics., 2019; 173 (5): 485–486. doi: 10.1001/jamapediatrics.2019.0170</mixed-citation><mixed-citation xml:lang="en">Barfield E., Parker M. W. Management of Pediatric Gastroesophageal Refl ux Disease. JAMA Pediatrics., 2019; 173 (5): 485–486. doi: 10.1001/jamapediatrics.2019.0170</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">De Benedictis F. M., Bush A. Respiratory manifestations of gastro- oesophageal refl ux in children. Arch. Dis. Child. 2018; 103 (3): 292–296. doi: 10.1136/archdischild-2017–312890</mixed-citation><mixed-citation xml:lang="en">De Benedictis F. M., Bush A. Respiratory manifestations of gastro- oesophageal refl ux in children. Arch. Dis. Child. 2018; 103 (3): 292–296. doi: 10.1136/archdischild-2017–312890</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Hu X., Lee J. S., Pianosi P. T., Ryu J. H. Aspiration- related pulmonary syndromes. Chest., 2015; 147 (3): 815–823.</mixed-citation><mixed-citation xml:lang="en">Hu X., Lee J. S., Pianosi P. T., Ryu J. H. Aspiration-related pulmonary syndromes. Chest., 2015; 147 (3): 815–823.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kolbe J. Bronchiectasis and gastro-o esophageal refl ux; Some progress but still a long way to go. Respirology. 2015; 20 (5): 691–692.</mixed-citation><mixed-citation xml:lang="en">Kolbe J. Bronchiectasis and gastro-o esophageal refl ux; Some progress but still a long way to go. Respirology. 2015; 20 (5): 691–692.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Quitadamo P., Di Nardo G., Miele E., et al. Gastroesophageal refl ux in young children and adolescents: Is there a relation between symptom severity and esophageal histological grade? J. Pediatr. Gastroenterol. Nutr., 2015; 60 (3): 318–321.</mixed-citation><mixed-citation xml:lang="en">Quitadamo P., Di Nardo G., Miele E., et al. Gastroesophageal refl ux in young children and adolescents: Is there a relation between symptom severity and esophageal histological grade? J. Pediatr. Gastroenterol. Nutr., 2015; 60 (3): 318–321.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Slater B., Rothenberg S. Gastroesophageal reflux. Seminars in Pediatric Surgery, 2017; 26 (2): 56–60.</mixed-citation><mixed-citation xml:lang="en">Slater B., Rothenberg S. Gastroesophageal reflux. Seminars in Pediatric Surgery, 2017; 26 (2): 56–60.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2021.</mixed-citation><mixed-citation xml:lang="en">Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2021.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Vishneva E.A., Namazova – Baranova L. S., Alekseeva A. A., et al. Actual management of children with bronchial asthma. Pediatric pharmacology, 2017; 14(6):443–458. (in Russ.) doi: 10.15690/pf.v14i6/1828</mixed-citation><mixed-citation xml:lang="en">Vishneva E.A., Namazova – Baranova L. S., Alekseeva A. A., et al. Actual management of children with bronchial asthma. Pediatric pharmacology, 2017; 14(6):443–458. (in Russ.) doi: 10.15690/pf.v14i6/1828</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Bystritskaya E.V., Bilichenko T. N. Morbidity, disability and mortality from respiratory diseases in the Russian Federation (2015–2019). Pulmonology, 2021;31(5): 551– 562. (in Russ.) doi: 10. 18093/0869–0189–2021–31–5– 551–556</mixed-citation><mixed-citation xml:lang="en">Bystritskaya E.V., Bilichenko T. N. Morbidity, disability and mortality from respiratory diseases in the Russian Federation (2015–2019). Pulmonology, 2021;31(5): 551– 562. (in Russ.) doi: 10.18093/0869–0189–2021–31–5–551–556</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Zaitseva S.V., Zaitseva O. V., Lokshina E. E., Zastro zhina A. K., et al. Severe bronchial asthma in children. Allergology and Immunology in Pediatrics, 2019; 3 (58): 4–14. (in Russ.)</mixed-citation><mixed-citation xml:lang="en">Zaitseva S.V., Zaitseva O. V., Lokshina E. E., Zastro zhina A. K., et al. Severe bronchial asthma in children. Allergology and Immunology in Pediatrics, 2019; 3 (58): 4–14. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Simanenkov V.I., Ilyashevich I. G., Konovalova N. V., Tikhonov S. V. Mechanisms of comorbidity of gastroesophageal refl ux disease and bronchial asthma. Bulletin of the Russian Military Medical Academy, 2011; (1): 124– 128. (in Russ.)</mixed-citation><mixed-citation xml:lang="en">Simanenkov V.I., Ilyashevich I. G., Konovalova N. V., Tikhonov S. V. Mechanisms of comorbidity of gastroesophageal refl ux disease and bronchial asthma. Bulletin of the Russian Military Medical Academy, 2011; (1): 124– 128. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ovsyannikov D. Yu., Eliseeva T. I., Khaled M., et al. Comorbidity of bronchial asthma in children: causal, complicated, unspecifi ed, reverse. Pediatrics, 2021; 100(2):127–137. (in Russ.) doi: 10.24110/0031–403X-2021– 100–2–127–137</mixed-citation><mixed-citation xml:lang="en">Ovsyannikov D. Yu., Eliseeva T. I., Khaled M., et al. Comorbidity of bronchial asthma in children: causal, complicated, unspecifi ed, reverse. Pediatrics, 2021; 100(2):127–137. (in Russ.) doi: 10.24110/0031–403X-2021–100–2–127–137</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">National program “Bronchial asthma in children. Treatment strategy and prevention” Moscow, 2017. 160 p. (in Russ.)</mixed-citation><mixed-citation xml:lang="en">National program “Bronchial asthma in children. Treatment strategy and prevention” Moscow, 2017. 160 p. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Drogonets Ya., Hollender P. Modern medicine and law: translation from Slovak. Moscow. Legal Literature Publ., 1991. 23 P. (in Russ.)</mixed-citation><mixed-citation xml:lang="en">Drogonets Ya., Hollender P. Modern medicine and law: translation from Slovak. Moscow. Legal Literature Publ., 1991. 23 P. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Bulletin of the highest attestation commission of the Ministry of Education of the Russian Federation. 2002; 3:46–48. (in Russ.)</mixed-citation><mixed-citation xml:lang="en">Bulletin of the highest attestation commission of the Ministry of Education of the Russian Federation. 2002; 3:46–48. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Vakil N., van Zanten S. V., Kahrilas P., Dent J., Jones R.; the Global Concensus Group. Montreal defi nition and classifi cation of gastroesophageal refl ux disease: a global evidence-based concensus. Am. Gastroenterol, 2006; 11 (8):1900–1920.</mixed-citation><mixed-citation xml:lang="en">Vakil N., van Zanten S. V., Kahrilas P., Dent J., Jones R.; the Global Concensus Group. Montreal defi nition and classifi cation of gastroesophageal refl ux disease: a global evidence- based concensus. Am. Gastroenterol, 2006; 11 (8):1900–1920.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Вёрткин А. Л. Коморбидность: история, современное представление, профилактика и лечение. Кардиоваскулярная терапия и профилактика. 2015;14(2):74–79. doi: 10.15829/1728–8800–2015–2– 74–79</mixed-citation><mixed-citation xml:lang="en">Vertkin A. L. Comorbidity: history, current presentation, prevention and treatment. Cardiovascular therapy and prevention. 2015; 14(2):74–79. (in Russ.) doi: 10.15829/1728–8800–2015–2–74–79</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
