nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-187-3-130-135nogr-1608Research ArticleКЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯCLINICAL GASTROENTEROLOGYЧастота дефицита железа и его патогенез у больных с инфекцией H. pyloriIncidence of iron deficiency and its pathogenesis in patients with H. pylori infectionhttps://orcid.org/0000-0002-8744-1604ШулятьеваН. В.Shulyat’EvaN. V.ninagunilla@gmail.comhttps://orcid.org/0000-0002-0535-2916ДроздовВ. Н.DrozdovV. N.noemail@neicon.ruhttps://orcid.org/0000-0001-6589-7654ШихЕ. В.ShikhE. V.noemail@neicon.ruФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава России (Сеченовский Университет)РоссияFGAOU VO First Moscow State Medical University. I. M. Sechenov, Ministry of Health of Russia (Sechenov University)Russian Federation20212205202103130135Copyright © Шулятьева Н.В., Дроздов В.Н., Ших Е.В., 20212021Шулятьева Н.В., Дроздов В.Н., Ших Е.В.Shulyat’Eva N.V., Drozdov V.N., Shikh E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1608

Было обследовано 606 пациентов (405 мужчин и 201 женщина), инфицированных НР, у 121 (м 67; ж 54) были обнаружены клинические или клинико-лабораторные признаки дефицита железа, частота железодефицита в обследованной группе больных с НР составила 19,9% (16,8-23,3; ДИ 95%). У 25 (20,7%) была выявлена анемия, у 66 (54,5%) человек установлен латентный дефицит железа, у 30 (24,8%) отмечалось только снижение НТЖ, что характерно для предлатентного дефицита железа. У 38 (31,4%) обследуемых был выявлен «истинный» дефицит железа, у 44 (36,4%) - комбинированный вариант железодефицита, а у 39 (32,2%) пациентов дефицит железа развивался вследствие хронического воспаления. Выявлена достоверная разница в уровне гепсидина у больных с различными вариантами дефицита железа. Так, у пациентов с «изолированным» дефицитом железа он составлял 12,4±2,3 нг/мл, vs 48,2±20,2 нг/мл vs 189,7±31,1 нг/мл у больных с комбинированным патогенетическим вариантом дефицита железа и у больных с дефицитом железа хронического воспаления соответственно.

606 patients (405 men and 201 women) with HP infection were examined, 121 (m 67; f 54) found clinical or clinical and laboratory signs of iron deficiency, the frequency of iron deficiency in the examined group of patients with HP was 19.9% (16.8-23.3; CI 95%). 25 (20.7%) were diagnosed with anaemia, 66 (54.5%) patients had a latent deficit of iron, 30 patients (24.8%) showed only a decrease in TS, which is typical for pre-latent iron deficiency. 38 (31.4%) patients had a «true» iron deficiency, 44 (36.4%) patients had a combined variant of iron deficiency, and 39 (32.2%) iron deficiency developed as a result of chronic inflammation. There was a significant difference in the level of hepcidin in patients with different options for iron deficiency. In patients with “isolated” iron deficiency, it was 12.4 ± 2.3 ng/ml, vs 48.2-± 20.2 ng/ml vs 189.7 ± 31.1 ng / ml in patients with a combined pathogenic variant of iron deficiency and in patients with iron deficiency of chronic inflammation, respectively.

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The authors declare that there are no conflicts of interest present.