nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-196-12-134-138nogr-1810Research ArticleОБЗОРREVIEWПолиморфизмы генов цитокинов в механизмах развития воспалительного и язвенного поражений желудкаPolymorphisms of cytokine genes in the mechanisms of development of inflammatory and ultrasonic gastric damageИсмоиловаФ. Р.IsmoilovaF. R.

Исмоилова Фазилат Рустамовна, ассистент кафедры внутренних болезней № 2

100109, г. Ташкент, ул. Фаробий, 2

Fazilat R. Ismoilova, Assistant of the Department of Internal Diseases No. 2

100109, Tashkent UZ, Farabi 2  

РустамоваМ. Т.RustamovaM. T.

Рустамова Мамлакат Тулябаевна, доктор медицинских наук, профессор кафедры пропедевтики внутренних болезней № 1

100109, г. Ташкент, ул. Фаробий, 2

Mamlakat T. Rustamova, Doctor of Medical Sciences, Professor of the Department of Propedeutics of Internal Diseases No. 1

100109, Tashkent UZ, Farabi 2  

mamlakatrustamova2018@mail.ruТашкентская медицинская академияУзбекистанTashkent Medical AcademyUzbekistan202116012022012134138Copyright © Исмоилова Ф.Р., Рустамова М.Т., 20222022Исмоилова Ф.Р., Рустамова М.Т.Ismoilova F.R., Rustamova M.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1810

На сегодняшний день накоплено достаточно достоверных данных о вовлеченности различных генов цитокинов, продукты которых принимают непосредственное участие в процессах регуляции иммунного ответа при воспалительных процессах слизистой желудка. Однако, среди этих работ, исследования, посвященные генетическим механизмам формирования воспалительных и язвенных поражений желудка, малочисленны, а полученные данные противоречивы. Между тем, выявление предрасполагающих факторов, способных модулировать прогрессирование воспалительного процесса ведущего к развитию язв желудка имеет весьма важное значение в плане разработки их ранних прогностических критериев, и, вместе с этим, профилактических и лечебных стратегий.

To date, sufficiently reliable data have been accumulated on the involvement of various cytokine genes, the products of which are directly involved in the regulation of the immune response in inflammatory processes of the gastric mucosa. However, among these works, studies devoted to the genetic mechanisms of the formation of inflammatory and ulcerative lesions of the stomach are few in number, and the data obtained are contradictory. Meanwhile, the identification of predisposing factors that can modulate the progression of the inflammatory process leading to the development of stomach ulcers is very important in terms of developing their early prognostic criteria, and, at the same time, preventive and therapeutic strategies.

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The authors declare that there are no conflicts of interest present.