nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-183-11-126-139nogr-1485Research ArticleОБЗОРREVIEWГерпесвирусы и воспалительные заболевания кишечникаHerpesvirus and inflammatory bowel diseasehttps://orcid.org/0000-0002-5413-9599ВолынецГ. В.VolynetsG. V.

Волынец Галина Васильевна, д. м. н., заведующая отделом гастроэнтерологии, главный научный сотрудник ОСП НИКИ педиатрии им. академика Ю. Е. Вельтищева

125412, Москва, Талдомская улица, дом 2

Galina V. Volynets, MD, PhD, Dr. Sci, Chief Researcher, Head of the Department of Gastroenterology of the Veltischev

125412, Moscow, Taldomskaya street, 2

https://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinA. I.

Хавкин Анатолий Ильич, д. м. н., профессор, главный научный сотрудник отдела гастроэнтерологии ОСП НИКИ педиатрии им. академика Ю. Е. Вельтищева

125412, Москва, Талдомская улица, дом 2

Anatoly I. Khavkin, MD, PhD, Dr. Sci, Professor, Chief Researcher Department of Gastroenterology of the Veltischev

125412, Moscow, Taldomskaya street, 2

gastropedclin@gmail.comhttps://orcid.org/0000-0001-8837-9243НикитинА. В.NikitinA. V.

Никитин Артём Вячеславович, к. м. н., ведущий научный сотрудник отдела гастроэнтерологии ОСП НИКИ педиатрии им. академика Ю. Е. Вельтищева

125412, Москва, Талдомская улица, дом 2

Artyom V. Nikitin, Ph D. Lead researcher Department of Gastroenterology of the Veltischev; Assistant of the Department of Gastroenterology

125412, Moscow, Taldomskaya street, 2

Российский национальный исследовательский медицинский университет им. Н. И. ПироговаРоссияPirogov Russian National Research Medical UniversityRussian Federation20201411202018311126139Copyright © Волынец Г.В., Хавкин А.И., Никитин А.В., 20202020Волынец Г.В., Хавкин А.И., Никитин А.В.Volynets G.V., Khavkin A.I., Nikitin A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1485Цель

Цель. Провести обзор исследований, характеризующих роль герпесвирусных инфекций в патогенезе воспалительных заболеваний кишечника (ВЗК).

Введение

Введение. Изучение роли герпесвирусных инфекций в патогенезе ВЗК в настоящее время вызывает значительный интерес исследователей разных стран.

Результат

Результат. Приведены результаты исследований о значении вирусов герпеса человека (HHV) при воспалительных заболеваниях кишечника (ВЗК) — язвенном колите (ЯК) и болезни Крона (БК), их влиянии на течение этих заболеваний, рефрактерности к лечению ЯК и БК в присутствии HHV. Показано, что большинство исследователей единодушно приходят к выводу о том, что основное внимание необходимо уделять вирусу Эпштейна-Барр (EBV), цитомегаловирусу (CMV) и вирусу герпеса человека 6 типа (HHV-6), которые обнаруживаются в слизистой оболочке толстой кишки у пациентов с ВЗК и влияют как на течение заболеваний, так и на эффективность лечения. Акцентируется внимание на том, что необходимо дифференцировать колит, обусловленный HHV, и ВЗК, протекающие на фоне реактивации HHV, так как подходы к терапии этих состояний различны.

Заключение

Заключение. Необходимы целенаправленные исследования на изучение роли герпесвирусов человека в патогенезе ВЗК.

Aim

Aim. Conduct a review of studies characterizing the role of herpesvirus infections in the pathogenesis of inflammatory bowel disease (IBD).

Introduction

Introduction. The study of the role of herpes virus infections in the pathogenesis of inflammatory bowel disease (IBD) is currently of considerable interest to researchers from different countries.

Result

Result. The results of studies on the significance of human herpes viruses (HHV) in inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn’s disease (CD), their effect on the course of these diseases, and refractory treatment of UC and CD in the presence of HHV are presented.It is shown that most researchers unanimously conclude that the main attention should be paid to Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human herpes simplex virus type 6 (HHV-6), which are found in the mucous membrane of the colon in patients with IBD and affect both the course of the disease and the effectiveness of the treatment. Attention is focused on the fact that it is necessary to differentiate colitis due to HHV and IBD, proceeding against the background of HHV reactivation, since approaches to the treatment of these conditions are different.

Conclusion

Conclusion. Requires targeted research on the role of human herpes viruses in the pathogenesis of IBD.

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The authors declare that there are no conflicts of interest present.