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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-196-12-94-101</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-1804</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Роль кишечной микробиоты в развитии пищевой аллергии</article-title><trans-title-group xml:lang="en"><trans-title>The role of the intestinal microbiota in the development of food allergy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4973-039X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Айтбаев</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Aitbaev</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Айтбаев Кубаныч Авенович, д. м. н., профессор., зав. лабораторией патологической физиологии</p><p>г. Бишкек</p></bio><bio xml:lang="en"><p>Kubanich A. Aitbaev, professor, doctor of medical sciences, Head of the Laboratory of Pathological Physiology</p><p>Bishkek</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8513-9279</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муркамилов</surname><given-names>И. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Murkamilov</surname><given-names>I. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Муркамилов Илхом Торобекович, к. м. н., и. о. доцента, врач-нефролог; Председатель правления общество специалистов по хронической болезни почек</p><p>г. Бишкек</p></bio><bio xml:lang="en"><p>Ilkhom T. Murkamilov, candidate of medical sciences, Acting Associate Professor; Chairman of the Board of the Society of Specialists in Chronic Kidney Disease</p><p>Bishkek</p></bio><email xlink:type="simple">murkamilov.i@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7653-0433</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муркамилова</surname><given-names>Ж, А.</given-names></name><name name-style="western" xml:lang="en"><surname>Murkamilova</surname><given-names>Z. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Муркамилова Жамила Абдилалимовна, заочный аспирант, врач-терапевт</p><p>г. Бишкек</p></bio><bio xml:lang="en"><p>Zhamila A. Murkamilova, Post-graduate Student, Therapist</p><p>Bishkek</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2682-4417</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фомин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fomin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фомин Виктор Викторович, д. м. н., профессор., член-корр. РАН, проректор по научно-исследовательской и клинической работе; зав. каф. факультетской терапии № 1. Главный внештатный специалист общей врачебной практики Департамента здравоохранения города Москвы</p><p>119048, г. Москва, ул. Трубецкая, д. 8/1</p></bio><bio xml:lang="en"><p>Viktor V. Fomin, professor, doctor of medical sciences, Corresponding member RAS, vice-rector for research and clinical work, head; Chair of Faculty Therapy № 1. The chief freelance specialist of general medical practice of the Moscow City Health Department</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт молекулярной биологии и медицины</institution><country>Кыргызстан</country></aff><aff xml:lang="en"><institution>Scientific Research Institute of Molecular Biology and Medicine</institution><country>Kyrgyzstan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Кыргызская государственная медицинская академия им. И. К. Ахунбаева</institution><country>Кыргызстан</country></aff><aff xml:lang="en"><institution>Kyrgyz State Medical Academy named after I. K. Akhunbayev;  Kyrgyz Russian Slavic University named after the First President of Russia B. N. Yeltsin</institution><country>Kyrgyzstan</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Кыргызско-Российский Славянский университет им. первого Президента России Б. Н. Ельцина</institution><country>Кыргызстан</country></aff><aff xml:lang="en"><institution>Kyrgyz Russian Slavic University named after the First President of Russia B. N. Yeltsin</institution><country>Kyrgyzstan</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSAEI HE First Moscow State Medical University named after I. M. Sechenov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>16</day><month>01</month><year>2022</year></pub-date><volume>0</volume><issue>12</issue><fpage>94</fpage><lpage>101</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Айтбаев К.А., Муркамилов И.Т., Муркамилова Ж.А., Фомин В.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Айтбаев К.А., Муркамилов И.Т., Муркамилова Ж.А., Фомин В.В.</copyright-holder><copyright-holder xml:lang="en">Aitbaev K.A., Murkamilov I.T., Murkamilova Z.A., Fomin V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/1804">https://www.nogr.org/jour/article/view/1804</self-uri><abstract><p>В обзорной статье представлены современные данные о возможной связи между возникновением аллергии и нарушениями в составе микробиоты кишечника. Обсуждается роль кишечной микробиоты в становлении иммунной системы ребёнка, а также поддержании его иммунной толерантности. Рассмотрены факторы, воздействие которых может быть связано с изменениями в микробиоте кишечника и развитием аллергических заболеваний.</p></abstract><trans-abstract xml:lang="en"><p>The review article presents current data on the possible connection between the occurrence of allergies and disorders in the intestinal microbiota. The role of the intestinal microbiota in the development of the immune system of a child, as well as the maintenance of its immune tolerance, is discussed. Factors whose effects can be associated with changes in the intestinal microbiota and the development of allergic diseases are considered.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>аллергия</kwd><kwd>аллергические заболевания</kwd><kwd>иммунная толерантность кишечная микробиота</kwd></kwd-group><kwd-group xml:lang="en"><kwd>allergy</kwd><kwd>allergic diseases</kwd><kwd>immune tolerance</kwd><kwd>intestinal microbiota</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Strachan D. P. Hay fever, hygiene, and household size. BMJ. 1989;299(6710):1259–1260. PMID:2513902.</mixed-citation><mixed-citation xml:lang="en">Strachan D. P. Hay fever, hygiene, and household size. BMJ. 1989;299(6710):1259–1260. PMID:2513902.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Penders J., Gerhold K., Stobberingh E. E., et al. Establishment of the intestinal microbiota and its role for atopic dermatitis in early childhood. J Allergy Clin Immunol. 2013;132(3):601–607. doi:10.1016/j.jaci.2013.05.043.</mixed-citation><mixed-citation xml:lang="en">Penders J., Gerhold K., Stobberingh E. E., et al. Establishment of the intestinal microbiota and its role for atopic dermatitis in early childhood. J Allergy Clin Immunol. 2013;132(3):601–607. doi:10.1016/j.jaci.2013.05.043.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Fagarasan S., Honjo T. Intestinal IgA synthesis: Regulation of front-line body defences. Nat.Rev.Immunol. 2003; 3:1:63–72.</mixed-citation><mixed-citation xml:lang="en">Fagarasan S., Honjo T. Intestinal IgA synthesis: Regulation of front-line body defences. Nat.Rev.Immunol. 2003; 3:1:63–72.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bemark M., Boysen P., Lycke N. Y. Induction of gut IgA production through T cell-dependent and T cell-independent pathways. Ann.N.Y.Acad.Sci. 2012;1247:97–116. doi:10.1111/j.1749–6632.2011.06378.x.</mixed-citation><mixed-citation xml:lang="en">Bemark M., Boysen P., Lycke N. Y. Induction of gut IgA production through T cell-dependent and T cell-independent pathways. Ann.N.Y.Acad.Sci. 2012;1247:97–116. doi:10.1111/j.1749–6632.2011.06378.x.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Berin M. C. Mucosal antibodies in the regulation of tolerance and allergy to foods. Semin.Immunopathol. 2012; 34:5:633–642.</mixed-citation><mixed-citation xml:lang="en">Berin M. C. Mucosal antibodies in the regulation of tolerance and allergy to foods. Semin.Immunopathol. 2012; 34:5:633–642.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Frossard C.P., Hauser C., Eigenmann P. A. Antigenspecific secretory IgA antibodies in the gut are decreased in a mouse model of food allergy. J. Allerg Clin.Immunol. 2004;114:2:377–382. doi:10.1016/j.jaci.2004.03.040.</mixed-citation><mixed-citation xml:lang="en">Frossard C.P., Hauser C., Eigenmann P. A. Antigenspecific secretory IgA antibodies in the gut are decreased in a mouse model of food allergy. J. Allerg Clin.Immunol. 2004;114:2:377–382. doi:10.1016/j.jaci.2004.03.040.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Janzi M., Kull I., Sjoberg R., et al. Selective IgA deficiency in early life: Association to infections and allergic diseases during childhood. Clin.Immunol. 2009;133:1:78–85. doi:10.1016/j.clim.2009.05.014.</mixed-citation><mixed-citation xml:lang="en">Janzi M., Kull I., Sjoberg R., et al. Selective IgA deficiency in early life: Association to infections and allergic diseases during childhood. Clin.Immunol. 2009;133:1:78–85. doi:10.1016/j.clim.2009.05.014.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Macpherson A.J., Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science. 2004; 303: 5664:1662–1665. doi:10.1126/science.1091334.</mixed-citation><mixed-citation xml:lang="en">Macpherson A.J., Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science. 2004; 303: 5664:1662–1665. doi:10.1126/science.1091334.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Groisman E.A., Parra-Lopez C., Salcedo M., et al. Resistance to host antimicrobial peptides is necessary for Salmonella virulence. Proc.Nat.Acad.Sci.USA. 1992;89:24:11939–11943. doi:10.1073/pnas.89.24.11939.</mixed-citation><mixed-citation xml:lang="en">Groisman E.A., Parra-Lopez C., Salcedo M., et al. Resistance to host antimicrobial peptides is necessary for Salmonella virulence. Proc.Nat.Acad.Sci.USA. 1992;89:24:11939–11943. doi:10.1073/pnas.89.24.11939.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kostic A.D., Howitt M. R., Garrett W. S. Exploring host-microbiota interactions in animal models and humans. Gene. Dev. 2013; 27:7:701–718. doi:10.1101/gad.212522.112.</mixed-citation><mixed-citation xml:lang="en">Kostic A.D., Howitt M. R., Garrett W. S. Exploring host-microbiota interactions in animal models and humans. Gene. Dev. 2013; 27:7:701–718. doi:10.1101/gad.212522.112.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sudo N., Sawamura S., Tanaka K., et al. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J. Immunol. 1997;159:4:1739–1745.</mixed-citation><mixed-citation xml:lang="en">Sudo N., Sawamura S., Tanaka K., et al. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J. Immunol. 1997;159:4:1739–1745.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Hrncir T., Stepankova R., Kozakova H., et al. Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: Studies in germ-free mice. BMC Immunol. 2008;9:1:65. doi:10.1186/1471–2172–9–65.</mixed-citation><mixed-citation xml:lang="en">Hrncir T., Stepankova R., Kozakova H., et al. Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: Studies in germ-free mice. BMC Immunol. 2008;9:1:65. doi:10.1186/1471–2172–9–65.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Mazmanian S.K., Liu C. H., Tzianabos A. O., Kasper D. L. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell. 2005;122:1:107–118. doi:10.1016/j.cell.2005.05.007.</mixed-citation><mixed-citation xml:lang="en">Mazmanian S.K., Liu C. H., Tzianabos A. O., Kasper D. L. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell. 2005;122:1:107–118. doi:10.1016/j.cell.2005.05.007.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Bauer H., Horowitz R. E., Levenson S. M., Popper H. The response of the lymphatic tissue to the microbialflora. Studies on germfree mice. Amer.J.Pathol. 1963;42:4:471–483. PMID:13966929.</mixed-citation><mixed-citation xml:lang="en">Bauer H., Horowitz R. E., Levenson S. M., Popper H. The response of the lymphatic tissue to the microbialflora. Studies on germfree mice. Amer.J.Pathol. 1963;42:4:471–483. PMID:13966929.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Prescott S.L., Macaubas C., Holt B. J., et al. Transplacental priming of the human immune system to environmental allergens: Universal skewing of initial T cell responses toward the Th2 cytokine profile. J. Immunol. 1998;160:10:730–4737.</mixed-citation><mixed-citation xml:lang="en">Prescott S.L., Macaubas C., Holt B. J., et al. Transplacental priming of the human immune system to environmental allergens: Universal skewing of initial T cell responses toward the Th2 cytokine profile. J. Immunol. 1998;160:10:730–4737.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Round J.L., Mazmanian S. K. Inducible foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc.Nat.Acad.Sci.USA. 2010;107:27:12204–12209. doi:10.1073/pnas.0909122107.</mixed-citation><mixed-citation xml:lang="en">Round J.L., Mazmanian S. K. Inducible foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc.Nat.Acad.Sci.USA. 2010;107:27:12204–12209. doi:10.1073/pnas.0909122107.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hooper L.V., Gordon J. I. Commensal host-bacterial relationships in the gut. Science. 2001; 292:5519:1115–1118. doi:10.1126/science.1058709.</mixed-citation><mixed-citation xml:lang="en">Hooper L.V., Gordon J. I. Commensal host-bacterial relationships in the gut. Science. 2001; 292:5519:1115–1118. doi:10.1126/science.1058709.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Jakobsson H.E., Abrahamsson T. R., Jenmalm M. C., et al. Decreased gut microbiota diversity, delayed bacteroidetes colonisation and reduced Th1 responses in infants delivered by caesarean section. Gut. 2014; 63(4):559–566. doi:10.1136/gutjnl-2012–303249.</mixed-citation><mixed-citation xml:lang="en">Jakobsson H.E., Abrahamsson T. R., Jenmalm M. C., et al. Decreased gut microbiota diversity, delayed bacteroidetes colonisation and reduced Th1 responses in infants delivered by caesarean section. Gut. 2014; 63(4):559–566. doi:10.1136/gutjnl-2012–303249.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Hooper L.V., Littman D. R., Macpherson A. J. Interactions between the microbiota and the immune system. Science. 2012;336(6086):1268–1273. doi:10.1126/science.1223490.</mixed-citation><mixed-citation xml:lang="en">Hooper L.V., Littman D. R., Macpherson A. J. Interactions between the microbiota and the immune system. Science. 2012;336(6086):1268–1273. doi:10.1126/science.1223490.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Chahine B.G., Bahna S. L. The role of the gut mucosal immunity in the development of tolerance versus development of allergy to food. Current Opinion in Allergy and Clinical Immunology. 2010;10(4):394–399. doi:10.1097/ACI.0b013e32833982ab.</mixed-citation><mixed-citation xml:lang="en">Chahine B.G., Bahna S. L. The role of the gut mucosal immunity in the development of tolerance versus development of allergy to food. Current Opinion in Allergy and Clinical Immunology. 2010;10(4):394–399. doi:10.1097/ACI.0b013e32833982ab.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Riedler J., Braun-Fahrlander C., Eder W., et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet. 2001;358(9288):1129–1133. doi:10.1016/S0140–6736(01)06252–3.</mixed-citation><mixed-citation xml:lang="en">Riedler J., Braun-Fahrlander C., Eder W., et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet. 2001;358(9288):1129–1133. doi:10.1016/S0140–6736(01)06252–3.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Alfven T., Braun-Fahrlander C., Brunekreef B., et al. Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle – the PARSIFAL study. Allergy. 2006; 61(4):414–421. doi:10.1111/j.1398–9995.2005.00939.x.</mixed-citation><mixed-citation xml:lang="en">Alfven T., Braun-Fahrlander C., Brunekreef B., et al. Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle – the PARSIFAL study. Allergy. 2006; 61(4):414–421. doi:10.1111/j.1398–9995.2005.00939.x.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Genuneit J., Strachan D. P., Buchele G., et al. The combined effects of family size and farm exposure on childhood hay fever and atopy. Pediatr Allergy Immunol. 2013;24(3):293–298. doi:10.1111/pai.12053.</mixed-citation><mixed-citation xml:lang="en">Genuneit J., Strachan D. P., Buchele G., et al. The combined effects of family size and farm exposure on childhood hay fever and atopy. Pediatr Allergy Immunol. 2013;24(3):293–298. doi:10.1111/pai.12053.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Gosalbes M.J., Llop S., Valles Y., et al. Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants. Clin Exp Allergy. 2013;43(2):198–211. doi:10.1111/cea.12063.</mixed-citation><mixed-citation xml:lang="en">Gosalbes M.J., Llop S., Valles Y., et al. Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants. Clin Exp Allergy. 2013;43(2):198–211. doi:10.1111/cea.12063.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Douwes J., Cheng S., Travier N., et al. Farm exposure in utero may protect against asthma, hay fever and eczema. European Respiratory Journal. 2008;32(3):603–611. doi:10.1183/09031936.00033707.</mixed-citation><mixed-citation xml:lang="en">Douwes J., Cheng S., Travier N., et al. Farm exposure in utero may protect against asthma, hay fever and eczema. European Respiratory Journal. 2008;32(3):603–611. doi:10.1183/09031936.00033707.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Ege M.J., Mayer M., Normand A-C., et al. Exposure to Environmental Microorganisms and Childhood Asthma. N. Engl. J. Med. 2011;364:701–709. doi:10.1056/NEJMoa1007302.</mixed-citation><mixed-citation xml:lang="en">Ege M.J., Mayer M., Normand A-C., et al. Exposure to Environmental Microorganisms and Childhood Asthma. N. Engl. J. Med. 2011;364:701–709. doi:10.1056/NEJMoa1007302.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Abrahamsson T.R., Jakobsson H. E., Andersson A. F., et al. Low gut microbiota diversity in early infancy precedes asthma at school age. Clin Exp Allergy. 2014;44(6):842–850. doi:10.1111/cea.12253.</mixed-citation><mixed-citation xml:lang="en">Abrahamsson T.R., Jakobsson H. E., Andersson A. F., et al. Low gut microbiota diversity in early infancy precedes asthma at school age. Clin Exp Allergy. 2014;44(6):842–850. doi:10.1111/cea.12253.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Bisgaard H., Li N., Bonnelykke K., et al. Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. J Allergy Clin Immunol. 2011;128(3):646–652. doi:10.1016/j.jaci.2011.04.060.</mixed-citation><mixed-citation xml:lang="en">Bisgaard H., Li N., Bonnelykke K., et al. Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. J Allergy Clin Immunol. 2011;128(3):646–652. doi:10.1016/j.jaci.2011.04.060.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Abrahamsson T.R., Jakobsson H. E., Andersson A. F., et al. Low diversity of the gut microbiota in infants with atopic eczema. J Allergy Clin Immunol. 2012;129(2):434– 440. doi:10.1016/j.jaci.2011.10.025.</mixed-citation><mixed-citation xml:lang="en">Abrahamsson T.R., Jakobsson H. E., Andersson A. F., et al. Low diversity of the gut microbiota in infants with atopic eczema. J Allergy Clin Immunol. 2012;129(2):434– 440. doi:10.1016/j.jaci.2011.10.025.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Fujimura K.E., Johnson C. C., Ownby D. R., et al. Man’s best friend? The effect of pet ownership on house dust microbial communities. J Allergy Clin Immunol. 2010;126(2):410–412. doi:10.1016/j.jaci.2010.05.042.</mixed-citation><mixed-citation xml:lang="en">Fujimura K.E., Johnson C. C., Ownby D. R., et al. Man’s best friend? The effect of pet ownership on house dust microbial communities. J Allergy Clin Immunol. 2010;126(2):410–412. doi:10.1016/j.jaci.2010.05.042.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Azad M.B., Konya T., Maughan H., et al. Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity. Allergy Asthma Clin Immunol. 2013; 9(1):15.</mixed-citation><mixed-citation xml:lang="en">Azad M.B., Konya T., Maughan H., et al. Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity. Allergy Asthma Clin Immunol. 2013; 9(1):15.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Wegienka G., Johnson C. C., Havstad S., et al. Lifetime dog and cat exposure and dog- and cat-specific sensitization at age 18 years. Clin Exp Allergy. 2011;41(7):979–986. doi:10.1111/j.1365–2222.2011.03747.x.</mixed-citation><mixed-citation xml:lang="en">Wegienka G., Johnson C. C., Havstad S., et al. Lifetime dog and cat exposure and dog- and cat-specific sensitization at age 18 years. Clin Exp Allergy. 2011;41(7):979–986. doi:10.1111/j.1365–2222.2011.03747.x.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">van Nimwegen F. A., Penders J., Stobberingh E. E., et al. Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. J Allergy Clin Immunol. 2011; 128(5):948–955. doi:10.1016/j.jaci.2011.07.027.</mixed-citation><mixed-citation xml:lang="en">van Nimwegen F. A., Penders J., Stobberingh E. E., et al. Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. J Allergy Clin Immunol. 2011; 128(5):948–955. doi:10.1016/j.jaci.2011.07.027.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Ege M.J., Bieli C., Frei R., et al. Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children. J Allergy Clin Immunol. 2006;117(4):817–823. doi:10.1016/j.jaci.2005.12.1307.</mixed-citation><mixed-citation xml:lang="en">Ege M.J., Bieli C., Frei R., et al. Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children. J Allergy Clin Immunol. 2006;117(4):817–823. doi:10.1016/j.jaci.2005.12.1307.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Stern D.A., Riedler J., Nowak D., et al. Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalants. J Allergy Clin Immunol. 2007;119(2):351–358. doi:10.1016/j.jaci.2006.10.013.</mixed-citation><mixed-citation xml:lang="en">Stern D.A., Riedler J., Nowak D., et al. Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalants. J Allergy Clin Immunol. 2007;119(2):351–358. doi:10.1016/j.jaci.2006.10.013.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Biasucci G., Rubini M., Riboni S., et al. Mode of delivery affects the bacterial community in the newborn gut. Early Hum Dev. 2010;86(Suppl1):13–15. doi:10.1016/j.earlhumdev.2010.01.004.</mixed-citation><mixed-citation xml:lang="en">Biasucci G., Rubini M., Riboni S., et al. Mode of delivery affects the bacterial community in the newborn gut. Early Hum Dev. 2010;86(Suppl1):13–15. doi:10.1016/j.earlhumdev.2010.01.004.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Dominguez-Bello M.G., Costello E. K., Contreras M., et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proceedings of the National Academy of Sciences. 2010;107(26):11971–11975. doi:10.1073/pnas.1002601107.</mixed-citation><mixed-citation xml:lang="en">Dominguez-Bello M.G., Costello E. K., Contreras M., et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proceedings of the National Academy of Sciences. 2010;107(26):11971–11975. doi:10.1073/pnas.1002601107.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Jakobsson H.E., Abrahamsson T. R., Jenmalm M. C., et al. Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by caesarean section. Gut. 2014;63(4):559–566. doi:10.1136/gutjnl-2012–303249.</mixed-citation><mixed-citation xml:lang="en">Jakobsson H.E., Abrahamsson T. R., Jenmalm M. C., et al. Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by caesarean section. Gut. 2014;63(4):559–566. doi:10.1136/gutjnl-2012–303249.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Karmaus W., Botezan C. Does a higher number of siblings protect against the development of allergy and asthma? A review. J Epidemiol Community Health. 2002;56(3):209–217. doi:10.1136/jech.56.3.209.</mixed-citation><mixed-citation xml:lang="en">Karmaus W., Botezan C. Does a higher number of siblings protect against the development of allergy and asthma? A review. J Epidemiol Community Health. 2002;56(3):209–217. doi:10.1136/jech.56.3.209.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Verani J.R., McGee L., Schrag S. J. Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC). Prevention of perinatal group B streptococcal disease – revised guidelines from CDC, 2010. MMWR Recomm Rep. 2010; 59(RR-10):1–36.</mixed-citation><mixed-citation xml:lang="en">Verani J.R., McGee L., Schrag S. J. Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC). Prevention of perinatal group B streptococcal disease – revised guidelines from CDC, 2010. MMWR Recomm Rep. 2010; 59(RR-10):1–36.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Bennet R., Eriksson M., Nord C. E., Zetterstrom R. Fecal bacterial microflora of newborn infants during intensive care management and treatment with five antibiotic regimens. Pediatr Infect Dis. 1986;5(5):533–539.</mixed-citation><mixed-citation xml:lang="en">Bennet R., Eriksson M., Nord C. E., Zetterstrom R. Fecal bacterial microflora of newborn infants during intensive care management and treatment with five antibiotic regimens. Pediatr Infect Dis. 1986;5(5):533–539.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Greenwood C., Morrow A. L., Lagomarcino A. J., et al. Early empiric antibiotic use in preterm infants is associated with lower bacterial diversity and higher relative abundance of Enterobacter. J Pediatr. 2014;165(1):23–29. doi:10.1016/j.jpeds.2014.01.010.</mixed-citation><mixed-citation xml:lang="en">Greenwood C., Morrow A. L., Lagomarcino A. J., et al. Early empiric antibiotic use in preterm infants is associated with lower bacterial diversity and higher relative abundance of Enterobacter. J Pediatr. 2014;165(1):23–29. doi:10.1016/j.jpeds.2014.01.010.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Fouhy F., Guinane C. M., Hussey S., et al. Highthroughput sequencing reveals the incomplete, shortterm recovery of infant gut microbiota following parenteral antibiotic treatment with ampicillin and gentamicin. Antimicrob Agents Chemother. 2012;56(11):5811–5820. doi:10.1128/AAC.00789–12.</mixed-citation><mixed-citation xml:lang="en">Fouhy F., Guinane C. M., Hussey S., et al. Highthroughput sequencing reveals the incomplete, shortterm recovery of infant gut microbiota following parenteral antibiotic treatment with ampicillin and gentamicin. Antimicrob Agents Chemother. 2012;56(11):5811–5820. doi:10.1128/AAC.00789–12.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Zivkovic A . M., German J. B., Lebrilla C . B., Mills D. A. Human milk glycobiome and its impact on the infant gastrointestinal microbiota. Proc Natl Acad Sci USA. 2011;108 (Suppl 1):4653–4658. doi:10.1073/pnas.1000083107.</mixed-citation><mixed-citation xml:lang="en">Zivkovic A . M., German J. B., Lebrilla C . B., Mills D. A. Human milk glycobiome and its impact on the infant gastrointestinal microbiota. Proc Natl Acad Sci USA. 2011;108 (Suppl 1):4653–4658. doi:10.1073/pnas.1000083107.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Benno Y., Sawada K., Mitsuoka T. The intestinal microflora of infants: composition of fecal flora in breast-fed and bottle-fed infants. Microbiol Immunol. 1984;28(9):975–986. doi:10.1111/j.1348–0421.1984.tb00754.x.</mixed-citation><mixed-citation xml:lang="en">Benno Y., Sawada K., Mitsuoka T. The intestinal microflora of infants: composition of fecal flora in breast-fed and bottle-fed infants. Microbiol Immunol. 1984;28(9):975–986. doi:10.1111/j.1348–0421.1984.tb00754.x.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Devereux G. The increase in the prevalence of asthma and allergy: food for thought. Nat Rev Immunol. 2006;6(11):869–874.</mixed-citation><mixed-citation xml:lang="en">Devereux G. The increase in the prevalence of asthma and allergy: food for thought. Nat Rev Immunol. 2006;6(11):869–874.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Wu G.D., Chen J., Hoffmann C., et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011;334:6052:105–108. doi:10.1126/science.1208344.</mixed-citation><mixed-citation xml:lang="en">Wu G.D., Chen J., Hoffmann C., et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011;334:6052:105–108. doi:10.1126/science.1208344.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Trompette A., Gollwitzer E. S., Yadava K., et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014; 20(2):159–166.</mixed-citation><mixed-citation xml:lang="en">Trompette A., Gollwitzer E. S., Yadava K., et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014; 20(2):159–166.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Ling Z., Li Z., Liu X., et al. Altered fecal microbiota composition associated with food allergy in infants. Applied and environmental microbiology. 2014;80:2546–2554. doi:10.1128/AEM.00003–14.</mixed-citation><mixed-citation xml:lang="en">Ling Z., Li Z., Liu X., et al. Altered fecal microbiota composition associated with food allergy in infants. Applied and environmental microbiology. 2014;80:2546–2554. doi:10.1128/AEM.00003–14.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Hua X., Goedert J. J., Pu A., et al. Allergy associations with the adult fecal microbiota: Analysis of the American Gut Project. EBioMedicine. 2016;3:172–179. doi:10.1016/j.ebiom.2015.11.038.</mixed-citation><mixed-citation xml:lang="en">Hua X., Goedert J. J., Pu A., et al. Allergy associations with the adult fecal microbiota: Analysis of the American Gut Project. EBioMedicine. 2016;3:172–179. doi:10.1016/j.ebiom.2015.11.038.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Round J.L., Mazmanian S. K. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proceedings of the National Academy of Sciences of the United States of America. 2010;107:27:12204–12209. doi:10.1073/pnas.0909122107.</mixed-citation><mixed-citation xml:lang="en">Round J.L., Mazmanian S. K. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proceedings of the National Academy of Sciences of the United States of America. 2010;107:27:12204–12209. doi:10.1073/pnas.0909122107.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Azad M.B., Konya T., Guttman D. S., et al. Infant gut microbiota and food sensitization: associations in the first year of life. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. 2015;45:3:632–643. doi:10.1111/cea.12487.</mixed-citation><mixed-citation xml:lang="en">Azad M.B., Konya T., Guttman D. S., et al. Infant gut microbiota and food sensitization: associations in the first year of life. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. 2015;45:3:632–643. doi:10.1111/cea.12487.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Wang M., Karlsson C., Olsson C., et al. Reduced diversity in the early fecal microbiota of infants with atopic eczema. The Journal of allergy and clinical immunology. 2008;121:1:129–134. doi:10.1016/j.jaci.2007.09.011</mixed-citation><mixed-citation xml:lang="en">Wang M., Karlsson C., Olsson C., et al. Reduced diversity in the early fecal microbiota of infants with atopic eczema. The Journal of allergy and clinical immunology. 2008;121:1:129–134. doi:10.1016/j.jaci.2007.09.011</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Fieten K.B., Totte J. E.E., Levin E., et al. Fecal Microbiome and Food Allergy in Pediatric Atopic Dermatitis: A Cross-Sectional Pilot Study. Int. Arch. Allergy Immunol. 2018;175(1–2):77–84. doi:10.1159/000484897.</mixed-citation><mixed-citation xml:lang="en">Fieten K.B., Totte J. E.E., Levin E., et al. Fecal Microbiome and Food Allergy in Pediatric Atopic Dermatitis: A Cross-Sectional Pilot Study. Int. Arch. Allergy Immunol. 2018;175(1–2):77–84. doi:10.1159/000484897.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Blazquez A.B., Berin M. C. Microbiome and Food Allergy. Transl. Res. 2017;179:199–203. doi:10.1016/j.trsl.2016.09.003</mixed-citation><mixed-citation xml:lang="en">Blazquez A.B., Berin M. C. Microbiome and Food Allergy. Transl. Res. 2017;179:199–203. doi:10.1016/j.trsl.2016.09.003</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
