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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-191-7-68-73</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-1702</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>S-адеметионин в терапии неалкогольной жировой болезни печени (НАЖБП)</article-title><trans-title-group xml:lang="en"><trans-title>S-ademetionine in the treatment of non-alcoholic fatty liver disease (NAFLD)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корочанская</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korochanskaya</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">nvk-gastro@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7420-0553</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дурлештер</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Durleshter</surname><given-names>V. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Басенко</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bacenko</surname><given-names>M. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Кубанский государственный медицинский университет МЗ РФ»; ГБУЗ «Краевая клиническая больница № 2» МЗ Краснодарского края</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSBEI HE “Kuban state medical university MHC RF”; SBIHC “Region clinic hospital N 2” MHC of Krasnodar region</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>27</day><month>09</month><year>2021</year></pub-date><volume>0</volume><issue>7</issue><fpage>68</fpage><lpage>73</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Корочанская Н.В., Дурлештер В.М., Басенко М.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Корочанская Н.В., Дурлештер В.М., Басенко М.А.</copyright-holder><copyright-holder xml:lang="en">Korochanskaya N.V., Durleshter V.M., Bacenko M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/1702">https://www.nogr.org/jour/article/view/1702</self-uri><abstract><p>Представлен обзор экспериментальных и клинических исследований, обосновывающих актуальность включения S-адемитионина в комплексную терапию НАЖБП, направленную на коррекцию оксидативного стресса в гепатоцитах и трансформацию пищевого поведения лиц с избыточной массой тела при развитии депрессивных расстройств.</p></abstract><trans-abstract xml:lang="en"><p>The experimental and clinic data supporting S- ademetionin application in NAFLD complex therapy were presented. The therapy corrects an oxidative stress in hepatocytes and transforms the nutrition behavior in patients with excessive body weight when depressive syndrome is developed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>S-адемитионин</kwd><kwd>неалкогольная жировая болезнь печени</kwd></kwd-group><kwd-group xml:lang="en"><kwd>S- ademetionin</kwd><kwd>non-alcoholic fatty liver disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Malhi H, Gores GJ. Cellular and molecular mechanisms of liver injury. Gastroenterology. 2008;134 (6):1641-1654.</mixed-citation><mixed-citation xml:lang="en">Malhi H, Gores GJ. Cellular and molecular mechanisms of liver injury. Gastroenterology. 2008;134 (6):1641-1654.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Lieber CS. S-adenosyl-L-methionine: its role in the treatment of liver disorders. Am J ClinNutr. 2002;76 (5):1183S-1187S.</mixed-citation><mixed-citation xml:lang="en">Lieber CS. S-adenosyl-L-methionine: its role in the treatment of liver disorders. Am J ClinNutr. 2002;76 (5):1183S-1187S.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez-Chantar ML, Garcia-Trevijano ER, Latasa MU, Perez-Mato I, Sanchez del Pino MM, Corrales FJ, et al. Importance of a deficiency in Sadenosyl-L-methionine synthesis in the pathogenesis of liver injury. Am J ClinNutr. 2002;76 (5):1177S-1182S.</mixed-citation><mixed-citation xml:lang="en">Martinez-Chantar ML, Garcia-Trevijano ER, Latasa MU, Perez-Mato I, Sanchez del Pino MM, Corrales FJ, et al. Importance of a deficiency in Sadenosyl-L-methionine synthesis in the pathogenesis of liver injury. Am J ClinNutr. 2002;76 (5):1177S-1182S.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Anstee QM, Daly AK, Day CP. Genetics of alcoholic and nonalcoholic fatty liver disease. Semin Liver Dis. 2011;31 (2):128-146.</mixed-citation><mixed-citation xml:lang="en">Anstee QM, Daly AK, Day CP. Genetics of alcoholic and nonalcoholic fatty liver disease. Semin Liver Dis. 2011;31 (2):128-146.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Plauth M, Cabre E, Riggio O, Assis-Camilo M, Pirlich M, Kondrup J, et al.ESPEN guidelines on enteral nutrition: liver disease. ClinNutr. 2006;25(2):285-294.</mixed-citation><mixed-citation xml:lang="en">Plauth M, Cabre E, Riggio O, Assis-Camilo M, Pirlich M, Kondrup J, et al.ESPEN guidelines on enteral nutrition: liver disease. ClinNutr. 2006;25(2):285-294.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez-Chantar ML, Garcia-Trevijano ER, Latasa MU, Perez-Mato I, Sanchez delPino MM, Corrales FJ, et al. Importance of a deficiency in adenosyl-L-methionine synthesis in the pathogenesis of liver injury. Am J ClinNutr. 2002;76 (5):1177S-1182S.</mixed-citation><mixed-citation xml:lang="en">Martinez-Chantar ML, Garcia-Trevijano ER, Latasa MU, Perez-Mato I, Sanchez delPino MM, Corrales FJ, et al. Importance of a deficiency in adenosyl-L-methionine synthesis in the pathogenesis of liver injury. Am J ClinNutr. 2002;76 (5):1177S-1182S.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mato JM, Lu SC. Role of S-adenosyl-L-methionine in liver health and injury. Hepatology. 2007;45 (5):1306-1312.</mixed-citation><mixed-citation xml:lang="en">Mato JM, Lu SC. Role of S-adenosyl-L-methionine in liver health and injury. Hepatology. 2007;45 (5):1306-1312.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Purohit V, Abdelmalek MF, Barve S, Benevenga NJ, Halsted CH, Kaplowitz N, et al. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J ClinNutr. 2007;86 (1):14-24.</mixed-citation><mixed-citation xml:lang="en">Purohit V, Abdelmalek MF, Barve S, Benevenga NJ, Halsted CH, Kaplowitz N, et al. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J ClinNutr. 2007;86 (1):14-24.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Sanyal AJ. American gastroenterological A. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology. 2002;123(5):1705-1725.</mixed-citation><mixed-citation xml:lang="en">Sanyal AJ. American gastroenterological A. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology. 2002;123(5):1705-1725.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Marchesini G, Brizi M, Morselli-Labate AM, Bianchi G, Bugianesi E, McCullough AJ, et al. Association of nonalcoholic fatty liver disease withinsulin resistance. Am J Med. 1999;107 (5):450-455.</mixed-citation><mixed-citation xml:lang="en">Marchesini G, Brizi M, Morselli-Labate AM, Bianchi G, Bugianesi E, McCullough AJ, et al. Association of nonalcoholic fatty liver disease withinsulin resistance. Am J Med. 1999;107 (5):450-455.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of fortytwo patients for up to 21 years. Hepatology. 1990;11 (1):74-80.</mixed-citation><mixed-citation xml:lang="en">Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of fortytwo patients for up to 21 years. Hepatology. 1990;11 (1):74-80.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology. 2007;45 (6):1366-1374.</mixed-citation><mixed-citation xml:lang="en">Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology. 2007;45 (6):1366-1374.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Anstee QM, Concas D, Kudo H, Levene A, Pollard J, Charlton P, et al. Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis. J Hepatol. 2010;53 (3):542-550.</mixed-citation><mixed-citation xml:lang="en">Anstee QM, Concas D, Kudo H, Levene A, Pollard J, Charlton P, et al. Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis. J Hepatol. 2010;53 (3):542-550.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Farrell GC, Larter CZ, Hou JY, Zhang RH, Yeh MM, Williams J, et al. Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression. J Gastroenterol Hepatol. 2009;24 (3):443-452.</mixed-citation><mixed-citation xml:lang="en">Farrell GC, Larter CZ, Hou JY, Zhang RH, Yeh MM, Williams J, et al. Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression. J Gastroenterol Hepatol. 2009;24 (3):443-452.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest. 2007;117 (3):539-54</mixed-citation><mixed-citation xml:lang="en">Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest. 2007;117 (3):539-54</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Lieber CS, Packer L. S-adenosylmethionine: molecular, biological, and clinical aspects - an introduction. Am J ClinNutr. 2002;76 (5):1148S-1150S.</mixed-citation><mixed-citation xml:lang="en">Lieber CS, Packer L. S-adenosylmethionine: molecular, biological, and clinical aspects - an introduction. Am J ClinNutr. 2002;76 (5):1148S-1150S.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ou X, Yang H, Ramani K, Ara AI, Chen H, Mato JM, et al. Inhibition of human betaine-homocysteine methyl transferase expression by S-adenosylmethionine and methylthioadenosine. Biochem. J. 2007;401 (1):87-96.</mixed-citation><mixed-citation xml:lang="en">Ou X, Yang H, Ramani K, Ara AI, Chen H, Mato JM, et al. Inhibition of human betaine-homocysteine methyl transferase expression by S-adenosylmethionine and methylthioadenosine. Biochem. J. 2007;401 (1):87-96.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Gil B, Casado M, Pajares MA, Bosca L, Mato JM, Martin-Sanz P, et al. Differential expression pattern of S-adenosylmethionine synthetases oenzymes during rat liver development. Hepatology. 1996;24 (4):876-881.</mixed-citation><mixed-citation xml:lang="en">Gil B, Casado M, Pajares MA, Bosca L, Mato JM, Martin-Sanz P, et al. Differential expression pattern of S-adenosylmethionine synthetases oenzymes during rat liver development. Hepatology. 1996;24 (4):876-881.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Jaeschke H. Reactive oxygen and mechanisms of inflammatory liver injury: present concepts. J Gastroenterol Hepatol. 2011;26 (Suppl. 1):173-179.</mixed-citation><mixed-citation xml:lang="en">Jaeschke H. Reactive oxygen and mechanisms of inflammatory liver injury: present concepts. J Gastroenterol Hepatol. 2011;26 (Suppl. 1):173-179.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Mato JM, Corrales FJ, Lu SC, Avila MA. S-adenosylmethionine: a control switch that regulates liver function. FASEB J. 2002;16 (1):15-26.</mixed-citation><mixed-citation xml:lang="en">Mato JM, Corrales FJ, Lu SC, Avila MA. S-adenosylmethionine: a control switch that regulates liver function. FASEB J. 2002;16 (1):15-26.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Song Z, Zhou Z, Chen T, Hill D, Kang J, Barve S, et al. S-denosylmethionine (SAMe) protects against acute alcohol induced hepatotoxicity in mice. J Nutr Biochem. 2003;14 (10):591-597.</mixed-citation><mixed-citation xml:lang="en">Song Z, Zhou Z, Chen T, Hill D, Kang J, Barve S, et al. S-denosylmethionine (SAMe) protects against acute alcohol induced hepatotoxicity in mice. J Nutr Biochem. 2003;14 (10):591-597.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia-Ruiz C, Morales A, Colell A, Ballesta A, Rodes J, Kaplowitz N, et al.Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes. Hepatology. 1995;21(1):207-214.</mixed-citation><mixed-citation xml:lang="en">Garcia-Ruiz C, Morales A, Colell A, Ballesta A, Rodes J, Kaplowitz N, et al.Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes. Hepatology. 1995;21(1):207-214.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Colell A, Garcia-Ruiz C, Miranda M, Ardite E, Mari M, Morales A, et al. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology. 1998;115(6):1541-1551.</mixed-citation><mixed-citation xml:lang="en">Colell A, Garcia-Ruiz C, Miranda M, Ardite E, Mari M, Morales A, et al. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology. 1998;115(6):1541-1551.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Colell A, Garcнa-Ruiz C, Morales A, Ballesta A, Ookhtens M, Rodйs J, et al. Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and adenosyl- L-methionine. Hepatology. 1997;26 (3):699-708.</mixed-citation><mixed-citation xml:lang="en">Colell A, Garcнa-Ruiz C, Morales A, Ballesta A, Ookhtens M, Rodйs J, et al. Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and adenosyl- L-methionine. Hepatology. 1997;26 (3):699-708.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Vendemiale G, Altomare E, Trizio T, Le Grazie C, Di Padova C, Salerno MT, et al. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol. 1989;24 (4):407-415</mixed-citation><mixed-citation xml:lang="en">Vendemiale G, Altomare E, Trizio T, Le Grazie C, Di Padova C, Salerno MT, et al. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol. 1989;24 (4):407-415</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Finkelstein JD. Methionine metabolism in mammals. J NutrBiochem. 1990; 1:228-37. [PubMed: 15539209]</mixed-citation><mixed-citation xml:lang="en">Finkelstein JD. Methionine metabolism in mammals. J NutrBiochem. 1990; 1:228-37. [PubMed: 15539209]</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Mudd SH, Poole JR. Labile methyl balances for normal humans on various dietary regimens. Metabolism. 1975; 24:721-35. [PubMed: 1128236]</mixed-citation><mixed-citation xml:lang="en">Mudd SH, Poole JR. Labile methyl balances for normal humans on various dietary regimens. Metabolism. 1975; 24:721-35. [PubMed: 1128236]</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Cano A, Buqué X, Martínez-Uña M, Aurrekoetxea I, Menor A, García-Rodríguez JL, Lu SC, et al. Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice. Hepatology. 2011; 54:1975-86. [PubMed: 21837751]</mixed-citation><mixed-citation xml:lang="en">Cano A, Buqué X, Martínez-Uña M, Aurrekoetxea I, Menor A, García-Rodríguez JL, Lu SC, et al. Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice. Hepatology. 2011; 54:1975-86. [PubMed: 21837751]</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Elfhag K, Morey LC. Personality traits and eating behavior in the obese: poor self-control in emotional and external eating but personality assets in restrained eating. Eat Behav. 2008; 2008:285-93. [PubMed: 18549987]</mixed-citation><mixed-citation xml:lang="en">Elfhag K, Morey LC. Personality traits and eating behavior in the obese: poor self-control in emotional and external eating but personality assets in restrained eating. Eat Behav. 2008; 2008:285-93. [PubMed: 18549987]</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Sutin A, Ferrucci L, Zonderman A, Terracciano A. Personality and obesity across the adult life span. J PersSoc Psychol. 2011; 101:579-92. [PubMed: 21744974]</mixed-citation><mixed-citation xml:lang="en">Sutin A, Ferrucci L, Zonderman A, Terracciano A. Personality and obesity across the adult life span. J PersSoc Psychol. 2011; 101:579-92. [PubMed: 21744974]</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Brummett BH, Babyak MA, Williams RB, et al. NEO personality domains and gender predict levels and trends in body mass index over 14 years during midlife. J Res Pers. 2006; 40:222-36.</mixed-citation><mixed-citation xml:lang="en">Brummett BH, Babyak MA, Williams RB, et al. NEO personality domains and gender predict levels and trends in body mass index over 14 years during midlife. J Res Pers. 2006; 40:222-36.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Bodenlos J, Lemon S, Schneider K, August M, Pagoto S. Associations of mood and anxiety disorders with obesity: comparisons by ethnicity. J Psychosom Res. 2011; 71:319-24. [PubMed: 21999975]</mixed-citation><mixed-citation xml:lang="en">Bodenlos J, Lemon S, Schneider K, August M, Pagoto S. Associations of mood and anxiety disorders with obesity: comparisons by ethnicity. J Psychosom Res. 2011; 71:319-24. [PubMed: 21999975]</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Luppino F, de Wit L, Bouvy P, et al. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010; 67:220-9. [PubMed: 20194822]</mixed-citation><mixed-citation xml:lang="en">Luppino F, de Wit L, Bouvy P, et al. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010; 67:220-9. [PubMed: 20194822]</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Pagoto S, Bodenlos JS, Kantor L, et al. Association of major depression and binge eating disorder with weight loss in a clinical setting. Obesity (Silver Spring). 2007; 15:2557-9. [PubMed: 18070746]</mixed-citation><mixed-citation xml:lang="en">Pagoto S, Bodenlos JS, Kantor L, et al. Association of major depression and binge eating disorder with weight loss in a clinical setting. Obesity (Silver Spring). 2007; 15:2557-9. [PubMed: 18070746]</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Smith E, Hay P, Campbell L, Trollor JN. A review of the association between obesity and cognitive function across the lifespan: implications for novel approaches to prevention and treatment. Obes Rev. 2011; 12:740-55. [PubMed: 21991597]</mixed-citation><mixed-citation xml:lang="en">Smith E, Hay P, Campbell L, Trollor JN. A review of the association between obesity and cognitive function across the lifespan: implications for novel approaches to prevention and treatment. Obes Rev. 2011; 12:740-55. [PubMed: 21991597]</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Allan JL, Johnston M, Campbell N. Missed by an inch or a mile? Predicting the size of intentionbehaviour gap from measures of executive control. Psychol Health. 2011; 26:635-50. [PubMed: 21360414]</mixed-citation><mixed-citation xml:lang="en">Allan JL, Johnston M, Campbell N. Missed by an inch or a mile? Predicting the size of intentionbehaviour gap from measures of executive control. Psychol Health. 2011; 26:635-50. [PubMed: 21360414]</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Spitznagel MB, Garcia S, Miller LA, et al. Cognitive function predicts weight loss after bariatric surgery. SurgObesRelat Dis. 2013; 9:453-9. [PubMed: 22133580]</mixed-citation><mixed-citation xml:lang="en">Spitznagel MB, Garcia S, Miller LA, et al. Cognitive function predicts weight loss after bariatric surgery. SurgObesRelat Dis. 2013; 9:453-9. [PubMed: 22133580]</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Weinstein AA, Kallman Price J, Stepanova M, et al. Depression in patients with nonalcoholic fatty liver disease and chronic viral hepatitis B and C. Psychosomatics. 2011; 52:127-32. [PubMed: 21397104]</mixed-citation><mixed-citation xml:lang="en">Weinstein AA, Kallman Price J, Stepanova M, et al. Depression in patients with nonalcoholic fatty liver disease and chronic viral hepatitis B and C. Psychosomatics. 2011; 52:127-32. [PubMed: 21397104]</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Linde JA, Simon GE, Ludman EJ, et al. A randomized controlled trial of behavioral weight loss treatment versus combined weight loss/depression treatment among women with comorbid obesity and depression. Ann Behav Med. 2011; 41:119-30. [PubMed: 20878292]</mixed-citation><mixed-citation xml:lang="en">Linde JA, Simon GE, Ludman EJ, et al. A randomized controlled trial of behavioral weight loss treatment versus combined weight loss/depression treatment among women with comorbid obesity and depression. Ann Behav Med. 2011; 41:119-30. [PubMed: 20878292]</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Pagoto S, Schneider KL, Whited MC, et al. Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the be active trial. Int J Obes. 2013; 37:1-8.</mixed-citation><mixed-citation xml:lang="en">Pagoto S, Schneider KL, Whited MC, et al. Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the be active trial. Int J Obes. 2013; 37:1-8.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Busch AM, Whited MC, Appelhans BM, et al. Reliable change in depression during behavioral weight loss treatment among women with major depression. Obesity (Silver Spring). 2013; 21: E211-8. [PubMed: 23592677]</mixed-citation><mixed-citation xml:lang="en">Busch AM, Whited MC, Appelhans BM, et al. Reliable change in depression during behavioral weight loss treatment among women with major depression. Obesity (Silver Spring). 2013; 21: E211-8. [PubMed: 23592677]</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Janicak PG, Lipinski JD, Comaty JE, et al. S-Adenosylmethionine: a literature review and preliminary report. Ala J Med Sci. 1988;25: 306-13.</mixed-citation><mixed-citation xml:lang="en">Janicak PG, Lipinski JD, Comaty JE, et al. S-Adenosylmethionine: a literature review and preliminary report. Ala J Med Sci. 1988;25: 306-13.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Friedel HA, Goa KL, Benfield P. S-Adenosyl-L-methionine: a review of its therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs. 1989;38:389-416.</mixed-citation><mixed-citation xml:lang="en">Friedel HA, Goa KL, Benfield P. S-Adenosyl-L-methionine: a review of its therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs. 1989;38:389-416.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Bressa GM. S-Adenosyl-L-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. ActaNeurolScand. 1994;154: 7-14.</mixed-citation><mixed-citation xml:lang="en">Bressa GM. S-Adenosyl-L-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. ActaNeurolScand. 1994;154: 7-14.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Brown R, Gerbarg P, Bottiglieri T. S-Adenosylmethionine in the clinical practice of psychiatry, neurology and internal medicine. ClinPract Intern Med. 2000;1:230-41.</mixed-citation><mixed-citation xml:lang="en">Brown R, Gerbarg P, Bottiglieri T. S-Adenosylmethionine in the clinical practice of psychiatry, neurology and internal medicine. ClinPract Intern Med. 2000;1:230-41.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">D Mello C., Swain M. Liver-brain interactions in inflammatory liver diseases: Implications for fatigue and mood disorders. Brain, Behavior, and Immuniti. 2014, vol.35, pp.9-20.</mixed-citation><mixed-citation xml:lang="en">D Mello C., Swain M. Liver-brain interactions in inflammatory liver diseases: Implications for fatigue and mood disorders. Brain, Behavior, and Immuniti. 2014, vol.35, pp.9-20.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma A, Gerbarg P, Bottiglieri T, Massoumi L, Carpenter LL, Lavretsky H, Muskin PR, Brown RP, Mischoulon D; as Work Group of the American Psychiatric Association Council on Research. S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research. J Clin Psychiatry. 2017;78(6): e656-e667. doi:10.4088/JCP.16r11113</mixed-citation><mixed-citation xml:lang="en">Sharma A, Gerbarg P, Bottiglieri T, Massoumi L, Carpenter LL, Lavretsky H, Muskin PR, Brown RP, Mischoulon D; as Work Group of the American Psychiatric Association Council on Research. S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research. J Clin Psychiatry. 2017;78(6): e656-e667. doi:10.4088/JCP.16r11113</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Elliott C, Frith J, Day CP, Jones DE, Newton JL. Functional impairment in alcoholic liver disease and non-alcoholic fatty liver disease is significant and persists over 3 years of follow-up. Dig Dis Sci. 2013;58(8):2383-91. doi: 10.1007/s10620-013-2657-2</mixed-citation><mixed-citation xml:lang="en">Elliott C, Frith J, Day CP, Jones DE, Newton JL. Functional impairment in alcoholic liver disease and non-alcoholic fatty liver disease is significant and persists over 3 years of follow-up. Dig Dis Sci. 2013;58(8):2383-91. doi: 10.1007/s10620-013-2657-2</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Chen SS, Yu KK, Huang C, Li N, Zheng JM, Bao SX, Chen MQ, Zhang WH. The characteristics and clinical outcome of drug-induced liver injury in a Chinese hospital: A retrospective cohort study. Medicine (Baltimore). 2016;95(34): e4683. doi: 10.1097/md.0000000000004683</mixed-citation><mixed-citation xml:lang="en">Chen SS, Yu KK, Huang C, Li N, Zheng JM, Bao SX, Chen MQ, Zhang WH. The characteristics and clinical outcome of drug-induced liver injury in a Chinese hospital: A retrospective cohort study. Medicine (Baltimore). 2016;95(34): e4683. doi: 10.1097/md.0000000000004683</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Raikhelson K.L., Kondrashina E. A. Àdåmethionine in the treatment of fatigue in liver diseases: a systematic review. Therapeutic Archive. 2019; 91 (2): 134-142. (in Russ.) DOI: 10.26442/00403660.2019.02.000130@@ Райхельсон К. Л., Кондрашина Э. А. Адеметионин в лечении повышенной утомляемости/слабости при заболеваниях печени: систематический обзор. Терапевтический архив. 2019. 91(2): 134-142</mixed-citation><mixed-citation xml:lang="en">Raikhelson K.L., Kondrashina E. A. Àdåmethionine in the treatment of fatigue in liver diseases: a systematic review. Therapeutic Archive. 2019; 91 (2): 134-142. (in Russ.) DOI: 10.26442/00403660.2019.02.000130@@ Райхельсон К. Л., Кондрашина Э. А. Адеметионин в лечении повышенной утомляемости/слабости при заболеваниях печени: систематический обзор. Терапевтический архив. 2019. 91(2): 134-142</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Frezza M, Surrenti C, Manzillo G, et al. Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. Gastroenterology. 1990;99(1):211-5. doi: 10.1016/0016-5085(90)91250-a</mixed-citation><mixed-citation xml:lang="en">Frezza M, Surrenti C, Manzillo G, et al. Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. Gastroenterology. 1990;99(1):211-5. doi: 10.1016/0016-5085(90)91250-a</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Fiorelli G. S-Adenosylmethionine in the treatment of intrahepatic cholestasis of chronic liver disease: A field trial. CurrTher Res. 1999;60(6):335-48. doi: 10.1016/s0011-393x(99)80010-1</mixed-citation><mixed-citation xml:lang="en">Fiorelli G. S-Adenosylmethionine in the treatment of intrahepatic cholestasis of chronic liver disease: A field trial. CurrTher Res. 1999;60(6):335-48. doi: 10.1016/s0011-393x(99)80010-1</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Di Perri T, Sacco T, Festi D. The SMACK Investigator Group. Ademetionine in the treatment of chronic hepatic disease. Gastroenterol Int. 1999;12(2):62-8.</mixed-citation><mixed-citation xml:lang="en">Di Perri T, Sacco T, Festi D. The SMACK Investigator Group. Ademetionine in the treatment of chronic hepatic disease. Gastroenterol Int. 1999;12(2):62-8.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Podymova SD, Nadinskaia MYu. Clinical trial of Heptral in patients with chronic diffuse liver disease with intrahepatic cholestasis syndrome. Klinicheskaia Meditsina. 1998;76(10):45-8 (InRuss.)@@ Подымова С. Д., Надинская М. Ю. Оценка эффективности препарата Гептрал у больных хроническими диффузными заболеваниями печени с синдромом внутрипеченочного холестаза. Клиническая медицина. 1998;76(10):45-8</mixed-citation><mixed-citation xml:lang="en">Podymova SD, Nadinskaia MYu. Clinical trial of Heptral in patients with chronic diffuse liver disease with intrahepatic cholestasis syndrome. Klinicheskaia Meditsina. 1998;76(10):45-8 (InRuss.)@@ Подымова С. Д., Надинская М. Ю. Оценка эффективности препарата Гептрал у больных хроническими диффузными заболеваниями печени с синдромом внутрипеченочного холестаза. Клиническая медицина. 1998;76(10):45-8</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">BaranovskyAYu, Raykhelson KL, Marchenko NV. Application of S-adenosylmethionine (Heptral®) in treatment of patients with non-alcoholic steatohepatitis. Klinicheskie Perspektivy Gastroenterologii, Gepatologii = Clin Perspect Gastroenterol Hepatol. 2010;9(1):3-10 (In Russ)@@ Барановский А. Ю., Райхельсон К. Л., Марченко Н. В. Применение S-аденозилметионина (Гептрала®) в терапии больных неалкогольным стеатогепатитом. Клинические перспективы гастроэнтерологии, гепатологии. 2010;9(1):3-10</mixed-citation><mixed-citation xml:lang="en">BaranovskyAYu, Raykhelson KL, Marchenko NV. Application of S-adenosylmethionine (Heptral®) in treatment of patients with non-alcoholic steatohepatitis. Klinicheskie Perspektivy Gastroenterologii, Gepatologii = Clin Perspect Gastroenterol Hepatol. 2010;9(1):3-10 (In Russ)@@ Барановский А. Ю., Райхельсон К. Л., Марченко Н. В. Применение S-аденозилметионина (Гептрала®) в терапии больных неалкогольным стеатогепатитом. Клинические перспективы гастроэнтерологии, гепатологии. 2010;9(1):3-10</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
