nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-196-12-110-118nogr-1806Research ArticleОБЗОРREVIEWБиологическая роль казоморфинов (часть 2): роль в патологии человекаThe biological role of casomorphins (part 2): role in human pathologyhttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinA. I.

Хавкин Анатолий Ильич, д. м. н., профессор, главный научный сотрудник отдела гастроэнтерологии Научно-исследовательского клинического института педиатрии им. академика Ю. Е. Вельтищева

125412, Москва, ул. Талдомская, 2308015, Белгородская область, Белгород, ул. Победы, д. 85

Anatoly I. Khavkin, MD, PhD, DSc, Professor, Chief Researcher of the Department of Gastroenterology of the Scientific Research Clinical Institute of Pediatrics named after Academician Yu. E. Veltischev

125412, Moscow, st. Taldomskaya, 2308015, the Belgorod region, Belgorod, Pobedy Street, 85

gastropedclin@gmail.comhttps://orcid.org/0000-0002-1927-6811ВасиаМ. Н.VasiaM. N.

Васиа Мари Нечеса, главный врач больницы

GA000, Аккра, а/я OS 3410 ОСУ

Marie Nechesa Vasia, MD, Chief Physician at Doctors on Duty Clinic Labadi

GA000, Accra, PO BOX OS 3410, OSU

https://orcid.org/0000-0002-0992-1709НовиковаВ. П.NovikovaV. P.

Новикова Валерия Павловна, д. м. н., профессор, зав. кафедрой пропедевтики детских болезней с курсом общего ухода за детьми, зав. лабораторией «Медико-социальных проблем в педиатрии»

194100, Санкт-Петербург, ул. Литовская, д. 2, литера Ж

Valeriya P. Novikova, MD, PhD, DSc, Professor, Head of Department of Propedeutics of Childhood Diseases with a course of general child care, head. laboratory “Medical and social problems in pediatrics”

194100, St. Petersburg, st. Litovskaya, 2, letter Zh  

Российский национальный исследовательский медицинский университет им. Н. И. Пирогова; Белгородский государственный исследовательский университет Министерства науки и высшего образования Российской ФедерацииРоссияRussian National Research Medical University named after N. I. Pirogov; Belgorod State Research University Russian FederationRussian FederationБольница “Doctors on duty clinic Labadi”РоссияDotors on duty clinic LabadiRussian FederationСанкт-Петербургский государственный педиатрический медицинский университетРоссияSaint Petersburg State Pediatric Medical UniversityRussian Federation202116012022012110118Copyright © Хавкин А.И., Васиа М.Н., Новикова В.П., 20222022Хавкин А.И., Васиа М.Н., Новикова В.П.Khavkin A.I., Vasia M.N., Novikova V.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1806

Вторая часть обзора о казоморфинах посвящена роли этих биологически активных пептидов—продуктов гидролиза фосфопротеинов. Приведены убедительные данные о влиянии на систему иммунитета, антионкогенном действии, на моторику и тонус гладких мышечных волокон, способности управлять и другими аспектами деятельности ЖКТ — транспортной функцией кишечного эпителия, всасыванием воды и пр. Доказано действие β–казоморфинов на эндокринную систему, прежде всего на выделение инсулина и соматостатина. Особого внимания заслуживает вопрос влияния β–казоморфинов на материнский организм во время беременности и вскармливания новорожденного. Это важно, поскольку β–казоморфины могут проникать в ЦНС, являясь одним из факторов послеродового психоза и депрессии. Изучение механизмов действия β–казоморфинов приблизит учёных к пониманию генеза и патогенеза значительного спектра патологий.

The second part of the review on casomorphins is devoted to the role of these biologically active peptides — products of phosphoprotein hydrolysis. Convincing data on the eff ect on the immune system, anti-oncogenic effect, on the motility and tone of smooth muscle fibers, the ability to control other aspects of the gastrointestinal tract activity—the transport function of the intestinal epithelium, water absorption, etc. The effect of β-casomorphins on the endocrine system, primarily on release of insulin and somatostatin. Particular attention should be paid to the question of the effect of β-casomorphins on the maternal organism during pregnancy and breastfeeding of the newborn. This is important because β-casomorphins can enter the central nervous system, being one of the factors in postpartum psychosis and depression. The study of the mechanisms of action of β-casomorphins will bring scientists closer to understanding the genesis and pathogenesis of a signifi cant spectrum of pathologies.

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The authors declare that there are no conflicts of interest present.