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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-198-2-148-158</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-1878</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Современный взгляд на роль таурина в терапии метаболических нарушений</article-title><trans-title-group xml:lang="en"><trans-title>Contemporary view of the role of taurine in the therapy of metabolic disorders</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8493-0058</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрова</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrova</surname><given-names>M. M.</given-names></name></name-alternatives><email xlink:type="simple">stk99@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0091-5265</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шимохина</surname><given-names>Н. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Shimokhina</surname><given-names>N. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО КрасГМУ им. проф. В. Ф. Войно-Ясенецкого Минздрава РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>05</day><month>04</month><year>2022</year></pub-date><volume>0</volume><issue>2</issue><fpage>148</fpage><lpage>158</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Петрова М.М., Шимохина Н.Ю., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Петрова М.М., Шимохина Н.Ю.</copyright-holder><copyright-holder xml:lang="en">Petrova M.M., Shimokhina N.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/1878">https://www.nogr.org/jour/article/view/1878</self-uri><abstract><p>Метаболический синдром (МС) - это понятие, объединяющее группу взаимосвязанных метаболических нарушений, которые включают абдоминальное ожирение, инсулинорезистентность, артериальную гипертензию и атерогенную дислипидемию. Наличие МС ассоциировано с повышенным риском развития сахарного диабета 2 типа и сердечно-сосудистых осложнений. В патогенезе МС ведущую роль играет провоспалительное состояние, характеризующееся повышенной активностью воспалительных цитокинов, и приводящее, в конечном итоге, к тяжелым сердечно-сосудистым осложнениям. Из-за экспоненциального роста ожирения во всем мире МС в последнее время приобретает все большее значение. В представленной статье рассмотрены эпидемиология и патогенез метаболического синдрома, роль воспаления в развитии метаболических нарушений, а также особое внимание уделено медикаментозной терапии с применением таурина. Таурин - это серосодержащая аминокислота, не принимающая участие в синтезе белка, которая присутствует в большинстве тканей животных. Обладая уникальными качествами, таурин влияет на многие клеточные функции, включая антиоксидантную, а также осморегуляцию, транспорт ионов и конъюгацию желчных кислот. Таурин оказывает противовоспалительное действие при сахарном диабете, а за счет подавления ренин-ангиотензиновой системы положительно влияет на сердечно-сосудистую систему. Дибикор® - отечественный лекарственный препарат на основе таурина, уровень которого снижается при ожирении, сахарном диабете, хронических заболеваниях печени. Дибикор® восполняет дефицит таурина и, тем самым, способствует снижению риска развития этих заболеваний.</p></abstract><trans-abstract xml:lang="en"><p>Metabolic syndrome (MS) is a term that unites a group of interrelated metabolic disorders that include abdominal obesity, insulin resistance, arterial hypertension, and atherogenic dyslipidemia. The presence of MS is associated with an increased risk of developing type 2 diabetes mellitus and cardiovascular complications. In the pathogenesis of MS, the leading role is played by the pro-inflammatory state, characterized by increased activity of inflammatory cytokines, and ultimately leading to severe cardiovascular complications. Due to the exponential rise in obesity around the world, MS has recently become increasingly important. In the presented article, the epidemiology and pathogenesis of metabolic syndrome, the role of inflammation in the development of metabolic disorders are considered, and special attention is paid to drug therapy with the use of taurine. Taurine is a sulfur-containing amino acid that is not involved in protein synthesis and is found in most animal tissues. With its unique properties, taurine affects many cellular functions, including antioxidant, as well as osmoregulation, ion transport and conjugation of bile acids. Taurine has an anti-inflammatory effect in diabetes mellitus, and by suppressing the renin-angiotensin system, it has a positive effect on the cardiovascular system. Dibikor® is a domestic drug based on taurine, the level of which decreases in obesity, diabetes mellitus, and non-alcoholic fatty liver disease. Dibikor® replenishes taurine deficiency and, thereby, helps to reduce the risk of developing these diseases.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>метаболический синдром</kwd><kwd>воспаление</kwd><kwd>таурин</kwd><kwd>медикаментозная терапия</kwd><kwd>обзор</kwd></kwd-group><kwd-group xml:lang="en"><kwd>metabolic syndrome</kwd><kwd>inflammation</kwd><kwd>taurine</kwd><kwd>drug therapy</kwd><kwd>review</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Zhernakova Yu.V., Zheleznova E. A., Chazova I. E., et al. 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