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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-192-8-5-117</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-1717</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РЕКОМЕНДАЦИИ НОГР &amp; РНМОТ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GUIDELINES</subject></subj-group></article-categories><title-group><article-title>Функциональные заболевания органов пищеварения. Синдромы перекреста  Клинические рекомендации Российского Научного Медицинского Общества Терапевтов и Научного Общества Гастроэнтерологов России</article-title><trans-title-group xml:lang="en"><trans-title>Functional gastrointestinal disorders. Overlap syndrome Clinical guidelines of the Russian Scientific Medical Society of Internal Medicine and Gastroenterological Scientific Society of Russia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8736-5851</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазебник</surname><given-names>Л. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazebnik</surname><given-names>L. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лазебник Леонид Борисович, вице-президент РНМОТ, Президент НОГР, член президиума Общества врачей России, член президиума Национальной медицинской палаты, д. м. н., профессор, профессор кафедры поликлинической терапии</p><p>ул. Делегатская, 20/1, г. Москва, 127473</p></bio><bio xml:lang="en"><p>Leonid B. Lazebnik, Vice President of the RSMST, President of theGSSR, Doctor of Medical Sciences, Professor of the Department of Polyclinic Therapy</p><p>Delegatskay str., 20/1, Moscow, 127473</p><p>Scopus Author ID: 7005446863</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голованова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Golovanova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Голованова Елена Владимировна, д. м. н., профессор кафедры поликлинической терапии</p><p>ул. Делегатская, 20/1, г. Москва, 127473</p></bio><bio xml:lang="en"><p>Elena V. Golovanova, Doctor of Medical Sciences, Professor of the Department of Polyclinic Therapy</p><p>Delegatskay str., 20/1, Moscow, 127473</p><p>Scopus Author ID: 6603930365</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Волель</surname><given-names>Б. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Volel</surname><given-names>B. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Волель Беатриса Альбертовна, д. м. н., профессор, директор Института клинической медицины им. Н. В. Склифосовского</p><p> ул. Трубецкая, д. 8, стр. 2, Москва 119991</p></bio><bio xml:lang="en"><p>Beatrice A. Volel, Doctor of Medical Sciences, Professor, Director of the Institute of Clinical Medicine named aft er V.I. N.V. Sklifosovsky</p><p>Trubetskaya St. 8/2, Moscow, 119991</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корочанская</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korochanskaya</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Корочанская Наталья Всеволодовна, д. м. н., профессор, руководитель гастроэнтерологического центра; профессор кафедры хирургии № 1 с курсами абдоминальной хирургии и гастроэнтерологии Факультета повышения квалификации и последипломной подготовки специалистов (ФПК и ППС); главный гастроэнтеролог Краснодарского края; Главный гастроэнтеролог Южного федерального округа (ЮФО)</p><p>ул. Митрофана Седина, 4, Краснодар, Краснодарский край,350063; ул. Красных Партизан, 6/2, г. Краснодар, 350012</p></bio><bio xml:lang="en"><p>Nataliya V. Korochanskaya, Doctor of Medical Sci ences, Professor of the Department of Surgery No. 1 of the Federal Penitentiary Service and PPP; chief gastroenterologist of Krasnodar region; Chief gastroenterologist of the Southern Federal District constituencies</p><p>st. Mitrofana Sedina, 4, Krasnodar, Krasnodar Territory, 350063; st. Red Partisans, 6/2, Krasnodar, 350012</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лялюкова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lyalyukova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лялюкова Елена Александровна, д. м. н., профессор кафедры внутренних болезней и семейной медицины ПДО (последипломного образования)</p><p>644099, Омская область, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>Elena A. Lyalyukova, gastroenterologist, professor of the Department of Internal Medicine and Family Medicine, DPO</p><p>st. Lenin, 12, Omsk Region, Omsk, 644099</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мокшина</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mokshina</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мокшина Маргарита Вадимовна, к. м. н., доцент института терапии и инструментальной диагностики; главный внештатный гастроэнтеролог Управления по здравоохранению г. Владивосток</p><p>690002 г.Владивосток, пр. Остякова, 2</p></bio><bio xml:lang="en"><p>Margarita V. Mokshina, Ph.D. (Medical), Associate Professor at the Institute of Th erapy and Instrumental Diagnostics; Chief freelance gastroenterologist of the Vladivostok Health Department</p><p>690002 Vladivistok, Ostjakova st., 2</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мехтиев</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Mekhtiev</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мехтиев Сабир Насрединович, д. м. н., профессор; Заведующий отделением гастроэнтерологии Института профессиональной переподготовки</p><p>197022, г. Санкт- Петербург, ул. Льва Толстого, д. 6–8</p></bio><bio xml:lang="en"><p>Sabir N. Mehtiev, Doctor of Medical Sciences, Professor, Head of the Department of Gastroenterology, Institute of Professional Retraining</p><p>L’va Tolstogo str. 6–8, Saint Petersburg, 197022</p></bio><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мехтиева</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mekhtieva</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мехтиева Ольга Александровна, к. м. н., доцент кафедры госпитальной терапии</p><p>197022, г. Санкт- Петербург, ул. Льва Толстого, д. 6–8</p></bio><bio xml:lang="en"><p>Ol'ga A. Mekhtieva, Candidate of Medical Sciences, Associate Professor of the Department of Hospital Therapy</p><p>L’va Tolstogo str. 6–8, Saint Petersburg, 197022</p></bio><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мецаева</surname><given-names>З. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Metsaeva</surname><given-names>Z. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мецаева Зарина Валерьевна, к. м. н., врач высшей квалификационной категогии; зав. отделением гастроэнтерологии; главный внештатный гастроэнтеролог МЗ Республики</p><p>362025, г. Владикавказ, ул. Бородинская 9 «а»</p></bio><bio xml:lang="en"><p>Zarina V. Metsaeva, Ph.D. (Medical), doctor of the highest qualifi cation category; head department of gastroenterology; chief freelance gastroenterologist of the Ministry of Health of the Republic</p><p>362025, Vladicaucas sity, Borodinskaja st, 9a</p></bio><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петелин</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Petelin</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петелин Дмитрий Сергеевич, к. м. н., сотрудник Института клинической медицины им. Н. В. Склифосовского</p><p>ул. Трубецкая, д. 8, стр. 2, Москва, 119991</p></bio><bio xml:lang="en"><p>Dmitry S. Petelin, Candidate of Medical Sciences, employee of the Institute of Clinical Medicine. N.V. Sklifosovsky</p><p>Trubetskaya St. 8/2, Moscow, 119991</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симаненков</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Simanenkov</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Симаненков Владимир Ильич, д. м. н., профессор, Заслуженный работник Высшей школы РФ; профессор Кафедры внутренних болезней, клинической фармакологии и нефрологии</p><p>191015, Санкт- Петербург, Кирочная ул., 41</p></bio><bio xml:lang="en"><p>Vladimir I. Simanenkov, Doctor of Medical Sciences, Professor, Honored Worker of the Higher School of the Russian Federation; Professor of the Departmentof Internal Medicine, Clinical Pharmacology and Nephrology</p><p>191015, St. Petersburg, Kirochnaya street, 41</p></bio><xref ref-type="aff" rid="aff-8"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0331-0963</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ситкин</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sitkin</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ситкин Станислав Игоревич, к. м. н., доцент кафедры пропедевтики внутренних болезней, гастроэнтерологии и диетологии имени С. М. Рысса</p><p>191015, Санкт- Петербург, Кирочная ул., 41</p></bio><bio xml:lang="en"><p>Stanislav I. Sitkin, Ph.D., MMS, associate professor of the Department of Propedeutics of Internal Diseases, Gastroenterology and Dietetics named after S. M. Ryss</p><p>191015, St. Petersburg, Kirochnaya street, 41</p><p>Scopus ID: 6603071466</p></bio><xref ref-type="aff" rid="aff-8"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черемушкин</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Cheremushkin</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черемушкин Сергей Викторович, к. м. н., доцент кафедры пропедевтики внутренних болезней и гастроэнтерологии; главный терапевт центральной дирекции здравоохранения – филиала ОАО «РЖД»; заведующий отделением, врач-терапевт высшей квалификационной категории </p><p>ул. Делегатская, 20/1, г. Москва, 127473</p></bio><bio xml:lang="en"><p>Sergey V. Cheremushkin, Candidate of Medical Sciences, Associate Professor of the Department of Propedeutics of Internal Diseases and Gastroenterology;chief physician of the central directorate of health care – a branch of Russian Railways; head of the department, therapist of the highest qualifi cation category</p><p>Delegatskay str., 20/1, Moscow, 127473</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черногорова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernogorova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черногорова Марина Викторовна, д. м. н., главный врач; профессор кафедры гастроэнтерологии Факультета усовершенствования врачей (ФУВ) </p><p>129110, г. Москва, ул. Щепкина 61/2;  г. Подольск, ул. Литейная, д. 40</p></bio><bio xml:lang="en"><p>Marina V. Chernogorova, MD, DSc, Chief Physician; Professor of the Department of Gastroenterology of the Faculty of Advanced Training for Doctors (FUV)</p><p>129110, Moscow;  Podolsk, st. Liteinaya, 40, </p></bio><xref ref-type="aff" rid="aff-9"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7308-7280</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хавкин</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Khavkin</surname><given-names>А. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хавкин Анатолий Ильич, д. м. н., проф., гл. научн. сотр. отдела гастроэнтерологии Научно- исследовательского клинического института педиатрии имени академика Ю. Е. Вельтищева</p><p>г. Москва, ул. Талдомская, д. 2</p></bio><bio xml:lang="en"><p>Anatoly I. Khavkin, MD, PhD, Dr Sci (Med), Prof., Ch. Chief Researcher of the Department of Gastroenterology</p><p>Moscow, st. Taldomskaya, 2</p></bio><xref ref-type="aff" rid="aff-10"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский государственный медико- стоматологический университет им. А. И. Евдокимова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education “A. I. Yevdokimov Moscow State University of Medicine and Dentistry” of the Ministry of Healthcare of the Russion Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый МГМУ им. И. М. Сеченова, Минздрава РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I. M. Sechenov First Moscow Medical State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО Кубанский Государственный медицинский университет Минздрава России;  Государственное бюджетное учреждение здравоохранения «Краевая клиническая больница № 2» Министерства здравоохранения Краснодарского края</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education “Kuban State Medical University” Health Ministry of Russian Federation; State Budgetary Institution of Health Care “Region Clinic Hospital Nr 2” Health Ministry of Krasnodar Region</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSBEI VO “Omsk State Medical University” of the Ministry of Health</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Институт терапии и инструментальной диагностики ФГБОУ Тихоокеанский государственный медицинский университет МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of therapy a. instrumental diagnostics of FSBEI VO “Pacifi c State Medical Unuversity”</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>Первый Санкт- Петербургский государственный медицинский университет им. акад. И. П. Павлова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pavlov First Saint Petersburg State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>Республиканская клиническая больница Республики Северная Осетия- Алания</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Republican clinical hospital of Health Care Ministry of Northen Ossetia- Alania Republic</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-8"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Северо- Западный государственный медицинский университет им. И. И. Мечникова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North- Western state medical University named after I. I. Mechnikov, Ministry of health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-9"><aff xml:lang="ru"><institution>ГБУЗ МО МОНИКИ им. М. Ф. Владимирского; ГБУЗ МО «Подольская городская клиническая больница № 3»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow regional research and clinical Institute of M. F. Vladimirsky; GBUZ MO “Podolsk City Clinical Hospital No. 3”</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-10"><aff xml:lang="ru"><institution>ФГБАУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSBAI HPE “N. I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>18</day><month>11</month><year>2021</year></pub-date><volume>0</volume><issue>8</issue><fpage>5</fpage><lpage>117</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лазебник Л.Б., Голованова Е.В., Волель Б.А., Корочанская Н.В., Лялюкова Е.А., Мокшина М.В., Мехтиев С.Н., Мехтиева О.А., Мецаева З.В., Петелин Д.С., Симаненков В.И., Ситкин С.И., Черемушкин С.В., Черногорова М.В., Хавкин А.И., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Лазебник Л.Б., Голованова Е.В., Волель Б.А., Корочанская Н.В., Лялюкова Е.А., Мокшина М.В., Мехтиев С.Н., Мехтиева О.А., Мецаева З.В., Петелин Д.С., Симаненков В.И., Ситкин С.И., Черемушкин С.В., Черногорова М.В., Хавкин А.И.</copyright-holder><copyright-holder xml:lang="en">Lazebnik L.B., Golovanova E.V., Volel B.A., Korochanskaya N.V., Lyalyukova E.A., Mokshina M.V., Mekhtiev S.N., Mekhtieva O.A., Metsaeva Z.V., Petelin D.S., Simanenkov V.I., Sitkin S.I., Cheremushkin S.V., Chernogorova M.V., Khavkin А.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/1717">https://www.nogr.org/jour/article/view/1717</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>Функциональные заболевания органов пищеварения</kwd><kwd>функциональная изжога</kwd><kwd>функциональная диспепсия</kwd><kwd>билиарные дисфункции</kwd><kwd>синдром раздраженного кишечника</kwd><kwd>синдром перекреста функциональных заболеваний органов пищеварения</kwd><kwd>overlap- syndrome</kwd><kwd>функциональная абдоминальная боль</kwd><kwd>функциональное расстройство</kwd><kwd>билиарная боль</kwd><kwd>синдром избыточного бактериального роста</kwd><kwd>синдром повышенной проницаемости слизистых</kwd><kwd>синдром повышенной эпителиальной проницаемости</kwd></kwd-group><kwd-group xml:lang="en"><kwd>functional diseases of the digestive system</kwd><kwd>functional heartburn</kwd><kwd>functional dyspepsia</kwd><kwd>biliary dysfunction</kwd><kwd>irritable bowel syndrome</kwd><kwd>overlap syndrome</kwd><kwd>functional abdominal pain</kwd><kwd>functional disorder</kwd><kwd>biliary pain</kwd><kwd>bacterial overgrowth syndrome</kwd><kwd>mucosal permeability syndrome</kwd><kwd>syndrome increased epithelial permeability</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Functional Gastroenterology: Assessing and Addressing the Causes of Functional Gastrointestinal Disorders. 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