nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-186-2-79-87nogr-1566Research ArticleКЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯCLINICAL GASTROENTEROLOGYСиндром избыточного бактериального роста с гипераммониемией как причина конгнитивных расстройствBacterial overgrowth syndrome with hyperammonemia as a cause of cognitive disordershttps://orcid.org/0000-0003-3105-4645ВологжанинаЛ. Г.VologzhaninaL. G.ludovica@mail.ruhttps://orcid.org/0000-0002-2411-8287БородинаЕ. Н.BorodinaE. N.noemail@neicon.ruhttps://orcid.org/0000-0001-9870-7132ИгумноваО. А.IgumnovaO. A.noemail@neicon.ruТрапезниковаА. А.TrapeznikovaA. A.noemail@neicon.ruФГБОУ ВО «Пермский государственный медицинский университет им. академика Е. А. Вагнера» Министерства здравоохранения Российской ФедерацииРоссияPerm State Medical University named after academician E. A. Vagner Ministry of Health care of RussiaRussian Federation202107042021027987Copyright © Вологжанина Л.Г., Бородина Е.Н., Игумнова О.А., Трапезникова А.А., 20212021Вологжанина Л.Г., Бородина Е.Н., Игумнова О.А., Трапезникова А.А.Vologzhanina L.G., Borodina E.N., Igumnova O.A., Trapeznikova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1566

Рост когнитивных нарушений (КН) в клинической практике заставляет проводить поиск их новых патогенетических механизмов, среди которых на сегодняшний день активно изучается влияние на головной мозг кишечной микробиоты. Механизмы взаимодействия оси «мозг - микробиота» окончательно не изучены. Целью данного исследования явилось подтверждение возможного влияния на мозг нейротоксина аммиака, повышающегося в крови вследствие синдрома избыточного бактериального роста (СИБР). Материалы и методы: В статье приводятся данные клинического наблюдения, включающего обследование 70 пациентов гастроцентра г. Перми с синдромом диспепсии, у которых проводилось изучение изменения кишечной микробиоты, уровня аммиака капиллярной крови и нарушений когнитивной сферы, проведен их корреляционный анализ. Результаты: По результатам статистического анализа полученных данных мы не обнаружили достоверных изменений или значимых корреляций между изучаемыми параметрами. Однако, выявленная тенденция в связи «СИБР - гипераммониемия - когнитивные нарушения» позволяет предположить, что наличие СИБР может усугублять тяжесть не только имеющихся гастроэнтерологических проявлений, но и являться фактором риска гипераммониемии, а также вносить свой вклад в формирование нарушений когнитивных функций человека.

The growth of cognitive impairment (CI) in clinical practice makes us search for their new pathogenetic mechanisms, among which the effect of intestinal microbiota on the brain is currently being actively studied. The mechanisms of interaction of the axis “brain - microbiota” have not been completely studied. The aim of this study was to confirm the possible effect on the brain of the neurotoxin ammonia, which rises in the blood due to the syndrome of excessive bacterial growth (SIBO). Materials and methods: The article presents data from a clinical observation, which included an examination of 70 patients of the gastrocenter in Perm with dyspepsia syndrome, who studied changes in the intestinal microbiota, the level of ammonia of capillary blood, and cognitive impairment, and conducted a correlation analysis. Results: According to the results of a statistical analysis of the obtained data, we did not find any significant changes or significant correlations between the studied parameters. However, the identified tendency in the connection “SIBO - hyperammonemia - cognitive impairment” suggests that the presence of SIBO can aggravate the severity of not only existing gastroenterological manifestations, but also be a risk factor for hyperammonemia, as well as contribute to the formation of impaired human cognitive functions.

кишечная микробиотаголовной мозгкогнитивные нарушениясиндром избыточного бактериального ростааммиакintestinal microbiotabraincognitive impairmentsmall bowel bacterial overgrowth syndromeammoniaReferencesEkusheva E. V. Cognitive impairment is a pressing interdisciplinary problem. Rus. med. Jour. 2018. Vol.12, no.1, pp. 32-37.@@ Екушева Е. В. Когнитивные нарушения - актуальная междисциплинарная проблема. Русс. мед. журн. - 2018. - Т. 12, № 1. - С. 32-37.Ekusheva E. V. Cognitive impairment is a pressing interdisciplinary problem. Rus. med. Jour. 2018. Vol.12, no.1, pp. 32-37.@@ Екушева Е. В. Когнитивные нарушения - актуальная междисциплинарная проблема. Русс. мед. журн. - 2018. - Т. 12, № 1. - С. 32-37.Markin S. P. Prevention and treatment of dementia. Rus. med. Jour. 2010, vol. 8, no.8, pp. 475-482.@@ Маркин С. П. Профилактика и лечение деменции. Русс. мед. журн. - 2010. - Т. 8, № 8. - С. 475-482.Markin S. P. Prevention and treatment of dementia. Rus. med. Jour. 2010, vol. 8, no.8, pp. 475-482.@@ Маркин С. П. Профилактика и лечение деменции. Русс. мед. журн. - 2010. - Т. 8, № 8. - С. 475-482.Zacharov V. V. Mild cognitive impairment. Diagnosis and treatment Rus. med. Jour. 2006, No. 9, pp. 685-689.@@ Захаров В. В. Умеренные когнитивные расстройства. Диагностика и лечение. Русс. мед. журн. - 2006. - № 9. - С. 685-689.Zacharov V. V. Mild cognitive impairment. Diagnosis and treatment Rus. med. Jour. 2006, No. 9, pp. 685-689.@@ Захаров В. В. Умеренные когнитивные расстройства. Диагностика и лечение. Русс. мед. журн. - 2006. - № 9. - С. 685-689.Sujata R, Susan D. Dementia and Cognitive Decline. Evidence Review, 2014, 38 р.Sujata R, Susan D. Dementia and Cognitive Decline. Evidence Review, 2014, 38 р.Global, regional, and national burden of Alzheimer`s disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet, 2019, Vol. 18, no.1, pp. 88-106. Doi: doi: 10.1016/S1474-4422(18)30403-4Global, regional, and national burden of Alzheimer`s disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet, 2019, Vol. 18, no.1, pp. 88-106. Doi: doi: 10.1016/S1474-4422(18)30403-4Prince M., Bryce R., Albanese E. et al. The global prevalence of dementia: a systematic review and meta-analysis. Alzheimers Dement. 2013, 2011, Vol. 9, no.1, pp.63-75.Prince M., Bryce R., Albanese E. et al. The global prevalence of dementia: a systematic review and meta-analysis. Alzheimers Dement. 2013, 2011, Vol. 9, no.1, pp.63-75.Colin Pritchard, Emily Rosenorn-Lanng. Neurological deaths of American adults (55-74) and the over 75's by sex compared with 20 Western countries 1989-2010: Cause for concern. Surgical Neurology International, 2015, Vol. 6, no.1, pp. 123. DOI: 10.4103/2152-7806.161420Colin Pritchard, Emily Rosenorn-Lanng. Neurological deaths of American adults (55-74) and the over 75's by sex compared with 20 Western countries 1989-2010: Cause for concern. Surgical Neurology International, 2015, Vol. 6, no.1, pp. 123. DOI: 10.4103/2152-7806.161420Early-Onset Dementia and Alzheimer’s Rates Grow for Younger Americans. Avalable at: https://www.bcbs.com/the-health-of-america/reports/early-onset-dementia-alzheimers-disease-affecting-younger-american-adults.Early-Onset Dementia and Alzheimer’s Rates Grow for Younger Americans. Avalable at: https://www.bcbs.com/the-health-of-america/reports/early-onset-dementia-alzheimers-disease-affecting-younger-american-adults.Golomb J., Kluger A., P. Garrard, Ferris S. Clinician’s manual on mild cognitive impairment. London: Science Press Ltd. 2001. 56 P.Golomb J., Kluger A., P. Garrard, Ferris S. Clinician’s manual on mild cognitive impairment. London: Science Press Ltd. 2001. 56 P.Petersеn P., Doody R., Kurz A. et al. Current concepts in mild cognitive impairment. Arch Neurol. 2001. Vol.58, pp.1985-1992.Petersеn P., Doody R., Kurz A. et al. Current concepts in mild cognitive impairment. Arch Neurol. 2001. Vol.58, pp.1985-1992.Rodríguez-Sánchez E., Mora-Simón S., Patino-Alonso M.C. et al. Prevalence of cognitive impairment in individuals aged over 65 in an urban area: DERIVA study. BMC Neurology, 2011, Vol. 11, 147 Р.Rodríguez-Sánchez E., Mora-Simón S., Patino-Alonso M.C. et al. Prevalence of cognitive impairment in individuals aged over 65 in an urban area: DERIVA study. BMC Neurology, 2011, Vol. 11, 147 Р.Michael Ganci, Emra Suleyman, Henry Butt, Michelle Ball.The role of the brain-gut-microbiota axis in psychology: The importance of considering gut microbiota in the development, perpetuation, and treatment of psychological disorders. Brain and Behavior, 2019, Vol. 9, no.11, pp. 1-19. doi: 10.1002/brb3.1408Michael Ganci, Emra Suleyman, Henry Butt, Michelle Ball.The role of the brain-gut-microbiota axis in psychology: The importance of considering gut microbiota in the development, perpetuation, and treatment of psychological disorders. Brain and Behavior, 2019, Vol. 9, no.11, pp. 1-19. doi: 10.1002/brb3.1408Kelly J. R., Clarke G., Cryan J. F., Dinan T. G. Brain-gut-microbiota axis: Challenges for translation in psychiatry. Annals of Epidemiology, 2016, Vol.26, no.5, pp. 366-372. doi: 10.1016/j.annepidem.2016.02.008Kelly J. R., Clarke G., Cryan J. F., Dinan T. G. Brain-gut-microbiota axis: Challenges for translation in psychiatry. Annals of Epidemiology, 2016, Vol.26, no.5, pp. 366-372. doi: 10.1016/j.annepidem.2016.02.008O’Hara AM, Shanahan F. The gut flora as a forgotten organ. EMBO, 2006, Rep 7, pp. 688-693.O’Hara AM, Shanahan F. The gut flora as a forgotten organ. EMBO, 2006, Rep 7, pp. 688-693.Campell, A. W. Autoimmunity and the gut. Autoimmune Diseases, 2014, pp. 1-12. doi: 10.1155/2014/152428Campell, A. W. Autoimmunity and the gut. Autoimmune Diseases, 2014, pp. 1-12. doi: 10.1155/2014/152428Linneberg A., Nielsen N. H., Madsen F., Frølund L. et al. Increasing prevalence of specific IgE to aeroallergens in an adult population: Two cross-sectional surveys 8 years apart: The Copenhagen Allergy Study. The Journal of Allergy and Clinical Immunology, 2000, Vol. 106, no.2, pp. 247-252. doi: 10.1067/mai.2000.108312Linneberg A., Nielsen N. H., Madsen F., Frølund L. et al. Increasing prevalence of specific IgE to aeroallergens in an adult population: Two cross-sectional surveys 8 years apart: The Copenhagen Allergy Study. The Journal of Allergy and Clinical Immunology, 2000, Vol. 106, no.2, pp. 247-252. doi: 10.1067/mai.2000.108312Broussard J. L., Devkota S. The changing microbial landscape of Western society: Diet, dwellings and discordance. Molecular Metabolism, 2016, Vol. 5, no.9, pp. 737-742. doi: 10.1016/j.molmet.2016.07.007Broussard J. L., Devkota S. The changing microbial landscape of Western society: Diet, dwellings and discordance. Molecular Metabolism, 2016, Vol. 5, no.9, pp. 737-742. doi: 10.1016/j.molmet.2016.07.007Gluckman P. D., Low F. M., Buklijas T., Hanson M. A., Beedle A. S. How evolutionary principles improve the understanding of human health and disease. Evolutionary Applications, 2011, Vol.4, no.2, pp. 249-263. doi: 10.1111/j.1752-4571.2010.00164.xGluckman P. D., Low F. M., Buklijas T., Hanson M. A., Beedle A. S. How evolutionary principles improve the understanding of human health and disease. Evolutionary Applications, 2011, Vol.4, no.2, pp. 249-263. doi: 10.1111/j.1752-4571.2010.00164.xUyeda J. C., Hansen T. F., Arnold S. J., Pienaar J. The million-year wait for macroevolutionary bursts. Proceedings of the National Academy of Sciences USA, 2011, Vol.108, no.38, pp. 15908-15913. doi: 10.1073/pnas.1014503108Uyeda J. C., Hansen T. F., Arnold S. J., Pienaar J. The million-year wait for macroevolutionary bursts. Proceedings of the National Academy of Sciences USA, 2011, Vol.108, no.38, pp. 15908-15913. doi: 10.1073/pnas.1014503108David L. A., Maurice C. F., Carmody R. N., Gootenberg D. B. et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature, 2014, Vol. 505, no.7484, pp. 559-563. doi: 10.1038/nature12820David L. A., Maurice C. F., Carmody R. N., Gootenberg D. B. et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature, 2014, Vol. 505, no.7484, pp. 559-563. doi: 10.1038/nature12820Grenham S., Clarke G., Cryan J. F., Dinan, T. G. Brain-gut-microbe communication in health and disease. Frontiers in Physiology, 2011, no.2, 94 Р. doi: 10.3389/fphys.2011.00094Grenham S., Clarke G., Cryan J. F., Dinan, T. G. Brain-gut-microbe communication in health and disease. Frontiers in Physiology, 2011, no.2, 94 Р. doi: 10.3389/fphys.2011.00094Rashad Alkasir, Jing Li, Xudong Li, et al. Human gut microbiota: the links with dementia development. Protein & Cell, 2017, vol. 8, Р. 90-102.Rashad Alkasir, Jing Li, Xudong Li, et al. Human gut microbiota: the links with dementia development. Protein & Cell, 2017, vol. 8, Р. 90-102.Carabotti M., Scirocco A., Maselli M. A., Severi C. The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology, 2015, Vol.28 no. 2, pp. 203-209.Carabotti M., Scirocco A., Maselli M. A., Severi C. The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology, 2015, Vol.28 no. 2, pp. 203-209.Smith P. M., Howitt M. R., Panikov N., Michaud M. et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science, Vol.341 no.6145, pp. 569-573. doi: 10.1126/science.1241165Smith P. M., Howitt M. R., Panikov N., Michaud M. et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science, Vol.341 no.6145, pp. 569-573. doi: 10.1126/science.1241165Bourassa M. W., Alim I., Bultman S. J., Ratan, R. R. Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health? Neuroscience Letters, 2016, Vol.625, pp. 56-63. doi: 10.1016/j.neulet.2016.02.009Bourassa M. W., Alim I., Bultman S. J., Ratan, R. R. Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health? Neuroscience Letters, 2016, Vol.625, pp. 56-63. doi: 10.1016/j.neulet.2016.02.009den Besten G., van Eunen K., Groen A. K., Venema K. et al. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research, 2013, Vol.54 no.9, pp. 2325-2340. doi: 10.1194/jlr.R036012den Besten G., van Eunen K., Groen A. K., Venema K. et al. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research, 2013, Vol.54 no.9, pp. 2325-2340. doi: 10.1194/jlr.R036012Sun J., Wang F., Li H., Zhang H. et al. Neuroprotective effect of sodium butyrate against cerebral ischemia/reperfusion injury in mice. BioMed Research International, 2015, 395895 p. doi: 10.1155/2015/395895Sun J., Wang F., Li H., Zhang H. et al. Neuroprotective effect of sodium butyrate against cerebral ischemia/reperfusion injury in mice. BioMed Research International, 2015, 395895 p. doi: 10.1155/2015/395895Hakansson A., Molin G. Gut microbiota and inflammation. Nutrients, 2011, Vol.3 no.6, pp. 637-682. doi: 10.3390/nu3060637Hakansson A., Molin G. Gut microbiota and inflammation. Nutrients, 2011, Vol.3 no.6, pp. 637-682. doi: 10.3390/nu3060637Anderson R. C., Cookson A. L., McNabb W. C., Park Z., et al. Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation. BMC Microbiology, 2010, Vol.10, 316 P. doi: 10.1186/1471-2180-10-316Anderson R. C., Cookson A. L., McNabb W. C., Park Z., et al. Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation. BMC Microbiology, 2010, Vol.10, 316 P. doi: 10.1186/1471-2180-10-316Bischoff S. C., Barbara G., Buurman W., Ockhuizen T., et al. Intestinal permeability - a new target for disease prevention and therapy. BMC Gastroenterology, 2014, Vol.14 no.1, 189 P. doi: 10.1186/s12876-014-0189-7Bischoff S. C., Barbara G., Buurman W., Ockhuizen T., et al. Intestinal permeability - a new target for disease prevention and therapy. BMC Gastroenterology, 2014, Vol.14 no.1, 189 P. doi: 10.1186/s12876-014-0189-7Berkes J., Viswanathan V. K., Savkovic S. D., Hecht, G. Intestinal epithelial responses to enteric pathogens: Effects on the tight junction barrier, ion transport, and inflammation. Gut, 2003, Vol.52 no.3, pp. 439-451. doi: 10.1136/gut.52.3.439Berkes J., Viswanathan V. K., Savkovic S. D., Hecht, G. Intestinal epithelial responses to enteric pathogens: Effects on the tight junction barrier, ion transport, and inflammation. Gut, 2003, Vol.52 no.3, pp. 439-451. doi: 10.1136/gut.52.3.439Fasano, A. Intestinal permeability and its regulation by zonulin: Diagnostic and therapeutic implications. Clinical Gastroenterology and Hepatology, 2012, Vol.10 no.10, pp. 1096-1100. doi: 10.1016/j.cgh.2012.08.012Fasano, A. Intestinal permeability and its regulation by zonulin: Diagnostic and therapeutic implications. Clinical Gastroenterology and Hepatology, 2012, Vol.10 no.10, pp. 1096-1100. doi: 10.1016/j.cgh.2012.08.012Braniste V., Al-Asmakh M., Kowal C., Anuar F. et al. The gut microbiota influences blood-brain barrier permeability in mice. Science Translational Medicine, 2014, Vol.6 no.263, 158 Р. doi: 10.1126/scitranslmed.3009759Braniste V., Al-Asmakh M., Kowal C., Anuar F. et al. The gut microbiota influences blood-brain barrier permeability in mice. Science Translational Medicine, 2014, Vol.6 no.263, 158 Р. doi: 10.1126/scitranslmed.3009759Kuhnke D., Jedlitschky G., Grube M., Krohn M. et al. MDR1-P-glycoprotein (ABCB1) mediates transport of Alzheimer’s Amyloid-β peptides - implications for the mechanisms of Aβ clearance at the blood-brain barrier. Brain Pathology, 2007, Vol.17 no.4, pp. 347-353. doi: 10.1111/j.1750-3639.2007.00075.xKuhnke D., Jedlitschky G., Grube M., Krohn M. et al. MDR1-P-glycoprotein (ABCB1) mediates transport of Alzheimer’s Amyloid-β peptides - implications for the mechanisms of Aβ clearance at the blood-brain barrier. Brain Pathology, 2007, Vol.17 no.4, pp. 347-353. doi: 10.1111/j.1750-3639.2007.00075.xByrne C. S., Chambers E. S., Morrison D. J., Frost, G. The role of short chain fatty acids in appetite regulation and energy homeostasis. International Journal of Obesity, 2015, Vol.39 no.9, pp. 1331-1338. doi: 10.1038/ijo.2015.84Byrne C. S., Chambers E. S., Morrison D. J., Frost, G. The role of short chain fatty acids in appetite regulation and energy homeostasis. International Journal of Obesity, 2015, Vol.39 no.9, pp. 1331-1338. doi: 10.1038/ijo.2015.84Chambers E. S., Viardot A., Psichas A., Morrison D. J. et al. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut, 2015, Vol. 64 no.11, pp. 1744-1754. doi: 10.1136/gutjnl-2014-307913Chambers E. S., Viardot A., Psichas A., Morrison D. J. et al. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut, 2015, Vol. 64 no.11, pp. 1744-1754. doi: 10.1136/gutjnl-2014-307913Kondo T., Kishi M., Fushimi T., Ugajin S., Kaga, T. Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects. Bioscience, Biotechnology, and Biochemistry, 2009. Vol.73, no.8, pp. 1837-1843. doi: 10.1271/bbb.90231Kondo T., Kishi M., Fushimi T., Ugajin S., Kaga, T. Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects. Bioscience, Biotechnology, and Biochemistry, 2009. Vol.73, no.8, pp. 1837-1843. doi: 10.1271/bbb.90231Morrison D. J., Preston, T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes, 2016, Vol.7 no.3, pp. 189-200. doi: 10.1080/19490976.2015.1134082Morrison D. J., Preston, T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes, 2016, Vol.7 no.3, pp. 189-200. doi: 10.1080/19490976.2015.1134082Clarke G., Stilling R. M., Kennedy P. J., Stanton C. et al. Minireview: Gut microbiota: The neglected endocrine organ. Molecular Endocrinology, 2014, Vol.28 no. 8, pp. 1221-1238. doi: 10.1210/me.2014-1108Clarke G., Stilling R. M., Kennedy P. J., Stanton C. et al. Minireview: Gut microbiota: The neglected endocrine organ. Molecular Endocrinology, 2014, Vol.28 no. 8, pp. 1221-1238. doi: 10.1210/me.2014-1108Evrensel A., Ceylan M. E. The gut-brain axis: The missing link in depression. Clinical Psychopharmacology and Neuroscience, 2015, Vol.13 no.3, pp. 239-244. doi: 10.9758/cpn.2015.13.3.239Evrensel A., Ceylan M. E. The gut-brain axis: The missing link in depression. Clinical Psychopharmacology and Neuroscience, 2015, Vol.13 no.3, pp. 239-244. doi: 10.9758/cpn.2015.13.3.239Jenkins T. A., Nguyen J. C., Polglaze K. E., Bertrand P. P. Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis. Nutrients, 2016, Vol.8 no.1, pp. 56. doi: 10.3390/nu8010056Jenkins T. A., Nguyen J. C., Polglaze K. E., Bertrand P. P. Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis. Nutrients, 2016, Vol.8 no.1, pp. 56. doi: 10.3390/nu8010056Zagajewski J., Drozdowicz D., Brzozowska I., Hubalewska-Mazgaj M. et al. Conversion L-tryptophan to melatonin in the gastrointestinal tract: The new high performance liquid chromatography method enabling simultaneous determination of six metabolites of L-tryptophan by native fluorescence and UV-VIS detection. Journal of Physiology and Pharmacology, 2012, Vol.63 no.6, pp. 613-621.Zagajewski J., Drozdowicz D., Brzozowska I., Hubalewska-Mazgaj M. et al. Conversion L-tryptophan to melatonin in the gastrointestinal tract: The new high performance liquid chromatography method enabling simultaneous determination of six metabolites of L-tryptophan by native fluorescence and UV-VIS detection. Journal of Physiology and Pharmacology, 2012, Vol.63 no.6, pp. 613-621.Welcome M. O. Current perspectives and mechanisms of relationship between intestinal microbiota dysfunction and dementia: A review. Dement Geriatr Cogn Disord Extra, 2018, no.8, pp. 360-381.Welcome M. O. Current perspectives and mechanisms of relationship between intestinal microbiota dysfunction and dementia: A review. Dement Geriatr Cogn Disord Extra, 2018, no.8, pp. 360-381.Cattaneo A. Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiology of Aging, 2017, no.49, pp. 60-68.Cattaneo A. Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiology of Aging, 2017, no.49, pp. 60-68.Gonzalez-Navajas J.M., Bellot P., Frances R., Zapater P. et al. Presence of bacterial-DNA in cirrhosis identifies a subgroup of patients with marked inflammatory response not related to endotoxin. J Hepatol, 2008, no.48, pp. 61-67. doi: 10.1016/j.jhep.2007.08.012Gonzalez-Navajas J.M., Bellot P., Frances R., Zapater P. et al. Presence of bacterial-DNA in cirrhosis identifies a subgroup of patients with marked inflammatory response not related to endotoxin. J Hepatol, 2008, no.48, pp. 61-67. doi: 10.1016/j.jhep.2007.08.012Zhao Y., Jaber V., Lukiw W. J. Secretory products of the human GI tract microbiome and their potential impact on Alzheimer’s disease (AD): detection of lipopolysaccharide (LPS) in AD hippocampus. Front Cell Infect Microbiol, 2017. no.7, 318 Р.Zhao Y., Jaber V., Lukiw W. J. Secretory products of the human GI tract microbiome and their potential impact on Alzheimer’s disease (AD): detection of lipopolysaccharide (LPS) in AD hippocampus. Front Cell Infect Microbiol, 2017. no.7, 318 Р.Paley E. L., Merkulova-Rainon T., Faynboym A., Shestopalov V. I., Aksenoff I. Geographical distribution and diversity of gut microbial NADH: ubiquinone oxidoreductase sequence associated with Alzheimer’s disease. J Alzheimers Dis, 2018, Vol.61 no.4, pp. 1531-1540.Paley E. L., Merkulova-Rainon T., Faynboym A., Shestopalov V. I., Aksenoff I. Geographical distribution and diversity of gut microbial NADH: ubiquinone oxidoreductase sequence associated with Alzheimer’s disease. J Alzheimers Dis, 2018, Vol.61 no.4, pp. 1531-1540.Biagi E., Nylund L., Candela M., Ostan R. et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One. 2010, no.5, 0010667 Р. doi: 10.1371/journal.pone.0010667Biagi E., Nylund L., Candela M., Ostan R. et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One. 2010, no.5, 0010667 Р. doi: 10.1371/journal.pone.0010667Balin B. J., Hudson A. P. Etiology and pathogenesis of late-onset Alzheimer’s disease. Curr Allergy Asthma Rep, 2014, no.14, pp. 013-0417. doi: 10.1007/s11882-013-0417-1Balin B. J., Hudson A. P. Etiology and pathogenesis of late-onset Alzheimer’s disease. Curr Allergy Asthma Rep, 2014, no.14, pp. 013-0417. doi: 10.1007/s11882-013-0417-1Lobzin V. Y., kolmakova K.A., Emelin A. Y. A new look at the pathogenesis of Alzheimer’s disease: current understanding of amyloid clearance. Review of Psychiatry and Medical Psychology. 2018, no.2, pp. 22-28. doi: 10.31363/2313-7053-2018-2-22-28@@ Лобзин В. Ю., Колмакова К. А., Емелин А. Ю. Новый взгляд на патогенез болезни Альцгеймера: современные представления о клиренсе амилоида. Обозрение психиатрии и медицинской психологии, 2018, no.2, С. 22-28. doi: 10.31363/2313-7053-2018-2-22-28Lobzin V. Y., kolmakova K.A., Emelin A. Y. A new look at the pathogenesis of Alzheimer’s disease: current understanding of amyloid clearance. Review of Psychiatry and Medical Psychology. 2018, no.2, pp. 22-28. doi: 10.31363/2313-7053-2018-2-22-28@@ Лобзин В. Ю., Колмакова К. А., Емелин А. Ю. Новый взгляд на патогенез болезни Альцгеймера: современные представления о клиренсе амилоида. Обозрение психиатрии и медицинской психологии, 2018, no.2, С. 22-28. doi: 10.31363/2313-7053-2018-2-22-28Hoban A. E., Stilling R. M., Ryan F. J., Shanahan F. et al. Regulation of prefrontal cortex myelination by the microbiota. Transl Psychiatry, 2016, no.5, 42 P.Hoban A. E., Stilling R. M., Ryan F. J., Shanahan F. et al. Regulation of prefrontal cortex myelination by the microbiota. Transl Psychiatry, 2016, no.5, 42 P.Lee Y. K., Menezes J. S., Umesaki Y., Mazmanian S. K. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA, 2011, no.1, pp. 4615-4622. doi: 10.1073/pnas.1000082107Lee Y. K., Menezes J. S., Umesaki Y., Mazmanian S. K. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA, 2011, no.1, pp. 4615-4622. doi: 10.1073/pnas.1000082107Schwartz K., Boles B. R. Microbial amyloids-functions and interactions within the host. Curr Opin Microbiol, 2013, no.16, pp. 93-99. doi: 10.1016/j.mib.2012.12.001Schwartz K., Boles B. R. Microbial amyloids-functions and interactions within the host. Curr Opin Microbiol, 2013, no.16, pp. 93-99. doi: 10.1016/j.mib.2012.12.001Hawkes C. H., Del Tredici K., Braak H. Parkinson’s disease: a dual-hit hypothesis. Neuropathol Appl Neurobiol, 2007, no.33, pp. 599-614. doi: 10.1111/j.1365-2990.2007.00874.xHawkes C. H., Del Tredici K., Braak H. Parkinson’s disease: a dual-hit hypothesis. Neuropathol Appl Neurobiol, 2007, no.33, pp. 599-614. doi: 10.1111/j.1365-2990.2007.00874.xBrenner SR. Blue-green algae or cyanobacteria in the intestinal micro-flora may produce neurotoxins such as Beta-N-Methylamino-l-Alanine (BMAA) which may be related to development of amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson-Dementia-Complex in humans and Equine Motor Neuron Disease in Horses. Med Hypotheses, 2013, no.80, 103 Р. doi: 10.1016/j.mehy.2012.10.010Brenner SR. Blue-green algae or cyanobacteria in the intestinal micro-flora may produce neurotoxins such as Beta-N-Methylamino-l-Alanine (BMAA) which may be related to development of amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson-Dementia-Complex in humans and Equine Motor Neuron Disease in Horses. Med Hypotheses, 2013, no.80, 103 Р. doi: 10.1016/j.mehy.2012.10.010Tran L., Greenwood-Van Meerveld B. Age-associated remodeling of the intestinal epithelial barrier. J Gerontol A Biol Sci Med Sci, 2013, no.68, pp. 1045-1056. doi: 10.1093/gerona/glt106Tran L., Greenwood-Van Meerveld B. Age-associated remodeling of the intestinal epithelial barrier. J Gerontol A Biol Sci Med Sci, 2013, no.68, pp. 1045-1056. doi: 10.1093/gerona/glt106Parodi A., Paolino S., Greco A., Drago F. et al. Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication. Clin Gastroenter Hepatol, 2008, no.6, Р. 759-764. doi: 10.1016/j.cgh.2008.02.054Parodi A., Paolino S., Greco A., Drago F. et al. Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication. Clin Gastroenter Hepatol, 2008, no.6, Р. 759-764. doi: 10.1016/j.cgh.2008.02.054Nursing-Standard Evidence suggests rosacea may be linked to Parkinson’s and Alzheimer’s disease. Nursing Standard, 2016, Vol.30 no.39, 14 Р.Nursing-Standard Evidence suggests rosacea may be linked to Parkinson’s and Alzheimer’s disease. Nursing Standard, 2016, Vol.30 no.39, 14 Р.Forsythe P., Bienenstock J., Kunze W. A. Vagal pathways for microbiome-brain-gut axis communication. Adv Exp Med Biol, 2014, no.817, pp. 115-133. doi: 10.1007/978-1-4939-0897-4_5Forsythe P., Bienenstock J., Kunze W. A. Vagal pathways for microbiome-brain-gut axis communication. Adv Exp Med Biol, 2014, no.817, pp. 115-133. doi: 10.1007/978-1-4939-0897-4_5Galland L. The gut microbiome and the brain. J Med Food, 2014, no.17, pp. 1261-1272. doi: 10.1089/jmf.2014.7000Galland L. The gut microbiome and the brain. J Med Food, 2014, no.17, pp. 1261-1272. doi: 10.1089/jmf.2014.7000

The authors declare that there are no conflicts of interest present.