nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-198-2-139-147nogr-1877Research ArticleОБЗОРREVIEWТрегалоза - дисахарид, сохраняющий жизньTrehalose is a Life-Saving Sugarhttps://orcid.org/0000-0002-4930-1424ХорошининаЛ. П.KhoroshininaL. P.solt54@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияSaint-Petersburg State Pediatric Medical UniversityRussian Federation20220504202202139147Copyright © Хорошинина Л.П., 20222022Хорошинина Л.П.Khoroshinina L.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1877

В последние десятилетия опубликовано значительное количество научных работ, посвященных изучению специфических физико -химических свойств особого сахара - трегалозы и ее роли в живых системах. Трегалоза широко распространена в природе. Этот уникальный дисахарид, состоящий из двух молекул глюкозы, защищает белки и мембраны клеток от инактивации или денатурации, вызванной различными стрессовыми условиями, включая высыхание, обезвоживание, жару, холод, окисление, тепловой шок, гипоксию, длительное отсутствие кислорода. Трегалоза усиливает аутофагию, защищая клетки организмов от различных стрессорных воздействий; является модификатором аномального накопления белка при нейродегенеративных заболеваниях человека; оказывает благоприятное действие на эндотелий сосудов; положительно влияет на обменные процессы в организме, в т. ч. на течение сахарного диабета 2-го типа - и это лишь незначительная часть положительных эффектов, которые оказывает трегалоза на организм.

In recent decades, a significant number of scientific papers have been published on the study of the specific physicochemical properties of a special sugar, trehalose, and its role in living systems. Trehalose is widely distributed in nature. This unique disaccharide, consisting of two glucose molecules, protects proteins and cell membranes from inactivation or denaturation caused by various stress conditions, including desiccation, dehydration, heat, cold, oxidation, heat shock, hypoxia, prolonged absence of oxygen. Trehalose enhances autophagy, protecting cells of organisms from various stress influences; is a modifier of abnormal protein accumulation in human neurodegenerative diseases; has a favorable effect on vascular endothelium; positively affects metabolic processes in the body, including the course of type 2 diabetes - and this is only a few of the positive effects that trehalose has on the body.

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The authors declare that there are no conflicts of interest present.