nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-188-4-155-160nogr-1642Research ArticleОБЗОРREVIEWПерспективные неинвазивные биомаркеры: интестинальные белки в диагностике повреждений слизистой оболочки кишечникаPerspective non-invasive biomarkers: intestinal proteins in the diagnosis for diagnosis and control of intestinal mucosal damagehttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinA. I.

Хавкин Анатолий Ильич, доктор медицинских наук, профессор, главный научный сотрудник отдела гастроэнтерологии Научно-исследовательского клинического института педиатрии им. академика Ю. Е. Вельтищева

191015, st. Kirochnaya, 41, St. Petersburg

Anatoly I. Khavkin, PhD, professor, Chief Researcher of the Department of Gastroenterology, Scientific Research Clinical Institute of Pediatrics named after I. I. Academician Yu. E. Veltischeva

125412, St. Taldomskaya 2, Moscow

https://orcid.org/0000-0002-0992-1709НовиковаВ. П.NovikovaV. P.

Новикова Валерия Павловна, доктор медицинских наук, проф. заведующая кафедрой пропедевтики детских болезней с курсом общего ухода за детьми, заведующая лабораторией медико- социальных проблем в педиатрии

 194100, Санкт- Петербург, ул. Литовская, 2

Valeria P. Novikova, MD, PhD, prof. Head of the Department of Propedeutics of Childhood Diseases with a course of general child care, head. laboratory of medical and social problems in pediatrics

194100, St. Petersburg, st. Lithuanian, 2

https://orcid.org/0000-0002-0364-6785ШаповаловаН. С.ShapovalovaN. S.

Шаповалова Наталья Сергеевна, младший научный сотрудник лаборатории медико-социальных проблем в педиатрии

194100, Санкт- Петербург, ул. Литовская, 2

Natalia S. Shapovalova, Junior Researcher, Laboratory of Medical and Social Problems in Pediatrics

194100, St. Petersburg, st. Lithuanian, 2

natasunday@mail.ruФГАУ ВО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова Министерства здравоохранения Российской ФедерацииРоссияN. I. Pirogov Russian National Research Medical UniversityRussian FederationФГБОУ ВО Санкт-Петербургский государственный педиатрический медицинский университет Минздрава РоссииРоссияSt. Petersburg State Pediatric Medical UniversityRussian Federation20212007202104155160Copyright © Хавкин А.И., Новикова В.П., Шаповалова Н.С., 20212021Хавкин А.И., Новикова В.П., Шаповалова Н.С.Khavkin A.I., Novikova V.P., Shapovalova N.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1642

Целью данного обзора литературы было рассмотреть диагностическую значимость лабораторных исследований потенциальных биомаркеров: цитруллина и интестинальных белков, призванных выявить повреждение слизистой оболочки кишечника. Заключение: определение I-FABP и I-BABP в крови являются перспективными методами неинвазивной диагностики повреждения кишечной стенки, поскольку эти белки освобождаются из гибнущих зрелых энтероцитов. Однако определение интестинальных белков имеет значение в комбинации с определением цитруллина. В ряде исследований было показано, что цитруллин возможно измерить в животных моделях, у взрослых пациентов и педиатрических больных. Он легко обнаруживается, последовательно измеряется и способен выявлять воспаление слизистой оболочки кишечника. Ограничением большинства исследований стала небольшая выборка. Неинвазивные методики диагностики и контроля терапии остаются важным направлением дальнейшего изучения.

The aim of this literature review was to consider the diagnostic value of potential biomarkers detection: citrulline and intestinal proteins, designed to detect intestinal mucosa damage.

Conclusion: determination of I-FABP and I-BABP in blood are promising methods for non-invasive diagnosis of the intestinal damage, since these proteins are released from the damaged enterocytes. However, the determination of intestinal proteins is important in combination with the determination of citrulline. Several studies have shown that citrulline can be measured in animal models, in adult and pediatric patients. It is easily detectable, consistently measured and capable of detecting inflammation of the intestinal mucosa. The limitation of most studies was the small sample size. Non-invasive diagnostic and therapeutic monitoring techniques remain an important area of further research.

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The authors declare that there are no conflicts of interest present.