nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-193-9-109-113nogr-1744Research ArticleДИСКУССИЯDISCUSSIONСмена парадигмы ведения пациентов с инфекцией H. pyloriParadigm shift in the management of patients with H. pylori infectionТряпышкоА. А.TryapyshkoA. A.

Тряпышко Андрей Андреевич - ассистент кафедры факультетской терапии.

Смоленск, Россия, 214019, ул. Крупской 28

Andrey A. Tryapyshko - Assistant of the Department of Faculty Therapy.

28, Krupskaya St., 214019, Smolensk

https://orcid.org/0000-0002-6144-3919ДехничН. Н.DekhnichN. N.

Дехнич Наталья Николаевна - доктор медицинских наук, доцент кафедры факультетской терапии, доцент.

Смоленск, Россия, 214019, ул. Крупской 28

Nataliya N. Dekhnich - Dr. of Med. Sci., Associate Professor of the Department of Faculty Therapy.

28, Krupskaya St., 214019, Smolensk

n.dekhnich@mail.ruФГБОУ ВО Смоленский государственный медицинский университет Минздрава России ассистент кафедры факультетской терапииРоссияSmolensk State Medical University of the Ministry of Health of RussiaRussian FederationФГБОУ ВО Смоленский государственный медицинский университет Минздрава РоссииРоссияSmolensk State Medical University of the Ministry of Health of RussiaRussian Federation20211112202109109113Copyright © Тряпышко А.А., Дехнич Н.Н., 20212021Тряпышко А.А., Дехнич Н.Н.Tryapyshko A.A., Dekhnich N.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1744

Инфекция H. pylori широко распространена в мире. Она вызывает прогрессирующее повреждение слизистой оболочки желудка и ассоциирована с такими состояниями, как хронический гастрит, язвенная болезнь, атрофический гастрит, кишечная метаплазия и рак желудка. Гастрит, ассоциированный с инфекцией H. pylori, - инфекционное заболевание. Основной путь передачи инфекции - внутрисемейный. Новая стратегия «скрининг и лечение всех членов семьи» в регионах с высокой распространённостью H. pylori, в том числе в России, обоснована и направлена на снижение риска распространения инфекции в популяции, уменьшение прогрессирования изменений слизистой оболочки желудка и возникновения рака желудка.

Helicobacter pyloriвнутрисемейная инфекцияскрининг и лечение всех членов семьиHelicobacter pyloriintra-familial infectionscreening and treatment of all family membersReferencesHooi J. K. Y., Lai W. Y., Ng W.K et al. Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. Gastroenterology, 2017;153(2):420-429. doi: 10.1053/j.gastro.2017.04.022.Hooi J. K. Y., Lai W. Y., Ng W.K et al. Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. Gastroenterology, 2017;153(2):420-429. doi: 10.1053/j.gastro.2017.04.022.Рахманин Ю. А., Зыкова И. Е., Федичкина Т. П. и соавт. Изучение территориального распределения инфицированности Helicobacter pylori трудоспособного населения г. Москвы в ходе диспансеризации производственных контингентов. Гигиена и санитария, 2013, Т. 92(5), С. 79-82Rakhmanin Yu.A., Zykova I. Ye., Fedichkina T. P. et al. Regional distribution of Helicobacter pylori infection of able-bodied population of Moscow at medical examination of the production staff. Gigiyena i sanitariya, 2013;92(5):79-82. (in Russian)Сварваль А. В., Ферман Р. С., Жебрун А. Б. Изучение динамики превалентности инфекции, обусловленной Helicobacter pylori, среди различных возрастных групп населения Санкт-Петербурга в 2007-2011 годах. Инфекция и иммунитет. 2012, Т. 2(4):741-746Svarval A.V., Ferman R. S., Zhebrun A. B. Dynamics of prevalence of the Helicobacter pylori-caused infection in various age groups of St. Petersburg population in 2007-2011. Infektion i immunitet. 2012;2(4):741-746. (in Russian)Reshetnikov O.V., Kurilovich S. A., Krotov S. A., Krotova V. A. Helicobacter pylori-associated infection Siberian populations Byul. SO RAMN. 2010, N.30 (2), pp.88-93. (in Russian)@@ Решетников О. В., Курилович С. А., Кротов С. А., Кротова В. А. Хеликобактерная инфекция в сибирских популяциях Бюл. СО РАМН 2010, № 30 (2), pp.88-93.Reshetnikov O.V., Kurilovich S. A., Krotov S. A., Krotova V. A. Helicobacter pylori-associated infection Siberian populations Byul. SO RAMN. 2010, N.30 (2), pp.88-93. (in Russian)@@ Решетников О. В., Курилович С. А., Кротов С. А., Кротова В. А. Хеликобактерная инфекция в сибирских популяциях Бюл. СО РАМН 2010, № 30 (2), pp.88-93.Sugano K., Tack J., Kuipers E. J. et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut, 2015;64(9):1353-1367. doi: 10.1136/gutjnl-2015-309252.Sugano K., Tack J., Kuipers E. J. et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut, 2015;64(9):1353-1367. doi: 10.1136/gutjnl-2015-309252.Kayali S., Manfredi M., Gaiani F, et al. Helicobacter pylori, transmission routes and recurrence of infection: state of the art. Acta Biomed. 2018;89(8-S):72-76. doi: 10.23750/abm.v89i8-S.7947.Kayali S., Manfredi M., Gaiani F, et al. Helicobacter pylori, transmission routes and recurrence of infection: state of the art. Acta Biomed. 2018;89(8-S):72-76. doi: 10.23750/abm.v89i8-S.7947.Quaglia N.C., Dambrosio A. Helicobacter pylori: A foodborne pathogen? World Journal of Gastroenterology. 2018 Aug 21;24(31):3472-3487. doi: 10.3748/wjg.v24.i31.3472.Quaglia N.C., Dambrosio A. Helicobacter pylori: A foodborne pathogen? World Journal of Gastroenterology. 2018 Aug 21;24(31):3472-3487. doi: 10.3748/wjg.v24.i31.3472.Fujimura S., Kato S., Kawamura T. Helicobacter pylori in Japanese river water and its prevalence in Japanese children. Letters in Applied Microbiology, 2004;38(6): 517-21. doi: 10.1111/j.1472-765X.2004.01529.x.Fujimura S., Kato S., Kawamura T. Helicobacter pylori in Japanese river water and its prevalence in Japanese children. Letters in Applied Microbiology, 2004;38(6): 517-21. doi: 10.1111/j.1472-765X.2004.01529.x.Parsonnet J., Shmuely H., Haggerty T. Fecal and oral shedding of Helicobacter pylori from healthy infected adults. JAMA. 1999 Dec 15;282(23):2240-5. doi: 10.1001/jama.282.23.2240.Parsonnet J., Shmuely H., Haggerty T. Fecal and oral shedding of Helicobacter pylori from healthy infected adults. JAMA. 1999 Dec 15;282(23):2240-5. doi: 10.1001/jama.282.23.2240.Gebara E.C., Faria C. M., Pannuti C. et al. Persistence of Helicobacter pylori in the oral cavity after systemic eradication therapy. Journal of Clinical Periodontology. 2006;33(5):329-333. doi: 10.1111/j.1600-051X.2006.00915.x.Gebara E.C., Faria C. M., Pannuti C. et al. Persistence of Helicobacter pylori in the oral cavity after systemic eradication therapy. Journal of Clinical Periodontology. 2006;33(5):329-333. doi: 10.1111/j.1600-051X.2006.00915.x.Momtaz H., Dabiri H., Souod N., Gholami M. Study of Helicobacter pylori genotype status in cows, sheep, goats and human beings. BMC Gastroenterology, 2014 Apr 3;14:61. doi: 10.1186/1471-230X-14-61.Momtaz H., Dabiri H., Souod N., Gholami M. Study of Helicobacter pylori genotype status in cows, sheep, goats and human beings. BMC Gastroenterology, 2014 Apr 3;14:61. doi: 10.1186/1471-230X-14-61.Breckan R.K., Paulssen E. J., Asfeldt A. M. et al. The All-Age Prevalence of Helicobacter pylori Infection and Potential Transmission Routes. A Population-Based Study. Helicobacter, 2016;21(6):586-595. doi: 10.1111/hel.12316.Breckan R.K., Paulssen E. J., Asfeldt A. M. et al. The All-Age Prevalence of Helicobacter pylori Infection and Potential Transmission Routes. A Population-Based Study. Helicobacter, 2016;21(6):586-595. doi: 10.1111/hel.12316.Okuda M., Lin Y., Kikuchi S. Helicobacter pylori Infection in Children and Adolescents. Advances in Experimental Medicine and Biology, 2019;1149:107-120. doi: 10.1007/5584_2019_361.Okuda M., Lin Y., Kikuchi S. Helicobacter pylori Infection in Children and Adolescents. Advances in Experimental Medicine and Biology, 2019;1149:107-120. doi: 10.1007/5584_2019_361.Kivi M., Tindberg Y., Sörberg M. et al. Concordance of Helicobacter pylori strains within families. Journal of Clinical Microbiology, 2003;41(12):5604-5608. doi: 10.1128/JCM.41.12.5604-5608.2003.Kivi M., Tindberg Y., Sörberg M. et al. Concordance of Helicobacter pylori strains within families. Journal of Clinical Microbiology, 2003;41(12):5604-5608. doi: 10.1128/JCM.41.12.5604-5608.2003.Yokota S., Konno M., Fujiwara S. et al. Intrafamilial, Preferentially Mother-to-Child and Intraspousal, Helicobacter pylori Infection in Japan Determined by Mutilocus Sequence Typing and Random Amplified Polymorphic DNA Fingerprinting. Helicobacter. 2015;20(5):334-342. doi: 10.1111/hel.12217. Epub 2015 Feb 9.Yokota S., Konno M., Fujiwara S. et al. Intrafamilial, Preferentially Mother-to-Child and Intraspousal, Helicobacter pylori Infection in Japan Determined by Mutilocus Sequence Typing and Random Amplified Polymorphic DNA Fingerprinting. Helicobacter. 2015;20(5):334-342. doi: 10.1111/hel.12217. Epub 2015 Feb 9.Osaki T., Konno M., Yonezawa H. et al. Analysis of intra-familial transmission of Helicobacter pylori in Japanese families. Journal of Medical Microbiology. 2015 Jan;64(Pt 1):67-73. doi: 10.1099/jmm.0.080507-0.Osaki T., Konno M., Yonezawa H. et al. Analysis of intra-familial transmission of Helicobacter pylori in Japanese families. Journal of Medical Microbiology. 2015 Jan;64(Pt 1):67-73. doi: 10.1099/jmm.0.080507-0.Mahachai V., Vilaichone R. K., Pittayanon R. et al. Helicobacter pylori management in ASEAN: The Bangkok consensus report. Journal of Gastroenterology and Hepatology. 2018;33(1):37-56. doi: 10.1111/jgh.13911.Mahachai V., Vilaichone R. K., Pittayanon R. et al. Helicobacter pylori management in ASEAN: The Bangkok consensus report. Journal of Gastroenterology and Hepatology. 2018;33(1):37-56. doi: 10.1111/jgh.13911.Yu Y., Su L., Wang X et al. Association between Helicobacter pylori infection and pathological changes in the gastric mucosa in Chinese children. Journal of Internal Medicine. 2014;53(2):83-8. doi: 10.2169/internalmedicine.53.0918.Yu Y., Su L., Wang X et al. Association between Helicobacter pylori infection and pathological changes in the gastric mucosa in Chinese children. Journal of Internal Medicine. 2014;53(2):83-8. doi: 10.2169/internalmedicine.53.0918.Schacher K., Spotts H., Correia C. et al. Individual and household correlates of Helicobacter pylori infection among Young Ethiopian children in Ziway, Central Ethiopia. BMC Infectious Diseases. 2020;25 20(1):310. doi: 10.1186/s12879-020-05043-1.Schacher K., Spotts H., Correia C. et al. Individual and household correlates of Helicobacter pylori infection among Young Ethiopian children in Ziway, Central Ethiopia. BMC Infectious Diseases. 2020;25 20(1):310. doi: 10.1186/s12879-020-05043-1.Fujimoto Y., Furusyo N., Toyoda K. et al. Intrafamilial transmission of Helicobacter pylori among the population of endemic areas in Japan. Helicobacter. 2007;12(2):170-176. doi: 10.1111/j.1523-5378.2007.00488.x.Fujimoto Y., Furusyo N., Toyoda K. et al. Intrafamilial transmission of Helicobacter pylori among the population of endemic areas in Japan. Helicobacter. 2007;12(2):170-176. doi: 10.1111/j.1523-5378.2007.00488.x.Kato M., Ota H., Okuda M. et al. Guidelines for the management of Helicobacter pylori infection in Japan: 2016 Revised Edition. Helicobacter. 2019;24(4): e.12597. doi: 10.1111/hel.12597.Kato M., Ota H., Okuda M. et al. Guidelines for the management of Helicobacter pylori infection in Japan: 2016 Revised Edition. Helicobacter. 2019;24(4): e.12597. doi: 10.1111/hel.12597.Yan T.L., Hu Q. D., Zhang Q. et al. National rates of Helicobacter pylori recurrence are significantly and inversely correlated with human development index. Alimentary Pharmacology & Therapeutics. 2013 May;37(10):963-8. doi: 10.1111/apt.12293.Yan T.L., Hu Q. D., Zhang Q. et al. National rates of Helicobacter pylori recurrence are significantly and inversely correlated with human development index. Alimentary Pharmacology & Therapeutics. 2013 May;37(10):963-8. doi: 10.1111/apt.12293.Kim M.S., Kim N., Kim S. E. et al. Long-term follow-up Helicobacter pylori reinfection rate and its associated factors in Korea. Helicobacter. 2013 Apr;18(2):135-42. doi: 10.1111/hel.12018.Kim M.S., Kim N., Kim S. E. et al. Long-term follow-up Helicobacter pylori reinfection rate and its associated factors in Korea. Helicobacter. 2013 Apr;18(2):135-42. doi: 10.1111/hel.12018.Morgan D.R., Torres J., Sexton R. et al. Risk of recurrent Helicobacter pylori infection 1 year after initial eradication therapy in 7 Latin American communities. JAMA, 2013;309(6): 578-586. doi: 10.1001/jama.2013.311.Morgan D.R., Torres J., Sexton R. et al. Risk of recurrent Helicobacter pylori infection 1 year after initial eradication therapy in 7 Latin American communities. JAMA, 2013;309(6): 578-586. doi: 10.1001/jama.2013.311.Xue Y., Zhou L. Y., Lu H. P., Liu J. Z. Recurrence of Helicobacter pylori infection: incidence and influential factors. Chinese Medical Journal (Engl). 2019;132(7):765-771. doi: 10.1097/CM9.0000000000000146.Xue Y., Zhou L. Y., Lu H. P., Liu J. Z. Recurrence of Helicobacter pylori infection: incidence and influential factors. Chinese Medical Journal (Engl). 2019;132(7):765-771. doi: 10.1097/CM9.0000000000000146.Sari Y.S., Can D., Tunali V. et al. H pylori: Treatment for the patient only or the whole family? World Journal of Gastroenterology. 2008 Feb 28;14(8):1244-7. doi: 10.3748/wjg.14.1244.Sari Y.S., Can D., Tunali V. et al. H pylori: Treatment for the patient only or the whole family? World Journal of Gastroenterology. 2008 Feb 28;14(8):1244-7. doi: 10.3748/wjg.14.1244.Liu W.Z., Xie Y., Lu H. et al. Fifth Chinese National Consensus Report on the management of Helicobacter pylori infection. Helicobacter. 2018 Apr;23(2): e12475. doi: 10.1111/hel.12475.Liu W.Z., Xie Y., Lu H. et al. Fifth Chinese National Consensus Report on the management of Helicobacter pylori infection. Helicobacter. 2018 Apr;23(2): e12475. doi: 10.1111/hel.12475.Malfertheiner P., Megraud F., O’Morain C.A et al. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut. 2017 Jan;66(1):6-30. doi: 10.1136/gutjnl-2016-312288.Malfertheiner P., Megraud F., O’Morain C.A et al. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut. 2017 Jan;66(1):6-30. doi: 10.1136/gutjnl-2016-312288.Rokkas T., Sechopoulos P., Pistiolas D., et al. Helicobacter pylori infection and gastric histology in first-degree relatives of gastric cancer patients: a meta-analysis. European Journal of Gastroenterology & Hepatology. 2010 Sep;22(9):1128-33. doi: 10.1097/MEG.0b013e3283398d37.Rokkas T., Sechopoulos P., Pistiolas D., et al. Helicobacter pylori infection and gastric histology in first-degree relatives of gastric cancer patients: a meta-analysis. European Journal of Gastroenterology & Hepatology. 2010 Sep;22(9):1128-33. doi: 10.1097/MEG.0b013e3283398d37.Ding S. Z. Global whole family based-Helicobacter pylori eradication strategy to prevent its related diseases and gastric cancer. World Journal of Gastroenterology, 2020 Mar 14;26(10):995-1004. doi: 10.3748/wjg.v26.i10.995.Ding S. Z. Global whole family based-Helicobacter pylori eradication strategy to prevent its related diseases and gastric cancer. World Journal of Gastroenterology, 2020 Mar 14;26(10):995-1004. doi: 10.3748/wjg.v26.i10.995.

The authors declare that there are no conflicts of interest present.