nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-186-2-120-134nogr-1571Research ArticleИНФОРМАЦИЯINFORMATIONМатериалы конференции Gastro Update Eвропа 2020, 4-5 сентября 2020 гMeeting report of Gastro Update Europe 2020, September 4-5, 2020ТитгатГвидоTytgatN. J.g.n.tytgat@amsterdamumc.nlАкадемический медицинский центр Медицинского унивирситета АмстердамаНидерландыAmsterdam UMC-location Academic Medical Center MeibergdreefNetherlands20210704202102120134Copyright © Титгат Г.J., 20212021Титгат Г.Tytgat N.J.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1571

В данном обзоре в повествовательной форме кратко изложены клинически важные передовые исследования представленные для обсуждения на конференции Gastro Update Europe 2020. По мнению выдающихся лекторов данная информация является жизненно необходимой в практике клинициста в области диагностики и лечения желудочно-кишечных заболеваний. Для повышения образовательной ценности, краткое резюме докладов сопровождается личными пояснениями автора обзора. Учитывая повествовательный характер обзора, выводы и заключения в значительной степени основаны на мнениях экспертов, а ссылки в настоящем резюме ограничиваются включенными слайд-изображениями.

This narrative review summarizes a selection of clinically-important novel gastrointestinal developments, presented and discussed at the virtual Gastro Update Europe. The selected topics, fully referenced, reflect what the distinguished faculty considered of vital importance to be communicated to the astute busy gastro-hep clinician who is eager to stay abreast of important novel developments. Whenever appropriate a personal comment or addition was added to further raise the educational value of this review. Given its narrative character, statements and conclusions are largely expert opinion-based, and referencing within this summary is limited to the included slide images.

ReferencesGBD 2017 Gastro-oesophageal Reflux Disease Collaborators. Lancet Gastroenterol Hepatol 2020 Jun;5(6):561-58 https://doi.org/10.1016/S2468-1253GBD 2017 Gastro-oesophageal Reflux Disease Collaborators. Lancet Gastroenterol Hepatol 2020 Jun;5(6):561-58 https://doi.org/10.1016/S2468-1253Kim et al. Gut Liver. 2019 Nov 15;13(6):642-648Kim et al. Gut Liver. 2019 Nov 15;13(6):642-648Xiao et al. Gut 2020;69:224-230Xiao et al. Gut 2020;69:224-230Thélin CS et al. Aliment Pharmacol Ther. 2020;51:421-434Thélin CS et al. Aliment Pharmacol Ther. 2020;51:421-434Cheng Mei Li et al. Aliment Pharmacol Ther. 2020;51:410-420Cheng Mei Li et al. Aliment Pharmacol Ther. 2020;51:410-420Delshad SD et al. Gastroenterology. 2020;158(5):1250-1261Delshad SD et al. Gastroenterology. 2020;158(5):1250-1261Fass R et al. Gastroenterology. 2020;158(8):2286-2293. doi:10.1053/j.gastro.2020.01.034Fass R et al. Gastroenterology. 2020;158(8):2286-2293. doi:10.1053/j.gastro.2020.01.034Naik RD et al. Curr Treat Options Gastroenterol. 2019;17(1):1-17Naik RD et al. Curr Treat Options Gastroenterol. 2019;17(1):1-17Patel DA et al. Gastroenterology. 2019;156(6):1617-1626Patel DA et al. Gastroenterology. 2019;156(6):1617-1626Zerbib et al. Aliment Pharmacol Ther. 2020;52:637-645Zerbib et al. Aliment Pharmacol Ther. 2020;52:637-645Vaezi MF et al. Gastroenterology. 2020;158(8):2093-2103Vaezi MF et al. Gastroenterology. 2020;158(8):2093-2103Akiyama et al. Digestion. 2020;101(2):174-183. doi:10.1159/000497775Akiyama et al. Digestion. 2020;101(2):174-183. doi:10.1159/000497775Spechler SJ et al. N Engl J Med. 2019;381(16):1513-1523Spechler SJ et al. N Engl J Med. 2019;381(16):1513-1523Jankowski et al. Lancet 2018; 392(10145): 400-408Jankowski et al. Lancet 2018; 392(10145): 400-408Shaheen et al, Am J Gastroenterol 2016; 111:30-50Shaheen et al, Am J Gastroenterol 2016; 111:30-50Weusten et al. Endoscopy. 2017 Feb;49(2):191-198Weusten et al. Endoscopy. 2017 Feb;49(2):191-198Tan MC et al. Aliment Pharmacol Ther. 2020;52(1):20-36Tan MC et al. Aliment Pharmacol Ther. 2020;52(1):20-36Rubenstein JH et al. Gastroenterology. 2020;158(8):2082-2092. doi:10.1053/j.gastro.2020.02.037Rubenstein JH et al. Gastroenterology. 2020;158(8):2082-2092. doi:10.1053/j.gastro.2020.02.037Fitzgerald RC et al. Lancet. 2020;396(10247):333-344Fitzgerald RC et al. Lancet. 2020;396(10247):333-344Adapted Malfertheiner et al. Nat Rev Gastroenterol and Hepatol 2017;14(12):697-710Adapted Malfertheiner et al. Nat Rev Gastroenterol and Hepatol 2017;14(12):697-710Brusselaers et al. J Gastroenterol. 2020;55(4):453-461Brusselaers et al. J Gastroenterol. 2020;55(4):453-461Almario et al. American Journal of Gastroenterology (pre-print posted online July 7, 2020)Almario et al. American Journal of Gastroenterology (pre-print posted online July 7, 2020)Lee SW et al. Gut 2020 Jul 30; gutjnl-2020-322248Lee SW et al. Gut 2020 Jul 30; gutjnl-2020-322248Dellon et al. Gastroenterology 2018; 155: 1022-1033Dellon et al. Gastroenterology 2018; 155: 1022-1033Rokkas T et al. J Clin Gastroenterol. [published online ahead of print, 2020 May 8Rokkas T et al. J Clin Gastroenterol. [published online ahead of print, 2020 May 8O’Shea KM et al. Gastroenterology. 2018 Jan;154(2):333-345O’Shea KM et al. Gastroenterology. 2018 Jan;154(2):333-345Hirano I et al. Gastroenterology 2019;156:592-603Hirano I et al. Gastroenterology 2019;156:592-603Dellon ES et al. Clin Gastroenterol Hepatol. 2020; S1542-3565(20)303487.doi:10.1016/j.cgh.2020.03.036Dellon ES et al. Clin Gastroenterol Hepatol. 2020; S1542-3565(20)303487.doi:10.1016/j.cgh.2020.03.036Dellon ES et al.Gastroenterology. 2019;157(1):65-73Dellon ES et al.Gastroenterology. 2019;157(1):65-73Hirano I et al.Gastroenterology. 2020;158(1):111-122Hirano I et al.Gastroenterology. 2020;158(1):111-122Abraham NS et al. [published online ahead of print, 2020 Jul 13]. Aliment Pharmacol Ther. 2020;10.1111/apt.15790Abraham NS et al. [published online ahead of print, 2020 Jul 13]. Aliment Pharmacol Ther. 2020;10.1111/apt.15790Malfertheiner et al. Curr Treat Options Gastroenterol. 2018 Dec;16(4):605-615Malfertheiner et al. Curr Treat Options Gastroenterol. 2018 Dec;16(4):605-615Doorakkers et al. Gut. 2018 Dec;67(12):2092-2096Doorakkers et al. Gut. 2018 Dec;67(12):2092-2096Choi IJ, Kim CG, Lee JY, et al. N Engl J Med. 2020;382(5):427-436Choi IJ, Kim CG, Lee JY, et al. N Engl J Med. 2020;382(5):427-436Kumar S et al. Gastroenterology. 2020;158(3):527-536.e7. doi:10.1053/j.gastro.2019.10.019Kumar S et al. Gastroenterology. 2020;158(3):527-536.e7. doi:10.1053/j.gastro.2019.10.019Chiang TH et al. [published online ahead of print, 2020 Aug 13]. Gut. 2020; gutjnl-2020-322200. doi:10.1136/gutjnl-2020-322200Chiang TH et al. [published online ahead of print, 2020 Aug 13]. Gut. 2020; gutjnl-2020-322200. doi:10.1136/gutjnl-2020-322200Beresniak A et al. Helicobacter. 2020;25(4): e12693.Beresniak A et al. Helicobacter. 2020;25(4): e12693.Chen Q et al. Aliment Pharmacol Ther. 2019;49(11):1385-1394Chen Q et al. Aliment Pharmacol Ther. 2019;49(11):1385-1394Fallone CA et al. Gastroenterology. 2019;157(1):44-53Fallone CA et al. Gastroenterology. 2019;157(1):44-53Graham et al. Ann Intern Med. 5 May 2020 doi:10.7326/M19-3734Graham et al. Ann Intern Med. 5 May 2020 doi:10.7326/M19-3734Saracino IM et al. Eur J Intern Med. 2020; S0953-6205(20)30275Saracino IM et al. Eur J Intern Med. 2020; S0953-6205(20)30275Suzuki S et al. Gut. 2020;69(6):1019-1026Suzuki S et al. Gut. 2020;69(6):1019-1026Liou JM et al. Lancet Infect Dis. 2019;19(10):1109-1120.Liou JM et al. Lancet Infect Dis. 2019;19(10):1109-1120.McFarland LV Dig Dis Sci. 2020;10.1007/s10620-020-06244-z. doi:10.1007/s10620-020-06244published online ahead of print, 2020 AprMcFarland LV Dig Dis Sci. 2020;10.1007/s10620-020-06244-z. doi:10.1007/s10620-020-06244published online ahead of print, 2020 AprCárdenas PA et al. Eur J Clin Microbiol Infect Dis. 2020;39(7):1365-1372Cárdenas PA et al. Eur J Clin Microbiol Infect Dis. 2020;39(7):1365-1372Rubin JE, Crowe SE. Celiac Disease. Ann Intern Med. 2020;172(1): ITC1-ITC16.Rubin JE, Crowe SE. Celiac Disease. Ann Intern Med. 2020;172(1): ITC1-ITC16.Uhde M, Caio G, De Giorgio R, Green PH, Volta U, Alaedini A. Subclass Profile of IgG Antibody Response to Gluten Differentiates Non-Celiac Gluten Sensitivity from Celiac Disease [published online ahead of print, 2020 Jul 20]. Gastroenterology. 2020; S0016-5085(20)34992-1.Uhde M, Caio G, De Giorgio R, Green PH, Volta U, Alaedini A. Subclass Profile of IgG Antibody Response to Gluten Differentiates Non-Celiac Gluten Sensitivity from Celiac Disease [published online ahead of print, 2020 Jul 20]. Gastroenterology. 2020; S0016-5085(20)34992-1.Airaksinen L, Myllymäki L, Kaukinen K, et al. Differences Between Familial and Sporadic Celiac Disease [published online ahead of print, 2020 Jul 23]. Dig Dis Sci. 2020;10.1007/s10620-020-06490-1Airaksinen L, Myllymäki L, Kaukinen K, et al. Differences Between Familial and Sporadic Celiac Disease [published online ahead of print, 2020 Jul 23]. Dig Dis Sci. 2020;10.1007/s10620-020-06490-1Huang X, Schuppan D, Rojas Tovar LE, Zevallos VF, Loponen J, Gänzle M. Sourdough Fermentation Degrades Wheat Alpha-Amylase/Trypsin Inhibitor (ATI) and Reduces Pro- Inflammatory Activity. Foods. 2020;9(7): E943. Published 2020 Jul 16. doi:10.3390/foods9070943Huang X, Schuppan D, Rojas Tovar LE, Zevallos VF, Loponen J, Gänzle M. Sourdough Fermentation Degrades Wheat Alpha-Amylase/Trypsin Inhibitor (ATI) and Reduces Pro- Inflammatory Activity. Foods. 2020;9(7): E943. Published 2020 Jul 16. doi:10.3390/foods9070943Caio G, Lungaro L, Segata N, et al. Effect of Gluten-Free Diet on Gut Microbiota Composition in Patients with Celiac Disease and Non-Celiac Gluten/Wheat Sensitivity. Nutrients. 2020;12(6):1832.Caio G, Lungaro L, Segata N, et al. Effect of Gluten-Free Diet on Gut Microbiota Composition in Patients with Celiac Disease and Non-Celiac Gluten/Wheat Sensitivity. Nutrients. 2020;12(6):1832.Koskinen I, Virta LJ, Huhtala H, Ilus T, Kaukinen K, Collin P. Overall and Cause-Specific Mortality in Adult Celiac Disease and Dermatitis Herpetiformis Diagnosed in the 21st Century. Am J Gastroenterol. 2020;115(7):1117-1124.Koskinen I, Virta LJ, Huhtala H, Ilus T, Kaukinen K, Collin P. Overall and Cause-Specific Mortality in Adult Celiac Disease and Dermatitis Herpetiformis Diagnosed in the 21st Century. Am J Gastroenterol. 2020;115(7):1117-1124.Lebwohl B, Green PHR, Söderling J, Roelstraete B, Ludvigsson JF. Association Between Celiac Disease and Mortality Risk in a Swedish Population. JAMA. 2020;323(13):1277-1285.Lebwohl B, Green PHR, Söderling J, Roelstraete B, Ludvigsson JF. Association Between Celiac Disease and Mortality Risk in a Swedish Population. JAMA. 2020;323(13):1277-1285.Kårhus LL, Skaaby T, Petersen J, et al. Long-term Consequences of Undiagnosed Celiac Seropositivity [published online ahead of print, 2020 Jun 16]. Am J Gastroenterol. 2020;10.14309/ajg.0000000000000737.Kårhus LL, Skaaby T, Petersen J, et al. Long-term Consequences of Undiagnosed Celiac Seropositivity [published online ahead of print, 2020 Jun 16]. Am J Gastroenterol. 2020;10.14309/ajg.0000000000000737.Silvester JA, Comino I, Kelly CP, Sousa C, Duerksen DR; DOGGIE BAG Study Group. Most Patients With Celiac Disease on Gluten-Free Diets Consume Measurable Amounts of Gluten. Gastroenterology. 2020;158(5):1497-1499.e1Silvester JA, Comino I, Kelly CP, Sousa C, Duerksen DR; DOGGIE BAG Study Group. Most Patients With Celiac Disease on Gluten-Free Diets Consume Measurable Amounts of Gluten. Gastroenterology. 2020;158(5):1497-1499.e1Elli L, Bascuñán K, di Lernia L, et al. Safety of occasional ingestion of gluten in patients with celiac disease: a real-life study. BMC Med. 2020;18(1):42.Elli L, Bascuñán K, di Lernia L, et al. Safety of occasional ingestion of gluten in patients with celiac disease: a real-life study. BMC Med. 2020;18(1):42.Pinto-Sanchez MI, Seiler CL, Santesso N, et al. Association Between Inflammatory Bowel Diseases and Celiac Disease: A Systematic Review and Meta-Analysis Gastroenterology. 2020; S0016-5085(20)30609-0.Pinto-Sanchez MI, Seiler CL, Santesso N, et al. Association Between Inflammatory Bowel Diseases and Celiac Disease: A Systematic Review and Meta-Analysis Gastroenterology. 2020; S0016-5085(20)30609-0.Andersen V, Möller S, Jensen PB, Møller FT, Green A. Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973-2016. Clin Epidemiol. 2020;12:287-293.Andersen V, Möller S, Jensen PB, Møller FT, Green A. Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973-2016. Clin Epidemiol. 2020;12:287-293.Croall ID, Sanders DS, Hadjivassiliou M, Hoggard N. Cognitive Deficit and White Matter Changes in Persons With Celiac Disease: A Population-Based Study. Gastroenterology. 2020;158(8):2112-2122.Croall ID, Sanders DS, Hadjivassiliou M, Hoggard N. Cognitive Deficit and White Matter Changes in Persons With Celiac Disease: A Population-Based Study. Gastroenterology. 2020;158(8):2112-2122.Caio G, Ciccocioppo R, Zoli G, De Giorgio R, Volta U. Therapeutic options for coeliac disease: What else beyond gluten-free diet?. Dig Liver Dis. 2020;52(2):130-137.Caio G, Ciccocioppo R, Zoli G, De Giorgio R, Volta U. Therapeutic options for coeliac disease: What else beyond gluten-free diet?. Dig Liver Dis. 2020;52(2):130-137.Freitag TL, Podojil JR, Pearson RM, et al. Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease. Gastroenterology. 2020;158(6):1667-1681.e12.Freitag TL, Podojil JR, Pearson RM, et al. Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease. Gastroenterology. 2020;158(6):1667-1681.e12.Andrén Aronsson C, Lee HS, Hård Af Segerstad EM, et al. Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk. JAMA. 2019;322(6):514-523. doi:10.1001/jama.2019.10329Andrén Aronsson C, Lee HS, Hård Af Segerstad EM, et al. Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk. JAMA. 2019;322(6):514-523. doi:10.1001/jama.2019.10329Scaldaferri F, Ianiro G, Privitera G, et al. The Thrilling Journey of SARS-CoV-2 into the Intestine: From Pathogenesis to Future Clinical Implications [published online ahead of print, 2020 Jul 28]. Inflamm Bowel Dis. 2020; izaa181. doi:10.1093/ibd/izaa181Scaldaferri F, Ianiro G, Privitera G, et al. The Thrilling Journey of SARS-CoV-2 into the Intestine: From Pathogenesis to Future Clinical Implications [published online ahead of print, 2020 Jul 28]. Inflamm Bowel Dis. 2020; izaa181. doi:10.1093/ibd/izaa181Shi Z, Zou J, Zhang Z, et al. Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection. Cell. 2019;179(3):644-658.Shi Z, Zou J, Zhang Z, et al. Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection. Cell. 2019;179(3):644-658.Andreyev HJN, Lalji A, Mohammed K, et al. The FOCCUS study: a prospective evaluation of the frequency, severity and treatable causes of gastrointestinal symptoms during and after chemotherapy [published online ahead of print, 2020 Jul 16]. Support Care Cancer. 2020;10.1007/s00520-020-05610-x.Andreyev HJN, Lalji A, Mohammed K, et al. The FOCCUS study: a prospective evaluation of the frequency, severity and treatable causes of gastrointestinal symptoms during and after chemotherapy [published online ahead of print, 2020 Jul 16]. Support Care Cancer. 2020;10.1007/s00520-020-05610-x.Kim BT, Kim KM, Kim KN. The Effect of Ursodeoxycholic Acid on Small Intestinal Bacterial Overgrowth in Patients with Functional Dyspepsia: A Pilot Randomized Controlled Trial. Nutrients. 2020;12(5):1410Kim BT, Kim KM, Kim KN. The Effect of Ursodeoxycholic Acid on Small Intestinal Bacterial Overgrowth in Patients with Functional Dyspepsia: A Pilot Randomized Controlled Trial. Nutrients. 2020;12(5):1410Mouillot T, Rhyman N, Gauthier C, et al. Study of Small Intestinal Bacterial Overgrowth in a Cohort of Patients with Abdominal Symptoms Who Underwent Bariatric Surgery. Obes Surg. 2020;30(6):2331-2337.Mouillot T, Rhyman N, Gauthier C, et al. Study of Small Intestinal Bacterial Overgrowth in a Cohort of Patients with Abdominal Symptoms Who Underwent Bariatric Surgery. Obes Surg. 2020;30(6):2331-2337.Nielsen HL, Dalager-Pedersen M, Nielsen H. High risk of microscopic colitis after Campylobacter concisus infection: population-based cohort study [published online ahead of print, 2020 Feb 28]. Gut. 2020; gutjnl-2019-319771. doi:10.1136/gutjnl-2019-319771Nielsen HL, Dalager-Pedersen M, Nielsen H. High risk of microscopic colitis after Campylobacter concisus infection: population-based cohort study [published online ahead of print, 2020 Feb 28]. Gut. 2020; gutjnl-2019-319771. doi:10.1136/gutjnl-2019-319771Babar S, El Kurdi B, El Iskandarani M, et al. Oral vancomycin prophylaxis for the prevention of Clostridium difficile infection: A systematic review and meta-analysis [published online ahead of print, 2020 Jun 29]. Infect Control Hosp Epidemiol. 2020;1-8.Babar S, El Kurdi B, El Iskandarani M, et al. Oral vancomycin prophylaxis for the prevention of Clostridium difficile infection: A systematic review and meta-analysis [published online ahead of print, 2020 Jun 29]. Infect Control Hosp Epidemiol. 2020;1-8.Wombwell E, Patterson ME, Bransteitter B, Gillen LR. The effect of Saccharomyces boulardii primary prevention on risk of Hospital Onset Clostridioides difficile infection in hospitalized patients administered antibiotics frequently associated with Clostridioides difficile infection [published online ahead of print, 2020 Jun 23]. Clin Infect Dis. 2020; ciaa808.Wombwell E, Patterson ME, Bransteitter B, Gillen LR. The effect of Saccharomyces boulardii primary prevention on risk of Hospital Onset Clostridioides difficile infection in hospitalized patients administered antibiotics frequently associated with Clostridioides difficile infection [published online ahead of print, 2020 Jun 23]. Clin Infect Dis. 2020; ciaa808.Kitchin N, Remich SA, Peterson J, et al. A Phase 2 Study Evaluating the Safety, Tolerability, and Immunogenicity of Two 3-Dose Regimens of a Clostridium difficile Vaccine in Healthy US Adults Aged 65 to 85 Years. Clin Infect Dis. 2020;70(1):1-10.Kitchin N, Remich SA, Peterson J, et al. A Phase 2 Study Evaluating the Safety, Tolerability, and Immunogenicity of Two 3-Dose Regimens of a Clostridium difficile Vaccine in Healthy US Adults Aged 65 to 85 Years. Clin Infect Dis. 2020;70(1):1-10.Khanna S, Pardi D. Fecal Microbiota Transplantation for Recurrent Clostridioides difficile infection: The COVID-19 Era. Am J Gastroenterol. 2020;115(7):971-974.Khanna S, Pardi D. Fecal Microbiota Transplantation for Recurrent Clostridioides difficile infection: The COVID-19 Era. Am J Gastroenterol. 2020;115(7):971-974.Connor BA, Martin GJ, Riddle MS. Use of the Multiplex Diagnostic PCR Panel in Diarrheal Disease: Expert Guidance on the Interpretation of Results With a Focus on Travelers’ Diarrhea [published online ahead of print, 2020 Jun 16]. Am J Gastroenterol. 2020;10.14309Connor BA, Martin GJ, Riddle MS. Use of the Multiplex Diagnostic PCR Panel in Diarrheal Disease: Expert Guidance on the Interpretation of Results With a Focus on Travelers’ Diarrhea [published online ahead of print, 2020 Jun 16]. Am J Gastroenterol. 2020;10.14309Schaumburg F, Correa-Martinez CL, Niemann S, Köck R, Becker K. Aetiology of traveller’s diarrhea: A nested case-control study [published online ahead of print, 2020 Apr 25]. Travel Med Infect Dis. 2020;101696.Schaumburg F, Correa-Martinez CL, Niemann S, Köck R, Becker K. Aetiology of traveller’s diarrhea: A nested case-control study [published online ahead of print, 2020 Apr 25]. Travel Med Infect Dis. 2020;101696.Boxall MD, Day MR, Greig DR, Jenkins C. Antimicrobial resistance profiles of diarrhoeagenic Escherichia coli isolated from travellers returning to the UK, 2015-2017 [published online ahead of print, 2020 Jun 12]. J Med Microbiol. 2020;10.1099/jmm.0.001214. doi:10.1099/jmm.0.001214Boxall MD, Day MR, Greig DR, Jenkins C. Antimicrobial resistance profiles of diarrhoeagenic Escherichia coli isolated from travellers returning to the UK, 2015-2017 [published online ahead of print, 2020 Jun 12]. J Med Microbiol. 2020;10.1099/jmm.0.001214. doi:10.1099/jmm.0.001214Furuya-Kanamori L, Stone J, Yakob L, et al. Risk factors for acquisition of multidrug- resistant Enterobacterales among international travellers: a synthesis of cumulative evidence. J Travel Med. 2020;27(1): taz083.Furuya-Kanamori L, Stone J, Yakob L, et al. Risk factors for acquisition of multidrug- resistant Enterobacterales among international travellers: a synthesis of cumulative evidence. J Travel Med. 2020;27(1): taz083.Halmos EP, Mack A, Gibson PR. Review article: emulsifiers in the food supply and implications for gastrointestinal disease. Aliment Pharmacol Ther. 2019;49(1):41-50.Halmos EP, Mack A, Gibson PR. Review article: emulsifiers in the food supply and implications for gastrointestinal disease. Aliment Pharmacol Ther. 2019;49(1):41-50.Peters RJB, Oomen AG, van Bemmel G, et al. Silicon dioxide and titanium dioxide particles found in human tissues. Nanotoxicology. 2020;14(3):420-432. doi:10.1080/17435390.2020.1718232Peters RJB, Oomen AG, van Bemmel G, et al. Silicon dioxide and titanium dioxide particles found in human tissues. Nanotoxicology. 2020;14(3):420-432. doi:10.1080/17435390.2020.1718232Talamini L, Gimondi S, Violatto MB, et al. Repeated administration of the food additive E171 to mice results in accumulation in intestine and liver and promotes an inflammatory status. Nanotoxicology. 2019;13(8):1087-1101.Talamini L, Gimondi S, Violatto MB, et al. Repeated administration of the food additive E171 to mice results in accumulation in intestine and liver and promotes an inflammatory status. Nanotoxicology. 2019;13(8):1087-1101.Stoffel EM et al., Gastroenterology, 2020, 158: 341Stoffel EM et al., Gastroenterology, 2020, 158: 341Jeon J et al., Gastroenterology, 2018, 154: 2152Jeon J et al., Gastroenterology, 2018, 154: 2152Robertson DJ et al., Gastroenterology, 219, 156: 904Robertson DJ et al., Gastroenterology, 219, 156: 904Zhang J et al., Gut, 2019, 68: 1971Zhang J et al., Gut, 2019, 68: 1971Echle A et al., Gastroenterology 2020, June 17Echle A et al., Gastroenterology 2020, June 17Pilonis ND et al., Annals Intern Med, 2020, 173: 81Pilonis ND et al., Annals Intern Med, 2020, 173: 81Lieberman A et al., Cancer Epidemiol Biomarkers Prev 2019, 28: 1902Lieberman A et al., Cancer Epidemiol Biomarkers Prev 2019, 28: 1902Helsingen L et al., BMJ, 2019, 367: l5515Helsingen L et al., BMJ, 2019, 367: l5515Zorzi M et al., J Med Screen, 2020, May 11Zorzi M et al., J Med Screen, 2020, May 11Terlouw LG, UEG Journal 2020, 8: 371Terlouw LG, UEG Journal 2020, 8: 371Parasa et al., Gut. 2019 Dec;68(12):2122-2128Parasa et al., Gut. 2019 Dec;68(12):2122-2128Wani et al., Am J Gastroenterol. 2019 Aug;114(8):1256-1264Wani et al., Am J Gastroenterol. 2019 Aug;114(8):1256-1264ESGE Position Statement; Weusten et al, Endoscopy 2017 Feb;49(2):191-198ESGE Position Statement; Weusten et al, Endoscopy 2017 Feb;49(2):191-198Minashi et al., Gastroenterology. 2019 157:382-390Minashi et al., Gastroenterology. 2019 157:382-390https://www.researchgate.net/profile/Uchenna_Odi2/publication/326834670/figure/fig 8/AS:656388581756929@1533506641355/Difference-between-traditional-machine-learning-and-deep-learning-Alex-2017_W640.jpghttps://www.researchgate.net/profile/Uchenna_Odi2/publication/326834670/figure/fig 8/AS:656388581756929@1533506641355/Difference-between-traditional-machine-learning-and-deep-learning-Alex-2017_W640.jpghttps://www.digitaltrends.com/cool-tech/what-is-an-artificial-neural-networkhttps://www.digitaltrends.com/cool-tech/what-is-an-artificial-neural-networkFons van der Sommen et al., Gut, 2020 May 11; gutjnl-2019-320466, (online ahead of print)Fons van der Sommen et al., Gut, 2020 May 11; gutjnl-2019-320466, (online ahead of print)Van Rijn, Am J Gastroenterol 2006 Feb;101(2):343-50Van Rijn, Am J Gastroenterol 2006 Feb;101(2):343-50Visrodia et al, Gastroenterology 2016 Mar;150(3):599-607.e7Visrodia et al, Gastroenterology 2016 Mar;150(3):599-607.e7Pimenta-Melo et al, Eur J Gastroenterol Hepatol 2016 Sep;28(9):1041-9Pimenta-Melo et al, Eur J Gastroenterol Hepatol 2016 Sep;28(9):1041-9Luo et al., Lancet Oncology, 2019, Dec;20(12):1645-1654Luo et al., Lancet Oncology, 2019, Dec;20(12):1645-1654Nakagawa et al., Gastrointestinal Endoscopy, 2019 Sep;90(3):407-414Nakagawa et al., Gastrointestinal Endoscopy, 2019 Sep;90(3):407-414Wu L et al., Gut. 2019 Dec;68(12):2161-2169Wu L et al., Gut. 2019 Dec;68(12):2161-2169Bisschops et al, Endoscopy 2016 Sep;48(9):843-64Bisschops et al, Endoscopy 2016 Sep;48(9):843-64Harvey PR et al., GUT 2019 Jul;68(7):1146-1151Harvey PR et al., GUT 2019 Jul;68(7):1146-1151Uemura KL et al., Endosc Int Open. 2020 Jul;8(7): E911-E923Uemura KL et al., Endosc Int Open. 2020 Jul;8(7): E911-E923Careyva B et al., Am Fam Physician. 2016 Dec 15;94(12):980-986Careyva B et al., Am Fam Physician. 2016 Dec 15;94(12):980-986Ibrahim M et al., Gut. 2019;68:844-853Ibrahim M et al., Gut. 2019;68:844-853Radaeli F et al., Gut. 2019 Jun;68(6):969-976Radaeli F et al., Gut. 2019 Jun;68(6):969-976Veitch AM et al, ESGE Guidelines. Endoscopy 2016; 48: 1-18Veitch AM et al, ESGE Guidelines. Endoscopy 2016; 48: 1-18Van Baar ACG et al., Gut. 2020 69:295-303 22. Peters Y et al., Gut. 2020 Jul;69(7):1169-1172Van Baar ACG et al., Gut. 2020 69:295-303 22. Peters Y et al., Gut. 2020 Jul;69(7):1169-1172Pekgoz M. World J Gastroenterol 2019; 25: 4019-42Pekgoz M. World J Gastroenterol 2019; 25: 4019-42Elzmunzer et al. N Engl J Med 2012; 366: 1414-22Elzmunzer et al. N Engl J Med 2012; 366: 1414-22Fogel et al. Lancet Gastroenterol Hepatol 2020; 5: 132-41Fogel et al. Lancet Gastroenterol Hepatol 2020; 5: 132-41Dumonceau et al. Endoscopy 2014; 46: 799-15Dumonceau et al. Endoscopy 2014; 46: 799-15Navaneethan et al. Gastrointest Endosc 2015; 81: 168-76Navaneethan et al. Gastrointest Endosc 2015; 81: 168-76Dorrell et al. Diagnostics 2020, 10, 337Dorrell et al. Diagnostics 2020, 10, 337Singhi et al. Gut 2020: 69: 52-61Singhi et al. Gut 2020: 69: 52-61Arvanitakis et al. Endoscopy 2018; 50: 524-46Arvanitakis et al. Endoscopy 2018; 50: 524-46Working Group IAP/APA Acute Pancreatitis Guidelines. Pancreatology 2013; 13: e1-15Working Group IAP/APA Acute Pancreatitis Guidelines. Pancreatology 2013; 13: e1-15Crockett et al. Gastroenterology 2018; 154: 1096-101Crockett et al. Gastroenterology 2018; 154: 1096-101Schepers et al, Bruno. Lancet 2020; 396: 167-76Schepers et al, Bruno. Lancet 2020; 396: 167-76Okamoto et al. Tokyo guidelines for the management of acute cholecystitis. J Hepatobiliary Pancreat Sci 2018;25:55-72Okamoto et al. Tokyo guidelines for the management of acute cholecystitis. J Hepatobiliary Pancreat Sci 2018;25:55-72Teoh et al. Endoscopy 2017; 49: 130-8Teoh et al. Endoscopy 2017; 49: 130-8Dollhopf et al. Gastrointest Endosc 2017; 86: 636-43Dollhopf et al. Gastrointest Endosc 2017; 86: 636-43Teoh et al. Gut 2020; 69: 1085-91Teoh et al. Gut 2020; 69: 1085-91McCarty et al. Endosc Ultrasound 2020; 9: 6-15McCarty et al. Endosc Ultrasound 2020; 9: 6-15Robles-Medrandra et al. Endoscopy 2020; 52: 268-75Robles-Medrandra et al. Endoscopy 2020; 52: 268-75He X, Hang D et al., Gastroenterology, 2020, volume: 158 page 852-861He X, Hang D et al., Gastroenterology, 2020, volume: 158 page 852-861Lee JK et al., Gastroenterology, 2020, volume: 158 page 884-894Lee JK et al., Gastroenterology, 2020, volume: 158 page 884-894Wieszczy P et al., Gastroenterology, 2020, volume: 158 page 875-883Wieszczy P et al., Gastroenterology, 2020, volume: 158 page 875-883Klein A, Tate DJ et al., Gastroenterology, 2019, volume: 156 page 604-613Klein A, Tate DJ et al., Gastroenterology, 2019, volume: 156 page 604-613Cross A, et al. Gut 2020, volume 69 page 1645-1658Cross A, et al. Gut 2020, volume 69 page 1645-1658Pohl H et al., Gastroenterology, 2020, volume: 159 page 119-128Pohl H et al., Gastroenterology, 2020, volume: 159 page 119-128Pohl H et al., Gastroenterology, 2019, volume: 157 page 977-984Pohl H et al., Gastroenterology, 2019, volume: 157 page 977-984Feagins LA et al., Gastroenterology, 2019, volume: 157 page 967-976Feagins LA et al., Gastroenterology, 2019, volume: 157 page 967-976Albeniz E et al., Gastroenterology, 2019, volume: 157 page 1213-1221Albeniz E et al., Gastroenterology, 2019, volume: 157 page 1213-1221Spadaccini M et al., Gastroenterology, 2020, volume: 159 page 148-1258Spadaccini M et al., Gastroenterology, 2020, volume: 159 page 148-1258Takeuchi Y et al., Ann Intern Med, 2019, volume: 171 page 229-237Takeuchi Y et al., Ann Intern Med, 2019, volume: 171 page 229-237Zwager LW et al., Endoscopy, 2020, Jun 4. doi: 10.1055/a-1176-1107Zwager LW et al., Endoscopy, 2020, Jun 4. doi: 10.1055/a-1176-1107Wang P, et et al., Lancet Gastroentero Hep, 2020, 5:343-351Wang P, et et al., Lancet Gastroentero Hep, 2020, 5:343-351Gong D, et et al., Lancet Gastroentero Hep, 2020, 5:352-361Gong D, et et al., Lancet Gastroentero Hep, 2020, 5:352-361Repici A, et et al., Gastroenterology, 2020, S0016-5085(20)30583-7Repici A, et et al., Gastroenterology, 2020, S0016-5085(20)30583-7Hassan C, et al., Gastrointest Endosc, 2020 Jun 26: S0016-5107(20)34523-5Hassan C, et al., Gastrointest Endosc, 2020 Jun 26: S0016-5107(20)34523-5Su, et et al., Gastrointest Endosc, 2020, 91:415Su, et et al., Gastrointest Endosc, 2020, 91:415Bretthauer M, Kaminski MF, et al., JAMA Intern Med., 2016 Jul 1;176(7):894-902Bretthauer M, Kaminski MF, et al., JAMA Intern Med., 2016 Jul 1;176(7):894-902Niikura R, et al., Gastroenterology, 2020, 158:168-175Niikura R, et al., Gastroenterology, 2020, 158:168-175Kherad O, et al., Aliment Pharmacol Ther, 2020, 00:1-15Kherad O, et al., Aliment Pharmacol Ther, 2020, 00:1-15Dobszai D et al, World J Gastroenterol 2019;25:729-43Dobszai D et al, World J Gastroenterol 2019;25:729-43Miko A et al, Pancreas 2018;47:917-23Miko A et al, Pancreas 2018;47:917-23Krishna SG et al. Pancreas 2018;47:996-1002Krishna SG et al. Pancreas 2018;47:996-1002Jones JD et al. Pancreas 2018;47:1317-1321Jones JD et al. Pancreas 2018;47:1317-1321Hollemans RA, et al. Gastroenterology 2019;156:1016-26Hollemans RA, et al. Gastroenterology 2019;156:1016-26Van Santvoort HC et al. NEJM 2010;362:1491Van Santvoort HC et al. NEJM 2010;362:1491Bang JY et al. Gastroenterology 2019;156:1027-1040Bang JY et al. Gastroenterology 2019;156:1027-1040Kamal A et al. Am J Gastroenterol 2019;114:339-347Kamal A et al. Am J Gastroenterol 2019;114:339-347Luo H et al. Clin Gastroenterol Hepatol 2019;17:1597-1606Luo H et al. Clin Gastroenterol Hepatol 2019;17:1597-1606Olesen SS et al, Am J Gastroenterol 2019;114:656-64Olesen SS et al, Am J Gastroenterol 2019;114:656-64Majumder S et al, Clin Gastroenterol Hepatol 2018;16:1947-53Majumder S et al, Clin Gastroenterol Hepatol 2018;16:1947-53Hart PA et al, Gut 2013;62:1607-15Hart PA et al, Gut 2013;62:1607-15Collaborators, Gut 2018;67:789-804Collaborators, Gut 2018;67:789-804Okazaki K et al, Am J Gastroenterol 2018;113:1412-6Okazaki K et al, Am J Gastroenterol 2018;113:1412-6Tavakkoli A et al, CGH 2020;18:171-8Tavakkoli A et al, CGH 2020;18:171-8Beatty G et al, ASCO 2017Beatty G et al, ASCO 2017Paiella S et al, Am J Gastroenterol 2019;114:665-70Paiella S et al, Am J Gastroenterol 2019;114:665-70Henrikson NB et al, Jama 2019;322:445-54Henrikson NB et al, Jama 2019;322:445-54Owens DK et al, Jama 2019;322:438-44Owens DK et al, Jama 2019;322:438-44Goggins M, et al, Gut 2020;69:7-17Goggins M, et al, Gut 2020;69:7-17Corral JE et al, Clin Gastroent Hepat 2019;17:41-53Corral JE et al, Clin Gastroent Hepat 2019;17:41-53Amodio A, et al, Pancreas 2019;48:544-7Amodio A, et al, Pancreas 2019;48:544-7Vanella et al, Pancreatology 2019;19:237-44Vanella et al, Pancreatology 2019;19:237-44Sharma A et al, Gastroenterology 2018;155:490-500Sharma A et al, Gastroenterology 2018;155:490-500Sah RP et al, Gastroenterology 2019;156:1742-52Sah RP et al, Gastroenterology 2019;156:1742-52Mueller AM et al, Pancreas 2018;47:807-15Mueller AM et al, Pancreas 2018;47:807-15Delshad et al., Gastroenterology 2020; 158: 1250-61Delshad et al., Gastroenterology 2020; 158: 1250-61Karamanolis et al., Dig Dis Sci 2008; 53: 2387-93Karamanolis et al., Dig Dis Sci 2008; 53: 2387-93Vaezi et al., Gastroenterology 2020; 158: 2093-103Vaezi et al., Gastroenterology 2020; 158: 2093-103Boeckxstaens et al., Lancet 2014; 383: 83-93Boeckxstaens et al., Lancet 2014; 383: 83-93Sediqi et al., Surgical Endoscopy, early online 4/2020Sediqi et al., Surgical Endoscopy, early online 4/2020Werner et al., NEJM 2019; 381; 2219-29Werner et al., NEJM 2019; 381; 2219-29Stanghellini et al., Gastroenterology 2016; 150: 1380-92Stanghellini et al., Gastroenterology 2016; 150: 1380-92Masuy et al., APT 2019; 49: 1134-72Masuy et al., APT 2019; 49: 1134-72Pittayanon et al., Am J Gastro 2019; 114: 233-243Pittayanon et al., Am J Gastro 2019; 114: 233-243Chey et al., Clin Transl Gastro 2019; 10(4)Chey et al., Clin Transl Gastro 2019; 10(4)Janssen et al., Am. J. Gastroenterol. 2013; 108(9):1382-91Janssen et al., Am. J. Gastroenterol. 2013; 108(9):1382-91Vijayvargiya et al., Gastroenterology. 2019; 156: 1650-60Vijayvargiya et al., Gastroenterology. 2019; 156: 1650-60Carbone et al., Am J Gastroenterol 2019; 114: 1265-74Carbone et al., Am J Gastroenterol 2019; 114: 1265-74Ducrotté et al., Gastroenterology 2020; 158: 506-14Ducrotté et al., Gastroenterology 2020; 158: 506-14Carlin et al., Gastroenterology; early online 7/2020Carlin et al., Gastroenterology; early online 7/2020Pasricha et al., Gastroenterology. 2018; 154: 65-76Pasricha et al., Gastroenterology. 2018; 154: 65-76Moayyedi et al., UEG Journal 2017; 5: 773-88Moayyedi et al., UEG Journal 2017; 5: 773-88Weerts et al., Gastroenterology 2020; 158: 123-36Weerts et al., Gastroenterology 2020; 158: 123-36Plasse et al., Am. J. Gastroenterol. 2020 Jun 24; online ahead of printPlasse et al., Am. J. Gastroenterol. 2020 Jun 24; online ahead of printDionne et al., Am. J. Gastroenterol. 2018; 113: 1290-1300Dionne et al., Am. J. Gastroenterol. 2018; 113: 1290-1300Barbara et al., Gastroenterology 2004; 126: 693-702Barbara et al., Gastroenterology 2004; 126: 693-702Fritscher-Ravens et al., Gastroenterology 2019; 157: 109-18 https://www.youtube.com/watch?v=Dim7YXYlRm0Fritscher-Ravens et al., Gastroenterology 2019; 157: 109-18 https://www.youtube.com/watch?v=Dim7YXYlRm0Xu et al., Am. J. Gastroenterol 2019; 114: 1043-50 25. Lahtinen et al., APT 2020; 51; 1321-31Xu et al., Am. J. Gastroenterol 2019; 114: 1043-50 25. Lahtinen et al., APT 2020; 51; 1321-31Holvoet et al., Gastroenterology 2020 Jul 15; S0016-5085(20)34937-4. Online ahead of print.Holvoet et al., Gastroenterology 2020 Jul 15; S0016-5085(20)34937-4. Online ahead of print.El-Salhy et al., Gut 2020; 69: 857-67El-Salhy et al., Gut 2020; 69: 857-67

The authors declare that there are no conflicts of interest present.