nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-186-2-88-93nogr-1567Research ArticleОБЗОРREVIEWНеобходимость индивидуального подбора пробиотиков, содержащих лактобацилы и энтерококки для повышения эффективности терапии кампилобактериозаThe need for individual selection of probiotics containing lactobacilli and enterococci to increase the effectiveness of therapy for campylobacteriosishttps://orcid.org/0000-0002-1730-8576ЕрмоленкоК. Д.ErmolenkoK. D.noemail@neicon.ruБолдыреваН. П.BoldyrevaN. P.noemail@neicon.ruhttps://orcid.org/0000-0001-6093-7493МартенсЭ. А.MartensE. A.noemail@neicon.ruhttps://orcid.org/0000-0001-8071-3243ЖелезоваЛ. И.ZhelezovaL. I.noemail@neicon.ruСидоренкоС. В.SidorenkoS. V.noemail@neicon.ruСуворовА. Н.SuvorovA. N.noemail@neicon.ruhttps://orcid.org/0000-0002-2569-6660ЕрмоленкоЕ. И.ErmolenkoE. I.lermolenko1@yandex.ruФГБУ ДНКЦИБ ФМБА РоссииРоссияPediatric Research and Clinical Center for Infectious DiseasesRussian FederationСанкт-Петербургский государственный университетРоссияSaint-Petersburg State UniversityRussian FederationСанкт-Петербургский государственный университет; ФГБНУ «Институт экспериментальной медицины»РоссияSaint-Petersburg State University; Institute of Experimental Medicine (FSBSI “IEM”)Russian Federation202107042021028893Copyright © Ермоленко К.Д., Болдырева Н.П., Мартенс Э.А., Железова Л.И., Сидоренко С.В., Суворов А.Н., Ермоленко Е.И., 20212021Ермоленко К.Д., Болдырева Н.П., Мартенс Э.А., Железова Л.И., Сидоренко С.В., Суворов А.Н., Ермоленко Е.И.Ermolenko K.D., Boldyreva N.P., Martens E.A., Zhelezova L.I., Sidorenko S.V., Suvorov A.N., Ermolenko E.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1567

В статье освещается проблема совершенствования рациональной терапии кампилобактериоза. В схемах лечения наряду с антибиотиками присутствуют пробиотики, которые в виде моно- или комплексной терапии имеют преимущества, так как они не нарушают кишечный микробиоценоз, а напротив, способны осуществлять коррекцию дисбиотических состояний. Также как антимикробные препараты пробиотики по-разному влияют на рост патогенных микроорганизмов. В обзоре приведены данные, полученные при исследовании влияния на рост клинических изолятов Campylobacter spp. пробиотиков в системе in vitro. В статье проведено исследование антикампилобактерной активности пробиотических культур Enterococcus faecium L3, Lactobacillus plantarum 8 R-A3, смеси Lactobacillus acidophilus и Saccharomyces boulardii методом двухслойного агара и капельным методом. Так же был проведен анализ антагонистической активности химически синтезированных бактериоцинов. Выявлена высокая чувствительность Campylobacter spp. к пробиотикам, содержащим лактобацилы и энтерококки, а также их метаболитам (в том числе бактериоцинам). Обнаружена штаммоспецифическая активность пробиотиков и ее зависимость от их способности продуцировать бактериоцины. Полученные результаты и данные других исследователей, проанализированные в статье, свидетельствуют о необходимости индивидуального подбора пробиотика для терапии кампилобактериоза, целесообразность анализа бактериоциногенности штаммов и тестирования их влияния на рост клинических изолятов.

The article highlights the problem of improving the rational treatment of campylobacteriosis. Probiotics are present in treatment regimens along with antibiotics, which have the advantage that they do not violate intestinal microbiocenosis and provide the ability to correct dysbiotic conditions. As well as antimicrobial agents, probiotics have different effects on the growth of pathogenic microorganisms. Campylobacter spp. probiotics in the in vitro system. The article studies the anticampylobacter activity of probiotic cultures of Enterococcus faecium L3, Lactobacillus plantarum 8 R-A3, a mixture of Lactobacillus acidophilus and Saccharomyces boulardii by two-layer agar and droplet method. Analysis of the antagonistic activity of chemically synthesized bacteriocins. The high sensitivity of Campylobacter spp was presented. to probiotics having lactobacilli and enterococci, as well as their metabolites (including bacteriocins). The strain-specific activity of probiotics and its dependence on their ability to produce bacteriocins were found. The results and data of other researchers indicate the need for individual selection of probiotics for the treatment of campylobacteriosis, the feasibility of analyzing the bacteriocinogenicity of the strains and testing their effect on the growth of clinical isolates.

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The authors declare that there are no conflicts of interest present.