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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-196-12-147-153</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-1812</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Редкий вариант синдрома Ремхельда</article-title><trans-title-group xml:lang="en"><trans-title>Rare variant of Remkheld syndrome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3834-4699</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чепурненко</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chepurnenko</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чепурненко Светлана Анатольевна, д. м. н., доцент кафедры общей врачебной практики (семейной медицины) с курсами гериатрии и физиотерапии; врач кардиолог Кардиологического диспансерного отделения</p><p>344015, г. Ростов-на- Дону, ул. Благодатная, 170 344022, г. Ростов-на- Дону, пер. Нахичеванский, 29</p></bio><bio xml:lang="en"><p>Svetlana A. Chepurnenko, Doctor of Medical Sciences; Associate Professor at the Department of General Medical Practice (Family Medicine) with courses in geriatrics and physiotherapy; cardiologist of the Cardiological dispensary department</p><p>344015, Rostov-on-Don, st. Blagodatnaya, 170344022, Rostov-on-Don, per. Nakhichevan, 29 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6341-6749</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Насытко</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Nasytko</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Насытко Алина Дмитриевна, лаборант кафедры общей врачебной практики (семейной медицины) с курсами гериатрии и физиотерапии</p><p>344022, г. Ростов-на- Дону, пер. Нахичеванский, 29</p></bio><bio xml:lang="en"><p>Alina D. Nasytko, Laboratory Assistant, Department of General Medical Practice (Family Medicine) with courses of geriatrics and physiotherapy</p><p>344022, Rostov-on-Don, per. Nakhichevan, 29 </p></bio><email xlink:type="simple">rainbow98al@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4160-8154</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шавкута</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shavkuta</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шавкута Галина Владимировна, д. м. н., профессор; заведующая кафедрой общей врачебной практики (семейной медицины) с курсами гериатрии и физиотерапии</p><p>344022, г. Ростов-на- Дону, пер. Нахичеванский, 29</p></bio><bio xml:lang="en"><p>Galina V. Shavkuta, Doctor of Medical Sciences, Professor; Head of the Department of General Medical Practice (Family Medicine) with courses of geriatrics and physiotherapy</p><p>344022, Rostov-on-Don, per. Nakhichevan, 29 </p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУ РО «Ростовская областная клиническая больница»; Федеральное государственное бюджетное образовательное учреждение высшего образования «Ростовский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov Regional Clinical Hospital; Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Ростовский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>16</day><month>01</month><year>2022</year></pub-date><volume>0</volume><issue>12</issue><fpage>147</fpage><lpage>153</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чепурненко С.А., Насытко А.Д., Шавкута Г.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Чепурненко С.А., Насытко А.Д., Шавкута Г.В.</copyright-holder><copyright-holder xml:lang="en">Chepurnenko S.A., Nasytko A.D., Shavkuta G.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/1812">https://www.nogr.org/jour/article/view/1812</self-uri><abstract><sec><title>Введение</title><p>Введение. Гастроэзофагеальная рефлюксная болезнь (ГЭРБ) может сопровождаться триадой кардиологических симптомов (аритмией, кардиалгией, признаками вегетативной дисфункции). Такой синдром получил название гастрокардиальный или синдром Ремхельда. Наиболее частыми нарушением ритма при синдроме Ремхельда являются фибрилляция предсердий , наджелудочковая экстрасистолия. В описанном нами клиническом случае представлен редкий вариант синдрома Ремхельда: пароксизмальная желудочковая тахикардия на фоне ГЭРБ.</p><p>Описание клинического случая. Пациент В., 48 лет обратился на прием к кардиологу 21.04.21 с жалобами на приступы внезапных сердцебиений, беспокоящих в течение полугода. Из анамнеза известно, что с 2017 года страдает ГЭРБ, самостоятельно прекратил прием препаратов в течение 6 месяцев. По данным холтеровского мониторирования ЭКГ от 20.03.21 выявлена пароксизмальная желудочковая тахикардия. По данным эхокардиоскопии от 26.04.21 структурных изменений, которые могли быть причиной данного жизнеугрожающего нарушения ритма не обнаружено. Видеогастроскопия от 28.04.21: дистальный рефлюкс- эзофагит. Эндоскопические признаки грыжи пищеводного отверстия диафрагмы. Недостаточность кардии 2 ст. Гастро-эзофагеальный пролапс. На консультации у гастроэнтеролога пациенту было назначено как немедикаментозное (коррекция образа жизни), так и медикаментозное лечение: рабепразол, кларитромицин, амоксициллин и другие. Для профилактики пароксизмов желудочковой тахикардии — амиодарон, омега 3 полиненасыщенные жирные кислоты.</p></sec><sec><title>Обсуждение</title><p>Обсуждение. По данным исследований, одним из механизмов возникновения аритмии при ГЭРБ связан с возбуждением рефлюктатом дистальной части пищевода с развитием висцеро-висцеральных рефлексов, опосредованных через n. vagus. Повышенная активация n. vagus создает аритмогенный субстрат для механизма re-entry, и, тем самым, увеличивает риск развития аритмий. Антиаритмическая терапия наряду с лечением ГЭРБ привели к устранению пароксизмов ЖТ. В дальнейшем через 2 месяца после отмены антиаритмических препаратов на фоне продолжающейся терапии ГЭРБ пароксизмы ЖТ не регистрировались. Это также являлось подтверждением патогенетической взаимосвязи ГЭРБ и пароксизмальной ЖТ.</p></sec><sec><title>Заключение</title><p>Заключение. Случай представляет интерес развитием жизнеугрожающего нарушения ритма: пароксизмальной желудочковой тахикардии на фоне ГЭРБ, что является очень редким вариантом синдрома Ремхельда и в доступной нами литературе не встречается.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Gastroesophageal reflux disease (GERD) can be accompanied by a triad of cardiac symptoms (arrhythmia, cardialgia, signs of autonomic dysfunction). This syndrome is called gastro-cardiac or Remheld syndrome. The most common rhythm disturbances in Remheld syndrome are atrial fibrillation, supraventricular extrasystole. In the clinical case we have described, a rare variant of Remheld’s syndrome is presented: paroxysmal ventricular tachycardia with GERD.</p><p>Description of the clinical case. Patient V., 48 years old, applied to a cardiologist on 21.04.21 with complaints of attacks of sudden palpitations, disturbing for six months. From the anamnesis it is known that since 2017 he has been suffering from GERD, he does not take drugs for stopping reflux attacks for 6 months, canceling it on his own. According to Holter ECG monitoring from 03/20/21, paroxysmal ventricular tachycardia was revealed. According to echocardioscopy data from 04/26/21, no structural changes that could be the cause of this life-threatening rhythm disturbance were found. Video gastroscopy from 04/28/21: distal reflux esophagitis. Endoscopic signs of hiatal hernia. Lack of cardia 2 tbsp. Gastroesophageal prolapse. At the consultation with a gastroenterologist, the patient was prescribed both non-drug (lifestyle correction) and drug treatment: rabeprozole, clarithromycin, amoxicillin and others. In addition for the relief of paroxysmal ventricular tachycardia—amiodarone, telmisartan.</p></sec><sec><title>Discussion</title><p>Discussion. According to studies, one of the mechanisms of arrhythmia in GERD is associated with the excitation of the distal esophagus by refluctate with the development of viscero-visceral reflexes mediated through n. vagus. Increased activation of n. vagus creates an arrhythmogenic substrate for the re-entry mechanism, and thus increases the risk of arrhythmias. Antiarrhythmic therapy along with the treatment of GERD led to the elimination of VT paroxysms. Later, 2 months after the withdrawal of antiarrhythmic drugs against the background of ongoing GERD therapy, paroxysms of VT were not recorded. This was also a confirmation of the pathogenetic relationship between GERD and paroxysmal VT.</p></sec><sec><title>Conclusion</title><p>Conclusion. The case is of interest to the development of a life-threatening rhythm disturbance: paroxysmal ventricular tachycardia against the background of GERD, which is a very rare variant of Remkheld’s syndrome and is not found in the available literature.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>гастроэзофагеальная рефлюксная болезнь</kwd><kwd>пароксизмальная желудочковая тахикардия</kwd><kwd>синдром Ремхельда</kwd><kwd>гастро-кардиальный синдром</kwd><kwd>рефлюкс</kwd></kwd-group><kwd-group xml:lang="en"><kwd>gastroesophageal reflux disease</kwd><kwd>paroxysmal ventricular tachycardia</kwd><kwd>Remheld’s syndrome</kwd><kwd>gastro-cardiac syndrome</kwd><kwd>reflux</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Saeed M., Bhandohal J. S., Visco F., Pekler G., Mushiyev S. Gastrocardiac syndrome: A forgotten entity. 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