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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-194-10-155-158</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-1772</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Тиреотоксический гепатит при беременности</article-title><trans-title-group xml:lang="en"><trans-title>Thyrotoxic hepatitis during pregnancy (clinical case)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8463-2379</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Апаркина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Aparkina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Апаркина Алёна Васильевна - ассистент кафедры госпитальной терапии лечебного факультета, кандидат медицинских наук.</p><p>410012, Саратов, ул. Б. Казачья, 112.</p></bio><bio xml:lang="en"><p>Alena V. Aparkina - Department of Hospital Therapy of medical faculty, Assistant, PhD in Medicine.</p><p>Bolshaya Kazachya str., 112, Saratov, 410012.</p></bio><email xlink:type="simple">alena437539@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кашкина</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kashkina</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кашкина Елена Игоревна - профессор кафедры госпитальной терапии лечебного факультета, профессор, доктор медицинских наук.</p><p>410012, Саратов, ул. Б. Казачья, 112.</p></bio><bio xml:lang="en"><p>Elena I. Kashkina - Department of Hospital Therapy of medical faculty, Professor, MD.</p><p>Bolshaya Kazachya str., 112, Saratov, 410012.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8561-2214</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маркова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Markova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маркова Анна Александровна - ассистент кафедры госпитальной терапии лечебного факультета, кандидат медицинских наук.</p><p>410012, Саратов, ул. Б. Казачья, 112.</p></bio><bio xml:lang="en"><p>Anna A. Markova - Department of Hospital Therapy of medical faculty, Assistant, PhD in Medicine.</p><p>Bolshaya Kazachya str., 112, Saratov, 410012.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1755-9279</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Азаркина</surname><given-names>К. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Azarkina</surname><given-names>K. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Азаркина Ксения Сергеевна - студентка.</p><p>410012, Саратов, ул. Б. Казачья, 112.</p></bio><bio xml:lang="en"><p>Kseniya S. Azarkina – Student.</p><p>Bolshaya Kazachya str., 112, Saratov, 410012.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4579-0822</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дарбинян</surname><given-names>В. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Darbinayn</surname><given-names>V. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дарбинян Володя Оникович - студент.</p><p>410012, Саратов, ул. Б. Казачья, 112.</p></bio><bio xml:lang="en"><p>Volodiya O. Darbinayn – Student.</p><p>Bolshaya Kazachya str., 112, Saratov, 410012.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Саратовский ГМУ им. В.И. Разумовского Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saratov State Medical University named after V.I. Razumovskyy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2021</year></pub-date><volume>0</volume><issue>10</issue><fpage>155</fpage><lpage>158</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Апаркина А.В., Кашкина Е.И., Маркова А.А., Азаркина К.С., Дарбинян В.О., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Апаркина А.В., Кашкина Е.И., Маркова А.А., Азаркина К.С., Дарбинян В.О.</copyright-holder><copyright-holder xml:lang="en">Aparkina A.V., Kashkina E.I., Markova A.A., Azarkina K.S., Darbinayn V.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/1772">https://www.nogr.org/jour/article/view/1772</self-uri><abstract><p>Представлен редкий клинический случай тиреотоксического гепатита, выявленного у беременной. Был проведен диагностический поиск для уточнения причины развития гепатита, в ходе которого выявлена патология щитовидной железы. Пациентке была назначена адекватная терапия тиреостатическим препаратом, который в короткие сроки позволил добиться существенного снижения активности печеночного патологического процесса, что дало возможность пролонгировать беременность.</p></abstract><trans-abstract xml:lang="en"><p>A rare clinical case of thyrotoxic hepatitis detected in a pregnant woman is presented. A diagnostic search was carried out to clarify the cause of hepatitis, during which the pathology of the thyroid gland was revealed. The patient was prescribed adequate therapy with a thyrostatic drug, which in a short time allowed to achieve a significant decrease in the activity of the hepatic pathological process, which made it possible to prolong pregnancy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>тиреотоксический гепатит</kwd><kwd>функция печени</kwd><kwd>диффузный токсический зоб</kwd></kwd-group><kwd-group xml:lang="en"><kwd>thyrotoxic hepatitis</kwd><kwd>liver function</kwd><kwd>diffuse toxic goiter</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И. И., Мельниченко Г. А., Фадеев В. В. Эндокринология. Москва: ГЭОТАР-Медиа; 2007.</mixed-citation><mixed-citation xml:lang="en">Dedov I. I., Melnichenko G. A., Fadeev V. V. Endo-krinologiya. Moscow. GEOTAR-Media Publ., 2007. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ross D. S., Burch H. B., Cooper D. S., et al. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidismand Other Causes of Thyrotoxicosis. Thyroid. 2016;26(10):1343-1421. Doi: 10.1089/thy.2016.0229.</mixed-citation><mixed-citation xml:lang="en">Ross D. S., Burch H. B., Cooper D. S., et al. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidismand Other Causes of Thyrotoxicosis. Thyroid. 2016;26(10):1343-1421. Doi: 10.1089/thy.2016.0229.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">de Campos Mazo D. F., de Vasconcelos G. B., Pereira M. A., et al. Clinical spectrum and therapeutic approach to hepatocellular injury in patients with hyperthyroidism. Clin Exp Gastroenterol. 2013;6:9-17. Doi: 10.2147/ceg.S393585.</mixed-citation><mixed-citation xml:lang="en">de Campos Mazo D. F., de Vasconcelos G. B., Pereira M. A., et al. Clinical spectrum and therapeutic approach to hepatocellular injury in patients with hyperthyroidism. Clin Exp Gastroenterol. 2013;6:9-17. Doi: 10.2147/ceg.S393585.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Khemichian S., Fong T. L. Hepatic dysfunction in hyperthyroidism. Gastroenterol Hepatol (N Y). 2011;7(5):337-339. PMC3127041.</mixed-citation><mixed-citation xml:lang="en">Khemichian S., Fong T. L. Hepatic dysfunction in hyperthyroidism. Gastroenterol Hepatol (N Y). 2011;7(5):337-339. PMC3127041.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Shetty S., Rajasekaran S., Venkatakrishnan L. Grave's disease and primary biliary cirrhosis-an unusual and challenging association. J Clin Exp Hepatol. 2014;4(1):66-67. Doi: 10.1016/j.jceh.2013.08.001</mixed-citation><mixed-citation xml:lang="en">Shetty S., Rajasekaran S., Venkatakrishnan L. Grave's disease and primary biliary cirrhosis-an unusual and challenging association. J Clin Exp Hepatol. 2014;4(1):66-67. Doi: 10.1016/j.jceh.2013.08.001</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Пикулев Д. В., Клеменов А. В. Тиреотоксический гепатит. Проблемы эндокринологии. 2017;63(1):46-50. Doi: 10.14341/probl201763146-50</mixed-citation><mixed-citation xml:lang="en">Pikulev D. V., Klemenov A. V. Thyrotoxic hepatitis. Problemy endokrinologii. 2017;63(1):46-0. (InRuss.) Doi: 10.14341/probl201763146-50.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Фадеев В. В., Лесникова С. В. Гипотиреоз и изолированная гипотироксинемия во время беременности. Клиническая и экспериментальная тиреоидология. 2011;7(1):6-14. Doi: 10.14341/ket2011716-14.</mixed-citation><mixed-citation xml:lang="en">Fadeyev V. V., Lesnikova S. V. Hypothyroidism and isolated hypothyroxinemia duri ngpregnancy. Clinical and Experimental Th yroidology. 2011;7(1):6-14 (In Russ.) Doi: 10.14341/ket2011716-14.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ловкова Ю. С., Потин В. В., Ткаченко Н. Н. и соавт. Лечение диффузного токсического зоба во время беременности. Журнал акушерства и женских болезней. 2017; 66 (3): 89-96. Doi: 10.17816/JOWD66389-96.</mixed-citation><mixed-citation xml:lang="en">Lovkova J. S., Potin V. V., Tkachenko N. N., et al. Treatment of diffuse toxic goiter during pregnancy. Journal of obstetrics and women's diseases. 2017; 66 (3): 89-96. (In Russ.) Doi: 10.17816/JOWD66389-96.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kishore K., Adhya A. K. Graves' disease with Pancytopenia and Hepatic Dysfunction: A Rare Case Presentation. Indian Journal of Nuclear Medicine. 2019;34:38-41. Doi: 10.4103/ijnm.IJNM_134_18.</mixed-citation><mixed-citation xml:lang="en">Kishore K., Adhya A. K. Graves' disease with Pancytopenia and Hepatic Dysfunction: A Rare Case Presentation. Indian Journal of Nuclear Medicine. 2019;34:38-41. Doi: 10.4103/ijnm.IJNM_134_18.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Павлова Т. В., Малютина Е. А., Петрухин В. А. Влияние патологии щитовидной железы на течение беременности и родов. литературный обзор. Фундаментальные исследования. 2011;3:15-21. Doi: fundamental-research.ru/ru/article/view?id=21112.</mixed-citation><mixed-citation xml:lang="en">Pavlova T. V., Malutina E. A., Petrukhin V. A. Effect of thyroid diseases in the course of pregnancy and delivery. literary review. Fundamental research. 2011; 3:15-21. (in Russ.) Doi: fundamental-research.ru/ru/article/view?id=21112.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Трошина Е. А., Свириденко Н. Ю., Ванушко В. Э. и соавт. Федеральные клинические рекомендации по диагностике и лечению токсического зоба. Проблемы эндокринологии. 2014; 60(6): 67-77.</mixed-citation><mixed-citation xml:lang="en">Troshina E. A., Sviridenko N. Yu., Vanushko V. E., et al. The federal clinical recommendations on diagnostics and treatment of toxic goiter. Problems of Endocrinology. 2014;60(6):67-77. (In Russ.) Doi: 10.14341/probl201460667-77.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
